LOCUS       NM_001206925            2670 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens CD86 molecule (CD86), transcript variant 5, mRNA.
ACCESSION   NM_001206925
VERSION     NM_001206925.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2670)
  AUTHORS   Gadjalova,I., Heinze,J.M., Goess,M.C., Hofmann,J., Buck,A.,
            Weber,M.C., Blissenbach,B., Kampick,M., Krut,O., Steiger,K.,
            Janssen,K.P., Neumann,P.A., Ruland,J. and Keppler,S.J.
  TITLE     B cell-mediated CD4 T-cell costimulation via CD86 exacerbates
            pro-inflammatory cytokine production during autoimmune intestinal
            inflammation
  JOURNAL   Mucosal Immunol 17 (1), 67-80 (2024)
   PUBMED   37918715
  REMARK    GeneRIF: B cell-mediated CD4 T-cell costimulation via CD86
            exacerbates pro-inflammatory cytokine production during autoimmune
            intestinal inflammation.
REFERENCE   2  (bases 1 to 2670)
  AUTHORS   Cobankent Aytekin,E., Unal,B., Bassorgun,C.I. and Ozkan,O.
  TITLE     Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions
            with Immunohistochemical Methods in Malignant Melanoma Patients
  JOURNAL   Turk Patoloji Derg 40 (1), 16-26 (2024)
   PUBMED   37614091
  REMARK    GeneRIF: Clinicopathologic Evaluation of CD80, CD86, and PD-L1
            Expressions with Immunohistochemical Methods in Malignant Melanoma
            Patients.
REFERENCE   3  (bases 1 to 2670)
  AUTHORS   Kinoshita,R., Ishibashi,M., Handa,H., Sasaki,M., Imai,Y.,
            Tanaka,N., Ito,S., Sunakawa-Kii,M., Kaito,Y., Asayama,T.,
            Komatsu,N., Tanaka,J., Odajima,T., Sugimori,H., Yamaguchi,H.,
            Inokuchi,K. and Tamura,H.
  TITLE     The levels of serum soluble CD86 are correlated with the expression
            of CD86 variant 3 gene and are prognostic indicators in patients
            with myeloma
  JOURNAL   Exp Hematol 121, 38-47 (2023)
   PUBMED   36796620
  REMARK    GeneRIF: The levels of serum soluble CD86 are correlated with the
            expression of CD86 variant 3 gene and are prognostic indicators in
            patients with myeloma.
REFERENCE   4  (bases 1 to 2670)
  AUTHORS   Sun,D., Lin,R. and Ouyang,Y.
  TITLE     The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in
            the Pathogenesis of Chronic Obstructive Pulmonary Disease
  JOURNAL   Can Respir J 2022, 6810745 (2022)
   PUBMED   36051533
  REMARK    GeneRIF: The Role of CD40, CD86, and Glutathione S-Transferase
            Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary
            Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2670)
  AUTHORS   Moser-Katz,T., Gavile,C.M., Barwick,B.G., Lee,K.P. and Boise,L.H.
  TITLE     PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86
            Expression, Growth, and Survival
  JOURNAL   Mol Cancer Res 20 (7), 1122-1136 (2022)
   PUBMED   35380688
  REMARK    GeneRIF: PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface
            CD86 Expression, Growth, and Survival.
REFERENCE   6  (bases 1 to 2670)
  AUTHORS   Vyth-Dreese,F.A., Dellemijn,T.A., Majoor,D. and de Jong,D.
  TITLE     Localization in situ of the co-stimulatory molecules B7.1, B7.2,
            CD40 and their ligands in normal human lymphoid tissue
  JOURNAL   Eur J Immunol 25 (11), 3023-3029 (1995)
   PUBMED   7489738
REFERENCE   7  (bases 1 to 2670)
  AUTHORS   Seino,K., Azuma,M., Bashuda,H., Fukao,K., Yagita,H. and Okumura,K.
