LOCUS       NM_001782               1531 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens CD72 molecule (CD72), mRNA.
ACCESSION   NM_001782
VERSION     NM_001782.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1531)
  AUTHORS   Buldini,B., Faggin,G., Porcu,E., Scarparo,P., Polato,K.,
            Tregnago,C., Varotto,E., Rizzardi,P., Rizzari,C., Locatelli,F.,
            Biffi,A. and Pigazzi,M.
  TITLE     CD72 is a pan-tumor antigen associated to pediatric acute leukemia
  JOURNAL   Cytometry A 103 (12), 1004-1009 (2023)
   PUBMED   37876342
  REMARK    GeneRIF: CD72 is a pan-tumor antigen associated to pediatric acute
            leukemia.
REFERENCE   2  (bases 1 to 1531)
  AUTHORS   Tian,L., Wang,Y., Zhang,Z., Feng,X., Xiao,F. and Zong,M.
  TITLE     CD72, a new immune checkpoint molecule, is a novel prognostic
            biomarker for kidney renal clear cell carcinoma
  JOURNAL   Eur J Med Res 28 (1), 531 (2023)
   PUBMED   37980541
  REMARK    GeneRIF: CD72, a new immune checkpoint molecule, is a novel
            prognostic biomarker for kidney renal clear cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1531)
  AUTHORS   Eiza,N., Sabag,A.D., Kessler,O., Neufeld,G. and Vadasz,Z.
  TITLE     CD72-semaphorin3A axis: A new regulatory pathway in systemic lupus
            erythematosus
  JOURNAL   J Autoimmun 134, 102960 (2023)
   PUBMED   36470209
  REMARK    GeneRIF: CD72-semaphorin3A axis: A new regulatory pathway in
            systemic lupus erythematosus.
REFERENCE   4  (bases 1 to 1531)
  AUTHORS   Xu,J., Du,J., Zhong,Y., Zhang,H., Zhou,L. and Yao,Q.
  TITLE     Blockage of CD72 reduces B cell proliferation in immune
            thrombocytopenic purpura, involving interleukin 1 and macrophage
            migration inhibitory factor secretion
  JOURNAL   Hematology 27 (1), 1196-1203 (2022)
   PUBMED   36326455
  REMARK    GeneRIF: Blockage of CD72 reduces B cell proliferation in immune
            thrombocytopenic purpura, involving interleukin 1 and macrophage
            migration inhibitory factor secretion.
REFERENCE   5  (bases 1 to 1531)
  AUTHORS   Asmiyou,A., Bakr,A.M., Shahin,D.A. and Wahba,Y.
  TITLE     CD40 and CD72 expression and prognostic values among children with
            systemic lupus erythematosus: a case-control study
  JOURNAL   Lupus 29 (10), 1270-1276 (2020)
   PUBMED   32700598
  REMARK    GeneRIF: CD40 and CD72 expression and prognostic values among
            children with systemic lupus erythematosus: a case-control study.
REFERENCE   6  (bases 1 to 1531)
  AUTHORS   Adachi,T., Flaswinkel,H., Yakura,H., Reth,M. and Tsubata,T.
  TITLE     The B cell surface protein CD72 recruits the tyrosine phosphatase
            SHP-1 upon tyrosine phosphorylation
  JOURNAL   J Immunol 160 (10), 4662-4665 (1998)
   PUBMED   9590210
REFERENCE   7  (bases 1 to 1531)
  AUTHORS   Van de Velde,H. and Thielemans,K.
  TITLE     Native soluble CD5 delivers a costimulatory signal to resting human
            B lymphocytes
  JOURNAL   Cell Immunol 172 (1), 84-91 (1996)
   PUBMED   8806810
REFERENCE   8  (bases 1 to 1531)
  AUTHORS   Van de Velde,H., von Hoegen,I., Luo,W., Parnes,J.R. and
            Thielemans,K.
  TITLE     The B-cell surface protein CD72/Lyb-2 is the ligand for CD5
  JOURNAL   Nature 351 (6328), 662-665 (1991)
   PUBMED   1711157
REFERENCE   9  (bases 1 to 1531)
  AUTHORS   Von Hoegen,I., Hsieh,C.L., Scharting,R., Francke,U. and Parnes,J.R.
  TITLE     Identity of human Lyb-2 and CD72 and localization of the gene to
            chromosome 9
  JOURNAL   Eur J Immunol 21 (6), 1425-1431 (1991)
   PUBMED   2044654
REFERENCE   10 (bases 1 to 1531)
  AUTHORS   Von Hoegen,I., Nakayama,E. and Parnes,J.R.
