LOCUS       NM_001025159            1653 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens CD74 molecule (CD74), transcript variant 1, mRNA.
ACCESSION   NM_001025159
VERSION     NM_001025159.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1653)
  AUTHORS   Ezaki,A., Yano,H., Pan,C., Fujiwara,Y., Anami,T., Ibe,Y.,
            Motoshima,T., Yatsuda,J., Esumi,S., Miura,Y., Kamba,T. and
            Komohara,Y.
  TITLE     Potential protumor function of CD74 in clear cell renal cell
            carcinoma
  JOURNAL   Hum Cell 37 (5), 1535-1543 (2024)
   PUBMED   39080216
  REMARK    GeneRIF: Potential protumor function of CD74 in clear cell renal
            cell carcinoma.
REFERENCE   2  (bases 1 to 1653)
  AUTHORS   Wu,S., Ouyang,Y., Hu,Y., Jiang,L., Fu,C., Lei,L., Zhang,Y., Guo,H.,
            Huang,J., Chen,J. and Zeng,Q.
  TITLE     Macrophage migration inhibitory factor mediates skin aging via
            CD74: Insights from single-cell and bulk RNA sequencing data
  JOURNAL   Clin Immunol 263, 110199 (2024)
   PUBMED   38565329
  REMARK    GeneRIF: Macrophage migration inhibitory factor mediates skin aging
            via CD74: Insights from single-cell and bulk RNA sequencing data.
REFERENCE   3  (bases 1 to 1653)
  AUTHORS   Bonnin,E., Rodrigo Riestra,M., Marziali,F., Mena Osuna,R.,
            Denizeau,J., Maurin,M., Saez,J.J., Jouve,M., Bonte,P.E., Richer,W.,
            Nevo,F., Lemoine,S., Girard,N., Lefevre,M., Borcoman,E.,
            Vincent-Salomon,A., Baulande,S., Moreau,H.D., Sedlik,C., Hivroz,C.,
            Lennon-Dumenil,A.M., Tosello Boari,J. and Piaggio,E.
  TITLE     CD74 supports accumulation and function of regulatory T cells in
            tumors
  JOURNAL   Nat Commun 15 (1), 3749 (2024)
   PUBMED   38702311
  REMARK    GeneRIF: CD74 supports accumulation and function of regulatory T
            cells in tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1653)
  AUTHORS   Xu,X., Li,Y., Xu,R., Meng,Y., Li,Z., Zuo,D. and Wu,Y.
  TITLE     CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK
            pathway to promote invasion, metastasis and crizotinib resistance
            in non-small cell lung cancer cells
  JOURNAL   FEBS J 291 (6), 1199-1219 (2024)
   PUBMED   38148635
  REMARK    GeneRIF: CD74-ROS1 L2026M mutant enhances autophagy through the
            MEK/ERK pathway to promote invasion, metastasis and crizotinib
            resistance in non-small cell lung cancer cells.
REFERENCE   5  (bases 1 to 1653)
  AUTHORS   Wang,J., Li,X., Xiao,G., Desai,J., Frentzas,S., Wang,Z.M., Xia,Y.
            and Li,B.
  TITLE     CD74 is associated with inflamed tumor immune microenvironment and
            predicts responsiveness to PD-1/CTLA-4 bispecific antibody in
            patients with solid tumors
  JOURNAL   Cancer Immunol Immunother 73 (2), 36 (2024)
   PUBMED   38280003
  REMARK    GeneRIF: CD74 is associated with inflamed tumor immune
            microenvironment and predicts responsiveness to PD-1/CTLA-4
            bispecific antibody in patients with solid tumors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1653)
  AUTHORS   Riberdy,J.M., Newcomb,J.R., Surman,M.J., Barbosa,J.A. and
            Cresswell,P.
  TITLE     HLA-DR molecules from an antigen-processing mutant cell line are
            associated with invariant chain peptides
  JOURNAL   Nature 360 (6403), 474-477 (1992)
   PUBMED   1448172
REFERENCE   7  (bases 1 to 1653)
  AUTHORS   Bakke,O. and Dobberstein,B.
  TITLE     MHC class II-associated invariant chain contains a sorting signal
            for endosomal compartments
  JOURNAL   Cell 63 (4), 707-716 (1990)
   PUBMED   2121367
REFERENCE   8  (bases 1 to 1653)
  AUTHORS   Marks,M.S., Blum,J.S. and Cresswell,P.
  TITLE     Invariant chain trimers are sequestered in the rough endoplasmic
            reticulum in the absence of association with HLA class II antigens
  JOURNAL   J Cell Biol 111 (3), 839-855 (1990)
   PUBMED   2391366
REFERENCE   9  (bases 1 to 1653)
  AUTHORS   Spiro,R.C. and Quaranta,V.
  TITLE     The invariant chain is a phosphorylated subunit of class II
            molecules
  JOURNAL   J Immunol 143 (8), 2589-2594 (1989)
   PUBMED   2507633
REFERENCE   10 (bases 1 to 1653)
  AUTHORS   Kudo,J., Chao,L.Y., Narni,F. and Saunders,G.F.
  TITLE     Structure of the human gene encoding the invariant gamma-chain of
            class II histocompatibility antigens
  JOURNAL   Nucleic Acids Res 13 (24), 8827-8841 (1985)
   PUBMED   3001652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011388.7 and AC011372.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 29, 2021 this sequence version replaced NM_001025159.2.
            
            Summary: The protein encoded by this gene associates with class II
            major histocompatibility complex (MHC) and is an important
            chaperone that regulates antigen presentation for immune response.
