LOCUS       NM_001349727            4851 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens CD8B family member 2 (CD8B2), transcript variant 1,
            mRNA.
ACCESSION   NM_001349727
VERSION     NM_001349727.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4851)
  AUTHORS   Dougherty,M.L., Underwood,J.G., Nelson,B.J., Tseng,E., Munson,K.M.,
            Penn,O., Nowakowski,T.J., Pollen,A.A. and Eichler,E.E.
  TITLE     Transcriptional fates of human-specific segmental duplications in
            brain
  JOURNAL   Genome Res 28 (10), 1566-1576 (2018)
   PUBMED   30228200
REFERENCE   2  (bases 1 to 4851)
  AUTHORS   Zhang,X.L., Heng,H.H., Yang,Y., Tsui,L.C., Parnes,J.R. and
            Chamberlain,J.W.
  TITLE     Chromosomal mapping of the second human CD8B gene locus
  JOURNAL   Immunogenetics 43 (4), 220-226 (1996)
   PUBMED   8575821
REFERENCE   3  (bases 1 to 4851)
  AUTHORS   Delarbre,C., Nakauchi,H., Bontrop,R., Kourilsky,P. and Gachelin,G.
  TITLE     Duplication of the CD8 beta-chain gene as a marker of the
            man-gorilla-chimpanzee clade
  JOURNAL   Proc Natl Acad Sci U S A 90 (15), 7049-7053 (1993)
   PUBMED   8346216
REFERENCE   4  (bases 1 to 4851)
  AUTHORS   DiSanto,J.P., Smith,D., de Bruin,D., Lacy,E. and Flomenberg,N.
  TITLE     Transcriptional diversity at the duplicated human CD8 beta loci
  JOURNAL   Eur J Immunol 23 (2), 320-326 (1993)
   PUBMED   8436166
REFERENCE   5  (bases 1 to 4851)
  AUTHORS   Nakayama,K., Kawachi,Y., Tokito,S., Minami,N., Yamamoto,R.,
            Imai,T., Gachelin,G. and Nakauchi,H.
  TITLE     Recent duplication of the two human CD8 beta-chain genes
  JOURNAL   J Immunol 148 (6), 1919-1927 (1992)
   PUBMED   1541829
REFERENCE   6  (bases 1 to 4851)
  AUTHORS   Tunnacliffe,A., Kefford,R., Milstein,C., Forster,A. and
            Rabbitts,T.H.
  TITLE     Sequence and evolution of the human T-cell antigen receptor
            beta-chain genes
  JOURNAL   Proc Natl Acad Sci U S A 82 (15), 5068-5072 (1985)
   PUBMED   3860845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY085838.1, CA867855.1 and AC108868.4.
            
            On May 17, 2019 this sequence version replaced NM_001349727.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.257842.1,
                                           SRR7410570.205435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643224.2/ ENSP00000496416.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               HY085838.1         10-352
            344-699             CA867855.1         199-554
            700-4851            AC108868.4         34634-38785
FEATURES             Location/Qualifiers
     source          1..4851
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.2"
     gene            1..4851
                     /gene="CD8B2"
                     /gene_synonym="CD8BP"
                     /note="CD8B family member 2"
                     /db_xref="GeneID:927"
                     /db_xref="HGNC:HGNC:1708"
     exon            1..106
                     /gene="CD8B2"
                     /gene_synonym="CD8BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..696
                     /gene="CD8B2"
                     /gene_synonym="CD8BP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD8 antigen, beta polypeptide pseudogene; CD8b
                     pseudogene; putative T-cell surface glycoprotein CD8
                     beta-2 chain; CD8b molecule pseudogene; CD8b2 molecule"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD8 beta-2 chain
                     isoform 1 precursor"
                     /protein_id="NP_001336656.1"
                     /db_xref="CCDS:CCDS86870.1"
