LOCUS       NM_003874               8204 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens CD84 molecule (CD84), transcript variant 2, mRNA.
ACCESSION   NM_003874
VERSION     NM_003874.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8204)
  AUTHORS   Kim,Y., Calderon,A.A., Favaro,P., Glass,D.R., Tsai,A.G., Ho,D.,
            Borges,L., Greenleaf,W.J. and Bendall,S.C.
  TITLE     Terminal deoxynucleotidyl transferase and CD84 identify human
            multi-potent lymphoid progenitors
  JOURNAL   Nat Commun 15 (1), 5910 (2024)
   PUBMED   39003273
  REMARK    GeneRIF: Terminal deoxynucleotidyl transferase and CD84 identify
            human multi-potent lymphoid progenitors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8204)
  AUTHORS   Lewinsky,H., Gunes,E.G., David,K., Radomir,L., Kramer,M.P.,
            Pellegrino,B., Perpinial,M., Chen,J., He,T.F., Mansour,A.G.,
            Teng,K.Y., Bhattacharya,S., Caserta,E., Troadec,E., Lee,P.,
            Feng,M., Keats,J., Krishnan,A., Rosenzweig,M., Yu,J.,
            Caligiuri,M.A., Cohen,Y., Shevetz,O., Becker-Herman,S.,
            Pichiorri,F., Rosen,S. and Shachar,I.
  TITLE     CD84 is a regulator of the immunosuppressive microenvironment in
            multiple myeloma
  JOURNAL   JCI Insight 6 (4), 141683 (2021)
   PUBMED   33465053
  REMARK    GeneRIF: CD84 is a regulator of the immunosuppressive
            microenvironment in multiple myeloma.
            Erratum:[JCI Insight. 2023 Jul 24;8(14):e173312. doi:
            10.1172/jci.insight.173312.. PMID: 37485873]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8204)
  AUTHORS   Barak,A.F., Lewinsky,H., Perpinial,M., Huber,V., Radomir,L.,
            Kramer,M.P., Sever,L., Wolf,Y., Shapiro,M., Herishanu,Y., Jung,S.,
            Becker-Herman,S. and Shachar,I.
  TITLE     Bone marrow dendritic cells support the survival of chronic
            lymphocytic leukemia cells in a CD84 dependent manner
  JOURNAL   Oncogene 39 (9), 1997-2008 (2020)
   PUBMED   31772329
  REMARK    GeneRIF: Bone marrow dendritic cells support the survival of
            chronic lymphocytic leukemia cells in a CD84 dependent manner.
REFERENCE   4  (bases 1 to 8204)
  AUTHORS   Vroegindewey,M.M., Oemrawsingh,R.M., Kardys,I., Asselbergs,F.W.,
            van der Harst,P., Oude Ophuis,A.J., Etienne Cramer,G., Maas,A.,
            Hong Kie The,S., Wardeh,A.J., Mouthaan,H., Boersma,E. and
            Akkerhuis,K.M.
  TITLE     The temporal pattern of immune and inflammatory proteins prior to a
            recurrent coronary event in post-acute coronary syndrome patients
  JOURNAL   Biomarkers 24 (2), 199-205 (2019)
   PUBMED   30514120
  REMARK    GeneRIF: Among 29 immune and inflammatory proteins, CXCL1, CD84 and
            TNFRSF10A were associated with early post-acute coronary syndrome
            (ACS) after initial ACS-admission
REFERENCE   5  (bases 1 to 8204)
  AUTHORS   Agod,Z., Pazmandi,K., Bencze,D., Vereb,G., Biro,T., Szabo,A.,
            Rajnavolgyi,E., Bacsi,A., Engel,P. and Lanyi,A.
  TITLE     Signaling Lymphocyte Activation Molecule Family 5 Enhances
            Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived
            Dendritic Cells via Stabilization of Interferon Regulatory Factor 8
  JOURNAL   Front Immunol 9, 62 (2018)
   PUBMED   29434592
  REMARK    GeneRIF: our experiments identified SLAMF5 as a novel cell surface
            receptor modulator of autophagy and revealed an unexpected link
            between the SLAMF and IRF8 signaling pathways, both implicated in
            multiple human pathologies.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8204)
  AUTHORS   Krause,S.W., Rehli,M., Heinz,S., Ebner,R. and Andreesen,R.
