LOCUS       NM_000626               1246 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens CD79b molecule (CD79B), transcript variant 1, mRNA.
ACCESSION   NM_000626
VERSION     NM_000626.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1246)
  AUTHORS   Li,Y., Shen,H., Zhang,R., Ji,C., Wang,Y., Su,C. and Xiao,J.
  TITLE     Immunoglobulin M perception by FcmuR
  JOURNAL   Nature 615 (7954), 907-912 (2023)
   PUBMED   36949194
REFERENCE   2  (bases 1 to 1246)
  AUTHORS   Yamaguchi,J., Ohka,F., Lushun,C., Motomura,K., Aoki,K.,
            Takeuchi,K., Nagata,Y., Ito,S., Mizutani,N., Ohno,M., Suzaki,N.,
            Takasu,S., Seki,Y., Kano,T., Wakabayashi,K., Oyama,H.,
            Kurahashi,S., Tanahashi,K., Hirano,M., Shimizu,H., Kitano,Y.,
            Maeda,S., Yamazaki,S., Wakabayashi,T., Kondo,Y., Natsume,A. and
            Saito,R.
  TITLE     CD79B Y196 mutation is a potent predictive marker for favorable
            response to R-MPV in primary central nervous system lymphoma
  JOURNAL   Cancer Med 12 (6), 7116-7126 (2023)
   PUBMED   36478416
  REMARK    GeneRIF: CD79B Y196 mutation is a potent predictive marker for
            favorable response to R-MPV in primary central nervous system
            lymphoma.
REFERENCE   3  (bases 1 to 1246)
  AUTHORS   Xu,P.P., Shen,R., Shi,Z.Y., Cheng,S., Wang,L., Liu,Y., Zhang,L.,
            Huang,R., Ma,X., Wu,X., Yao,H., Yu,Y. and Zhao,W.L.
  TITLE     The Prognostic Significance of CD79B Mutation in Diffuse Large
            B-Cell Lymphoma: A Meta-analysis and Systematic Literature Review
  JOURNAL   Clin Lymphoma Myeloma Leuk 22 (12), e1051-e1058.e1 (2022)
   PUBMED   36182550
  REMARK    GeneRIF: The Prognostic Significance of CD79B Mutation in Diffuse
            Large B-Cell Lymphoma: A Meta-analysis and Systematic Literature
            Review.
            Review article
REFERENCE   4  (bases 1 to 1246)
  AUTHORS   Huse,K., Bai,B., Hilden,V.I., Bollum,L.K., Vatsveen,T.K.,
            Munthe,L.A., Smeland,E.B., Irish,J.M., Walchli,S. and
            Myklebust,J.H.
  TITLE     Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness
            through B Cell Receptor Surface Expression
  JOURNAL   J Immunol 209 (10), 2042-2053 (2022)
   PUBMED   36426942
  REMARK    GeneRIF: Mechanism of CD79A and CD79B Support for IgM+ B Cell
            Fitness through B Cell Receptor Surface Expression.
REFERENCE   5  (bases 1 to 1246)
  AUTHORS   Su,Q., Chen,M., Shi,Y., Zhang,X., Huang,G., Huang,B., Liu,D.,
            Liu,Z. and Shi,Y.
  TITLE     Cryo-EM structure of the human IgM B cell receptor
  JOURNAL   Science 377 (6608), 875-880 (2022)
   PUBMED   35981043
REFERENCE   6  (bases 1 to 1246)
  AUTHORS   Brown,V.K., Ogle,E.W., Burkhardt,A.L., Rowley,R.B., Bolen,J.B. and
            Justement,L.B.
  TITLE     Multiple components of the B cell antigen receptor complex
            associate with the protein tyrosine phosphatase, CD45
  JOURNAL   J Biol Chem 269 (25), 17238-17244 (1994)
   PUBMED   7516335
REFERENCE   7  (bases 1 to 1246)
  AUTHORS   Vasile,S., Coligan,J.E., Yoshida,M. and Seon,B.K.
  TITLE     Isolation and chemical characterization of the human B29 and mb-1
            proteins of the B cell antigen receptor complex
  JOURNAL   Mol Immunol 31 (6), 419-427 (1994)
   PUBMED   7514267
REFERENCE   8  (bases 1 to 1246)
  AUTHORS   Lankester,A.C., van Schijndel,G.M., Cordell,J.L., van Noesel,C.J.
            and van Lier,R.A.
  TITLE     CD5 is associated with the human B cell antigen receptor complex
  JOURNAL   Eur J Immunol 24 (4), 812-816 (1994)
   PUBMED   7512031
REFERENCE   9  (bases 1 to 1246)
  AUTHORS   Muller,B., Cooper,L. and Terhorst,C.
  TITLE     Cloning and sequencing of the cDNA encoding the human homologue of
            the murine immunoglobulin-associated protein B29
  JOURNAL   Eur J Immunol 22 (6), 1621-1625 (1992)
   PUBMED   1534761
REFERENCE   10 (bases 1 to 1246)
  AUTHORS   Reth,M.
  TITLE     Antigen receptors on B lymphocytes
  JOURNAL   Annu Rev Immunol 10, 97-121 (1992)
   PUBMED   1591006
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M89957.1, AC127029.12 and
            AA804163.1.
            
            On Jun 2, 2019 this sequence version replaced NM_000626.3.
            
            Summary: The B lymphocyte antigen receptor is a multimeric complex
            that includes the antigen-specific component, surface
            immunoglobulin (Ig). Surface Ig non-covalently associates with two
            other proteins, Ig-alpha and Ig-beta, which are necessary for
            expression and function of the B-cell antigen receptor. This gene
            encodes the Ig-beta protein of the B-cell antigen component.
