LOCUS       NM_176892               2696 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens CD86 molecule (CD86), transcript variant 3, mRNA.
ACCESSION   NM_176892
VERSION     NM_176892.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2696)
  AUTHORS   Gadjalova,I., Heinze,J.M., Goess,M.C., Hofmann,J., Buck,A.,
            Weber,M.C., Blissenbach,B., Kampick,M., Krut,O., Steiger,K.,
            Janssen,K.P., Neumann,P.A., Ruland,J. and Keppler,S.J.
  TITLE     B cell-mediated CD4 T-cell costimulation via CD86 exacerbates
            pro-inflammatory cytokine production during autoimmune intestinal
            inflammation
  JOURNAL   Mucosal Immunol 17 (1), 67-80 (2024)
   PUBMED   37918715
  REMARK    GeneRIF: B cell-mediated CD4 T-cell costimulation via CD86
            exacerbates pro-inflammatory cytokine production during autoimmune
            intestinal inflammation.
REFERENCE   2  (bases 1 to 2696)
  AUTHORS   Cobankent Aytekin,E., Unal,B., Bassorgun,C.I. and Ozkan,O.
  TITLE     Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions
            with Immunohistochemical Methods in Malignant Melanoma Patients
  JOURNAL   Turk Patoloji Derg 40 (1), 16-26 (2024)
   PUBMED   37614091
  REMARK    GeneRIF: Clinicopathologic Evaluation of CD80, CD86, and PD-L1
            Expressions with Immunohistochemical Methods in Malignant Melanoma
            Patients.
REFERENCE   3  (bases 1 to 2696)
  AUTHORS   Kinoshita,R., Ishibashi,M., Handa,H., Sasaki,M., Imai,Y.,
            Tanaka,N., Ito,S., Sunakawa-Kii,M., Kaito,Y., Asayama,T.,
            Komatsu,N., Tanaka,J., Odajima,T., Sugimori,H., Yamaguchi,H.,
            Inokuchi,K. and Tamura,H.
  TITLE     The levels of serum soluble CD86 are correlated with the expression
            of CD86 variant 3 gene and are prognostic indicators in patients
            with myeloma
  JOURNAL   Exp Hematol 121, 38-47 (2023)
   PUBMED   36796620
  REMARK    GeneRIF: The levels of serum soluble CD86 are correlated with the
            expression of CD86 variant 3 gene and are prognostic indicators in
            patients with myeloma.
REFERENCE   4  (bases 1 to 2696)
  AUTHORS   Sun,D., Lin,R. and Ouyang,Y.
  TITLE     The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in
            the Pathogenesis of Chronic Obstructive Pulmonary Disease
  JOURNAL   Can Respir J 2022, 6810745 (2022)
   PUBMED   36051533
  REMARK    GeneRIF: The Role of CD40, CD86, and Glutathione S-Transferase
            Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary
            Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2696)
  AUTHORS   Moser-Katz,T., Gavile,C.M., Barwick,B.G., Lee,K.P. and Boise,L.H.
  TITLE     PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86
            Expression, Growth, and Survival
  JOURNAL   Mol Cancer Res 20 (7), 1122-1136 (2022)
   PUBMED   35380688
  REMARK    GeneRIF: PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface
            CD86 Expression, Growth, and Survival.
REFERENCE   6  (bases 1 to 2696)
  AUTHORS   Vyth-Dreese,F.A., Dellemijn,T.A., Majoor,D. and de Jong,D.
  TITLE     Localization in situ of the co-stimulatory molecules B7.1, B7.2,
            CD40 and their ligands in normal human lymphoid tissue
  JOURNAL   Eur J Immunol 25 (11), 3023-3029 (1995)
   PUBMED   7489738
REFERENCE   7  (bases 1 to 2696)
  AUTHORS   Seino,K., Azuma,M., Bashuda,H., Fukao,K., Yagita,H. and Okumura,K.
  TITLE     CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4+
            T cells
  JOURNAL   Int Immunol 7 (8), 1331-1337 (1995)
   PUBMED   7495740
REFERENCE   8  (bases 1 to 2696)
  AUTHORS   Lanier,L.L., O'Fallon,S., Somoza,C., Phillips,J.H., Linsley,P.S.,
            Okumura,K., Ito,D. and Azuma,M.