  TITLE     Characterization of MAX.3 antigen, a glycoprotein expressed on
            mature macrophages, dendritic cells and blood platelets: identity
            with CD84
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 729-736 (2000)
   PUBMED   10698700
REFERENCE   7  (bases 1 to 8204)
  AUTHORS   Palou,E., Pirotto,F., Sole,J., Freed,J.H., Peral,B., Vilardell,C.,
            Vilella,R., Vives,J. and Gaya,A.
  TITLE     Genomic characterization of CD84 reveals the existence of five
            isoforms differing in their cytoplasmic domains
  JOURNAL   Tissue Antigens 55 (2), 118-127 (2000)
   PUBMED   10746783
REFERENCE   8  (bases 1 to 8204)
  AUTHORS   de la Fuente,M.A., Pizcueta,P., Nadal,M., Bosch,J. and Engel,P.
  TITLE     CD84 leukocyte antigen is a new member of the Ig superfamily
  JOURNAL   Blood 90 (6), 2398-2405 (1997)
   PUBMED   9310491
REFERENCE   9  (bases 1 to 8204)
  AUTHORS   Kingsmore,S.F., Souryal,C.A., Watson,M.L., Patel,D.D. and
            Seldin,M.F.
  TITLE     Physical and genetic linkage of the genes encoding Ly-9 and CD48 on
            mouse and human chromosomes 1
  JOURNAL   Immunogenetics 42 (1), 59-62 (1995)
   PUBMED   7797269
REFERENCE   10 (bases 1 to 8204)
  AUTHORS   Andreesen,R., Bross,K.J., Osterholz,J. and Emmrich,F.
  TITLE     Human macrophage maturation and heterogeneity: analysis with a
            newly generated set of monoclonal antibodies to differentiation
            antigens
  JOURNAL   Blood 67 (5), 1257-1264 (1986)
   PUBMED   3008886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138930.15, BC020063.1 and CA448708.1.
            
            On Jun 2, 2019 this sequence version replaced NM_003874.3.
            
            Summary: This gene encodes a membrane glycoprotein that is a member
            of the signaling lymphocyte activation molecule (SLAM) family. This
            family forms a subset of the larger CD2 cell-surface receptor Ig
            superfamily. The encoded protein is a homophilic adhesion molecule
            that is expressed in numerous immune cells types and is involved in
            regulating receptor-mediated signaling in those cells. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (2) lacks an alternate, in-frame
            segment, compared to variant 1. The resulting protein (isoform 2)
            is shorter when it is compared to isoform 1. This variant has also
            been called CD84c.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020063.1, AJ223324.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368054.8/ ENSP00000357033.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL138930.15        140125-140159       c
            36-3311             BC020063.1         1-3276
            3312-8181           AL138930.15        101784-106653       c
            8182-8204           CA448708.1         22-44               c
FEATURES             Location/Qualifiers
     source          1..8204
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..8204
                     /gene="CD84"
                     /gene_synonym="hCD84; LY9B; mCD84; SLAMF5"
                     /note="CD84 molecule"
                     /db_xref="GeneID:8832"
                     /db_xref="HGNC:HGNC:1704"
                     /db_xref="MIM:604513"
