LOCUS       NM_001769               1225 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens CD9 molecule (CD9), transcript variant 1, mRNA.
ACCESSION   NM_001769
VERSION     NM_001769.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Huang,W., Zhang,Z., Li,X., Zheng,Q., Wu,C., Liu,L., Chen,Y.,
            Zhang,J. and Jiang,X.
  TITLE     CD9 promotes TbetaR2-TbetaR1 association driving the transition of
            human dermal fibroblasts to myofibroblast under hypoxia
  JOURNAL   Mol Med 30 (1), 162 (2024)
   PUBMED   39333849
  REMARK    GeneRIF: CD9 promotes TbetaR2-TbetaR1 association driving the
            transition of human dermal fibroblasts to myofibroblast under
            hypoxia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Zhang,C., Chan,K.Y.Y., Ng,W.H., Cheung,J.T.K., Sun,Q., Wang,H.,
            Chung,P.Y., Cheng,F.W.T., Leung,A.W.K., Zhang,X.B., Lee,P.Y.,
            Fok,S.P., Lin,G., Poon,E.N.Y., Feng,J.H., Tang,Y.L., Luo,X.Q.,
            Huang,L.B., Kang,W., Tang,P.M.K., Huang,J., Chen,C., Dong,J.,
            Mejstrikova,E., Cai,J., Liu,Y., Shen,S., Yang,J.J., Yuen,P.M.P.,
            Li,C.K. and Leung,K.T.
  TITLE     CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor
            acute lymphoblastic leukemia
  JOURNAL   Haematologica 109 (9), 2833-2845 (2024)
   PUBMED   38572553
  REMARK    GeneRIF: CD9 shapes glucocorticoid sensitivity in pediatric B-cell
            precursor acute lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   Suhasini,P.C., Bhat,V., Shetty,S.S., Shetty,P.K., Roopashree,P.G.
            and Kumari,N.S.
  TITLE     High expression of CD9 and Epidermal Growth Factor Receptor
            promotes the development of tongue cancer
  JOURNAL   Med Oncol 41 (4), 86 (2024)
   PUBMED   38472425
  REMARK    GeneRIF: High expression of CD9 and Epidermal Growth Factor
            Receptor promotes the development of tongue cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   Leung,K.T., Cai,J., Liu,Y., Chan,K.Y.Y., Shao,J., Yang,H., Hu,Q.,
            Xue,Y., Wu,X., Guo,X., Zhai,X., Wang,N., Li,X., Tian,X., Li,Z.,
            Xue,N., Guo,Y., Wang,L., Zou,Y., Xiao,P., He,Y., Jin,R., Tang,J.,
            Yang,J.J., Shen,S., Pui,C.H. and Li,C.K.
  TITLE     Prognostic implications of CD9 in childhood acute lymphoblastic
            leukemia: insights from a nationwide multicenter study in China
  JOURNAL   Leukemia 38 (2), 250-257 (2024)
   PUBMED   38001171
  REMARK    GeneRIF: Prognostic implications of CD9 in childhood acute
            lymphoblastic leukemia: insights from a nationwide multicenter
            study in China.
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Ondrussek,R., Brychtova,S., Bezdekova,M., Bouchalova,K.,
            Vavrova,Z., Soucek,K. and Bouchal,J.
  TITLE     Immunohistochemical analysis of CD9, CD29 and epithelial to
            mesenchymal transition in triple-negative breast cancer
  JOURNAL   Klin Onkol 38 (1), 50-56 (2024)
   PUBMED   39183551
  REMARK    GeneRIF: Immunohistochemical analysis of CD9, CD29 and epithelial
            to mesenchymal transition in triple-negative breast cancer.
REFERENCE   6  (bases 1 to 1225)
  AUTHORS   Rubinstein,E., Benoit,P., Billard,M., Plaisance,S., Prenant,M.,
            Uzan,G. and Boucheix,C.
  TITLE     Organization of the human CD9 gene
  JOURNAL   Genomics 16 (1), 132-138 (1993)
   PUBMED   8486348
REFERENCE   7  (bases 1 to 1225)
  AUTHORS   Ninomiya,H. and Sims,P.J.
  TITLE     The human complement regulatory protein CD59 binds to the
            alpha-chain of C8 and to the 'b'domain of C9
  JOURNAL   J Biol Chem 267 (19), 13675-13680 (1992)
   PUBMED   1377690
REFERENCE   8  (bases 1 to 1225)
  AUTHORS   Miyake,M., Koyama,M., Seno,M. and Ikeyama,S.
  TITLE     Identification of the motility-related protein (MRP-1), recognized
            by monoclonal antibody M31-15, which inhibits cell motility
  JOURNAL   J Exp Med 174 (6), 1347-1354 (1991)
   PUBMED   1720807
REFERENCE   9  (bases 1 to 1225)
  AUTHORS   Horejsi,V. and Vlcek,C.
  TITLE     Novel structurally distinct family of leucocyte surface
            glycoproteins including CD9, CD37, CD53 and CD63
  JOURNAL   FEBS Lett 288 (1-2), 1-4 (1991)
   PUBMED   1879540
  REMARK    Review article
REFERENCE   10 (bases 1 to 1225)
  AUTHORS   Boucheix,C., Benoit,P., Frachet,P., Billard,M., Worthington,R.E.,
            Gagnon,J. and Uzan,G.