  TITLE     CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4+
            T cells
  JOURNAL   Int Immunol 7 (8), 1331-1337 (1995)
   PUBMED   7495740
REFERENCE   8  (bases 1 to 2670)
  AUTHORS   Lanier,L.L., O'Fallon,S., Somoza,C., Phillips,J.H., Linsley,P.S.,
            Okumura,K., Ito,D. and Azuma,M.
  TITLE     CD80 (B7) and CD86 (B70) provide similar costimulatory signals for
            T cell proliferation, cytokine production, and generation of CTL
  JOURNAL   J Immunol 154 (1), 97-105 (1995)
   PUBMED   7527824
REFERENCE   9  (bases 1 to 2670)
  AUTHORS   Engel,P., Gribben,J.G., Freeman,G.J., Zhou,L.J., Nozawa,Y., Abe,M.,
            Nadler,L.M., Wakasa,H. and Tedder,T.F.
  TITLE     The B7-2 (B70) costimulatory molecule expressed by monocytes and
            activated B lymphocytes is the CD86 differentiation antigen
  JOURNAL   Blood 84 (5), 1402-1407 (1994)
   PUBMED   7520767
REFERENCE   10 (bases 1 to 2670)
  AUTHORS   Chen,C., Gault,A., Shen,L. and Nabavi,N.
  TITLE     Molecular cloning and expression of early T cell costimulatory
            molecule-1 and its characterization as B7-2 molecule
  JOURNAL   J Immunol 152 (10), 4929-4936 (1994)
   PUBMED   7513726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068630.21.
            
            On Aug 14, 2020 this sequence version replaced NM_001206925.1.
            
            Summary: This gene encodes a type I membrane protein that is a
            member of the immunoglobulin superfamily. This protein is expressed
            by antigen-presenting cells, and it is the ligand for two proteins
            at the cell surface of T cells, CD28 antigen and cytotoxic
            T-lymphocyte-associated protein 4. Binding of this protein with
            CD28 antigen is a costimulatory signal for activation of the
            T-cell. Binding of this protein with cytotoxic
            T-lymphocyte-associated protein 4 negatively regulates T-cell
            activation and diminishes the immune response. Alternative splicing
            results in several transcript variants encoding different
            isoforms.[provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (5) lacks an alternate coding exon
            compared to variant 1, that causes a frameshift. The resulting
            isoform (5) is made from a downstream translation start site
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK316203.1, AK301237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC068630.21        150435-150576       c
            143-478             AC068630.21        102091-102426       c
            479-781             AC068630.21        99438-99740         c
            782-925             AC068630.21        96530-96673         c
            926-971             AC068630.21        87845-87890         c
            972-2670            AC068630.21        84802-86500         c
FEATURES             Location/Qualifiers
     source          1..2670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..2670
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="CD86 molecule"
                     /db_xref="GeneID:942"
                     /db_xref="HGNC:HGNC:1705"
                     /db_xref="MIM:601020"
     exon            1..142
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            143..478
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            479..781
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            782..925
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            926..971
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            972..2670
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1068..1073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: ATTAAA"
     polyA_site      1085