  TITLE     CD80 (B7) and CD86 (B70) provide similar costimulatory signals for
            T cell proliferation, cytokine production, and generation of CTL
  JOURNAL   J Immunol 154 (1), 97-105 (1995)
   PUBMED   7527824
REFERENCE   9  (bases 1 to 2696)
  AUTHORS   Engel,P., Gribben,J.G., Freeman,G.J., Zhou,L.J., Nozawa,Y., Abe,M.,
            Nadler,L.M., Wakasa,H. and Tedder,T.F.
  TITLE     The B7-2 (B70) costimulatory molecule expressed by monocytes and
            activated B lymphocytes is the CD86 differentiation antigen
  JOURNAL   Blood 84 (5), 1402-1407 (1994)
   PUBMED   7520767
REFERENCE   10 (bases 1 to 2696)
  AUTHORS   Chen,C., Gault,A., Shen,L. and Nabavi,N.
  TITLE     Molecular cloning and expression of early T cell costimulatory
            molecule-1 and its characterization as B7-2 molecule
  JOURNAL   J Immunol 152 (10), 4929-4936 (1994)
   PUBMED   7513726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068630.21.
            
            On Aug 13, 2020 this sequence version replaced NM_176892.1.
            
            Summary: This gene encodes a type I membrane protein that is a
            member of the immunoglobulin superfamily. This protein is expressed
            by antigen-presenting cells, and it is the ligand for two proteins
            at the cell surface of T cells, CD28 antigen and cytotoxic
            T-lymphocyte-associated protein 4. Binding of this protein with
            CD28 antigen is a costimulatory signal for activation of the
            T-cell. Binding of this protein with cytotoxic
            T-lymphocyte-associated protein 4 negatively regulates T-cell
            activation and diminishes the immune response. Alternative splicing
            results in several transcript variants encoding different
            isoforms.[provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (3) includes an alternate exon in
            the 5' UTR, resulting in the use of a downstream start codon
            compared to variant 1. It also lacks an in-frame exon compared to
            variant 1. The resulting isoform (3, also known as CD86deltaTM) has
            a shorter N-terminus and lacks an internal segment compared to
            isoform 1. This isoform is the soluble form of this protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: PMID: 11021528, 11986949
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AC068630.21        127893-128154       c
            263-312             AC068630.21        114288-114337       c
            313-648             AC068630.21        102091-102426       c
            649-951             AC068630.21        99438-99740         c
            952-997             AC068630.21        87845-87890         c
            998-2696            AC068630.21        84802-86500         c
FEATURES             Location/Qualifiers
     source          1..2696
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..2696
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="CD86 molecule"
                     /db_xref="GeneID:942"
                     /db_xref="HGNC:HGNC:1705"
                     /db_xref="MIM:601020"
     exon            1..262
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            263..312
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            313..648
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            649..951
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            952..997
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            998..2696
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1094..1099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: ATTAAA"
     polyA_site      1111
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="major polyA site"
