LOCUS       NM_006889               2840 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens CD86 molecule (CD86), transcript variant 2, mRNA.
ACCESSION   NM_006889
VERSION     NM_006889.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2840)
  AUTHORS   Gadjalova,I., Heinze,J.M., Goess,M.C., Hofmann,J., Buck,A.,
            Weber,M.C., Blissenbach,B., Kampick,M., Krut,O., Steiger,K.,
            Janssen,K.P., Neumann,P.A., Ruland,J. and Keppler,S.J.
  TITLE     B cell-mediated CD4 T-cell costimulation via CD86 exacerbates
            pro-inflammatory cytokine production during autoimmune intestinal
            inflammation
  JOURNAL   Mucosal Immunol 17 (1), 67-80 (2024)
   PUBMED   37918715
  REMARK    GeneRIF: B cell-mediated CD4 T-cell costimulation via CD86
            exacerbates pro-inflammatory cytokine production during autoimmune
            intestinal inflammation.
REFERENCE   2  (bases 1 to 2840)
  AUTHORS   Cobankent Aytekin,E., Unal,B., Bassorgun,C.I. and Ozkan,O.
  TITLE     Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions
            with Immunohistochemical Methods in Malignant Melanoma Patients
  JOURNAL   Turk Patoloji Derg 40 (1), 16-26 (2024)
   PUBMED   37614091
  REMARK    GeneRIF: Clinicopathologic Evaluation of CD80, CD86, and PD-L1
            Expressions with Immunohistochemical Methods in Malignant Melanoma
            Patients.
REFERENCE   3  (bases 1 to 2840)
  AUTHORS   Kinoshita,R., Ishibashi,M., Handa,H., Sasaki,M., Imai,Y.,
            Tanaka,N., Ito,S., Sunakawa-Kii,M., Kaito,Y., Asayama,T.,
            Komatsu,N., Tanaka,J., Odajima,T., Sugimori,H., Yamaguchi,H.,
            Inokuchi,K. and Tamura,H.
  TITLE     The levels of serum soluble CD86 are correlated with the expression
            of CD86 variant 3 gene and are prognostic indicators in patients
            with myeloma
  JOURNAL   Exp Hematol 121, 38-47 (2023)
   PUBMED   36796620
  REMARK    GeneRIF: The levels of serum soluble CD86 are correlated with the
            expression of CD86 variant 3 gene and are prognostic indicators in
            patients with myeloma.
REFERENCE   4  (bases 1 to 2840)
  AUTHORS   Sun,D., Lin,R. and Ouyang,Y.
  TITLE     The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in
            the Pathogenesis of Chronic Obstructive Pulmonary Disease
  JOURNAL   Can Respir J 2022, 6810745 (2022)
   PUBMED   36051533
  REMARK    GeneRIF: The Role of CD40, CD86, and Glutathione S-Transferase
            Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary
            Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2840)
  AUTHORS   Moser-Katz,T., Gavile,C.M., Barwick,B.G., Lee,K.P. and Boise,L.H.
  TITLE     PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86
            Expression, Growth, and Survival
  JOURNAL   Mol Cancer Res 20 (7), 1122-1136 (2022)
   PUBMED   35380688
  REMARK    GeneRIF: PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface
            CD86 Expression, Growth, and Survival.
REFERENCE   6  (bases 1 to 2840)
  AUTHORS   Vyth-Dreese,F.A., Dellemijn,T.A., Majoor,D. and de Jong,D.
  TITLE     Localization in situ of the co-stimulatory molecules B7.1, B7.2,
            CD40 and their ligands in normal human lymphoid tissue
  JOURNAL   Eur J Immunol 25 (11), 3023-3029 (1995)
   PUBMED   7489738
REFERENCE   7  (bases 1 to 2840)
  AUTHORS   Seino,K., Azuma,M., Bashuda,H., Fukao,K., Yagita,H. and Okumura,K.
  TITLE     CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4+
            T cells
  JOURNAL   Int Immunol 7 (8), 1331-1337 (1995)
   PUBMED   7495740
REFERENCE   8  (bases 1 to 2840)
  AUTHORS   Lanier,L.L., O'Fallon,S., Somoza,C., Phillips,J.H., Linsley,P.S.,
            Okumura,K., Ito,D. and Azuma,M.