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="major polyA site"
     regulatory      1335..1340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: AATAAA"
     polyA_site      1363
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
     regulatory      2650..2655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: AATAAA"
     polyA_site      2670
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
ORIGIN      
        1 agtcattgcc gaggaaggct tgcacagggt gaaagctttg cttctctgct gctgtaacag
       61 ggactagcac agacacacgg atgagtgggg tcatttccag atattaggtc acagcagaag
      121 cagccaaaat ggatccccag tggtgctgct cctctgaaga ttcaagctta tttcaatgag
      181 actgcagacc tgccatgcca atttgcaaac tctcaaaacc aaagcctgag tgagctagta
      241 gtattttggc aggaccagga aaacttggtt ctgaatgagg tatacttagg caaagagaaa
      301 tttgacagtg ttcattccaa gtatatgggc cgcacaagtt ttgattcgga cagttggacc
      361 ctgagacttc acaatcttca gatcaaggac aagggcttgt atcaatgtat catccatcac
      421 aaaaagccca caggaatgat tcgcatccac cagatgaatt ctgaactgtc agtgcttgct
      481 aacttcagtc aacctgaaat agtaccaatt tctaatataa cagaaaatgt gtacataaat
      541 ttgacctgct catctataca cggttaccca gaacctaaga agatgagtgt tttgctaaga
      601 accaagaatt caactatcga gtatgatggt gttatgcaga aatctcaaga taatgtcaca
      661 gaactgtacg acgtttccat cagcttgtct gtttcattcc ctgatgttac gagcaatatg
      721 accatcttct gtattctgga aactgacaag acgcggcttt tatcttcacc tttctctata
      781 gagcttgagg accctcagcc tcccccagac cacattcctt ggattacagc tgtacttcca
      841 acagttatta tatgtgtgat ggttttctgt ctaattctat ggaaatggaa gaagaagaag
      901 cggcctcgca actcttataa atgtggaacc aacacaatgg agagggaaga gagtgaacag
      961 accaagaaaa gagaaaaaat ccatatacct gaaagatctg atgaagccca gcgtgttttt
     1021 aaaagttcga agacatcttc atgcgacaaa agtgatacat gtttttaatt aaagagtaaa
     1081 gcccatacaa gtattcattt tttctaccct ttcctttgta agttcctggg caaccttttt
     1141 gatttcttcc agaaggcaaa aagacattac catgagtaat aagggggctc caggactccc
     1201 tctaagtgga atagcctccc tgtaactcca gctctgctcc gtatgccaag aggagacttt
     1261 aattctctta ctgcttcttt tcacttcaga gcacacttat gggccaagcc cagcttaatg
     1321 gctcatgacc tggaaataaa atttaggacc aatacctcct ccagatcaga ttcttctctt
     1381 aatttcatag attgtgtttt ttttttaaat agacctctca atttctggaa aactgccttt
     1441 tatctgccca gaattctaag ctggtgcccc actgaatttt gtgtgtacct gtgactaaac
     1501 aactacctcc tcagtctggg tgggacttat gtatttatga ccttatagtg ttaatatctt
     1561 gaaacataga gatctatgta ctgtaatagt gtgattacta tgctctagag aaaagtctac
     1621 ccctgctaag gagttctcat ccctctgtca gggtcagtaa ggaaaacggt ggcctagggt
     1681 acaggcaaca atgagcagac caacctaaat ttggggaaat taggagaggc agagatagaa
     1741 cctggagcca cttctatctg ggctgttgct aatattgagg aggcttgccc cacccaacaa
     1801 gccatagtgg agagaactga ataaacagga aaatgccaga gcttgtgaac cctgtttctc
     1861 ttgaagaact gactagtgag atggcctggg gaagctgtga aagaaccaaa agagatcaca
     1921 atactcaaaa gagagagaga gagaaaaaag agagatcttg atccacagaa atacatgaaa
     1981 tgtctggtct gtccacccca tcaacaagtc ttgaaacaag caacagatgg atagtctgtc
     2041 caaatggaca taagacagac agcagtttcc ctggtggtca gggaggggtt ttggtgatac
     2101 ccaagttatt gggatgtcat cttcctggaa gcagagctgg ggagggagag ccatcacctt
     2161 gataatggga tgaatggaag gaggcttagg actttccact cctggctgag agaggaagag
     2221 ctgcaacgga attaggaaga ccaagacaca gatcacccgg ggcttactta gcctacagat
     2281 gtcctacggg aacgtgggct ggcccagcat agggctagca aatttgagtt ggatgattgt
     2341 ttttgctcaa ggcaaccaga ggaaacttgc atacagagac agatatactg ggagaaatga
     2401 ctttgaaaac ctggctctaa ggtgggatca ctaagggatg gggcagtctc tgcccaaaca
     2461 taaagagaac tctggggagc ctgagccaca aaaatgttcc tttattttat gtaaaccctc
     2521 aagggttata gactgccatg ctagacaagc ttgtccatgt aatattccca tgtttttacc
     2581 ctgcccctgc cttgattaga ctcctagcac ctggctagtt tctaacatgt tttgtgcagc
     2641 acagttttta ataaatgctt gttacattca
//