  TITLE     Identification of a human protein homologous to the mouse Lyb-2 B
            cell differentiation antigen and sequence of the corresponding cDNA
  JOURNAL   J Immunol 144 (12), 4870-4877 (1990)
   PUBMED   2141045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL357874.13, M54992.1 and BC030227.1.
            
            On Jul 3, 2019 this sequence version replaced NM_001782.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030227.1, M54992.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259633.9/ ENSP00000259633.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL357874.13        26521-26522         c
            3-45                M54992.1           1-43
            46-1531             BC030227.1         1-1486
FEATURES             Location/Qualifiers
     source          1..1531
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1531
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /note="CD72 molecule"
                     /db_xref="GeneID:971"
                     /db_xref="HGNC:HGNC:1696"
                     /db_xref="MIM:107272"
     exon            1..192
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1190
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /note="CD72 antigen; lyb-2"
                     /codon_start=1
                     /product="B-cell differentiation antigen CD72"
                     /protein_id="NP_001773.1"
                     /db_xref="CCDS:CCDS6581.1"
                     /db_xref="GeneID:971"
                     /db_xref="HGNC:HGNC:1696"
                     /db_xref="MIM:107272"
                     /translation="MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQV
                     PAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLRYLLLGLLL
                     TCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGS
                     RRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMEN
                     RLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYP
                     QSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSW
                     WTLESESCRSSLPYICEMTAFRFPD"
     exon            193..300
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /inference="alignment:Splign:2.1.0"
     exon            301..372
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /inference="alignment:Splign:2.1.0"
     exon            373..462
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..798
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /inference="alignment:Splign:2.1.0"
     exon            799..944
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1060
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1212
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1531
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1531
                     /gene="CD72"
                     /gene_synonym="CD72b; LYB2"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcacag agggaacaca gagcctagtt gtaaacggac agagacgaga ggggcaaggg
       61 aggacagtgg atgacaggga agacgagtgg gggcagagct gctcaggacc atggctgagg
      121 ccatcaccta tgcagatctg aggtttgtga aggctcccct gaagaagagc atctccagcc
      181 ggttaggaca ggacccaggg gctgatgatg atggggaaat cacctacgag aatgttcaag
      241 tgcccgcagt cctaggggtg ccctcaagct tggcttcttc tgtactaggg gacaaagcag
      301 cggtcaagtc ggagcagcca actgcgtcct ggagagccgt gacgtcacca gctgtcgggc
      361 ggattctccc ctgccgcaca acctgcctgc gatacctcct gctcggcctg ctcctcacct
      421 gcctgctgtt aggagtgacc gccatctgcc tgggagtgcg ctatctgcag gtgtctcagc
      481 agctccagca gacgaacagg gttctggaag tcactaacag cagcctgagg cagcagctcc
      541 gcctcaagat aacgcagctg ggacagagtg cagaggatct gcaggggtcc aggagagagc
      601 tggcgcagag tcaggaagca ctacaggtgg aacagagggc tcatcaggcg gccgaagggc
      661 agctacaggc ctgccaggca gacagacaga agacgaagga gaccttgcaa agtgaggagc
      721 aacagaggag ggccttggag cagaagctga gcaacatgga gaacagactg aagcccttct
      781 tcacatgcgg ctcagcagac acctgctgtc cgtcgggatg gataatgcat cagaaaagct
      841 gcttttacat ctcacttact tcaaaaaatt ggcaggagag ccaaaaacaa tgtgaaactc
      901 tgtcttccaa gctggccaca ttcagtgaaa tttatccaca atcacactct tactacttct
      961 taaattcact gttgccaaat ggtggttcag ggaattcata ttggactggc ctcagctcta
     1021 acaaggattg gaagttgact gatgatacac aacgcactag gacttatgct caaagctcaa
     1081 aatgtaacaa ggtacataaa acttggtcat ggtggacact ggagtcagag tcatgtagaa
     1141 gttctcttcc ctacatctgt gagatgacag ctttcaggtt tccagattag gacagtcctt
     1201 tgcactgagt tgacactcat gccaacaaga acctgtgccc ctccttccta acctgaggcc
     1261 tggggttcct cagaccatct ccttcattct gggcagtgcc cagccaccgg ctgacccaca
     1321 cctgacactt ccagccagtc tgctgcctgc tccctcttcc tgaaactgga ctgttcctgg
     1381 gaaaagggtg aagccacctc tagaagggac tttggcctcc ccccaagaac ttcccatggt
     1441 agaatggggt gggggaggag ggcgcacggg ctgagcggat aggggcggcc cggagccagc
     1501 caggcagttt tattgaaatc tttttaaata a
//
