LOCUS       NM_002231               2212 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens CD82 molecule (CD82), transcript variant 1, mRNA.
ACCESSION   NM_002231
VERSION     NM_002231.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2212)
  AUTHORS   Park,J.W., Kim,W., Kang,H.G., Kim,W.J., Lee,H., Choi,D. and
            Kim,S.J.
  TITLE     DNA Hypermethylation Inhibits the CD82 Metastasis Suppressor Gene
            in Gastric Cancer
  JOURNAL   Anticancer Res 44 (6), 2459-2470 (2024)
   PUBMED   38821592
  REMARK    GeneRIF: DNA Hypermethylation Inhibits the CD82 Metastasis
            Suppressor Gene in Gastric Cancer.
REFERENCE   2  (bases 1 to 2212)
  AUTHORS   Na,K., Lee,S., Kim,D.K., Kim,Y.S., Hwang,J.Y., Kang,S.S., Baek,S.,
            Lee,C.Y., Yang,S.M., Han,Y.J., Kim,M.H., Han,H., Kim,Y., Kim,J.H.,
            Jeon,S., Byeon,Y., Lee,J.B., Lim,S.M., Hong,M.H., Pyo,K.H. and
            Cho,B.C.
  TITLE     CD81 and CD82 expressing tumor-infiltrating lymphocytes in the
            NSCLC tumor microenvironment play a crucial role in T-cell
            activation and cytokine production
  JOURNAL   Front Immunol 15, 1336246 (2024)
   PUBMED   38515751
  REMARK    GeneRIF: CD81 and CD82 expressing tumor-infiltrating lymphocytes in
            the NSCLC tumor microenvironment play a crucial role in T-cell
            activation and cytokine production.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2212)
  AUTHORS   Reddi,K.K., Zhang,W., Shahrabi-Farahani,S., Anderson,K.M., Liu,M.,
            Kakhniashvili,D., Wang,X. and Zhang,Y.H.
  TITLE     Tetraspanin CD82 Correlates with and May Regulate S100A7 Expression
            in Oral Cancer
  JOURNAL   Int J Mol Sci 25 (5), 2659 (2024)
   PUBMED   38473906
  REMARK    GeneRIF: Tetraspanin CD82 Correlates with and May Regulate S100A7
            Expression in Oral Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2212)
  AUTHORS   Fontelonga,T., Hall,A.J., Brown,J.L., Jung,Y.L., Alexander,M.S.,
            Dominov,J.A., Mouly,V., Vieira,N., Zatz,M., Vainzof,M. and
            Gussoni,E.
  TITLE     Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle
            Cells and Binds to Dysferlin and Myoferlin
  JOURNAL   Adv Biol (Weinh) 7 (12), e2300157 (2023)
   PUBMED   37434585
  REMARK    GeneRIF: Tetraspanin CD82 Associates with Trafficking Vesicle in
            Muscle Cells and Binds to Dysferlin and Myoferlin.
REFERENCE   5  (bases 1 to 2212)
  AUTHORS   Ci,H. and Wu,L.
  TITLE     Expression of KAI1 and AGR2 in lung adenocarcinoma and their
            clinicopathological significance
  JOURNAL   Medicine (Baltimore) 101 (51), e32498 (2022)
   PUBMED   36595821
  REMARK    GeneRIF: Expression of KAI1 and AGR2 in lung adenocarcinoma and
            their clinicopathological significance.
REFERENCE   6  (bases 1 to 2212)
  AUTHORS   Imai,T., Kakizaki,M., Nishimura,M. and Yoshie,O.
  TITLE     Molecular analyses of the association of CD4 with two members of
            the transmembrane 4 superfamily, CD81 and CD82
  JOURNAL   J Immunol 155 (3), 1229-1239 (1995)
   PUBMED   7636191
REFERENCE   7  (bases 12 to 278)
  AUTHORS   Dong,J.T., Lamb,P.W., Rinker-Schaeffer,C.W., Vukanovic,J.,
            Ichikawa,T., Isaacs,J.T. and Barrett,J.C.
  TITLE     KAI1, a metastasis suppressor gene for prostate cancer on human
            chromosome 11p11.2
  JOURNAL   Science 268 (5212), 884-886 (1995)
   PUBMED   7754374
REFERENCE   8  (bases 1 to 2212)
  AUTHORS   Imai,T., Fukudome,K., Takagi,S., Nagira,M., Furuse,M., Fukuhara,N.,
            Nishimura,M., Hinuma,Y. and Yoshie,O.
