LOCUS       NM_005191               2737 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens CD80 molecule (CD80), mRNA.
ACCESSION   NM_005191
VERSION     NM_005191.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2737)
  AUTHORS   Cobankent Aytekin,E., Unal,B., Bassorgun,C.I. and Ozkan,O.
  TITLE     Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions
            with Immunohistochemical Methods in Malignant Melanoma Patients
  JOURNAL   Turk Patoloji Derg 40 (1), 16-26 (2024)
   PUBMED   37614091
  REMARK    GeneRIF: Clinicopathologic Evaluation of CD80, CD86, and PD-L1
            Expressions with Immunohistochemical Methods in Malignant Melanoma
            Patients.
REFERENCE   2  (bases 1 to 2737)
  AUTHORS   Ahmed,M.H., Hernandez-Verdin,I., Bielle,F., Verreault,M.,
            Lerond,J., Alentorn,A., Sanson,M. and Idbaih,A.
  TITLE     Expression and Prognostic Value of CD80 and CD86 in the Tumor
            Microenvironment of Newly Diagnosed Glioblastoma
  JOURNAL   Can J Neurol Sci 50 (2), 234-242 (2023)
   PUBMED   35022089
  REMARK    GeneRIF: Expression and Prognostic Value of CD80 and CD86 in the
            Tumor Microenvironment of Newly Diagnosed Glioblastoma.
REFERENCE   3  (bases 1 to 2737)
  AUTHORS   Morano,N.C., Smith,R.S., Danelon,V., Schreiner,R., Patel,U.,
            Herrera,N.G., Smith,C., Olson,S.M., Laerke,M.K., Celikgil,A.,
            Garforth,S.J., Garrett-Thomson,S.C., Lee,F.S., Hempstead,B.L. and
            Almo,S.C.
  TITLE     Human immunomodulatory ligand B7-1 mediates synaptic remodeling via
            the p75 neurotrophin receptor
  JOURNAL   J Clin Invest 132 (22), e157002 (2022)
   PUBMED   36107635
  REMARK    GeneRIF: Human immunomodulatory ligand B7-1 mediates synaptic
            remodeling via the p75 neurotrophin receptor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2737)
  AUTHORS   Matsuyama,Y., Asanuma,K., Yoshida,K., Hagi,T., Iino,T., Nakamura,T.
            and Sudo,A.
  TITLE     The role of soluble CD80 in patients with soft tissue tumors
  JOURNAL   J Orthop Surg Res 17 (1), 404 (2022)
   PUBMED   36064421
  REMARK    GeneRIF: The role of soluble CD80 in patients with soft tissue
            tumors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2737)
  AUTHORS   Sakamoto,Y., Ishida,T., Masaki,A., Takeshita,M., Iwasaki,H.,
            Yonekura,K., Tashiro,Y., Ito,A., Kusumoto,S., Iida,S.,
            Utsunomiya,A., Ueda,R. and Inagaki,H.
  TITLE     Clinicopathological significance of CD28 overexpression in adult
            T-cell leukemia/lymphoma
  JOURNAL   Cancer Sci 113 (1), 349-361 (2022)
   PUBMED   34738707
  REMARK    GeneRIF: Clinicopathological significance of CD28 overexpression in
            adult T-cell leukemia/lymphoma.
REFERENCE   6  (bases 1 to 2737)
  AUTHORS   Weiskirchen,R., Pino,J.D., Macalma,T., Bister,K. and Beckerle,M.C.
  TITLE     The cysteine-rich protein family of highly related LIM domain
            proteins
  JOURNAL   J Biol Chem 270 (48), 28946-28954 (1995)
   PUBMED   7499425
REFERENCE   7  (bases 1 to 2737)
  AUTHORS   Freeman,G.J., Disteche,C.M., Gribben,J.G., Adler,D.A.,
            Freedman,A.S., Dougery,J. and Nadler,L.M.
  TITLE     The gene for B7, a costimulatory signal for T-cell activation, maps
            to chromosomal region 3q13.3-3q21
  JOURNAL   Blood 79 (2), 489-494 (1992)
   PUBMED   1370389
REFERENCE   8  (bases 1 to 2737)
  AUTHORS   Selvakumar,A., Mohanraj,B.K., Eddy,R.L., Shows,T.B., White,P.C. and
            Dupont,B.