                     /db_xref="GeneID:927"
                     /db_xref="HGNC:HGNC:1708"
                     /translation="MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAK
                     ISLSNMCIYWLRQRQAPSSDSHHEFLTLWDSAKGTIHGEEVEQEKIAVFRDASRFILN
                     LTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRP
                     ETQKGPLCSPVTLGLLVAGVLVLLVSLGVAMHLCCRRRRARLRFMKQFYK"
     exon            107..466
                     /gene="CD8B2"
                     /gene_synonym="CD8BP"
                     /inference="alignment:Splign:2.1.0"
     exon            467..556
                     /gene="CD8B2"
                     /gene_synonym="CD8BP"
                     /inference="alignment:Splign:2.1.0"
     exon            557..646
                     /gene="CD8B2"
                     /gene_synonym="CD8BP"
                     /inference="alignment:Splign:2.1.0"
     exon            647..683
                     /gene="CD8B2"
                     /gene_synonym="CD8BP"
                     /inference="alignment:Splign:2.1.0"
     exon            684..4851
                     /gene="CD8B2"
                     /gene_synonym="CD8BP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccacccca gccgcgactg tctccgccga gcccccgggg ccaggtgtcc cgggcgcgcc
       61 ccgatgcggc cgcggctgtg gctcctcctg gccgcgcagc tgacagttct ccatggcaac
      121 tcagtcctcc agcagacccc tgcatacata aaggtgcaaa ccaacaagat ggtgatgctg
      181 tcctgcgagg ctaaaatctc cctcagtaac atgtgcatct actggctgag acagcgccag
      241 gccccgagca gtgatagtca ccacgagttc ctgaccctct gggattccgc aaaagggact
      301 atccacggtg aagaggtgga acaggagaag atagctgtgt ttcgggatgc aagccggttc
      361 attctcaatc tcacaagcgt gaagccggag gacagtggca tctacttctg catgatcgtc
      421 gggagccccg agctgacctt cgggaaggga actcagctga gtgtggttga tttccttccc
      481 accactgccc agcccaccaa gaagtccacc ctcaagaaga gagtgtgccg gttacccagg
      541 ccagagaccc agaagggccc actttgtagc cccgtcaccc ttggcctgct ggtggctggc
      601 gtcctggttc tgctggtttc cctgggagtg gccatgcacc tgtgctgccg gcggaggaga
      661 gcccggcttc gtttcatgaa acaattttac aaatgagcag agaatacggt tttggtgtcc
      721 tgctacaaaa agacatcggt cagtaacgag cacgatgtgg aaaaatgaga gaagggacac
      781 attcaaccct ggagagttca atggctgctg aagctgcctg cttttcactg ctgcaaggcc
      841 tttctgtgtg tgacgtgcat gggagcaact tgtttgtggg tcatcgggaa tactagggag
      901 aaggtttcat tgcccccagg gcacttcaca gagtgtgctg gaggactgag taagaaatgc
      961 tgcccatgcc accgcttccg gctcctgtgc tttccctgag ctgggacctt tagtggtggc
     1021 cgtttagcca ccatctttgc aagttgcttt gccctggtag ggcagtaaca ttgggtcctg
     1081 ggtctttcat ggggtgatgc tgggctggct ccctcttggt cttcccaggc tggggctgac
     1141 cttcctcgca gagaggccag gtgcaggttg ggaatgaggc ttgctgagag gggctgtcca
     1201 gttcccagaa gccatgtcag tctctgaggg cttcctttgg ggccgggaac ttgcgggttt
     1261 gaggatagga gttcacttca tcttcttagc tccaatttct actcttaagt ttctcagctc
     1321 ccatttctac tctcccatgg cttaatgctt ctttcatttt ctgtttgttt tatacaaatg
     1381 tcttagttgt acaaataaag tcccaggtta aagataacaa acgggtcctg tgacataaac
     1441 gtacgaaagc ccatctacag caaagacatc agtgctcagt ggaacagaaa ccagaaggag
     1501 aaaatttgta catcctcctt ttgcacctga gatcctcatt tgcccgacat tgtaggtgtg
     1561 gagagtccta gagaggctag gaagcgccca gggcacccag agccaggctg caggtgcctc
     1621 aggcccctct cccagcccac tcccaagctg aactagcacg tgttcatttc taccgcgggt
     1681 tgaaccgcag ggatccctgg cttcaagtca ggcaccaaac agaaggtagg aggcatgagg
     1741 ggttctgtca catgtctctt cattttctta ttgattctta gccttgacag ttggagaagg
     1801 aaaaagcaag gagaaagtgc tgagcaggag tggagagtga agagcaggac ctcgtgcctg
     1861 ggtttgaaaa agtgcctgag acccatctta gccgccccta cctgagcttt agcagcctag
