LOCUS       NM_004233               2328 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens CD83 molecule (CD83), transcript variant 1, mRNA.
ACCESSION   NM_004233
VERSION     NM_004233.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2328)
  AUTHORS   Peckert-Maier,K., Wild,A.B., Sprissler,L., Fuchs,M., Beck,P.,
            Auger,J.P., Sinner,P., Strack,A., Muhl-Zurbes,P., Ramadan,N.,
            Kunz,M., Kronke,G., Stich,L., Steinkasserer,A. and Royzman,D.
  TITLE     Soluble CD83 modulates human-monocyte-derived macrophages toward
            alternative phenotype, function, and metabolism
  JOURNAL   Front Immunol 14, 1293828 (2023)
   PUBMED   38162675
  REMARK    GeneRIF: Soluble CD83 modulates human-monocyte-derived macrophages
            toward alternative phenotype, function, and metabolism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2328)
  AUTHORS   Holtan,S.G., Savid-Frontera,C., Walton,K., Eaton,A.A., Demorest,C.,
            Hoeschen,A., Zhang,L., Reid,K., Kurian,T., Sayegh,Z., Julia,E.,
            Maakaron,J., Bachanova,V., Jurdi,N.E., MacMillan,M.L.,
            Weisdorf,D.J., Felices,M., Miller,J.S., Blazar,B.R., Davila,M.L.
            and Betts,B.C.
  TITLE     Human Effectors of Acute and Chronic GVHD Overexpress CD83 and
            Predict Mortality
  JOURNAL   Clin Cancer Res 29 (6), 1114-1124 (2023)
   PUBMED   36622700
  REMARK    GeneRIF: Human Effectors of Acute and Chronic GVHD Overexpress CD83
            and Predict Mortality.
REFERENCE   3  (bases 1 to 2328)
  AUTHORS   Riaz,B., Islam,S.M.S., Ryu,H.M. and Sohn,S.
  TITLE     CD83 Regulates the Immune Responses in Inflammatory Disorders
  JOURNAL   Int J Mol Sci 24 (3), 2831 (2023)
   PUBMED   36769151
  REMARK    GeneRIF: CD83 Regulates the Immune Responses in Inflammatory
            Disorders.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2328)
  AUTHORS   Royzman,D., Andreev,D., Stich,L., Peckert-Maier,K., Wild,A.B.,
            Zinser,E., Muhl-Zurbes,P., Jones,E., Adam,S., Frey,S., Fuchs,M.,
            Kunz,M., Bauerle,T., Nagel,L., Schett,G., Bozec,A. and
            Steinkasserer,A.
  TITLE     The soluble CD83 protein prevents bone destruction by inhibiting
            the formation of osteoclasts and inducing resolution of
            inflammation in arthritis
  JOURNAL   Front Immunol 13, 936995 (2022)
   PUBMED   36003376
  REMARK    GeneRIF: The soluble CD83 protein prevents bone destruction by
            inhibiting the formation of osteoclasts and inducing resolution of
            inflammation in arthritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2328)
  AUTHORS   Biele,E., Schober,S.J., Prexler,C., Thiede,M., Heyking,K.V.,
            Gassmann,H., Eck,J., Xue,B., Burdach,S. and Thiel,U.
  TITLE     Monocyte Maturation Mediators Upregulate CD83, ICAM-1 and MHC Class
            1 Expression on Ewing's Sarcoma, Enhancing T Cell Cytotoxicity
  JOURNAL   Cells 10 (11), 3070 (2021)
   PUBMED   34831294
  REMARK    GeneRIF: Monocyte Maturation Mediators Upregulate CD83, ICAM-1 and
            MHC Class 1 Expression on Ewing's Sarcoma, Enhancing T Cell
            Cytotoxicity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2328)
  AUTHORS   Olavesen,M.G., Bentley,E., Mason,R.V., Stephens,R.J. and
            Ragoussis,J.
  TITLE     Fine mapping of 39 ESTs on human chromosome 6p23-p25
  JOURNAL   Genomics 46 (2), 303-306 (1997)
   PUBMED   9417921
REFERENCE   7  (bases 1 to 2328)
  AUTHORS   de la Fuente,M.A., Pizcueta,P., Nadal,M., Bosch,J. and Engel,P.