  TITLE     Genomic organization and chromosomal location of the human gene
            encoding the B-lymphocyte activation antigen B7
  JOURNAL   Immunogenetics 36 (3), 175-181 (1992)
   PUBMED   1377173
REFERENCE   9  (bases 1 to 2737)
  AUTHORS   Freeman,G.J., Gray,G.S., Gimmi,C.D., Lombard,D.B., Zhou,L.J.,
            White,M., Fingeroth,J.D., Gribben,J.G. and Nadler,L.M.
  TITLE     Structure, expression, and T cell costimulatory activity of the
            murine homologue of the human B lymphocyte activation antigen B7
  JOURNAL   J Exp Med 174 (3), 625-631 (1991)
   PUBMED   1714935
REFERENCE   10 (bases 1 to 2737)
  AUTHORS   Freeman,G.J., Freedman,A.S., Segil,J.M., Lee,G., Whitman,J.F. and
            Nadler,L.M.
  TITLE     B7, a new member of the Ig superfamily with unique expression on
            activated and neoplastic B cells
  JOURNAL   J Immunol 143 (8), 2714-2722 (1989)
   PUBMED   2794510
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP225173.1, BC042665.1 and
            AC073352.22.
            
            On Nov 23, 2018 this sequence version replaced NM_005191.3.
            
            Summary: The protein encoded by this gene is a membrane receptor
            that is activated by the binding of CD28 or CTLA-4. The activated
            protein induces T-cell proliferation and cytokine production. This
            protein can act as a receptor for adenovirus subgroup B and may
            play a role in lupus neuropathy. [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042665.1, SRR1163657.50936.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264246.8/ ENSP00000264246.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BP225173.1         48-59
            13-1283             BC042665.1         1-1271
            1284-1456           AC073352.22        116809-116981
            1457-2737           BC042665.1         1445-2725
FEATURES             Location/Qualifiers
     source          1..2737
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..2737
                     /gene="CD80"
                     /gene_synonym="B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7"
                     /note="CD80 molecule"
                     /db_xref="GeneID:941"
                     /db_xref="HGNC:HGNC:1700"
                     /db_xref="MIM:112203"
     exon            1..175
                     /gene="CD80"
                     /gene_synonym="B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            176..475
                     /gene="CD80"
                     /gene_synonym="B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1242
                     /gene="CD80"
                     /gene_synonym="B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7"
                     /note="CD80 antigen (CD28 antigen ligand 1, B7-1 antigen);
                     costimulatory molecule variant IgV-CD80; costimulatory
                     factor CD80; T-lymphocyte activation antigen CD80;
                     B-lymphocyte activation antigen B7; activation B7-1
                     antigen; CTLA-4 counter-receptor B7.1"
                     /codon_start=1
                     /product="T-lymphocyte activation antigen CD80 precursor"
                     /protein_id="NP_005182.1"
                     /db_xref="CCDS:CCDS2989.1"
                     /db_xref="GeneID:941"
                     /db_xref="HGNC:HGNC:1700"
                     /db_xref="MIM:112203"
                     /translation="MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKE
                     VATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIV
                     ILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRI
                     ICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLI
                     KYGHLRVNQTFNWNTTKQEHFPDNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRR
                     NERLRRESVRPV"
     exon            476..793
                     /gene="CD80"
                     /gene_synonym="B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1075
                     /gene="CD80"
                     /gene_synonym="B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1171
                     /gene="CD80"