  TITLE     C33 antigen recognized by monoclonal antibodies inhibitory to human
            T cell leukemia virus type 1-induced syncytium formation is a
            member of a new family of transmembrane proteins including CD9,
            CD37, CD53, and CD63
  JOURNAL   J Immunol 149 (9), 2879-2886 (1992)
   PUBMED   1401919
REFERENCE   9  (bases 1 to 2212)
  AUTHORS   Ichikawa,T., Ichikawa,Y., Dong,J., Hawkins,A.L., Griffin,C.A.,
            Isaacs,W.B., Oshimura,M., Barrett,J.C. and Isaacs,J.T.
  TITLE     Localization of metastasis suppressor gene(s) for prostatic cancer
            to the short arm of human chromosome 11
  JOURNAL   Cancer Res 52 (12), 3486-3490 (1992)
   PUBMED   1596907
REFERENCE   10 (bases 1 to 2212)
  AUTHORS   Ichikawa,T., Ichikawa,Y. and Isaacs,J.T.
  TITLE     Genetic factors and suppression of metastatic ability of prostatic
            cancer
  JOURNAL   Cancer Res 51 (14), 3788-3792 (1991)
   PUBMED   2065333
REFERENCE   11 (bases 1 to 2212)
  AUTHORS   Gaugitsch,H.W., Hofer,E., Huber,N.E., Schnabl,E. and Baumruker,T.
  TITLE     A new superfamily of lymphoid and melanoma cell proteins with
            extensive homology to Schistosoma mansoni antigen Sm23
  JOURNAL   Eur J Immunol 21 (2), 377-383 (1991)
   PUBMED   1842498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB127804.1, U20770.1 and
            AC010768.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002231.3.
            
            Summary: This metastasis suppressor gene product is a membrane
            glycoprotein that is a member of the transmembrane 4 superfamily.
            Expression of this gene has been shown to be downregulated in tumor
            progression of human cancers and can be activated by p53 through a
            consensus binding sequence in the promoter. Its expression and that
            of p53 are strongly correlated, and the loss of expression of these
            two proteins is associated with poor survival for prostate cancer
            patients. Two alternatively spliced transcript variants encoding
            distinct isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.344065.1,
                                           SRR3476690.362601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227155.9/ ENSP00000227155.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CB127804.1         89-99
            12-1095             U20770.1           1-1084
            1096-1643           AC010768.10        16151-16698         c
            1644-2212           AC010768.10        15582-16150         c
FEATURES             Location/Qualifiers
     source          1..2212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..2212
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /note="CD82 molecule"
                     /db_xref="GeneID:3732"
                     /db_xref="HGNC:HGNC:6210"
                     /db_xref="MIM:600623"
     exon            1..74
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /inference="alignment:Splign:2.1.0"
     exon            75..156
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /inference="alignment:Splign:2.1.0"
     exon            157..239
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..980
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kangai 1 (suppression of tumorigenicity 6, prostate; CD82
                     antigen (R2 leukocyte antigen, antigen detected by
                     monoclonal and antibody IA4)); C33 antigen; inducible
                     membrane protein R2; tspan-27; tetraspanin-27; metastasis
                     suppressor Kangai-1"
                     /codon_start=1
                     /product="CD82 antigen isoform 1"
                     /protein_id="NP_002222.1"
                     /db_xref="CCDS:CCDS7909.1"
                     /db_xref="GeneID:3732"
                     /db_xref="HGNC:HGNC:6210"
                     /db_xref="MIM:600623"
                     /translation="MGSACIKVTKYFLFLFNLIFFILGAVILGFGVWILADKSSFISV
                     LQTSSSSLRMGAYVFIGVGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQVTA
                     GALFYFNMGKLKQEMGGIVTELIRDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTD
                     NAELMNRPEVTYPCSCEVKGEEDNSLSVRKGFCEAPGNRTQSGNHPEDWPVYQEGCME
                     KVQAWLQENLGIILGVGVGVAIIELLGMVLSICLCRHVHSEDYSKVPKY"
     exon            240..312
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /inference="alignment:Splign:2.1.0"
     exon            313..437
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /inference="alignment:Splign:2.1.0"
     exon            438..512
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /inference="alignment:Splign:2.1.0"
     exon            513..614
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /inference="alignment:Splign:2.1.0"
     exon            615..818
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /inference="alignment:Splign:2.1.0"
     exon            819..902
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /inference="alignment:Splign:2.1.0"
     exon            903..2212
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2193..2198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /note="hexamer: ATTAAA"
     polyA_site      2212
                     /gene="CD82"
                     /gene_synonym="4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6;
                     TSPAN27"
                     /note="major polyA site"
ORIGIN      
        1 gcagtccgac gccgactgag gcacgagcgg gtgacgctgg gcctgcagcg cggagcagaa
       61 agcagaaccc gcagagtcct ccctgctgct gtgtggacga cacgtgggca caggcagaag
      121 tgggccctgt gaccagctgc actggtttcg tggaaggaag ctccaggact ggcgggatgg
      181 gctcagcctg tatcaaagtc accaaatact ttctcttcct cttcaacttg atcttcttta
      241 tcctgggcgc agtgatcctg ggcttcgggg tgtggatcct ggccgacaag agcagtttca
      301 tctctgtcct gcaaacctcc tccagctcgc ttaggatggg ggcctatgtc ttcatcggcg
      361 tgggggcagt cactatgctc atgggcttcc tgggctgcat cggcgccgtc aacgaggtcc
      421 gctgcctgct ggggctgtac tttgctttcc tgctcctgat cctcattgcc caggtgacgg
      481 ccggggccct cttctacttc aacatgggca agctgaagca ggagatgggc ggcatcgtga
      541 ctgagctcat tcgagactac aacagcagtc gcgaggacag cctgcaggat gcctgggact
      601 acgtgcaggc tcaggtgaag tgctgcggct gggtcagctt ctacaactgg acagacaacg
      661 ctgagctcat gaatcgccct gaggtcacct acccctgttc ctgcgaagtc aagggggaag
      721 aggacaacag cctttctgtg aggaagggct tctgcgaggc ccccggcaac aggacccaga
      781 gtggcaacca ccctgaggac tggcctgtgt accaggaggg ctgcatggag aaggtgcagg
      841 cgtggctgca ggagaacctg ggcatcatcc tcggcgtggg cgtgggtgtg gccatcatcg
      901 agctcctggg gatggtcctg tccatctgct tgtgccggca cgtccattcc gaagactaca
      961 gcaaggtccc caagtactga ggcagctgct atccccatct ccctgcctgg cccccaacct
     1021 cagggctccc aggggtctcc ctggctccct cctccaggcc tgcctcccac ttcactgcga
     1081 agaccctctt gcccatcctg actgaaagta gggggctttc tggggcctag cgatctctcc
     1141 tggcctatcc gctgccagcc ttgagccctg gctgttctgt ggttcctctg ctcaccgccc
     1201 atcagggttc tcttagcaac tcagagaaaa atgctcccca cagcgtccct ggcgcaggtg
     1261 ggctggactt ctacctgccc tcaagggtgt gtatattgta taggggcaac tgtatgaaaa
     1321 attggggagg agggggccgg gcgcggtggc tcacgcctgt aatcccagca ctttgggagg
     1381 ccgaggcggg tggatcacga ggtcaggaga tcgagaccat cctggctaac atggtgaaac
     1441 cccgtctcta ctaaaaatac aaaaaaaatt tagccgggcg cggtggcggg cacctgtagt
     1501 cccagctact tgggaggctg aggcaggaga atggtgtgaa cccgggagcg gaggttgcag
     1561 tgagctgaga tcgtgctact gcactccagc ctgggggaca gaaagagact ccgtctcaaa
     1621 aaaaaaaaaa aaaaaaaaaa aaattgggga gggaagggcg ttagataagg cactctgggc
     1681 tgtcaggaga ctgcctactg ggtgggtcaa cttatttccc actatgacat ttatatcttt
     1741 atttttcaca attatattga aggcagtggg agaggggaga gggtgggttt tacctgatat
     1801 taaggggtgg caccccttcc ccaggcctga tgcaggtcca tctagacagc tcagattagc
     1861 ctaggccatg ccctagggac acggcctagg ggagctgggc tggagggggt ctgcctgggt
     1921 aaggggatct ggcttggccc tgagctgctt agggacaggt gagtccttgg gggcatggca
     1981 cagagctggt cctgtattct ccagggtccg gagctggcca ggggcgggga ggaggaggat
     2041 ggcttctcct gggagaaggt gggctggcct ttcttggcaa gcggtcctct ggcccctggg
     2101 gagtggggtg ggtgaggctg tgccttgtag ggggagaggg gagggggctt tgtgtgcacc
     2161 attctgtaaa acacactcaa gattctaaga ctattaaaga ggatttataa ca
//
