LOCUS       NM_001781               1676 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens CD69 molecule (CD69), mRNA.
ACCESSION   NM_001781
VERSION     NM_001781.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Mei,J., Cai,Y., Chen,L., Wu,Y., Liu,J., Qian,Z., Jiang,Y.,
            Zhang,P., Xia,T., Pan,X. and Zhang,Y.
  TITLE     The heterogeneity of tumour immune microenvironment revealing the
            CRABP2/CD69 signature discriminates distinct clinical outcomes in
            breast cancer
  JOURNAL   Br J Cancer 129 (10), 1645-1657 (2023)
   PUBMED   37715025
  REMARK    GeneRIF: The heterogeneity of tumour immune microenvironment
            revealing the CRABP2/CD69 signature discriminates distinct clinical
            outcomes in breast cancer.
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Koizume,S., Kanayama,T., Kimura,Y., Hirano,H., Takahashi,T.,
            Ota,Y., Miyazaki,K., Yoshihara,M., Nakamura,Y., Yokose,T., Kato,H.,
            Takenaka,K., Sato,S., Tadokoro,H., Miyagi,E. and Miyagi,Y.
  TITLE     Cancer cell-derived CD69 induced under lipid and oxygen starvation
            promotes ovarian cancer progression through fibronectin
  JOURNAL   Cancer Sci 114 (6), 2485-2498 (2023)
   PUBMED   36854451
  REMARK    GeneRIF: Cancer cell-derived CD69 induced under lipid and oxygen
            starvation promotes ovarian cancer progression through fibronectin.
REFERENCE   3  (bases 1 to 1676)
  AUTHORS   Tang,K., Li,X., Mo,J., Chen,Y., Huang,C., Li,T., Luo,T., Zhong,Z.,
            Jiang,Y., Yang,D. and Mo,W.
  TITLE     CD69 serves as a potential diagnostic and prognostic biomarker for
            hepatocellular carcinoma
  JOURNAL   Sci Rep 13 (1), 7452 (2023)
   PUBMED   37156819
  REMARK    GeneRIF: CD69 serves as a potential diagnostic and prognostic
            biomarker for hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1676)
  AUTHORS   Chen,H., Qin,Y., Chou,M., Cyster,J.G. and Li,X.
  TITLE     Transmembrane protein CD69 acts as an S1PR1 agonist
  JOURNAL   Elife 12, e88204 (2023)
   PUBMED   37039481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1676)
  AUTHORS   Lopez-Cabrera,M., Munoz,E., Blazquez,M.V., Ursa,M.A., Santis,A.G.
            and Sanchez-Madrid,F.
  TITLE     Transcriptional regulation of the gene encoding the human C-type
            lectin leukocyte receptor AIM/CD69 and functional characterization
            of its tumor necrosis factor-alpha-responsive elements
  JOURNAL   J Biol Chem 270 (37), 21545-21551 (1995)
   PUBMED   7665567
REFERENCE   6  (bases 1 to 1676)
  AUTHORS   Bezouska,K., Nepovim,A., Horvath,O., Pospisil,M., Hamann,J. and
            Feizi,T.
  TITLE     CD 69 antigen of human lymphocytes is a calcium-dependent
            carbohydrate-binding protein
  JOURNAL   Biochem Biophys Res Commun 208 (1), 68-74 (1995)
   PUBMED   7887967
REFERENCE   7  (bases 1 to 1676)
  AUTHORS   Santis,A.G., Lopez-Cabrera,M., Hamann,J., Strauss,M. and
            Sanchez-Madrid,F.
  TITLE     Structure of the gene coding for the human early lymphocyte
            activation antigen CD69: a C-type lectin receptor evolutionarily
            related with the gene families of natural killer cell-specific
            receptors
  JOURNAL   Eur J Immunol 24 (7), 1692-1697 (1994)
   PUBMED   8026529
REFERENCE   8  (bases 1 to 1676)
  AUTHORS   Lopez-Cabrera,M., Santis,A.G., Fernandez-Ruiz,E., Blacher,R.,
            Esch,F., Sanchez-Mateos,P. and Sanchez-Madrid,F.
