LOCUS       NM_001206924            2384 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens CD86 molecule (CD86), transcript variant 4, mRNA.
ACCESSION   NM_001206924
VERSION     NM_001206924.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2384)
  AUTHORS   Gadjalova,I., Heinze,J.M., Goess,M.C., Hofmann,J., Buck,A.,
            Weber,M.C., Blissenbach,B., Kampick,M., Krut,O., Steiger,K.,
            Janssen,K.P., Neumann,P.A., Ruland,J. and Keppler,S.J.
  TITLE     B cell-mediated CD4 T-cell costimulation via CD86 exacerbates
            pro-inflammatory cytokine production during autoimmune intestinal
            inflammation
  JOURNAL   Mucosal Immunol 17 (1), 67-80 (2024)
   PUBMED   37918715
  REMARK    GeneRIF: B cell-mediated CD4 T-cell costimulation via CD86
            exacerbates pro-inflammatory cytokine production during autoimmune
            intestinal inflammation.
REFERENCE   2  (bases 1 to 2384)
  AUTHORS   Cobankent Aytekin,E., Unal,B., Bassorgun,C.I. and Ozkan,O.
  TITLE     Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions
            with Immunohistochemical Methods in Malignant Melanoma Patients
  JOURNAL   Turk Patoloji Derg 40 (1), 16-26 (2024)
   PUBMED   37614091
  REMARK    GeneRIF: Clinicopathologic Evaluation of CD80, CD86, and PD-L1
            Expressions with Immunohistochemical Methods in Malignant Melanoma
            Patients.
REFERENCE   3  (bases 1 to 2384)
  AUTHORS   Kinoshita,R., Ishibashi,M., Handa,H., Sasaki,M., Imai,Y.,
            Tanaka,N., Ito,S., Sunakawa-Kii,M., Kaito,Y., Asayama,T.,
            Komatsu,N., Tanaka,J., Odajima,T., Sugimori,H., Yamaguchi,H.,
            Inokuchi,K. and Tamura,H.
  TITLE     The levels of serum soluble CD86 are correlated with the expression
            of CD86 variant 3 gene and are prognostic indicators in patients
            with myeloma
  JOURNAL   Exp Hematol 121, 38-47 (2023)
   PUBMED   36796620
  REMARK    GeneRIF: The levels of serum soluble CD86 are correlated with the
            expression of CD86 variant 3 gene and are prognostic indicators in
            patients with myeloma.
REFERENCE   4  (bases 1 to 2384)
  AUTHORS   Sun,D., Lin,R. and Ouyang,Y.
  TITLE     The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in
            the Pathogenesis of Chronic Obstructive Pulmonary Disease
  JOURNAL   Can Respir J 2022, 6810745 (2022)
   PUBMED   36051533
  REMARK    GeneRIF: The Role of CD40, CD86, and Glutathione S-Transferase
            Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary
            Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2384)
  AUTHORS   Moser-Katz,T., Gavile,C.M., Barwick,B.G., Lee,K.P. and Boise,L.H.
  TITLE     PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86
            Expression, Growth, and Survival
  JOURNAL   Mol Cancer Res 20 (7), 1122-1136 (2022)
   PUBMED   35380688
  REMARK    GeneRIF: PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface
            CD86 Expression, Growth, and Survival.
REFERENCE   6  (bases 1 to 2384)
  AUTHORS   Vyth-Dreese,F.A., Dellemijn,T.A., Majoor,D. and de Jong,D.
  TITLE     Localization in situ of the co-stimulatory molecules B7.1, B7.2,
            CD40 and their ligands in normal human lymphoid tissue
  JOURNAL   Eur J Immunol 25 (11), 3023-3029 (1995)
   PUBMED   7489738
REFERENCE   7  (bases 1 to 2384)
  AUTHORS   Seino,K., Azuma,M., Bashuda,H., Fukao,K., Yagita,H. and Okumura,K.