  TITLE     Molecular cloning of the CD9 antigen. A new family of cell surface
            proteins
  JOURNAL   J Biol Chem 266 (1), 117-122 (1991)
   PUBMED   1840589
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM763066.1, X60111.1 and
            AI003581.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001769.3.
            
            Summary: This gene encodes a member of the transmembrane 4
            superfamily, also known as the tetraspanin family. Tetraspanins are
            cell surface glycoproteins with four transmembrane domains that
            form multimeric complexes with other cell surface proteins. The
            encoded protein functions in many cellular processes including
            differentiation, adhesion, and signal transduction, and expression
            of this gene plays a critical role in the suppression of cancer
            cell motility and metastasis. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1
            and 5 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.5906.1,
                                           SRR5189652.106102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000009180.10/ ENSP00000009180.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BM763066.1         85-117
            34-1109             X60111.1           45-1120
            1110-1225           AI003581.1         13-128              c
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1225
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /note="CD9 molecule"
                     /db_xref="GeneID:928"
                     /db_xref="HGNC:HGNC:1709"
                     /db_xref="MIM:143030"
     exon            1..166
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..787
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     motility related protein-1; leukocyte antigen MIC3; 5H9
                     antigen; BA-2/p24 antigen; CD9 antigen (p24); antigen CD9;
                     tetraspanin-29; cell growth-inhibiting gene 2 protein"
                     /codon_start=1
                     /product="CD9 antigen isoform 1"
                     /protein_id="NP_001760.1"
                     /db_xref="CCDS:CCDS8540.1"
                     /db_xref="GeneID:928"
                     /db_xref="HGNC:HGNC:1709"
                     /db_xref="MIM:143030"
                     /translation="MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSI
                     FEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAI
                     EIAAAIWGYSHKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVE
                     QFISDICPKKDVLETFTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILC
                     CAIRRNREMV"
     exon            167..275
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /inference="alignment:Splign:2.1.0"
     exon            276..373
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /inference="alignment:Splign:2.1.0"
     exon            374..448
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /inference="alignment:Splign:2.1.0"
     exon            449..547
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /inference="alignment:Splign:2.1.0"
     exon            548..637
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /inference="alignment:Splign:2.1.0"
     exon            638..721
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /inference="alignment:Splign:2.1.0"
     exon            722..1225
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1199..1204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /note="hexamer: AATAAA"
     polyA_site      1225
                     /gene="CD9"
                     /gene_synonym="BTCC-1; DRAP-27; MIC3; MRP-1; TSPAN-29;
                     TSPAN29"
                     /note="major polyA site"
ORIGIN      
        1 agccgcctgc atctgtatcc agcgccaggt cccgccagtc ccagctgcgc gcgcccccca
       61 gtcccgcacc cgttcggccc aggctaagtt agccctcacc atgccggtca aaggaggcac
      121 caagtgcatc aaatacctgc tgttcggatt taacttcatc ttctggcttg ccgggattgc
      181 tgtccttgcc attggactat ggctccgatt cgactctcag accaagagca tcttcgagca
      241 agaaactaat aataataatt ccagcttcta cacaggagtc tatattctga tcggagccgg
      301 cgccctcatg atgctggtgg gcttcctggg ctgctgcggg gctgtgcagg agtcccagtg
      361 catgctggga ctgttcttcg gcttcctctt ggtgatattc gccattgaaa tagctgcggc
      421 catctgggga tattcccaca aggatgaggt gattaaggaa gtccaggagt tttacaagga
      481 cacctacaac aagctgaaaa ccaaggatga gccccagcgg gaaacgctga aagccatcca
      541 ctatgcgttg aactgctgtg gtttggctgg gggcgtggaa cagtttatct cagacatctg
      601 ccccaagaag gacgtactcg aaaccttcac cgtgaagtcc tgtcctgatg ccatcaaaga
      661 ggtcttcgac aataaattcc acatcatcgg cgcagtgggc atcggcattg ccgtggtcat
      721 gatatttggc atgatcttca gtatgatctt gtgctgtgct atccgcagga accgcgagat
      781 ggtctagagt cagcttacat ccctgagcag gaaagtttac ccatgaagat tggtgggatt
      841 ttttgtttgt ttgttttgtt ttgtttgttg tttgttgttt gtttttttgc cactaatttt
      901 agtattcatt ctgcattgct agataaaagc tgaagttact ttatgtttgt cttttaatgc
      961 ttcattcaat attgacattt gtagttgagc ggggggtttg gtttgctttg gtttatattt
     1021 tttcagttgt ttgtttttgc ttgttatatt aagcagaaat cctgcaatga aaggtactat
     1081 atttgctaga ctctagacaa gatattgtac ataaaagaat ttttttgtct ttaaatagat
     1141 acaaatgtct atcaacttta atcaagttgt aacttatatt gaagacaatt tgatacataa
     1201 taaaaaatta tgacaatgtc ctgga
//
