LOCUS       NM_001768               2106 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens CD8 subunit alpha (CD8A), transcript variant 1, mRNA.
ACCESSION   NM_001768
VERSION     NM_001768.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2106)
  AUTHORS   Dodhiawala,P.B. and Cichocki,F.
  TITLE     Striking a balance: the Goldilocks effect of CD8alpha expression on
            NK cells
  JOURNAL   J Clin Invest 134 (15), e182905 (2024)
   PUBMED   39087476
  REMARK    GeneRIF: Striking a balance: the Goldilocks effect of CD8alpha
            expression on NK cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2106)
  AUTHORS   Meng,L.B., Li,Y., Lv,T., Lv,C., Liu,L. and Zhang,P.
  TITLE     Joint effects of CD8A and ICOS in Long QT Syndrome (LQTS) and
            Beckwith-Wiedemann Syndrome (BWS)
  JOURNAL   J Cardiothorac Surg 19 (1), 321 (2024)
   PUBMED   38845009
  REMARK    GeneRIF: Joint effects of CD8A and ICOS in Long QT Syndrome (LQTS)
            and Beckwith-Wiedemann Syndrome (BWS).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2106)
  AUTHORS   Cubitt,C.C., Wong,P., Dorando,H.K., Foltz,J.A., Tran,J.,
            Marsala,L., Marin,N.D., Foster,M., Schappe,T., Fatima,H.,
            Becker-Hapak,M., Zhou,A.Y., Hwang,K., Jacobs,M.T.,
            Russler-Germain,D.A., Mace,E.M., Berrien-Elliott,M.M., Payton,J.E.
            and Fehniger,T.A.
  TITLE     Induced CD8alpha identifies human NK cells with enhanced
            proliferative fitness and modulates NK cell activation
  JOURNAL   J Clin Invest 134 (15), e173602 (2024)
   PUBMED   38805302
  REMARK    GeneRIF: Induced CD8alpha identifies human NK cells with enhanced
            proliferative fitness and modulates NK cell activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2106)
  AUTHORS   Tio,M., Wen,R., Choo,C.N., Tan,J.B., Chua,A., Xiao,B.,
            Sundaram,J.R., Chan,C.H.S. and Tan,E.K.
  TITLE     Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked
            Parkinson's disease phenotypes in vivo and in cell models
  JOURNAL   J Biomed Sci 31 (1), 24 (2024)
   PUBMED   38395904
  REMARK    GeneRIF: Genetic and pharmacologic p32-inhibition rescue
            CHCHD2-linked Parkinson's disease phenotypes in vivo and in cell
            models.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2106)
  AUTHORS   Chu,J., Tang,S., Li,T. and Fan,H.
  TITLE     The Role of CD8A in the Immune Microenvironment of Breast Cancer
  JOURNAL   Front Biosci (Landmark Ed) 29 (2), 73 (2024)
   PUBMED   38420798
  REMARK    GeneRIF: The Role of CD8A in the Immune Microenvironment of Breast
            Cancer.
REFERENCE   6  (bases 1 to 2106)
  AUTHORS   Leahy,D.J., Axel,R. and Hendrickson,W.A.
  TITLE     Crystal structure of a soluble form of the human T cell coreceptor
            CD8 at 2.6 A resolution
  JOURNAL   Cell 68 (6), 1145-1162 (1992)
   PUBMED   1547508
REFERENCE   7  (bases 1 to 2106)
  AUTHORS   Mittler,R.S., Rankin,B.M. and Kiener,P.A.
  TITLE     Physical associations between CD45 and CD4 or CD8 occur as late
            activation events in antigen receptor-stimulated human T cells
  JOURNAL   J Immunol 147 (10), 3434-3440 (1991)
   PUBMED   1834739
REFERENCE   8  (bases 1 to 2106)
  AUTHORS   Moebius,U., Kober,G., Griscelli,A.L., Hercend,T. and Meuer,S.C.
  TITLE     Expression of different CD8 isoforms on distinct human lymphocyte
            subpopulations
  JOURNAL   Eur J Immunol 21 (8), 1793-1800 (1991)
   PUBMED   1831127
REFERENCE   9  (bases 1 to 2106)
  AUTHORS   Erickson,J.D., Trojanowski,J.Q. and Eiden,L.E.