  TITLE     CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4+
            T cells
  JOURNAL   Int Immunol 7 (8), 1331-1337 (1995)
   PUBMED   7495740
REFERENCE   8  (bases 1 to 2384)
  AUTHORS   Lanier,L.L., O'Fallon,S., Somoza,C., Phillips,J.H., Linsley,P.S.,
            Okumura,K., Ito,D. and Azuma,M.
  TITLE     CD80 (B7) and CD86 (B70) provide similar costimulatory signals for
            T cell proliferation, cytokine production, and generation of CTL
  JOURNAL   J Immunol 154 (1), 97-105 (1995)
   PUBMED   7527824
REFERENCE   9  (bases 1 to 2384)
  AUTHORS   Engel,P., Gribben,J.G., Freeman,G.J., Zhou,L.J., Nozawa,Y., Abe,M.,
            Nadler,L.M., Wakasa,H. and Tedder,T.F.
  TITLE     The B7-2 (B70) costimulatory molecule expressed by monocytes and
            activated B lymphocytes is the CD86 differentiation antigen
  JOURNAL   Blood 84 (5), 1402-1407 (1994)
   PUBMED   7520767
REFERENCE   10 (bases 1 to 2384)
  AUTHORS   Chen,C., Gault,A., Shen,L. and Nabavi,N.
  TITLE     Molecular cloning and expression of early T cell costimulatory
            molecule-1 and its characterization as B7-2 molecule
  JOURNAL   J Immunol 152 (10), 4929-4936 (1994)
   PUBMED   7513726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068630.21.
            
            On Aug 13, 2020 this sequence version replaced NM_001206924.1.
            
            Summary: This gene encodes a type I membrane protein that is a
            member of the immunoglobulin superfamily. This protein is expressed
            by antigen-presenting cells, and it is the ligand for two proteins
            at the cell surface of T cells, CD28 antigen and cytotoxic
            T-lymphocyte-associated protein 4. Binding of this protein with
            CD28 antigen is a costimulatory signal for activation of the
            T-cell. Binding of this protein with cytotoxic
            T-lymphocyte-associated protein 4 negatively regulates T-cell
            activation and diminishes the immune response. Alternative splicing
            results in several transcript variants encoding different
            isoforms.[provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (4) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK294663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC068630.21        150435-150576       c
            143-192             AC068630.21        114288-114337       c
            193-495             AC068630.21        99438-99740         c
            496-639             AC068630.21        96530-96673         c
            640-685             AC068630.21        87845-87890         c
            686-2384            AC068630.21        84802-86500         c
FEATURES             Location/Qualifiers
     source          1..2384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..2384
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="CD86 molecule"
                     /db_xref="GeneID:942"
                     /db_xref="HGNC:HGNC:1705"
                     /db_xref="MIM:601020"
     exon            1..142
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            143..192
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            193..495
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            496..639
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            640..685
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     exon            686..2384
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      782..787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: ATTAAA"