  TITLE     Molecular cloning, expression, and chromosomal localization of the
            human earliest lymphocyte activation antigen AIM/CD69, a new member
            of the C-type animal lectin superfamily of signal-transmitting
            receptors
  JOURNAL   J Exp Med 178 (2), 537-547 (1993)
   PUBMED   8340758
REFERENCE   9  (bases 1 to 1676)
  AUTHORS   Ziegler,S.F., Ramsdell,F., Hjerrild,K.A., Armitage,R.J.,
            Grabstein,K.H., Hennen,K.B., Farrah,T., Fanslow,W.C., Shevach,E.M.
            and Alderson,M.R.
  TITLE     Molecular characterization of the early activation antigen CD69: a
            type II membrane glycoprotein related to a family of natural killer
            cell activation antigens
  JOURNAL   Eur J Immunol 23 (7), 1643-1648 (1993)
   PUBMED   8100776
REFERENCE   10 (bases 1 to 1676)
  AUTHORS   Cambiaggi,C., Scupoli,M.T., Cestari,T., Gerosa,F., Carra,G.,
            Tridente,G. and Accolla,R.S.
  TITLE     Constitutive expression of CD69 in interspecies T-cell hybrids and
            locus assignment to human chromosome 12
  JOURNAL   Immunogenetics 36 (2), 117-120 (1992)
   PUBMED   1612643
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z22576.1 and AC007068.17.
            
            On Jan 27, 2009 this sequence version replaced NM_001781.1.
            
            Summary: This gene encodes a member of the calcium dependent lectin
            superfamily of type II transmembrane receptors. Expression of the
            encoded protein is induced upon activation of T lymphocytes, and
            may play a role in proliferation. Furthermore, the protein may act
            to transmit signals in natural killer cells and platelets.
            [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z22576.1, BC007037.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228434.7/ ENSP00000228434.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1067              Z22576.1           1-1067
            1068-1068           AC007068.17        110422-110422
            1069-1281           Z22576.1           1069-1281
            1282-1282           AC007068.17        110636-110636
            1283-1676           Z22576.1           1283-1676
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1676
                     /gene="CD69"
                     /gene_synonym="AIM; BL-AC/P26; CLEC2C; EA1; GP32/28;
                     MLR-3"
                     /note="CD69 molecule"
                     /db_xref="GeneID:969"
                     /db_xref="HGNC:HGNC:1694"
                     /db_xref="MIM:107273"
     exon            1..145
                     /gene="CD69"
                     /gene_synonym="AIM; BL-AC/P26; CLEC2C; EA1; GP32/28;
                     MLR-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..681
                     /gene="CD69"
                     /gene_synonym="AIM; BL-AC/P26; CLEC2C; EA1; GP32/28;
                     MLR-3"
                     /note="CD69 antigen (p60, early T-cell activation
                     antigen); C-type lectin domain family 2, member C;
                     activation inducer molecule (AIM/CD69); early lymphocyte
                     activation antigen; leukocyte surface antigen Leu-23;
                     early T-cell activation antigen p60"
                     /codon_start=1
                     /product="early activation antigen CD69"
                     /protein_id="NP_001772.1"
                     /db_xref="CCDS:CCDS8604.1"
                     /db_xref="GeneID:969"
                     /db_xref="HGNC:HGNC:1694"
                     /db_xref="MIM:107273"