  TITLE     CD80 (B7) and CD86 (B70) provide similar costimulatory signals for
            T cell proliferation, cytokine production, and generation of CTL
  JOURNAL   J Immunol 154 (1), 97-105 (1995)
   PUBMED   7527824
REFERENCE   9  (bases 1 to 2840)
  AUTHORS   Engel,P., Gribben,J.G., Freeman,G.J., Zhou,L.J., Nozawa,Y., Abe,M.,
            Nadler,L.M., Wakasa,H. and Tedder,T.F.
  TITLE     The B7-2 (B70) costimulatory molecule expressed by monocytes and
            activated B lymphocytes is the CD86 differentiation antigen
  JOURNAL   Blood 84 (5), 1402-1407 (1994)
   PUBMED   7520767
REFERENCE   10 (bases 1 to 2840)
  AUTHORS   Chen,C., Gault,A., Shen,L. and Nabavi,N.
  TITLE     Molecular cloning and expression of early T cell costimulatory
            molecule-1 and its characterization as B7-2 molecule
  JOURNAL   J Immunol 152 (10), 4929-4936 (1994)
   PUBMED   7513726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068630.21.
            
            On Aug 13, 2020 this sequence version replaced NM_006889.4.
            
            Summary: This gene encodes a type I membrane protein that is a
            member of the immunoglobulin superfamily. This protein is expressed
            by antigen-presenting cells, and it is the ligand for two proteins
            at the cell surface of T cells, CD28 antigen and cytotoxic
            T-lymphocyte-associated protein 4. Binding of this protein with
            CD28 antigen is a costimulatory signal for activation of the
            T-cell. Binding of this protein with cytotoxic
            T-lymphocyte-associated protein 4 negatively regulates T-cell
            activation and diminishes the immune response. Alternative splicing
            results in several transcript variants encoding different
            isoforms.[provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (2) includes an alternate exon in
            the 5' UTR, resulting in the use of a downstream start codon
            compared to variant 1. Isoform 2 has a shorter N-terminus than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.2821212.1,
                                           SRR14038193.3303534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AC068630.21        127893-128154       c
            263-312             AC068630.21        114288-114337       c
            313-648             AC068630.21        102091-102426       c
            649-951             AC068630.21        99438-99740         c
            952-1095            AC068630.21        96530-96673         c
            1096-1141           AC068630.21        87845-87890         c
            1142-2840           AC068630.21        84802-86500         c
FEATURES             Location/Qualifiers
     source          1..2840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..2840
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="CD86 molecule"
                     /db_xref="GeneID:942"
                     /db_xref="HGNC:HGNC:1705"
                     /db_xref="MIM:601020"
     exon            1..262
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            263..312
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            313..648
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            649..951
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1095
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1141
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..2840
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1238..1243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: ATTAAA"
     polyA_site      1255
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="major polyA site"
     regulatory      1505..1510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: AATAAA"
     polyA_site      1533