     polyA_site      799
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="major polyA site"
     regulatory      1049..1054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: AATAAA"
     polyA_site      1077
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
     regulatory      2364..2369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
                     /note="hexamer: AATAAA"
     polyA_site      2384
                     /gene="CD86"
                     /gene_synonym="B7-2; B7.2; B70; CD28LG2; LAB72"
ORIGIN      
        1 agtcattgcc gaggaaggct tgcacagggt gaaagctttg cttctctgct gctgtaacag
       61 ggactagcac agacacacgg atgagtgggg tcatttccag atattaggtc acagcagaag
      121 cagccaaaat ggatccccag tgcactatgg gactgagtaa cattctcttt gtgatggcct
      181 tcctgctctc tgctaacttc agtcaacctg aaatagtacc aatttctaat ataacagaaa
      241 atgtgtacat aaatttgacc tgctcatcta tacacggtta cccagaacct aagaagatga
      301 gtgttttgct aagaaccaag aattcaacta tcgagtatga tggtgttatg cagaaatctc
      361 aagataatgt cacagaactg tacgacgttt ccatcagctt gtctgtttca ttccctgatg
      421 ttacgagcaa tatgaccatc ttctgtattc tggaaactga caagacgcgg cttttatctt
      481 cacctttctc tatagagctt gaggaccctc agcctccccc agaccacatt ccttggatta
      541 cagctgtact tccaacagtt attatatgtg tgatggtttt ctgtctaatt ctatggaaat
      601 ggaagaagaa gaagcggcct cgcaactctt ataaatgtgg aaccaacaca atggagaggg
      661 aagagagtga acagaccaag aaaagagaaa aaatccatat acctgaaaga tctgatgaag
      721 cccagcgtgt ttttaaaagt tcgaagacat cttcatgcga caaaagtgat acatgttttt
      781 aattaaagag taaagcccat acaagtattc attttttcta ccctttcctt tgtaagttcc
      841 tgggcaacct ttttgatttc ttccagaagg caaaaagaca ttaccatgag taataagggg
      901 gctccaggac tccctctaag tggaatagcc tccctgtaac tccagctctg ctccgtatgc
      961 caagaggaga ctttaattct cttactgctt cttttcactt cagagcacac ttatgggcca
     1021 agcccagctt aatggctcat gacctggaaa taaaatttag gaccaatacc tcctccagat
     1081 cagattcttc tcttaatttc atagattgtg tttttttttt aaatagacct ctcaatttct
     1141 ggaaaactgc cttttatctg cccagaattc taagctggtg ccccactgaa ttttgtgtgt
     1201 acctgtgact aaacaactac ctcctcagtc tgggtgggac ttatgtattt atgaccttat
     1261 agtgttaata tcttgaaaca tagagatcta tgtactgtaa tagtgtgatt actatgctct
     1321 agagaaaagt ctacccctgc taaggagttc tcatccctct gtcagggtca gtaaggaaaa
     1381 cggtggccta gggtacaggc aacaatgagc agaccaacct aaatttgggg aaattaggag
     1441 aggcagagat agaacctgga gccacttcta tctgggctgt tgctaatatt gaggaggctt
     1501 gccccaccca acaagccata gtggagagaa ctgaataaac aggaaaatgc cagagcttgt
     1561 gaaccctgtt tctcttgaag aactgactag tgagatggcc tggggaagct gtgaaagaac
     1621 caaaagagat cacaatactc aaaagagaga gagagagaaa aaagagagat cttgatccac
     1681 agaaatacat gaaatgtctg gtctgtccac cccatcaaca agtcttgaaa caagcaacag
     1741 atggatagtc tgtccaaatg gacataagac agacagcagt ttccctggtg gtcagggagg
     1801 ggttttggtg atacccaagt tattgggatg tcatcttcct ggaagcagag ctggggaggg
     1861 agagccatca ccttgataat gggatgaatg gaaggaggct taggactttc cactcctggc
     1921 tgagagagga agagctgcaa cggaattagg aagaccaaga cacagatcac ccggggctta
     1981 cttagcctac agatgtccta cgggaacgtg ggctggccca gcatagggct agcaaatttg
     2041 agttggatga ttgtttttgc tcaaggcaac cagaggaaac ttgcatacag agacagatat
     2101 actgggagaa atgactttga aaacctggct ctaaggtggg atcactaagg gatggggcag
     2161 tctctgccca aacataaaga gaactctggg gagcctgagc cacaaaaatg ttcctttatt
     2221 ttatgtaaac cctcaagggt tatagactgc catgctagac aagcttgtcc atgtaatatt
     2281 cccatgtttt taccctgccc ctgccttgat tagactccta gcacctggct agtttctaac
     2341 atgttttgtg cagcacagtt tttaataaat gcttgttaca ttca
//