  TITLE     Regional distribution and partial molecular characterization of
            CD4-related mRNA in human brain and peripheral tissues
  JOURNAL   Brain Res Mol Brain Res 10 (1), 23-31 (1991)
   PUBMED   1676132
REFERENCE   10 (bases 1 to 2106)
  AUTHORS   Littman,D.R., Thomas,Y., Maddon,P.J., Chess,L. and Axel,R.
  TITLE     The isolation and sequence of the gene encoding T8: a molecule
            defining functional classes of T lymphocytes
  JOURNAL   Cell 40 (2), 237-246 (1985)
   PUBMED   3871356
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC064848.5, BC025715.1 and
            AK124156.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001768.6.
            
            Summary: The CD8 antigen is a cell surface glycoprotein found on
            most cytotoxic T lymphocytes that mediates efficient cell-cell
            interactions within the immune system. The CD8 antigen acts as a
            coreceptor with the T-cell receptor on the T lymphocyte to
            recognize antigens displayed by an antigen presenting cell in the
            context of class I MHC molecules. The coreceptor functions as
            either a homodimer composed of two alpha chains or as a heterodimer
            composed of one alpha and one beta chain. Both alpha and beta
            chains share significant homology to immunoglobulin variable light
            chains. This gene encodes the CD8 alpha chain. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            The major protein isoforms of this gene differ by the presence or
            absence of a transmembrane domain and thus differ in being a
            membrane-anchored or secreted protein. [provided by RefSeq, May
            2020].
            
            Transcript Variant: This variant (1) encodes the longer, membrane
            associated isoform (1). Both variants 1 and 3 encode the same
            isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025715.1, M12824.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for COVID-19 prognosis
            MANE Ensembl match     :: ENST00000283635.8/ ENSP00000283635.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC064848.5         17429-17511
            84-422              BC025715.1         1-339
            423-423             AC064848.5         17946-17946
            424-1438            BC025715.1         341-1355
            1439-2105           AK124156.1         2382-3048
            2106-2106           BC025715.1         2022-2022
FEATURES             Location/Qualifiers
     source          1..2106
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..2106
                     /gene="CD8A"
                     /gene_synonym="CD8; CD8alpha; IMD116; Leu2; p32"
                     /note="CD8 subunit alpha"
                     /db_xref="GeneID:925"
                     /db_xref="HGNC:HGNC:1706"
                     /db_xref="MIM:186910"
     exon            1..137
                     /gene="CD8A"
                     /gene_synonym="CD8; CD8alpha; IMD116; Leu2; p32"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..796
                     /gene="CD8A"
                     /gene_synonym="CD8; CD8alpha; IMD116; Leu2; p32"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD8 antigen, alpha polypeptide (p32); T-cell
                     surface glycoprotein CD8 alpha chain; T-lymphocyte
                     differentiation antigen T8/Leu-2; T cell co-receptor; OKT8
                     T-cell antigen; Leu2 T-lymphocyte antigen; T8 T-cell
                     antigen; T-cell antigen Leu2; CD8a molecule"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD8 alpha chain
                     isoform 1 precursor"
                     /protein_id="NP_001759.3"
                     /db_xref="CCDS:CCDS1992.1"
                     /db_xref="GeneID:925"
                     /db_xref="HGNC:HGNC:1706"
                     /db_xref="MIM:186910"
                     /translation="MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQ
                     VLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTL
                     SDFRRENEGYYFCSALSNSIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLR
                     PEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCP
                     RPVVKSGDKPSLSARYV"
     exon            138..491
                     /gene="CD8A"
                     /gene_synonym="CD8; CD8alpha; IMD116; Leu2; p32"
                     /inference="alignment:Splign:2.1.0"
     exon            492..602
                     /gene="CD8A"
                     /gene_synonym="CD8; CD8alpha; IMD116; Leu2; p32"
                     /inference="alignment:Splign:2.1.0"
     exon            603..713
                     /gene="CD8A"
                     /gene_synonym="CD8; CD8alpha; IMD116; Leu2; p32"
                     /inference="alignment:Splign:2.1.0"
     exon            714..744
                     /gene="CD8A"
                     /gene_synonym="CD8; CD8alpha; IMD116; Leu2; p32"
                     /inference="alignment:Splign:2.1.0"
     exon            745..2106
                     /gene="CD8A"
                     /gene_synonym="CD8; CD8alpha; IMD116; Leu2; p32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2067..2072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD8A"
                     /gene_synonym="CD8; CD8alpha; IMD116; Leu2; p32"
                     /note="hexamer: AATAAA"
     polyA_site      2106
                     /gene="CD8A"
                     /gene_synonym="CD8; CD8alpha; IMD116; Leu2; p32"
                     /note="major polyA site"
ORIGIN      
        1 aactttcccc cctcggcgcc ccaccggctc ccgcgcgcct cccctcgcgc ccgagcttcg
       61 agccaagcag cgtcctgggg agcgcgtcat ggccttacca gtgaccgcct tgctcctgcc
      121 gctggccttg ctgctccacg ccgccaggcc gagccagttc cgggtgtcgc cgctggatcg
      181 gacctggaac ctgggcgaga cagtggagct gaagtgccag gtgctgctgt ccaacccgac
      241 gtcgggctgc tcgtggctct tccagccgcg cggcgccgcc gccagtccca ccttcctcct
      301 atacctctcc caaaacaagc ccaaggcggc cgaggggctg gacacccagc ggttctcggg
      361 caagaggttg ggggacacct tcgtcctcac cctgagcgac ttccgccgag agaacgaggg
      421 ctactatttc tgctcggccc tgagcaactc catcatgtac ttcagccact tcgtgccggt
      481 cttcctgcca gcgaagccca ccacgacgcc agcgccgcga ccaccaacac cggcgcccac
      541 catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc
      601 agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg
      661 gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcaacc acaggaaccg
      721 aagacgtgtt tgcaaatgtc cccggcctgt ggtcaaatcg ggagacaagc ccagcctttc
      781 ggcgagatac gtctaaccct gtgcaacagc cactacatta cttcaaactg agatccttcc
      841 ttttgaggga gcaagtcctt ccctttcatt ttttccagtc ttcctccctg tgtattcatt
      901 ctcatgatta ttattttagt gggggcgggg tgggaaagat tactttttct ttatgtgttt
      961 gacgggaaac aaaactaggt aaaatctaca gtacaccaca agggtcacaa tactgttgtg
     1021 cgcacatcgc ggtagggcgt ggaaaggggc aggccagagc tacccgcaga gttctcagaa
     1081 tcatgctgag agagctggag gcacccatgc catctcaacc tcttccccgc ccgttttaca
     1141 aagggggagg ctaaagccca gagacagctt gatcaaaggc acacagcaag tcagggttgg
     1201 agcagtagct ggagggacct tgtctcccag ctcagggctc tttcctccac accattcagg
     1261 tctttctttc cgaggcccct gtctcagggt gaggtgcttg agtctccaac ggcaagggaa
     1321 caagtacttc ttgatacctg ggatactgtg cccagagcct cgaggaggta atgaattaaa
     1381 gaagagaact gcctttggca gagttctata atgtaaacaa tatcagactt ttttttttta
     1441 taatcaagcc taaaattgta tagacctaaa ataaaatgaa gtggtgagct taaccctgga
     1501 aaatgaatcc ctctatctct aaagaaaatc tctgtgaaac ccctatgtgg aggcggaatt
     1561 gctctcccag cccttgcatt gcagaggggc ccatgaaaga ggacaggcta cccctttaca
     1621 aatagaattt gagcatcagt gaggttaaac taaggccctc ttgaatctct gaatttgaga
     1681 tacaaacatg ttcctgggat cactgatgac tttttatact ttgtaaagac aattgttgga
     1741 gagcccctca cacagccctg gcctctgctc aactagcaga tacagggatg aggcagacct
     1801 gactctctta aggaggctga gagcccaaac tgctgtccca aacatgcact tccttgctta
     1861 aggtatggta caagcaatgc ctgcccattg gagagaaaaa acttaagtag ataaggaaat
     1921 aagaaccact cataattctt caccttagga ataatctcct gttaatatgg tgtacattct
     1981 tcctgattat tttctacaca tacatgtaaa atatgtcttt cttttttaaa tagggttgta
     2041 ctatgctgtt atgagtggct ttaatgaata aacatttgta gcatcctctt taatgggtaa
     2101 acagca
//
