LOCUS       NM_004356               1482 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens CD81 molecule (CD81), transcript variant 1, mRNA.
ACCESSION   NM_004356
VERSION     NM_004356.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1482)
  AUTHORS   Cone,A.S., Zhou,Y., McNamara,R.P., Eason,A.B., Arias,G.F.,
            Landis,J.T., Shifflett,K.W., Chambers,M.G., Yuan,R., Willcox,S.,
            Griffith,J.D. and Dittmer,D.P.
  TITLE     CD81 fusion alters SARS-CoV-2 Spike trafficking
  JOURNAL   mBio 15 (9), e0192224 (2024)
   PUBMED   39140770
  REMARK    GeneRIF: CD81 fusion alters SARS-CoV-2 Spike trafficking.
REFERENCE   2  (bases 1 to 1482)
  AUTHORS   Schwerdtfeger,F., Hoogvliet,I., van Deventer,S. and van Spriel,A.B.
  TITLE     The conformation of tetraspanins CD53 and CD81 differentially
            affects their nanoscale organization and interaction with their
            partners
  JOURNAL   J Biol Chem 300 (9), 107685 (2024)
   PUBMED   39159818
  REMARK    GeneRIF: The conformation of tetraspanins CD53 and CD81
            differentially affects their nanoscale organization and interaction
            with their partners.
REFERENCE   3  (bases 1 to 1482)
  AUTHORS   Na,K., Lee,S., Kim,D.K., Kim,Y.S., Hwang,J.Y., Kang,S.S., Baek,S.,
            Lee,C.Y., Yang,S.M., Han,Y.J., Kim,M.H., Han,H., Kim,Y., Kim,J.H.,
            Jeon,S., Byeon,Y., Lee,J.B., Lim,S.M., Hong,M.H., Pyo,K.H. and
            Cho,B.C.
  TITLE     CD81 and CD82 expressing tumor-infiltrating lymphocytes in the
            NSCLC tumor microenvironment play a crucial role in T-cell
            activation and cytokine production
  JOURNAL   Front Immunol 15, 1336246 (2024)
   PUBMED   38515751
  REMARK    GeneRIF: CD81 and CD82 expressing tumor-infiltrating lymphocytes in
            the NSCLC tumor microenvironment play a crucial role in T-cell
            activation and cytokine production.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1482)
  AUTHORS   Ye,X., Deng,J., Dong,C., Pan,X. and Lu,Y.
  TITLE     Characterization and verification of CD81 as a potential target in
            lung squamous cell carcinoma
  JOURNAL   Biochem Biophys Res Commun 692, 149344 (2024)
   PUBMED   38070275
  REMARK    GeneRIF: Characterization and verification of CD81 as a potential
            target in lung squamous cell carcinoma.
            Erratum:[Biochem Biophys Res Commun. 2024 Oct 15;729:150352. doi:
            10.1016/j.bbrc.2024.150352.. PMID: 38972138]
REFERENCE   5  (bases 1 to 1482)
  AUTHORS   Jovanovic,E., Babic,T., Dragicevic,S., Kmezic,S. and Nikolic,A.
  TITLE     Transcript CD81-215 may be a long noncoding RNA of stromal origin
            with tumor-promoting role in colon cancer
  JOURNAL   Cell Biochem Funct 41 (8), 1503-1513 (2023)
   PUBMED   38014564
  REMARK    GeneRIF: Transcript CD81-215 may be a long noncoding RNA of stromal
            origin with tumor-promoting role in colon cancer.
            Erratum:[Cell Biochem Funct. 2024 Dec;42(8):e70018. doi:
            10.1002/cbf.70018.. PMID: 39572866]
REFERENCE   6  (bases 1 to 1482)
  AUTHORS   Bradbury,L.E., Kansas,G.S., Levy,S., Evans,R.L. and Tedder,T.F.
  TITLE     The CD19/CD21 signal transducing complex of human B lymphocytes
            includes the target of antiproliferative antibody-1 and Leu-13
            molecules
  JOURNAL   J Immunol 149 (9), 2841-2850 (1992)
   PUBMED   1383329
REFERENCE   7  (bases 1 to 1482)
  AUTHORS   Levy,S., Nguyen,V.Q., Andria,M.L. and Takahashi,S.
  TITLE     Structure and membrane topology of TAPA-1
  JOURNAL   J Biol Chem 266 (22), 14597-14602 (1991)
   PUBMED   1860863
REFERENCE   8  (bases 1 to 1482)
  AUTHORS   Andria,M.L., Hsieh,C.L., Oren,R., Francke,U. and Levy,S.
  TITLE     Genomic organization and chromosomal localization of the TAPA-1
            gene
  JOURNAL   J Immunol 147 (3), 1030-1036 (1991)
   PUBMED   1650385
REFERENCE   9  (bases 1 to 1482)
  AUTHORS   Takahashi,S., Doss,C., Levy,S. and Levy,R.
  TITLE     TAPA-1, the target of an antiproliferative antibody, is associated
            on the cell surface with the Leu-13 antigen
  JOURNAL   J Immunol 145 (7), 2207-2213 (1990)
   PUBMED   2398277
REFERENCE   10 (bases 1 to 1482)
  AUTHORS   Oren,R., Takahashi,S., Doss,C., Levy,R. and Levy,S.