     exon            1..105
                     /gene="CD84"
                     /gene_synonym="hCD84; LY9B; mCD84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1046
                     /gene="CD84"
                     /gene_synonym="hCD84; LY9B; mCD84; SLAMF5"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; CD84 antigen (leukocyte antigen); leukocyte
                     antigen CD84; SLAM family member 5; leukocyte
                     differentiation antigen CD84; leucocyte differentiation
                     antigen CD84; hly9-beta; cell surface antigen MAX.3;
                     signaling lymphocytic activation molecule 5"
                     /codon_start=1
                     /product="SLAM family member 5 isoform 2 precursor"
                     /protein_id="NP_003865.1"
                     /db_xref="CCDS:CCDS1206.1"
                     /db_xref="GeneID:8832"
                     /db_xref="HGNC:HGNC:1704"
                     /db_xref="MIM:604513"
                     /translation="MAQHHLWILLLCLQTWPEAAGKDSEIFTVNGILGESVTFPVNIQ
                     EPRQVKIIAWTSKTSVAYVTPGDSETAPVVTVTHRNYYERIHALGPNYNLVISDLRME
                     DAGDYKADINTQADPYTTTKRYNLQIYRRLGKPKITQSLMASVNSTCNVTLTCSVEKE
                     EKNVTYNWSPLGEEGNVLQIFQTPEDQELTYTCTAQNPVSNNSDSISARQLCADIAMG
                     FRTHHTGLLSVLAMFFLLVLILSSVFLFRLFKRRQDAASKKTIYTYIMASRNTQPAES
                     RIYDEILQSKVLPSKEEPVNTVYSEVQFADKMGKASTQDSKPPGTSSYEIVI"
     exon            106..447
                     /gene="CD84"
                     /gene_synonym="hCD84; LY9B; mCD84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            448..699
                     /gene="CD84"
                     /gene_synonym="hCD84; LY9B; mCD84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            700..819
                     /gene="CD84"
                     /gene_synonym="hCD84; LY9B; mCD84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            820..917
                     /gene="CD84"
                     /gene_synonym="hCD84; LY9B; mCD84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            918..980
                     /gene="CD84"
                     /gene_synonym="hCD84; LY9B; mCD84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            981..8204
                     /gene="CD84"
                     /gene_synonym="hCD84; LY9B; mCD84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8182..8187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD84"
                     /gene_synonym="hCD84; LY9B; mCD84; SLAMF5"
                     /note="hexamer: AATAAA"
     polyA_site      8204
                     /gene="CD84"
                     /gene_synonym="hCD84; LY9B; mCD84; SLAMF5"
                     /note="major polyA site"
ORIGIN      
        1 aaactgactc tgctagaaca gtgccgtgct tttccacaga aggttagacc ctgaaagaga
       61 tggctcagca ccacctatgg atcttgctcc tttgcctgca aacctggccg gaagcagctg
      121 gaaaagactc agaaatcttc acagtgaatg ggattctggg agagtcagtc actttccctg
      181 taaatatcca agaaccacgg caagttaaaa tcattgcttg gacttctaaa acatctgttg
      241 cttatgtaac accaggagac tcagaaacag cacccgtagt tactgtgacc cacagaaatt
      301 attatgaacg gatacatgcc ttaggtccga actacaatct ggtcattagc gatctgagga
      361 tggaagacgc aggagactac aaagcagaca taaatacaca ggctgatccc tacaccacca
