LOCUS       NM_001252                911 bp    mRNA    linear   PRI 12-JUN-2025
DEFINITION  Homo sapiens CD70 molecule (CD70), transcript variant 1, mRNA.
ACCESSION   NM_001252
VERSION     NM_001252.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 911)
  AUTHORS   Nagato,T., Komatsuda,H., Hayashi,R., Takahara,M., Ujiie,N.,
            Kosaka,A., Ohkuri,T., Oikawa,K., Sato,R., Wakisaka,R., Kono,M.,
            Yamaki,H., Ohara,K., Kumai,T., Kishibe,K., Katada,A., Hayashi,T.
            and Kobayashi,H.
  TITLE     Soluble CD27 as a predictive biomarker for intra-tumoral CD70/CD27
            interaction in nasopharyngeal carcinoma
  JOURNAL   Cancer Sci 115 (4), 1073-1084 (2024)
   PUBMED   38279834
  REMARK    GeneRIF: Soluble CD27 as a predictive biomarker for intra-tumoral
            CD70/CD27 interaction in nasopharyngeal carcinoma.
REFERENCE   2  (bases 1 to 911)
  AUTHORS   Jaeger-Ruckstuhl,C.A., Lo,Y., Fulton,E., Waltner,O.G.,
            Shabaneh,T.B., Simon,S., Muthuraman,P.V., Correnti,C.E.,
            Newsom,O.J., Engstrom,I.A., Kanaan,S.B., Bhise,S.S.,
            Peralta,J.M.C., Ruff,R., Price,J.P., Stull,S.M., Stevens,A.R.,
            Bugos,G., Kluesner,M.G., Voillet,V., Muhunthan,V., Morrish,F.,
            Olson,J.M., Gottardo,R., Sarthy,J.F., Henikoff,S., Sullivan,L.B.,
            Furlan,S.N. and Riddell,S.R.
  TITLE     Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell
            activation promotes memory-associated gene regulatory networks
  JOURNAL   Immunity 57 (2), 287-302 (2024)
   PUBMED   38354704
REFERENCE   3  (bases 1 to 911)
  AUTHORS   Somers,E.C., Goodrich,J.M., Wang,L., Harlow,S.D., Marder,W.,
            Hassett,A.L., Zick,S.M., McCune,W.J., Gordon,C., Barbour,K.E.,
            Helmick,C.G. and Strickland,F.M.
  TITLE     Associations between CD70 methylation of T cell DNA and age in
            adults with systemic lupus erythematosus and population controls:
            The Michigan Lupus Epidemiology & Surveillance (MILES) Program
  JOURNAL   J Autoimmun 142, 103137 (2024)
   PUBMED   38064919
  REMARK    GeneRIF: Associations between CD70 methylation of T cell DNA and
            age in adults with systemic lupus erythematosus and population
            controls: The Michigan Lupus Epidemiology & Surveillance (MILES)
            Program.
REFERENCE   4  (bases 1 to 911)
  AUTHORS   Wang,X., Wei,Y., He,Z., Wang,D., Zhang,L., Du,J., Zhang,M.,
            Jiang,M., Chen,N., Deng,M., Li,B., Song,C., Chen,D., Liu,H.,
            Xiao,J., Liang,H., Zhao,H. and Kong,Y.
  TITLE     CD70-induced differentiation of proinflammatory Th1/17/22/GM
            lymphocytes associated with disease progression and immune
            reconstitution during HIV infection
  JOURNAL   Emerg Microbes Infect 12 (2), 2271068 (2023)
   PUBMED   37824079
  REMARK    GeneRIF: CD70-induced differentiation of proinflammatory
            Th1/17/22/GM lymphocytes associated with disease progression and
            immune reconstitution during HIV infection.
REFERENCE   5  (bases 1 to 911)
  AUTHORS   van der Sluis,T.C., van Haften,F.J., van Duikeren,S.,
            Pardieck,I.N., de Graaf,J.F., Vleeshouwers,W., van der Maaden,K.,
            Melief,C.J.M., van der Burg,S.H. and Arens,R.
  TITLE     Delayed vaccine-induced CD8+ T cell expansion by topoisomerase I
            inhibition mediates enhanced CD70-dependent tumor eradication
  JOURNAL   J Immunother Cancer 11 (11), e007158 (2023)
   PUBMED   38030302
  REMARK    GeneRIF: Delayed vaccine-induced CD8[+] T cell expansion by
            topoisomerase I inhibition mediates enhanced CD70-dependent tumor
            eradication.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 911)
  AUTHORS   Kobata,T., Jacquot,S., Kozlowski,S., Agematsu,K., Schlossman,S.F.
            and Morimoto,C.
  TITLE     CD27-CD70 interactions regulate B-cell activation by T cells
  JOURNAL   Proc Natl Acad Sci U S A 92 (24), 11249-11253 (1995)
   PUBMED   7479974
REFERENCE   7  (bases 1 to 911)
  AUTHORS   Brown,G.R., Meek,K., Nishioka,Y. and Thiele,D.L.
  TITLE     CD27-CD27 ligand/CD70 interactions enhance alloantigen-induced
            proliferation and cytolytic activity in CD8+ T lymphocytes
  JOURNAL   J Immunol 154 (8), 3686-3695 (1995)
   PUBMED   7706711
REFERENCE   8  (bases 1 to 911)
  AUTHORS   Hintzen,R.Q., Lens,S.M., Koopman,G., Pals,S.T., Spits,H. and van
            Lier,R.A.