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
     regulatory      2820..2825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: AATAAA"
     polyA_site      2840
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
ORIGIN      
        1 agaagttatt tggaaccaag caagagcact gtccctggct gtggtgttgt ttctctagtc
       61 agttcccctt tctgtatttg agttctaccg tcagtcctgg cattatttct ctctctacaa
      121 ggagccttag gaggtacggg gagctcgcaa atactccttt tggtttattc ttaccacctt
      181 gcttctgtgt tccttgggaa tgctgctgtg cttatgcatc tggtctcttt ttggagctac
      241 agtggacagg catttgtgac agcactatgg gactgagtaa cattctcttt gtgatggcct
      301 tcctgctctc tggtgctgct cctctgaaga ttcaagctta tttcaatgag actgcagacc
      361 tgccatgcca atttgcaaac tctcaaaacc aaagcctgag tgagctagta gtattttggc
      421 aggaccagga aaacttggtt ctgaatgagg tatacttagg caaagagaaa tttgacagtg
      481 ttcattccaa gtatatgggc cgcacaagtt ttgattcgga cagttggacc ctgagacttc
      541 acaatcttca gatcaaggac aagggcttgt atcaatgtat catccatcac aaaaagccca
      601 caggaatgat tcgcatccac cagatgaatt ctgaactgtc agtgcttgct aacttcagtc
      661 aacctgaaat agtaccaatt tctaatataa cagaaaatgt gtacataaat ttgacctgct
      721 catctataca cggttaccca gaacctaaga agatgagtgt tttgctaaga accaagaatt
      781 caactatcga gtatgatggt gttatgcaga aatctcaaga taatgtcaca gaactgtacg
      841 acgtttccat cagcttgtct gtttcattcc ctgatgttac gagcaatatg accatcttct
      901 gtattctgga aactgacaag acgcggcttt tatcttcacc tttctctata gagcttgagg
      961 accctcagcc tcccccagac cacattcctt ggattacagc tgtacttcca acagttatta
     1021 tatgtgtgat ggttttctgt ctaattctat ggaaatggaa gaagaagaag cggcctcgca
     1081 actcttataa atgtggaacc aacacaatgg agagggaaga gagtgaacag accaagaaaa
     1141 gagaaaaaat ccatatacct gaaagatctg atgaagccca gcgtgttttt aaaagttcga
     1201 agacatcttc atgcgacaaa agtgatacat gtttttaatt aaagagtaaa gcccatacaa
     1261 gtattcattt tttctaccct ttcctttgta agttcctggg caaccttttt gatttcttcc
     1321 agaaggcaaa aagacattac catgagtaat aagggggctc caggactccc tctaagtgga
     1381 atagcctccc tgtaactcca gctctgctcc gtatgccaag aggagacttt aattctctta
     1441 ctgcttcttt tcacttcaga gcacacttat gggccaagcc cagcttaatg gctcatgacc
     1501 tggaaataaa atttaggacc aatacctcct ccagatcaga ttcttctctt aatttcatag
     1561 attgtgtttt ttttttaaat agacctctca atttctggaa aactgccttt tatctgccca
     1621 gaattctaag ctggtgcccc actgaatttt gtgtgtacct gtgactaaac aactacctcc
     1681 tcagtctggg tgggacttat gtatttatga ccttatagtg ttaatatctt gaaacataga
     1741 gatctatgta ctgtaatagt gtgattacta tgctctagag aaaagtctac ccctgctaag
     1801 gagttctcat ccctctgtca gggtcagtaa ggaaaacggt ggcctagggt acaggcaaca
     1861 atgagcagac caacctaaat ttggggaaat taggagaggc agagatagaa cctggagcca
     1921 cttctatctg ggctgttgct aatattgagg aggcttgccc cacccaacaa gccatagtgg
     1981 agagaactga ataaacagga aaatgccaga gcttgtgaac cctgtttctc ttgaagaact
     2041 gactagtgag atggcctggg gaagctgtga aagaaccaaa agagatcaca atactcaaaa
     2101 gagagagaga gagaaaaaag agagatcttg atccacagaa atacatgaaa tgtctggtct
     2161 gtccacccca tcaacaagtc ttgaaacaag caacagatgg atagtctgtc caaatggaca
     2221 taagacagac agcagtttcc ctggtggtca gggaggggtt ttggtgatac ccaagttatt
     2281 gggatgtcat cttcctggaa gcagagctgg ggagggagag ccatcacctt gataatggga
     2341 tgaatggaag gaggcttagg actttccact cctggctgag agaggaagag ctgcaacgga
     2401 attaggaaga ccaagacaca gatcacccgg ggcttactta gcctacagat gtcctacggg
     2461 aacgtgggct ggcccagcat agggctagca aatttgagtt ggatgattgt ttttgctcaa
     2521 ggcaaccaga ggaaacttgc atacagagac agatatactg ggagaaatga ctttgaaaac
     2581 ctggctctaa ggtgggatca ctaagggatg gggcagtctc tgcccaaaca taaagagaac
     2641 tctggggagc ctgagccaca aaaatgttcc tttattttat gtaaaccctc aagggttata
     2701 gactgccatg ctagacaagc ttgtccatgt aatattccca tgtttttacc ctgcccctgc
     2761 cttgattaga ctcctagcac ctggctagtt tctaacatgt tttgtgcagc acagttttta
     2821 ataaatgctt gttacattca
//