      421 ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa accaaaaatt acacagagtt
      481 taatggcatc tgtgaacagc acctgtaatg tcacactgac atgctctgta gagaaagaag
      541 aaaagaatgt gacatacaat tggagtcccc tgggagaaga gggtaatgtc cttcaaatct
      601 tccagactcc tgaggaccaa gagctgactt acacgtgtac agcccagaac cctgtcagca
      661 acaattctga ctccatctct gcccggcagc tctgtgcaga catcgcaatg ggcttccgta
      721 ctcaccacac cgggttgctg agcgtgctgg ctatgttctt tctgcttgtt ctcattctgt
      781 cttcagtgtt tttgttccgt ttgttcaaga gaagacaaga tgctgcctca aagaaaacca
      841 tatacacata tatcatggct tcaaggaaca cccagccagc agagtccaga atctatgatg
      901 aaatcctgca gtccaaggtg cttccctcca aggaagagcc agtgaacaca gtttattccg
      961 aagtgcagtt tgctgataag atggggaaag ccagcacaca ggacagtaaa cctcctggga
     1021 cttcaagcta tgaaattgtg atctaggctg ctgggctgaa ttctccctct ggaaactgag
     1081 ttacaaccac caatactggc aggttccctg gatccagatc ttctctgccc aactcttact
     1141 gggagattgc aaactgccac atctcagcct gtaagcaaag caggaaacct tctgctgggc
     1201 atagcttgtg cctaaatgga caaatggatg catacccttc ctgaaatgac tcccttctga
     1261 atgaatgaca aagcaggtta cctagtatag ttttcccaaa cttcttccca tcatagcaca
     1321 tgtagaaaat aatattttta tggcacactg ggataaacaa gcaagattgc tcacttctgg
     1381 aagctgcata tgactagagg cctcttgtga ctggaggtaa caaccctgcc cagtaactgt
     1441 gggagaaggg gatcaatatt ttgcacacct gtaataggcc atggcacacc agccaagatg
     1501 ctctgctcac agtcagtatg tgtgaagatc cctggtgcgt ggccttcacc acgcatcttg
     1561 agcaaattag gaaaatgtac ccttcgcttg aggcagatgc agcccttccc ccgagtgcat
     1621 ggcttggaga gcagaatgtg ggctgcatat aagcacactc atccctttgt ctgggaatct
     1681 ttgtgcaggg cataacaggc ttagtaagtc caaacacaga tgacagtgct gtgtgggtct
     1741 ctgtcagagt tgtggctctc agccatgtag acacactctc caaatggagt gttggaaaat
     1801 gttctttctg cagggtctag agactgctgg gacacttttc ttggagtgct acttcagaag
     1861 ccttatagga ttttctttct ggccaagatt tccttctgta tcactccaag cagcctcagc
     1921 agaagaagca gccatgccca gtattcccac tctccaaaag gaactgacca gcttatattt
     1981 ctcacacttc tggggaactg ggtataatcc aaccatcaaa atagaagacc ttgcaagaag
     2041 cagagtcatt ctccagaagg aacttgggag atgatggtgc agatgatgaa actgggttca
     2101 tcccagttcc aaagactcag agaactagag tttaagctga ggcagagtgc cgccaccctg
     2161 gcatgcccca caaacagatc accagccagc ttacacaggc attaactctc ctcaatgagg
     2221 aagaatcatt cacaactgag caagacattc atatgatcat ttaaggaagt gtttccctta
     2281 tgtgttagca agtataatcg gctaactcct aaatcccaat gaatagtcct aggctggaca
     2341 gcaatgggct gcaattaggc agataaagac atcagtccca gtaaatgaat ccatagactc
     2401 atctagcacc aactaccatt agcactatgt taggagctgc aaggccccaa agtagaagat
     2461 gtgcataatg tctgctcttg tgtagctcag gagacaattc cagcacagac actacagtta
     2521 acgctgaact gcagctgcaa gtaatagcat gaacagtcag aaaaatacct tatgaggggg
     2581 cagggctgaa gctgggcctt gaaggatgga tgaaatttgg atagagaatg aggaagacag
     2641 agggcctcca agtgagagaa gcatgaaaaa tgagcagggg cctggatcag tggggtgtat
     2701 tcagagcacc tctccagatg caccatgcat gctcacagtc ccttgcctat gtgtggcaga
     2761 gtgtcccagc cagatgtgtg ccctcacccc atgtccattt acatgtcctt caatgcccac
     2821 ctcaaaaggt acctcttctg taaagctttc cctggtatca ggaatcaaaa ttaatcaggg
     2881 atcttttcac actgctgttt tttcctcttt ggtccttcta tcactaaaac tcatctcatt
     2941 cagccttaca gcataactaa ttatttgttt tcctcactac attgtacatg tgggaattac