  TITLE     CD70 represents the human ligand for CD27
  JOURNAL   Int Immunol 6 (3), 477-480 (1994)
   PUBMED   8186199
REFERENCE   9  (bases 1 to 911)
  AUTHORS   Hintzen,R.Q., Lens,S.M., Beckmann,M.P., Goodwin,R.G., Lynch,D. and
            van Lier,R.A.
  TITLE     Characterization of the human CD27 ligand, a novel member of the
            TNF gene family
  JOURNAL   J Immunol 152 (4), 1762-1773 (1994)
   PUBMED   8120385
REFERENCE   10 (bases 1 to 911)
  AUTHORS   Bowman,M.R., Crimmins,M.A., Yetz-Aldape,J., Kriz,R., Kelleher,K.
            and Herrmann,S.
  TITLE     The cloning of CD70 and its identification as the ligand for CD27
  JOURNAL   J Immunol 152 (4), 1756-1761 (1994)
   PUBMED   8120384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008760.7 and KC877696.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001252.4.
            
            Summary: The protein encoded by this gene is a cytokine that
            belongs to the tumor necrosis factor (TNF) ligand family. This
            cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on
            activated, but not on resting, T and B lymphocytes. It induces
            proliferation of costimulated T cells, enhances the generation of
            cytolytic T cells, and contributes to T cell activation. This
            cytokine is also reported to play a role in regulating B-cell
            activation, cytotoxic function of natural killer cells, and
            immunoglobulin sythesis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L08096.1, SRR1163657.324732.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245903.4/ ENSP00000245903.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AC008760.7         26527-26836         c
            311-344             AC008760.7         25789-25822         c
            345-839             AC008760.7         21597-22091         c
            840-840             KC877696.1         279-279
            841-911             AC008760.7         21525-21595         c
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..911
                     /gene="CD70"
                     /gene_synonym="CD27-L; CD27L; CD27LG; LPFS3; TNFSF7;
                     TNLG8A"
                     /note="CD70 molecule"
                     /db_xref="GeneID:970"
                     /db_xref="HGNC:HGNC:11937"
                     /db_xref="MIM:602840"
     exon            1..310
                     /gene="CD70"
                     /gene_synonym="CD27-L; CD27L; CD27LG; LPFS3; TNFSF7;
                     TNLG8A"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..730
                     /gene="CD70"
                     /gene_synonym="CD27-L; CD27L; CD27LG; LPFS3; TNFSF7;
                     TNLG8A"
                     /note="isoform 1 is encoded by transcript variant 1; CD70
                     antigen; surface antigen CD70; Ki-24 antigen; CD27 ligand;
                     tumor necrosis factor ligand superfamily member 7; tumor
                     necrosis factor ligand 8A"
                     /codon_start=1
                     /product="CD70 antigen isoform 1"
                     /protein_id="NP_001243.1"
                     /db_xref="CCDS:CCDS12170.1"
                     /db_xref="GeneID:970"
                     /db_xref="HGNC:HGNC:11937"
                     /db_xref="MIM:602840"
                     /translation="MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQA
                     QQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDG
                     IYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTP
                     LARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP"
     exon            311..344
                     /gene="CD70"
                     /gene_synonym="CD27-L; CD27L; CD27LG; LPFS3; TNFSF7;
                     TNLG8A"
                     /inference="alignment:Splign:2.1.0"
     exon            345..911
                     /gene="CD70"
                     /gene_synonym="CD27-L; CD27L; CD27LG; LPFS3; TNFSF7;
                     TNLG8A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      892..897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD70"
                     /gene_synonym="CD27-L; CD27L; CD27LG; LPFS3; TNFSF7;
                     TNLG8A"
                     /note="hexamer: ATTAAA"
     polyA_site      911
                     /gene="CD70"
                     /gene_synonym="CD27-L; CD27L; CD27LG; LPFS3; TNFSF7;
                     TNLG8A"
                     /note="major polyA site"
ORIGIN      
        1 agagaggggc aggctggtcc cctgacaggt tgaagcaagt agacgcccag gagccccggg
       61 agggggctgc agtttccttc cttccttctc ggcagcgctc cgcgccccca tcgcccctcc
      121 tgcgctagcg gaggtgatcg ccgcggcgat gccggaggag ggttcgggct gctcggtgcg
      181 gcgcaggccc tatgggtgcg tcctgcgggc tgctttggtc ccattggtcg cgggcttggt
      241 gatctgcctc gtggtgtgca tccagcgctt cgcacaggct cagcagcagc tgccgctcga
      301 gtcacttggg tgggacgtag ctgagctgca gctgaatcac acaggacctc agcaggaccc
      361 caggctatac tggcaggggg gcccagcact gggccgctcc ttcctgcatg gaccagagct
      421 ggacaagggg cagctacgta tccatcgtga tggcatctac atggtacaca tccaggtgac
      481 gctggccatc tgctcctcca cgacggcctc caggcaccac cccaccaccc tggccgtggg
      541 aatctgctct cccgcctccc gtagcatcag cctgctgcgt ctcagcttcc accaaggttg
      601 taccattgcc tcccagcgcc tgacgcccct ggcccgaggg gacacactct gcaccaacct
      661 cactgggaca cttttgcctt cccgaaacac tgatgagacc ttctttggag tgcagtgggt
      721 gcgcccctga ccactgctgc tgattagggt tttttaaatt ttattttatt ttatttaagt
      781 tcaagagaaa aagtgtacac acaggggcca cccggggttg gggtgggagt gtggtggggg
      841 gtagtggtgg caggacaaga gaaggcattg agctttttct ttcattttcc tattaaaaaa
      901 tacaaaaatc a
//
