LOCUS       NM_006137               1284 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens CD7 molecule (CD7), mRNA.
ACCESSION   NM_006137
VERSION     NM_006137.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Papadimitriou,T.I., Singh,P., van Caam,A., Walgreen,B.,
            Gorris,M.A.J., Vitters,E.L., van Ingen,I.L., Koenders,M.I.,
            Smeets,R.L., Vonk,M., de Vries,J.M., van der Kraan,P.M., van
            Oosterhout,Y., Huynen,M.A., Koenen,H.J.P.M. and Thurlings,R.M.
  TITLE     CD7 activation regulates cytotoxicity-driven pathology in systemic
            sclerosis, yielding a target for selective cell depletion
  JOURNAL   Ann Rheum Dis 83 (4), 488-498 (2024)
   PUBMED   38123919
  REMARK    GeneRIF: CD7 activation regulates cytotoxicity-driven pathology in
            systemic sclerosis, yielding a target for selective cell depletion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Chiesa,R., Georgiadis,C., Syed,F., Zhan,H., Etuk,A., Gkazi,S.A.,
            Preece,R., Ottaviano,G., Braybrook,T., Chu,J., Kubat,A., Adams,S.,
            Thomas,R., Gilmour,K., O'Connor,D., Vora,A. and Qasim,W.
  CONSRTM   Base-Edited CAR T Group
  TITLE     Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic
            Leukemia
  JOURNAL   N Engl J Med 389 (10), 899-910 (2023)
   PUBMED   37314354
  REMARK    GeneRIF: Base-Edited CAR7 T Cells for Relapsed T-Cell Acute
            Lymphoblastic Leukemia.
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Dai,Z., Mu,W., Zhao,Y., Cheng,J., Lin,H., Ouyang,K., Jia,X.,
            Liu,J., Wei,Q., Wang,M., Liu,C., Tan,T. and Zhou,J.
  TITLE     T cells expressing CD5/CD7 bispecific chimeric antigen receptors
            with fully human heavy-chain-only domains mitigate tumor antigen
            escape
  JOURNAL   Signal Transduct Target Ther 7 (1), 85 (2022)
   PUBMED   35332132
  REMARK    GeneRIF: T cells expressing CD5/CD7 bispecific chimeric antigen
            receptors with fully human heavy-chain-only domains mitigate tumor
            antigen escape.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Soare,D.S., Radu,E., Dumitru,I., Vladareanu,A.M. and Bumbea,H.
  TITLE     Quantitative analyses of CD7, CD33, CD34, CD56, and CD123 within
            the FLT3-ITD/NPM1-MUT myeloblastic/monocytic bulk AML blastic
            populations
  JOURNAL   Leuk Lymphoma 62 (11), 2716-2726 (2021)
   PUBMED   34034609
  REMARK    GeneRIF: Quantitative analyses of CD7, CD33, CD34, CD56, and CD123
            within the FLT3-ITD/NPM1-MUT myeloblastic/monocytic bulk AML
            blastic populations.
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Lv,K., Cai,C., Chen,J., Xu,M., Wan,L., Zhou,M., Du,Y., Ma,X.,
            Wu,X., Tang,X., Qiu,H., Wu,D., Han,Y. and Liu,Y.
  TITLE     Prognostic value of lymphoid marker CD7 expression in acute myeloid
            leukemia patients undergoing allogeneic hematopoietic cell
            transplantation in first morphological complete remission
  JOURNAL   Int J Hematol 114 (4), 464-471 (2021)
   PUBMED   34176091
  REMARK    GeneRIF: Prognostic value of lymphoid marker CD7 expression in
            acute myeloid leukemia patients undergoing allogeneic hematopoietic
            cell transplantation in first morphological complete remission.
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Schanberg,L.E., Fleenor,D.E., Kurtzberg,J., Haynes,B.F. and
            Kaufman,R.E.
  TITLE     Isolation and characterization of the genomic human CD7 gene:
            structural similarity with the murine Thy-1 gene
  JOURNAL   Proc Natl Acad Sci U S A 88 (2), 603-607 (1991)
   PUBMED   1703303
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Yoshikawa,K., Seto,M., Ueda,R., Obata,Y., Notake,K., Yokochi,T. and
            Takahashi,T.
  TITLE     Molecular cloning of the gene coding for the human T cell
            differentiation antigen CD7
  JOURNAL   Immunogenetics 33 (5-6), 352-360 (1991)
   PUBMED   1711009
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Baker,E., Sandrin,M.S., Garson,O.M., Sutherland,G.R., McKenzie,I.F.
            and Webber,L.M.
  TITLE     Localization of the cell surface antigen CD7 by chromosomal in situ
            hybridization
  JOURNAL   Immunogenetics 31 (5-6), 412-413 (1990)
   PUBMED   1695199
REFERENCE   9  (bases 1 to 1284)
  AUTHORS   Ware,R.E., Scearce,R.M., Dietz,M.A., Starmer,C.F., Palker,T.J. and
            Haynes,B.F.
  TITLE     Characterization of the surface topography and putative tertiary
            structure of the human CD7 molecule
  JOURNAL   J Immunol 143 (11), 3632-3640 (1989)
   PUBMED   2479685
REFERENCE   10 (bases 1 to 1284)
  AUTHORS   Osada,S., Utsumi,K.R., Ueda,R., Akao,Y., Tsuge,I., Nishida,K.,
            Okada,J., Matsuoka,H. and Takahashi,T.