     3001 agataaacgg aagccggctg gggtggtggc tcacgcctgt aatcccaaca ctttgggagg
     3061 ccaaggcagg cggatcacct gaggtcagga gttcgagatt agtctggcca acatggtgaa
     3121 accccatctc tactaaaaat acgaaattag ccaggtgtgg tggcacacat ctgtagtccc
     3181 agctactctg gaggctgaga caggagaatc gcttgaaccc aggaagtgga ggttgcagtg
     3241 agctgagatc acaccactgc actccagcct gggagagaca gagtgagact ccatctcgaa
     3301 aaaaaaaaaa agatagaagc caataagcat ggtgcaatca aattctggca agcattaaat
     3361 atcaggatgc agctgggcac ggtggctcac gcctgtaatc ccagcacttt gggaggccaa
     3421 ggtgggcgga tcacttgagg tcaggaattt gagaggatcc tggccagcat ggcaaaaccc
     3481 catctgtact taaaatacaa aaaaattagc tgggcgtggt ggtgcacacc tgtaatccca
     3541 gctacttggg aggctgaggt gggagaattg cttgaacctg ggaggtggag gttgcagtga
     3601 gctgagatcc tgccactgca ctccaggctg ggcaacagag tgagaccatg tctcaaaaaa
     3661 taaaaataaa ataaaataat atcaggatgc atacatcaga ggctgttcct agtgtaaagg
     3721 cactttggag ggagaagact ttcagagtta ggcagaccaa ctaagaggtc agctgaagca
     3781 cctaaccagt tgtaaggagg tgaaagacag caccccaaga agagacgtgc aggaaggagg
     3841 aaagaggctt ggtcataaag gatggaggaa ttccaaagtg acactgaaca ggctgcgttt
     3901 atcctaaaat aaaaccactc ctcactctgt ggatgcgttg aagactcatt cccaaacatc
     3961 tttattctct aacttgccct cttcctcttc ctaatatgct cactcaagta aaattactag
     4021 tgtcctaatg cccctatgca tattgtcaaa aataaaaatc agaagcaggt tagatctgtt
     4081 aggtcttcca gaagagcaaa cctgggatga agccagagcc caggaattct gaaggtagcc
     4141 tttggactca ggacacccta ctcttgtctc tcctctcagt ttctctgcta tgaatctcct
     4201 gattcatgaa cacgttatct gttcaccctt ctctctaggt cttagttctt agattttcct
     4261 tctgtaaaat gcatgtgatc ttattttccc ctccacaact ttccagatga actagactgt
     4321 gaccaagagg tctataaaat caaagcatca tggaacagga tcttgtatca gaccaaagtg
     4381 tgccagtttt taaaaatgtg catcaaaatg gaagtctcag agacagagcc ctctggtgga
     4441 aagttctagt aggttaggac agtcctgcct gcagacacct tgggctttac tgagggactc
     4501 aactgagaaa atgaggaatg ttgcagctca tgattcttag aagaagaaag tgaagcttgt
     4561 ttaaaatatg atttaaaaaa tctgtagaac actgtaaact acacaggcta tgagggaata
     4621 gcctggttgg gccagcttgg aaatcgggca caggcaggaa ggggcctgtc tggtttgggc
     4681 cgtgtccaca gagagcactt cttaggtcct gcctggagag aaggaatggc tgggctatat
     4741 tttcttccag actcattatt tttcttctgt ttgacttttc tctgaatttc ccttgatttg
     4801 tataaatttt ctcaataatt agtgacagtg tctactgatt gtaaaatgaa gcttgaaggc
     4861 caggcgcagt ggctcatgcc tgtaatccta gaattttggg aggccaaggt gggtggatca
     4921 caaggagttc gagaccagcc tggccaaggt tgtgaaaccg cgtctctact aaaaatacaa
     4981 aaaaattagc cgggcatggt ggcacgtgcc tgtagtccca gctactcagg aagctgaggc
     5041 aacagaatca cttgaacctg ggaggtggag gttgcagtga gccgagatca cgccactgca
     5101 ctccagcctg ggcgagagag tgagactccg tctcaaaaaa aaaaaaaaaa aaaaaagttt
     5161 gaagaacaaa gacaataaga ggaaatataa tgagtggtca taaatgtggg ctctgacagt
     5221 agagtgcctg ggtctgcatc ctggtttctt agtcatgtga ccttaggcaa gttactttaa
     5281 cctcgctgta cctcaggttg tccatctgta aaatggggat aataatagtg cctacctttt
     5341 aaggttgatg tggggattaa atgaggtgtt gctcatacag gaatgtgcct gtgcatggca
     5401 aagttcggga aattttttat aagctgttct aggcctgaaa tcttcagaag atgctaatct
     5461 aaattcatga aataagcttc ttacaacaga aatgctgcta gtattatgca aaattaatgt
     5521 tgtatatcaa acttttaact ctcatccctc cttattcaga tatattttgt tataagcaat