  TITLE     CD84 leukocyte antigen is a new member of the Ig superfamily
  JOURNAL   Blood 90 (6), 2398-2405 (1997)
   PUBMED   9310491
REFERENCE   8  (bases 1 to 2328)
  AUTHORS   Zhou,L.J. and Tedder,T.F.
  TITLE     Human blood dendritic cells selectively express CD83, a member of
            the immunoglobulin superfamily
  JOURNAL   J Immunol 154 (8), 3821-3835 (1995)
   PUBMED   7706722
REFERENCE   9  (bases 1 to 2328)
  AUTHORS   Kozlow,E.J., Wilson,G.L., Fox,C.H. and Kehrl,J.H.
  TITLE     Subtractive cDNA cloning of a novel member of the Ig gene
            superfamily expressed at high levels in activated B lymphocytes
  JOURNAL   Blood 81 (2), 454-461 (1993)
   PUBMED   8422464
REFERENCE   10 (bases 1 to 2328)
  AUTHORS   Zhou,L.J., Schwarting,R., Smith,H.M. and Tedder,T.F.
  TITLE     A novel cell-surface molecule expressed by human interdigitating
            reticulum cells, Langerhans cells, and activated lymphocytes is a
            new member of the Ig superfamily
  JOURNAL   J Immunol 149 (2), 735-742 (1992)
   PUBMED   1378080
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB178710.1, BC030830.1 and
            AL133259.24.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004233.3.
            
            Summary: The protein encoded by this gene is a single-pass type I
            membrane protein and member of the immunoglobulin superfamily of
            receptors. The encoded protein may be involved in the regulation of
            antigen presentation. A soluble form of this protein can bind to
            dendritic cells and inhibit their maturation. Three transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.56811.1,
                                           SRR1803615.275246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379153.4/ ENSP00000368450.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               DB178710.1         139-384
            247-1067            BC030830.1         339-1159
            1068-2328           AL133259.24        13548-14808
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p23"
     gene            1..2328
                     /gene="CD83"
                     /gene_synonym="BL11; HB15"
                     /note="CD83 molecule"
                     /db_xref="GeneID:9308"
                     /db_xref="HGNC:HGNC:1703"
                     /db_xref="MIM:604534"
     exon            1..77
                     /gene="CD83"
                     /gene_synonym="BL11; HB15"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..658
                     /gene="CD83"
                     /gene_synonym="BL11; HB15"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; cell-surface glycoprotein; CD83 antigen
                     (activated B lymphocytes, immunoglobulin superfamily);
                     hCD83; B-cell activation protein; cell surface protein
                     HB15"
                     /codon_start=1
                     /product="CD83 antigen isoform a precursor"
                     /protein_id="NP_004224.1"
                     /db_xref="CCDS:CCDS4532.1"
                     /db_xref="GeneID:9308"
                     /db_xref="HGNC:HGNC:1703"
                     /db_xref="MIM:604534"
                     /translation="MSRGLQLLLLSCAYSLAPATPEVKVACSEDVDLPCTAPWDPQVP
                     YTVSWVKLLEGGEERMETPQEDHLRGQHYHQKGQNGSFDAPNERPYSLKIRNTTSCNS
                     GTYRCTLQDPDGQRNLSGKVILRVTGCPAQRKEETFKKYRAEIVLLLALVIFYLTLII
                     FTCKFARLQSIFPDFSKAGMERAFLPVTSPNKHLGLVTPHKTELV"
     exon            78..193
                     /gene="CD83"
                     /gene_synonym="BL11; HB15"
                     /inference="alignment:Splign:2.1.0"
     exon            194..422
                     /gene="CD83"
                     /gene_synonym="BL11; HB15"
                     /inference="alignment:Splign:2.1.0"