                     /gene_synonym="B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1280
                     /gene="CD80"
                     /gene_synonym="B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..2737
                     /gene="CD80"
                     /gene_synonym="B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2711..2716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD80"
                     /gene_synonym="B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7"
                     /note="hexamer: AACAAA"
     polyA_site      2737
                     /gene="CD80"
                     /gene_synonym="B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7"
                     /note="major polyA site"
ORIGIN      
        1 aaaccctctg taaagtaaca gaagttagaa ggggaaatgt cgcctctctg aagattaccc
       61 aaagaaaaag tgatttgtca ttgctttata gactgtaaga agagaacatc tcagaagtgg
      121 agtcttaccc tgaaatcaaa ggatttaaag aaaaagtgga atttttcttc agcaagctgt
      181 gaaactaaat ccacaacctt tggagaccca ggaacaccct ccaatctctg tgtgttttgt
      241 aaacatcact ggagggtctt ctacgtgagc aattggattg tcatcagccc tgcctgtttt
      301 gcacctggga agtgccctgg tcttacttgg gtccaaattg ttggctttca cttttgaccc
      361 taagcatctg aagccatggg ccacacacgg aggcagggaa catcaccatc caagtgtcca
      421 tacctcaatt tctttcagct cttggtgctg gctggtcttt ctcacttctg ttcaggtgtt
      481 atccacgtga ccaaggaagt gaaagaagtg gcaacgctgt cctgtggtca caatgtttct
      541 gttgaagagc tggcacaaac tcgcatctac tggcaaaagg agaagaaaat ggtgctgact
      601 atgatgtctg gggacatgaa tatatggccc gagtacaaga accggaccat ctttgatatc
      661 actaataacc tctccattgt gatcctggct ctgcgcccat ctgacgaggg cacatacgag
      721 tgtgttgttc tgaagtatga aaaagacgct ttcaagcggg aacacctggc tgaagtgacg
      781 ttatcagtca aagctgactt ccctacacct agtatatctg actttgaaat tccaacttct
      841 aatattagaa ggataatttg ctcaacctct ggaggttttc cagagcctca cctctcctgg
      901 ttggaaaatg gagaagaatt aaatgccatc aacacaacag tttcccaaga tcctgaaact
      961 gagctctatg ctgttagcag caaactggat ttcaatatga caaccaacca cagcttcatg
     1021 tgtctcatca agtatggaca tttaagagtg aatcagacct tcaactggaa tacaaccaag
     1081 caagagcatt ttcctgataa cctgctccca tcctgggcca ttaccttaat ctcagtaaat
     1141 ggaatttttg tgatatgctg cctgacctac tgctttgccc caagatgcag agagagaagg
     1201 aggaatgaga gattgagaag ggaaagtgta cgccctgtat aacagtgtcc gcagaagcaa
     1261 ggggctgaaa agatctgaag gtcccacctc catttgcaat tgacctcttc tgggaacttc
     1321 ctcagatgga caagattacc ccaccttgcc ctttacgtat ctgctcttag gtgcttcttc
     1381 acttcagttg ctttgcagga agtgtctaga ggaatatggt gggcacagaa gtagctctgg
     1441 tgaccttgat caaggtgttt tgaaatgcag aattcttgag ttctggaagg gactttagag
     1501 aataccagtg ttattaatga caaaggcact gaggcccagg gaggtgaccc gaattataaa
     1561 ggccagcgcc agaacccaga tttcctaact ctggtgctct ttccctttat cagtttgact
     1621 gtggcctgtt aactggtata tacatatata tgtcaggcaa agtgctgctg gaagtagaat
     1681 ttgtccaata acaggtcaac ttcagagact atctgatttc ctaatgtcag agtagaagat
     1741 tttatgctgc tgtttacaaa agcccaatgt aatgcatagg aagtatggca tgaacatctt
     1801 taggagacta atggaaatat tattggtgtt tacccagtat tccatttttt tcattgtgtt
     1861 ctctattgct gctctctcac tcccccatga ggtacagcag aaaggagaac tatccaaaac
     1921 taatttcctc tgacatgtaa gacgaatgat ttaggtacgt caaagcagta gtcaaggagg
     1981 aaagggatag tccaaagact taactggttc atattggact gataatctct ttaaatggct
     2041 ttatgctagt ttgacctcat ttgtaaaata tttatgagaa agttctcatt taaaatgaga
     2101 tcgttgttta cagtgtatgt actaagcagt aagctatctt caaatgtcta aggtagtaac
     2161 tttccatagg gcctccttag atccctaaga tggctttttc tccttggtat ttctgggtct
     2221 ttctgacatc agcagagaac tggaaagaca tagccaactg ctgttcatgt tactcatgac
     2281 tcctttctct aaaactgcct tccacaattc actagaccag aagtggacgc aacttaagct
     2341 gggataatca cattatcatc tgaaaatctg gagttgaaca gcaaaagaag acaacatttc
     2401 tcaaatgcac atctcatggc agctaagcca catggctggg atttaaagcc tttagagcca
     2461 gcccatggct ttagctacct cactatgctg cttcacaaac cttgctcctg tgtaaaacta
     2521 tattctcagt gtagggcaga gaggtctaac accaacataa ggtactagca gtgtttcccg
     2581 tattgacagg aatacttaac tcaataattc ttttcttttc catttagtaa cagttgtgat
     2641 gactatgttt ctattctaag taattcctgt attctacagc agatactttg tcagcaatac
     2701 taagggaaga aacaaagttg aaccgtttct ttaataa
//