            Alternatively spliced transcript variants encoding different
            isoforms have been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 3. The
            encoded isoform (1) is shorter compared to isoform 3, but has
            identical N- and C- termini.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.327065.1, BC002975.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149876 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000006750.8/ ENSP00000006750.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 M89957.1           25-32
            9-137               AC127029.12        41324-41452         c
            138-188             AC127029.12        40464-40514         c
            189-500             AC127029.12        39203-39514         c
            501-619             AC127029.12        38899-39017         c
            620-661             AC127029.12        38563-38604         c
            662-1211            AC127029.12        37904-38453         c
            1212-1246           AA804163.1         12-46               c
FEATURES             Location/Qualifiers
     source          1..1246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..1246
                     /gene="CD79B"
                     /gene_synonym="AGM6; B29; IGB; Igbeta"
                     /note="CD79b molecule"
                     /db_xref="GeneID:974"
                     /db_xref="HGNC:HGNC:1699"
                     /db_xref="MIM:147245"
     exon            1..137
                     /gene="CD79B"
                     /gene_synonym="AGM6; B29; IGB; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..760
                     /gene="CD79B"
                     /gene_synonym="AGM6; B29; IGB; Igbeta"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; B-cell-specific glycoprotein B29; CD79b antigen
                     (immunoglobulin-associated beta); Ig-beta; B-cell antigen
                     receptor complex-associated protein beta chain;
                     immunoglobulin-associated B29 protein; CD79b molecule,
                     immunoglobulin-associated beta"
                     /codon_start=1
                     /product="B-cell antigen receptor complex-associated
                     protein beta chain isoform 1 precursor"
                     /protein_id="NP_000617.1"
                     /db_xref="CCDS:CCDS11655.1"
                     /db_xref="GeneID:974"
                     /db_xref="HGNC:HGNC:1699"
                     /db_xref="MIM:147245"
                     /translation="MARLALSPVPSHWMVALLLLLSAEPVPAARSEDRYRNPKGSACS
                     RIWQSPRFIARKRGFTVKMHCYMNSASGNVSWLWKQEMDENPQQLKLEKGRMEESQNE
                     SLATLTIQGIRFEDNGIYFCQQKCNNTSEVYQGCGTELRVMGFSTLAQLKQRNTLKDG
                     IIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEV
                     KWSVGEHPGQE"
     exon            138..188
                     /gene="CD79B"
                     /gene_synonym="AGM6; B29; IGB; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            189..500
                     /gene="CD79B"
                     /gene_synonym="AGM6; B29; IGB; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            501..619
                     /gene="CD79B"
                     /gene_synonym="AGM6; B29; IGB; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            620..661
                     /gene="CD79B"
                     /gene_synonym="AGM6; B29; IGB; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1246
                     /gene="CD79B"
                     /gene_synonym="AGM6; B29; IGB; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1221..1226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD79B"
                     /gene_synonym="AGM6; B29; IGB; Igbeta"
                     /note="hexamer: AATAAA"
     polyA_site      1246
                     /gene="CD79B"
                     /gene_synonym="AGM6; B29; IGB; Igbeta"
                     /note="major polyA site"
ORIGIN      
        1 agttacacgt tttcctccaa ggagcctcgg acgttgtcac gggtttgggg tcggggacag
       61 agcggtgacc atggccaggc tggcgttgtc tcctgtgccc agccactgga tggtggcgtt
      121 gctgctgctg ctctcagctg agccagtacc agcagccaga tcggaggacc ggtaccggaa
      181 tcccaaaggt agtgcttgtt cgcggatctg gcagagccca cgtttcatag ccaggaaacg
      241 gggcttcacg gtgaaaatgc actgctacat gaacagcgcc tccggcaatg tgagctggct
      301 ctggaagcag gagatggacg agaatcccca gcagctgaag ctggaaaagg gccgcatgga
      361 agagtcccag aacgaatctc tcgccaccct caccatccaa ggcatccggt ttgaggacaa
      421 tggcatctac ttctgtcagc agaagtgcaa caacacctcg gaggtctacc agggctgcgg
      481 cacagagctg cgagtcatgg gattcagcac cttggcacag ctgaagcaga ggaacacgct
      541 gaaggatggt atcatcatga tccagacgct gctgatcatc ctcttcatca tcgtgcctat
      601 cttcctgctg ctggacaagg atgacagcaa ggctggcatg gaggaagatc acacctacga
      661 gggcctggac attgaccaga cagccaccta tgaggacata gtgacgctgc ggacagggga
      721 agtgaagtgg tctgtaggtg agcacccagg ccaggagtga gagccaggtc gccccatgac
      781 ctgggtgcag gctccctggc ctcagtgact gcttcggagc tgcctggctc atggcccaac
      841 ccctttcctg gaccccccag ctggcctctg aagctggccc accagagctg ccatttgtct
      901 ccagcccctg gtccccagct cttgccaaag ggcctggagt agaaggacaa cagggcagca
      961 acttggaggg agttctctgg ggatggacgg gacccagcct tctgggggtg ctatgaggtg
     1021 atccgtcccc acacatggga tgggggaggc agagactggt ccagagcccg caaatggact
     1081 cggagccgag ggcctcccag cagagcttgg gaagggccat ggacccaact gggccccaga
     1141 agagccacag gaacatcatt cctctcccgc aaccactccc accccaggga ggccctggcc
     1201 tccagtgcct tcccccgtgg aataaacggt gtgtcctgag aaacca
//