     5581 gtttgttccc ctcgttatta taccacagtc tacttacctg atgctatatc tgcctcccca
     5641 gttagactga gagaacaggg gatataccta aataataata ataataataa taataataaa
     5701 taataatgga gagctccttg aagataggga gcctgtaaga atcattgagg gcttattttg
     5761 tataccaact gctaaactag atgcttcata cattgttgtc aatactcatg acagccttgt
     5821 aaagtagaaa ttaattcttc cagttaacac taaggctgac atatgaatac cttggcaaat
     5881 ctggaaagct gggaagacag tatttgaatt caagacttct tgtcaccaag ggccatgcac
     5941 ttgtactctg ccatgtggcc cttttttacc tcctgtggat tctccctacc tggtacttgg
     6001 ccttaggtgt acacacacct ggcactttgc ttgacacata ataggtggac cacaaatatc
     6061 tactaaatga atatttgcat atagtaatat tttaaggtac taaaagcagc tcaaagtaaa
     6121 tatattaata tattaattcc attgctatct ggataaccac tcaactttcc tgctgaaaat
     6181 gcccatttaa ttaaagaagg ttggatagag ctctctatat gcattttgga caggcagggg
     6241 tttcaggtca taaacattct gatgagttaa tataaaataa gagaaactgt aaatttccac
     6301 tactaaaaat cacaaaaata acagaaacaa aagaagagat aagaatttgg ggaattgtgc
     6361 tgaacaattt agtggttaaa aaaaacaact gtgcatgttt agacttaaat aagcccccat
     6421 ccaagtgtga ggggtccagt aatttttcaa aacatatgaa agtgttaata catttcgaca
     6481 aaggaccatt aaaaaagtcc tgaattctga cttgagggag gaaagtaatg actaatacat
     6541 tctctagaga cttgcagact ttgggaattc ataaaggaat ggatgataat tattaactgt
     6601 tgctggctga ttgcccagac agttctcaac agccctgtac aagtctctgg gtttgggatg
     6661 gatcaattct gagactggaa aatggccaaa tctttgcaaa tgagaaatat ttttcttata
     6721 agttcttatt gtaggcaaat aattacatag attattcatc agagaatttt taaatgctca
     6781 taatctcaac tctttcattt acaacttgta tttccaatag tttatgggtc atctctgcat
     6841 agatgtcaga agtcacctca agtttagcgt gtccaaaatc taactcacag gtctgtttct
     6901 gacctcccaa cttgctttcc ttgtgttttt cctatgctaa tgatccacca taatcaaaat
     6961 aattaacatt tatccagtgc ctactatgta ctattccctg tcctgtttta catttactca
     7021 tttaaagtcc ataagaaaca ttaaatctca tctgccttct gaagaagata caaccatgct
     7081 ctcttttaca aagtaggaaa ctgggtcaca gaaaggtgaa gtctttaagg ctgaatcaca
     7141 gtagctcatc ctagtaaata gaaaagccag gattcaactc caggggctgg gtgcagaact
     7201 gctattcttc actgcttcac caatcagcag ctacccaagg cagaaaactt tttcatcctt
     7261 ggctccttca ttctccctgt caccccagat cccctctaca tctagtcaga gaataggtcc
     7321 tgtcaattcc aacttctcta tatggctcct ctcaggcatg tgcccttaat tggcctaatt
     7381 ctctaataca ccttccctct acatgctcac tccctcagat cattgcttta tcacgtgtta
     7441 cctgggttgc tattacataa agagcaatct ttctaaaatg aggatcttat cacttcactt
     7501 ccacactaaa atgtttttcc tggggaacca cactccttag caatctgacc catcagacct
     7561 tccaggctgt ctcctgcctg ctccctaagg ctccagccac acagaattat catgggccca
     7621 cacacccacc aaatcctccc atgcctttgc ccatgttgtc tgggatgccc ttctctccct
     7681 tctgtctaca tcaagcatca gactgaatat ccctcttgtg cggccttcta aaacctcccg
     7741 tccaaagcga aatatattgc cctctattta tacttttaca gcatttggca cacaagtaca
     7801 gagtagtagc tttttatcac attctctgat aattatatag atatggtatt tcttagctct
     7861 ctctccaact ggctaataag ttgctttttg tctgagtgcc taattttgtg ttttgtgtct
     7921 gagtgcctca gttcctcaaa aaaaggtttt ttgattagtt cattattcat ttgaacatgg
     7981 aaattatgct cactagtggc aaatgccact aaccgtattc cagaagctag gtgtcatgtt
     8041 tgcaataaga tatattatcc cttctacaag tcacctttta tttcaggcat ttgtaaatgc
     8101 ccattaataa agtatggttc ataaatttta ccttgtaagt gcctaagaaa tgagactaca
     8161 agctccattt cagcaggaca caataaatat tattttataa tgca
//