            It also serves as cell surface receptor for the cytokine macrophage
            migration inhibitory factor (MIF) which, when bound to the encoded
            protein, initiates survival pathways and cell proliferation. This
            protein also interacts with amyloid precursor protein (APP) and
            suppresses the production of amyloid beta (Abeta). Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2939810.1,
                                           SRR14038192.2535787.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000009530.13/ ENSP00000009530.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AC011388.7         46383-46668
            287-459             AC011388.7         51969-52141
            460-539             AC011388.7         52333-52412
            540-602             AC011388.7         52972-53034
            603-698             AC011388.7         54113-54208
            699-786             AC011388.7         54526-54613
            787-978             AC011388.7         55981-56172
            979-1041            AC011388.7         56668-56730
            1042-1593           AC011388.7         57043-57594
            1594-1653           AC011372.7         183271-183330       c
FEATURES             Location/Qualifiers
     source          1..1653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..1653
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /note="CD74 molecule"
                     /db_xref="GeneID:972"
                     /db_xref="HGNC:HGNC:1697"
                     /db_xref="MIM:142790"
     exon            1..286
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1052
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /note="isoform a is encoded by transcript variant 1;
                     Ia-associated invariant chain; CD74 molecule, major
                     histocompatibility complex, class II invariant chain; CD74
                     antigen (invariant polypeptide of major histocompatibility
                     complex, class II antigen-associated); gamma chain of
                     class II antigens; HLA-DR-gamma; HLA class II
                     histocompatibility antigen gamma chain; MHC HLA-DR gamma
                     chain; HLA-DR antigens-associated invariant chain; class
                     II MHC-associated invariant chain peptide"
                     /codon_start=1
                     /product="HLA class II histocompatibility antigen gamma
                     chain isoform a"
                     /protein_id="NP_001020330.1"
                     /db_xref="CCDS:CCDS47309.1"
                     /db_xref="GeneID:972"
                     /db_xref="HGNC:HGNC:1697"
                     /db_xref="MIM:142790"
                     /translation="MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKC
                     SRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPK
                     PVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKG
                     SFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVS
                     HIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLE
                     LEDPSSGLGVTKQDLGPVPM"
     exon            287..459
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /inference="alignment:Splign:2.1.0"
     exon            460..539
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /inference="alignment:Splign:2.1.0"
     exon            540..602
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /inference="alignment:Splign:2.1.0"
     exon            603..698
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /inference="alignment:Splign:2.1.0"
     exon            699..786
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /inference="alignment:Splign:2.1.0"
     exon            787..978
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1041
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1653
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1633..1638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /note="hexamer: AATAAA"
     polyA_site      1653
                     /gene="CD74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33"
                     /note="major polyA site"
ORIGIN      
        1 atcctgcccc gcaaaaggca gcttcaccaa agtggggtat ttccagcctt tgtagctttc
       61 acttccacat ctaccaagtg ggcggagtgg ccttctgtgg acgaatcaga ttcctctcca
      121 gcaccgactt taagaggcga gccggggggt cagggtccca gatgcacagg aggagaagca
      181 ggagctgtcg ggaagatcag aagccagtca tggatgacca gcgcgacctt atctccaaca
      241 atgagcaact gcccatgctg ggccggcgcc ctggggcccc ggagagcaag tgcagccgcg
      301 gagccctgta cacaggcttt tccatcctgg tgactctgct cctcgctggc caggccacca
      361 ccgcctactt cctgtaccag cagcagggcc ggctggacaa actgacagtc acctcccaga
      421 acctgcagct ggagaacctg cgcatgaagc ttcccaagcc tcccaagcct gtgagcaaga
      481 tgcgcatggc caccccgctg ctgatgcagg cgctgcccat gggagccctg ccccaggggc
      541 ccatgcagaa tgccaccaag tatggcaaca tgacagagga ccatgtgatg cacctgctcc
      601 agaatgctga ccccctgaag gtgtacccgc cactgaaggg gagcttcccg gagaacctga
      661 gacaccttaa gaacaccatg gagaccatag actggaaggt ctttgagagc tggatgcacc
      721 attggctcct gtttgaaatg agcaggcact ccttggagca aaagcccact gacgctccac
      781 cgaaagtact gaccaagtgc caggaagagg tcagccacat ccctgctgtc cacccgggtt
      841 cattcaggcc caagtgcgac gagaacggca actatctgcc actccagtgc tatgggagca
      901 tcggctactg ctggtgtgtc ttccccaacg gcacggaggt ccccaacacc agaagccgcg
      961 ggcaccataa ctgcagtgag tcactggaac tggaggaccc gtcttctggg ctgggtgtga
     1021 ccaagcagga tctgggccca gtccccatgt gagagcagca gaggcggtct tcaacatcct
     1081 gccagcccca cacagctaca gctttcttgc tcccttcagc ccccagcccc tcccccatct
     1141 cccaccctgt acctcatccc atgagaccct ggtgcctggc tctttcgtca cccttggaca
     1201 agacaaacca agtcggaaca gcagataaca atgcagcaag gccctgctgc ccaatctcca
     1261 tctgtcaaca ggggcgtgag gtcccaggaa gtggccaaaa gctagacaga tccccgttcc
     1321 tgacatcaca gcagcctcca acacaaggct ccaagaccta ggctcatgga cgagatggga
     1381 aggcacaggg agaagggata accctacacc cagaccccag gctggacatg ctgactgtcc
     1441 tctcccctcc agcctttggc cttggctttt ctagcctatt tacctgcagg ctgagccact
     1501 ctcttccctt tccccagcat cactccccaa ggaagagcca atgttttcca cccataatcc
     1561 tttctgccga cccctagttc cctctgctca gccaagcttg ttatcagctt tcagggccat
     1621 ggttcacatt agaataaaag gtagtaatta gaa
//