     regulatory      1361..1366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: AATAAA"
     polyA_site      1389
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
     regulatory      2676..2681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: AATAAA"
     polyA_site      2696
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
ORIGIN      
        1 agaagttatt tggaaccaag caagagcact gtccctggct gtggtgttgt ttctctagtc
       61 agttcccctt tctgtatttg agttctaccg tcagtcctgg cattatttct ctctctacaa
      121 ggagccttag gaggtacggg gagctcgcaa atactccttt tggtttattc ttaccacctt
      181 gcttctgtgt tccttgggaa tgctgctgtg cttatgcatc tggtctcttt ttggagctac
      241 agtggacagg catttgtgac agcactatgg gactgagtaa cattctcttt gtgatggcct
      301 tcctgctctc tggtgctgct cctctgaaga ttcaagctta tttcaatgag actgcagacc
      361 tgccatgcca atttgcaaac tctcaaaacc aaagcctgag tgagctagta gtattttggc
      421 aggaccagga aaacttggtt ctgaatgagg tatacttagg caaagagaaa tttgacagtg
      481 ttcattccaa gtatatgggc cgcacaagtt ttgattcgga cagttggacc ctgagacttc
      541 acaatcttca gatcaaggac aagggcttgt atcaatgtat catccatcac aaaaagccca
      601 caggaatgat tcgcatccac cagatgaatt ctgaactgtc agtgcttgct aacttcagtc
      661 aacctgaaat agtaccaatt tctaatataa cagaaaatgt gtacataaat ttgacctgct
      721 catctataca cggttaccca gaacctaaga agatgagtgt tttgctaaga accaagaatt
      781 caactatcga gtatgatggt gttatgcaga aatctcaaga taatgtcaca gaactgtacg
      841 acgtttccat cagcttgtct gtttcattcc ctgatgttac gagcaatatg accatcttct
      901 gtattctgga aactgacaag acgcggcttt tatcttcacc tttctctata ggaaccaaca
      961 caatggagag ggaagagagt gaacagacca agaaaagaga aaaaatccat atacctgaaa
     1021 gatctgatga agcccagcgt gtttttaaaa gttcgaagac atcttcatgc gacaaaagtg
     1081 atacatgttt ttaattaaag agtaaagccc atacaagtat tcattttttc taccctttcc
     1141 tttgtaagtt cctgggcaac ctttttgatt tcttccagaa ggcaaaaaga cattaccatg
     1201 agtaataagg gggctccagg actccctcta agtggaatag cctccctgta actccagctc
     1261 tgctccgtat gccaagagga gactttaatt ctcttactgc ttcttttcac ttcagagcac
     1321 acttatgggc caagcccagc ttaatggctc atgacctgga aataaaattt aggaccaata
     1381 cctcctccag atcagattct tctcttaatt tcatagattg tgtttttttt ttaaatagac
     1441 ctctcaattt ctggaaaact gccttttatc tgcccagaat tctaagctgg tgccccactg
     1501 aattttgtgt gtacctgtga ctaaacaact acctcctcag tctgggtggg acttatgtat
     1561 ttatgacctt atagtgttaa tatcttgaaa catagagatc tatgtactgt aatagtgtga
     1621 ttactatgct ctagagaaaa gtctacccct gctaaggagt tctcatccct ctgtcagggt
     1681 cagtaaggaa aacggtggcc tagggtacag gcaacaatga gcagaccaac ctaaatttgg
     1741 ggaaattagg agaggcagag atagaacctg gagccacttc tatctgggct gttgctaata
     1801 ttgaggaggc ttgccccacc caacaagcca tagtggagag aactgaataa acaggaaaat
     1861 gccagagctt gtgaaccctg tttctcttga agaactgact agtgagatgg cctggggaag
     1921 ctgtgaaaga accaaaagag atcacaatac tcaaaagaga gagagagaga aaaaagagag
     1981 atcttgatcc acagaaatac atgaaatgtc tggtctgtcc accccatcaa caagtcttga
     2041 aacaagcaac agatggatag tctgtccaaa tggacataag acagacagca gtttccctgg
     2101 tggtcaggga ggggttttgg tgatacccaa gttattggga tgtcatcttc ctggaagcag
     2161 agctggggag ggagagccat caccttgata atgggatgaa tggaaggagg cttaggactt
     2221 tccactcctg gctgagagag gaagagctgc aacggaatta ggaagaccaa gacacagatc
     2281 acccggggct tacttagcct acagatgtcc tacgggaacg tgggctggcc cagcataggg
     2341 ctagcaaatt tgagttggat gattgttttt gctcaaggca accagaggaa acttgcatac
     2401 agagacagat atactgggag aaatgacttt gaaaacctgg ctctaaggtg ggatcactaa
     2461 gggatggggc agtctctgcc caaacataaa gagaactctg gggagcctga gccacaaaaa
     2521 tgttccttta ttttatgtaa accctcaagg gttatagact gccatgctag acaagcttgt
     2581 ccatgtaata ttcccatgtt tttaccctgc ccctgccttg attagactcc tagcacctgg
     2641 ctagtttcta acatgttttg tgcagcacag tttttaataa atgcttgtta cattca
//