                     /translation="MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCA
                     VMNVVFITILIIALIALSVGQYNCPGQYTFSMPSDSHVSSCSEDWVGYQRKCYFISTV
                     KRSWTSAQNACSEHGATLAVIDSEKDMNFLKRYAGREEHWVGLKKEPGHPWKWSNGKE
                     FNNWFNVTGSDKCVFLKNTEVSSMECEKNLYWICNKPYK"
     exon            146..268
                     /gene="CD69"
                     /gene_synonym="AIM; BL-AC/P26; CLEC2C; EA1; GP32/28;
                     MLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            269..468
                     /gene="CD69"
                     /gene_synonym="AIM; BL-AC/P26; CLEC2C; EA1; GP32/28;
                     MLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            469..572
                     /gene="CD69"
                     /gene_synonym="AIM; BL-AC/P26; CLEC2C; EA1; GP32/28;
                     MLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            573..1676
                     /gene="CD69"
                     /gene_synonym="AIM; BL-AC/P26; CLEC2C; EA1; GP32/28;
                     MLR-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1655..1660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD69"
                     /gene_synonym="AIM; BL-AC/P26; CLEC2C; EA1; GP32/28;
                     MLR-3"
                     /note="hexamer: AATAAA"
     polyA_site      1676
                     /gene="CD69"
                     /gene_synonym="AIM; BL-AC/P26; CLEC2C; EA1; GP32/28;
                     MLR-3"
                     /note="major polyA site"
ORIGIN      
        1 agactcaaca agagctccag caaagacttt cactgtagct tgacttgacc tgagattaac
       61 tagggaatct tgagaataaa gatgagctct gaaaattgtt tcgtagcaga gaacagctct
      121 ttgcatccgg agagtggaca agaaaatgat gccaccagtc cccatttctc aacacgtcat
      181 gaagggtcct tccaagttcc tgtcctgtgt gctgtaatga atgtggtctt catcaccatt
      241 ttaatcatag ctctcattgc cttatcagtg ggccaataca attgtccagg ccaatacaca
      301 ttctcaatgc catcagacag ccatgtttct tcatgctctg aggactgggt tggctaccag
      361 aggaaatgct actttatttc tactgtgaag aggagctgga cttcagccca aaatgcttgt
      421 tctgaacatg gtgctactct tgctgtcatt gattctgaaa aggacatgaa ctttctaaaa
      481 cgatacgcag gtagagagga acactgggtt ggactgaaaa aggaacctgg tcacccatgg
      541 aagtggtcaa atggcaaaga atttaacaac tggttcaacg ttacagggtc tgacaagtgt
      601 gtttttctga aaaacacaga ggtcagcagc atggaatgtg agaagaattt atactggata
      661 tgtaacaaac cttacaaata ataaggaaac atgttcactt attgactatt atagaatgga
      721 actcaaggaa atctgtgtca gtggatgctg ctctgtggtc cgaagtcttc catagagact
      781 ttgtgaaaaa aaattttata gtgtcttggg aattttcttc caaacagaac tatggaaaaa
      841 aaggaagaaa ttccaggaaa atctgcactg tgggctttta ttgccatgag ctagaagcat
      901 cacaggttga ccaataacca tgcccaagaa tgagaagaat gactatgcaa cctttggatg
      961 cactttatat tattttgaat ccagaaataa tgaaataact aggcgtggac ttactattta
     1021 ttgctgaatg actaccaaca gtgagagccc ttcatgcatt tgcactattg gaaggagtta
     1081 gatgttggta ctagatactg aatgtaaaca aaggaattat ggctggtaac ataggttttt
     1141 agtctaattg aatcccttaa actcagggag catttataaa tggacaaatg cttatgaaac
     1201 taagatttgt aatatttctc tctttttaga gaaatttgcc aatttacttt gttatttttc
     1261 cccaaaaaga atgggatgat catgtattta tttttttact tcctcagctg tagacaggtc
     1321 cttttcgatg gtacatattt ctttgccttt ataatctttt atacagtgtc ttacagagaa
     1381 aagacataag caaagactat gaggaatatt tgcaagacat agaatagtgt tggaaaatgt
     1441 gcaatatgtg atgtggcaaa tctctattag gaaatattct gtaatcttca gacctagaat
     1501 aatactagtc ttataatagg tttgtgactt tcctaaatca attctattac gtgcaatact
     1561 tcaatacttc atttaaaata tttttatgtg caataaaatg tatttgtttg tattttgtgt
     1621 tcagtacaat tataagctgt ttttatatat gtgaaataaa agtagaataa acacaa
//