  TITLE     TAPA-1, the target of an antiproliferative antibody, defines a new
            family of transmembrane proteins
  JOURNAL   Mol Cell Biol 10 (8), 4007-4015 (1990)
   PUBMED   1695320
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC129929.5, BG397506.1,
            BQ709484.1, M33680.1 and BC002978.1.
            
            On Dec 4, 2019 this sequence version replaced NM_004356.3.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            This encoded protein is a cell surface glycoprotein that is known
            to complex with integrins. This protein appears to promote muscle
            cell fusion and support myotube maintenance. Also it may be
            involved in signal transduction. This gene is localized in the
            tumor-suppressor gene region and thus it is a candidate gene for
            malignancies. Two transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002978.1, M33680.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263645.10/ ENSP00000263645.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC129929.5         9781-9787           c
            8-25                BG397506.1         4-21
            26-111              BQ709484.1         16-101
            112-200             M33680.1           110-198
            201-1482            BC002978.1         1-1282
FEATURES             Location/Qualifiers
     source          1..1482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1482
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /note="CD81 molecule"
                     /db_xref="GeneID:975"
                     /db_xref="HGNC:HGNC:1701"
                     /db_xref="MIM:186845"
     exon            1..306
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..951
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /note="isoform 1 is encoded by transcript variant 1; CD81
                     antigen (target of antiproliferative antibody 1); 26 kDa
                     cell surface protein TAPA-1; tspan-28; tetraspanin-28"
                     /codon_start=1
                     /product="CD81 antigen isoform 1"
                     /protein_id="NP_004347.1"
                     /db_xref="CCDS:CCDS7734.1"
                     /db_xref="GeneID:975"
                     /db_xref="HGNC:HGNC:1701"
                     /db_xref="MIM:186845"
                     /translation="MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNL
                     LYLELGDKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILF
                     ACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSS
                     TLTALTTSVLKNNLCPSGSNIISNLFKEDCHQKIDDLFSGKLYLIGIAAIVVAVIMIF
                     EMILSMVLCCGIRNSSVY"
     exon            307..421
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /inference="alignment:Splign:2.1.0"
     exon            422..519
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /inference="alignment:Splign:2.1.0"
     exon            520..594
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /inference="alignment:Splign:2.1.0"
     exon            595..699
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /inference="alignment:Splign:2.1.0"
     exon            700..801
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /inference="alignment:Splign:2.1.0"
     exon            802..888
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1482
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1456..1461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /note="hexamer: AATAAA"
     polyA_site      1482
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /note="major polyA site"
ORIGIN      
        1 ggccagagag cgagcgcgca acggcggcga cggcggcgac cccaccgcgc atcctgccag
       61 gcctccggcg cccagcgccc cacgcgcccc cgcgcccccg cgcccccgcg cccctttctt
      121 cgcgcccccg cccctcggcc cgccaggccc ccttgccggc cacccgccag gccccgcgcc
      181 ggcccgcccg ccgcccagga ccggcccgcg ccccgcaggc cgcccgccgc ccgcgccgcc
      241 atgggagtgg agggctgcac caagtgcatc aagtacctgc tcttcgtctt caatttcgtc
      301 ttctggctgg ctggaggcgt gatcctgggt gtggccctgt ggctccgcca tgacccgcag
      361 accaccaacc tcctgtatct ggagctggga gacaagcccg cgcccaacac cttctatgta
      421 ggcatctaca tcctcatcgc tgtgggcgct gtcatgatgt tcgttggctt cctgggctgc
      481 tacggggcca tccaggaatc ccagtgcctg ctggggacgt tcttcacctg cctggtcatc
      541 ctgtttgcct gtgaggtggc cgccggcatc tggggctttg tcaacaagga ccagatcgcc
      601 aaggatgtga agcagttcta tgaccaggcc ctacagcagg ccgtggtgga tgatgacgcc
      661 aacaacgcca aggctgtggt gaagaccttc cacgagacgc ttgactgctg tggctccagc
      721 acactgactg ctttgaccac ctcagtgctc aagaacaatt tgtgtccctc gggcagcaac
      781 atcatcagca acctcttcaa ggaggactgc caccagaaga tcgatgacct cttctccggg
      841 aagctgtacc tcatcggcat tgctgccatc gtggtcgctg tgatcatgat cttcgagatg
      901 atcctgagca tggtgctgtg ctgtggcatc cggaacagct ccgtgtactg aggccccgca
      961 gctctggcca cagggacctc tgcagtgccc cctaagtgac ccggacactt ccgagggggc
     1021 catcaccgcc tgtgtatata acgtttccgg tattactctg ctacacgtag cctttttact
     1081 tttggggttt tgtttttgtt ctgaactttc ctgttacctt ttcagggctg acgtcacatg
     1141 taggtggcgt gtatgagtgg agacgggcct gggtcttggg gactggaggg caggggtcct
     1201 tctgccctgg ggtcccaggg tgctctgcct gctcagccag gcctctcctg ggagccactc
     1261 gcccagagac tcagcttggc caacttgggg ggctgtgtcc acccagcccg cccgtcctgt
     1321 gggctgcaca gctcaccttg ttccctcctg ccccggttcg agagccgagt ctgtgggcac
     1381 tctctgcctt catgcacctg tcctttctaa cacgtcgcct tcaactgtaa tcacaacatc
     1441 ctgactccgt catttaataa agaaggaaca tcaggcatgc ta
//