  TITLE     Assignment of a gene coding for a human T-cell antigen with a
            molecular weight of 40,000 daltons to chromosome 17
  JOURNAL   Cytogenet Cell Genet 47 (1-2), 8-10 (1988)
   PUBMED   3258561
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC132872.17, BI906419.1,
            BM917451.1 and BC009293.2.
            
            On Nov 23, 2018 this sequence version replaced NM_006137.6.
            
            Summary: This gene encodes a transmembrane protein which is a
            member of the immunoglobulin superfamily. This protein is found on
            thymocytes and mature T cells. It plays an essential role in T-cell
            interactions and also in T-cell/B-cell interaction during early
            lymphoid development. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY935536.1, AY935535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312648.8/ ENSP00000312027.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC132872.17        28469-28472
            5-29                BI906419.1         1-25
            30-60               BM917451.1         8-38
            61-1284             BC009293.2         1-1224
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1284
                     /gene="CD7"
                     /gene_synonym="GP40; LEU-9; Tp40; TP41"
                     /note="CD7 molecule"
                     /db_xref="GeneID:924"
                     /db_xref="HGNC:HGNC:1695"
                     /db_xref="MIM:186820"
     exon            1..195
                     /gene="CD7"
                     /gene_synonym="GP40; LEU-9; Tp40; TP41"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..836
                     /gene="CD7"
                     /gene_synonym="GP40; LEU-9; Tp40; TP41"
                     /note="CD7 antigen (p41); p41 protein; T-cell leukemia
                     antigen; T-cell antigen CD7; T-cell surface antigen Leu-9"
                     /codon_start=1
                     /product="T-cell antigen CD7 precursor"
                     /protein_id="NP_006128.1"
                     /db_xref="CCDS:CCDS11807.1"
                     /db_xref="GeneID:924"
                     /db_xref="HGNC:HGNC:1695"
                     /db_xref="MIM:186820"
                     /translation="MAGPPRLLLLPLLLALARGLPGALAAQEVQQSPHCTTVPVGASV
                     NITCSTSGGLRGIYLRQLGPQPQDIIYYEDGVVPTTDRRFRGRIDFSGSQDNLTITMH
                     RLQLSDTGTYTCQAITEVNVYGSGTLVLVTEEQSQGWHRCSDAPPRASALPAPPTGSA
                     LPDPQTASALPDPPAASALPAALAVISFLLGLGLGVACVLARTQIKKLCSWRDKNSAA
                     CVVYEDMSHSRCNTLSSPNQYQ"
     exon            196..510
                     /gene="CD7"
                     /gene_synonym="GP40; LEU-9; Tp40; TP41"
                     /inference="alignment:Splign:2.1.0"
     exon            511..725
                     /gene="CD7"
                     /gene_synonym="GP40; LEU-9; Tp40; TP41"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1284
                     /gene="CD7"
                     /gene_synonym="GP40; LEU-9; Tp40; TP41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1264..1269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD7"
                     /gene_synonym="GP40; LEU-9; Tp40; TP41"
                     /note="hexamer: AATAAA"
     polyA_site      1284
                     /gene="CD7"
                     /gene_synonym="GP40; LEU-9; Tp40; TP41"
                     /note="major polyA site"
ORIGIN      
        1 ctctctgagc tctgagcgcc tgcggtctcc tgtgtgctgc tctctgtggg gtcctgtaga
       61 cccagagagg ctcagctgca ctcgcccggc tgggagagct gggtgtgggg aacatggccg
      121 ggcctccgag gctcctgctg ctgcccctgc ttctggcgct ggctcgcggc ctgcctgggg
      181 ccctggctgc ccaagaggtg cagcagtctc cccactgcac gactgtcccc gtgggagcct
      241 ccgtcaacat cacctgctcc accagcgggg gcctgcgtgg gatctacctg aggcagctcg
      301 ggccacagcc ccaagacatc atttactacg aggacggggt ggtgcccact acggacagac
      361 ggttccgggg ccgcatcgac ttctcagggt cccaggacaa cctgactatc accatgcacc
      421 gcctgcagct gtcggacact ggcacctaca cctgccaggc catcacggag gtcaatgtct
      481 acggctccgg caccctggtc ctggtgacag aggaacagtc ccaaggatgg cacagatgct
      541 cggacgcccc accaagggcc tctgccctcc ctgccccacc gacaggctcc gccctccctg
      601 acccgcagac agcctctgcc ctccctgacc cgccagcagc ctctgccctc cctgcggccc
      661 tggcggtgat ctccttcctc ctcgggctgg gcctgggggt ggcgtgtgtg ctggcgagga
      721 cacagataaa gaaactgtgc tcgtggcggg ataagaattc ggcggcatgt gtggtgtacg
      781 aggacatgtc gcacagccgc tgcaacacgc tgtcctcccc caaccagtac cagtgaccca
      841 gtgggcccct gcacgtcccg cctgtggtcc ccccagcacc ttccctgccc caccatgccc
      901 cccaccctgc cacacccctc accctgctgt cctcccacgg ctgcagcaga gtttgaaggg
      961 cccagccgtg cccagctcca agcagacaca caggcagtgg ccaggcccca cggtgcttct
     1021 cagtggacaa tgatgcctcc tccgggaagc cttccctgcc cagcccacgc cgccaccggg
     1081 aggaagcctg actgtccttt ggctgcatct cccgaccatg gccaaggagg gcttttctgt
     1141 gggatgggcc tgggcacgcg gccctctcct gtcagtgccg gcccacccac cagcaggccc
     1201 ccaaccccca ggcagcccgg cagaggacgg gaggagacca gtcccccacc cagccgtacc
     1261 agaaataaag gcttctgtgc ttcc
//