     1921 gagctattgc accataaaac actgcaacct gaggctgcat taacagaagc accacgtcca
     1981 ggtccaggga gaatccagcc tcacctgctt ctcctggcca gctcaaggaa ggacattgac
     2041 aaatcaggtt atgttcagtt acctgtgaca accacagaat gtaagaaatg ttacaaaaaa
     2101 aacaggaaag gaaagacgac tctggggaag gggcagtggg accttctcct ggcatctggg
     2161 gtgcggccgc agcagaatga ggtgtggtgg gtggagttag aaaggcatag atgcagtgtt
     2221 accggaagga gggccttgag tgtaagttgt ccaggtcctt ggcattttga acaaagaact
     2281 gaacaaaaca tacaaagtaa taaaggaata aacgcagcaa aaggaagaat ttattgaagt
     2341 gagaaagcac tccacatggt aggagtggac cctaagcaga tagcccatgg gcccaattgc
     2401 aaagttttct gggttttaag tacccctttt gaggtacctg tcggctaccc cttaatctgg
     2461 gtgaaggatt tggtccatgg ctaatgaaag gctgaggtga attgacgccc tatgcggatg
     2521 aagggatggc ccgtgcttgg tctgtggtca atccagggca gtctcccttt ccatctgaga
     2581 tgcagtggaa gggggagggt tgtagggaga gtagcctttg atccttggtt actcagtgtg
     2641 gggagatggg gtttttcctt ttggtgtacg ttaattggcc ttagatgccc tgcccccaga
     2701 cccaggtgtt ttccgtttgc tccagctttg agaagtcagc acaaattggc ctcagattcc
     2761 ctgcccccag acgtaggtgt ttctccttca ttcagcacga attggcctta gatgccctgc
     2821 ccccagaccc aggtgttttc catttgatcc agctttgaga agtcagcaca aattggcctc
     2881 agattccctg cccccagaca tagatgtttc tccttgattc agcacgaatt ggccttagat
     2941 tccctggccc cagaccctag actcctgcct cagcaagagt tgttcaaaag aaacaaaagc
     3001 tctgcccatc agctctgagg acaagggaca ggctgccttc caaggctgag gggaggggtg
     3061 aaagaattgg ggtcagctgg accagactcc tctagggttc gtgtttcagg tgggcccctc
     3121 acccggccca tcacaaacaa ataagagatt aaggcctgca gtgcacgtgg tctgccctcc
     3181 ttgaaggctc acacccagtg cacagcggaa gtaagaacag gccacaaggc cccttgtccc
     3241 actgcaggct ttgaaatttg accatctccc tgctgctgtc tttgcaattg catgtacttg
     3301 ttcacaagtt ctcatggggt tgggctgggg gcaggggtgg tttgtgctcc tccgtcagtt
     3361 ttctgtgcag caggcacctg ccgaggcggg ctcagctccg gccacccagg gagctggagc
     3421 aggctgggct gccaatggtg ggggctgcag tgagaaggtc tgcacccagc acctgacctt
     3481 tgtttgaaga aggaactgag ctgctactac actctatagg gccattatga tgaaatatgc
     3541 cccccaaact ccatccagct atcttttgac tagcagttcc acttgttggc atttatctga
     3601 aagaaataca tcaaaaagtg gcatgcacaa agaaatacgc atcagattgt tccttctagt
     3661 gctgcttact agctaaaaat gggaaataat ccaaatgtcc atcaaaaggg actggtcaga
     3721 taaattcaga cacagtctaa taagggggtt taggcggctg ctaaggaatg agctagatcc
     3781 atatatgctg atatcaaatg atggtcatga caaatgcata tatttttaaa acatctgtat
     3841 agattattct taatacaata tatggcgcaa tacgtagtca ctgttaaaat tcaagcacag
     3901 aagaaaacaa gcaaaacaaa tatatgttgt tagaagttag gatacagtta cccttggtcc
     3961 agtgatggtc attaggaggg agcatgaggt ttgaaggtga gcgtttctgc ttctcaatct
     4021 gggaatcact tatatgagtg tgtttcatta gtaaaagtca tcaagctgta cactcagata
     4081 tgttgacttt agagctatgg atatagatgt aaattatact tcaagaaaga gactttttaa
     4141 aatccaagta cagaacattg tagaaccgtg taaaattggt atttggaagt ttcttcagca
     4201 agcacatggg attacagctc atgcctgtaa tcccagtact ttgggaggcc cacacagaat
     4261 gatcacttga gctcaggagt ttgagagcag cctaggcaac atagcaagac ctcgactcta
     4321 caaaaaattt ttaaattttt ttctgggcat ggtggtgctt gcctggagtc ccagctatta
     4381 gggaggatga ggtgggagga tctcctgagc ccaggagttt gagactgcag tgagctgtga
     4441 tcacgccact gcactccagc ctgggcaaca cagacagacc ttgtctcaaa aataaatttt
     4501 ttctaaaaaa agtttcttgt ttttttttct tcccatattt tttaaaacat aaaattgaaa
     4561 tctcgagaat ataatacata aaatagagaa tatagaaaat taaatcttct aatattgttc
     4621 tgcagatttg atcttttttc tctaataata aatcaaggcc tccgggtata tttgtttgta
     4681 tatgtacagg aaaaggtctg taaggattta ctttcagctg ttaattgcag tgactctggg
     4741 gaatttccac ttctgctttg tacagttcct tgtgtgaatt tttacatcat gtattacttt
     4801 tgtagttggg gaaaaagcaa ttaaaagttt ggaaaaaaag aacctctagc c
//