     exon            423..529
                     /gene="CD83"
                     /gene_synonym="BL11; HB15"
                     /inference="alignment:Splign:2.1.0"
     exon            530..2328
                     /gene="CD83"
                     /gene_synonym="BL11; HB15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2079..2084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD83"
                     /gene_synonym="BL11; HB15"
                     /note="hexamer: ATTAAA"
     polyA_site      2102
                     /gene="CD83"
                     /gene_synonym="BL11; HB15"
                     /note="major polyA site"
     regulatory      2296..2301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD83"
                     /gene_synonym="BL11; HB15"
                     /note="hexamer: AATAAA"
     polyA_site      2305
                     /gene="CD83"
                     /gene_synonym="BL11; HB15"
ORIGIN      
        1 acagctctgc agctcgtggc agcggcgcag cgctccagcc atgtcgcgcg gcctccagct
       61 tctgctcctg agctgcgcct acagcctggc tcccgcgacg ccggaggtga aggtggcttg
      121 ctccgaagat gtggacttgc cctgcaccgc cccctgggat ccgcaggttc cctacacggt
      181 ctcctgggtc aagttattgg agggtggtga agagaggatg gagacacccc aggaagacca
      241 cctcagggga cagcactatc atcagaaggg gcaaaatggt tctttcgacg cccccaatga
      301 aaggccctat tccctgaaga tccgaaacac taccagctgc aactcgggga catacaggtg
      361 cactctgcag gacccggatg ggcagagaaa cctaagtggc aaggtgatct tgagagtgac
      421 aggatgccct gcacagcgta aagaagagac ttttaagaaa tacagagcgg agattgtcct
      481 gctgctggct ctggttattt tctacttaac actcatcatt ttcacttgta agtttgcacg
      541 gctacagagt atcttcccag atttttctaa agctggcatg gaacgagctt ttctcccagt
      601 tacctcccca aataagcatt tagggctagt gactcctcac aagacagaac tggtatgagc
      661 aggatttctg caggttcttc ttcctgaagc tgaggctcag gggtgtgcct gtctgttaca
      721 ctggaggaga gaagaatgag cctacgctga agatggcatc ctgtgaagtc cttcacctca
      781 ctgaaaacat ctggaagggg atcccacccc attttctgtg ggcaggcctc gaaaaccatc
      841 acatgaccac atagcatgag gccactgctg cttctccatg gccacctttt cagcgatgta
      901 tgcagctatc tggtcaacct cctggacatt ttttcagtca tataaaagct atggtgagat
      961 gcagctggaa aagggtcttg ggaaatatga atgcccccag ctggcccgtg acagactcct
     1021 gaggacagct gtcctcttct gcatcttggg gacatctctt tgaattttct gtgttttgct
     1081 gtaccagccc agatgtttta cgtctgggag aaattgacag atcaagctgt gagacagtgg
     1141 gaaatattta gcaaataatt tcctggtgtg aaggtcctgc tattactaag gagtaatctg
     1201 tgtacaaaga aataacaagt cgatgaacta ttccccagca gggtcttttc atctgggaaa
     1261 gacatccata aagaagcaat aaagaagagt gccacattta tttttatatc tatatgtact
     1321 tgtcaaagaa ggtttgtgtt tttctgcttt tgaaatctgt atctgtagtg agatagcatt
     1381 gtgaactgac aggcagcctg gacatagaga gggagaagaa gtcagagagg gtgacaagat
     1441 agagagctat ttaatggccg gctggaaatg ctgggctgac ggtgcagtct gggtgctcgc
     1501 ccacttgtcc cactatctgg gtgcatgatc ttgagcaagt tccttctggt gtctgctttc
     1561 tccattgtaa accacaaggc tgttgcatgg gctaatgaag atcatatacg tgaaaattat
     1621 ttgaaaacat ataaagcact atacagattc gaaactccat tgagtcatta tccttgctat
     1681 gatgatggtg ttttggggat gagagggtgc tatccatttc tcatgttttc cattgtttga
     1741 aacaaagaag gttaccaaga agcctttcct gtagccttct gtaggaattc ttttggggaa
     1801 gtgaggaagc caggtccacg gtctgttctt gaagcagtag cctaacacac tccaagatat
     1861 ggacacacgg gagccgctgg cagaagggac ttcacgaagt gttgcatgga tgttttagcc
     1921 attgttggct ttcccttatc aaacttgggc ccttcccttc ttggtttcca aaggcatttt
     1981 attgcttgag ttatatgttc actgtccccc taatattagg gagtaaaacg gataccaagt
     2041 tgatttagtg tttttacctc tgtcttggct ttcatgttat taaacgtatg catgtgaaga
     2101 aagggtgttt ttctgtttta tattcaactc ataagacttt gggataggaa aaatgagtaa
     2161 tggttactag gcttaatacc tgggtgatta cataatctgt acaatgaacc cccatgatgt
     2221 aagtttacct atgtaacaaa cctgcactta tacccatgaa cttaaaatga aagttaaaaa
     2281 taaaaaacat atacaaataa aaaaatcccg actttgggat gagtgcta
//
