LOCUS       NM_006725               3252 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens CD6 molecule (CD6), transcript variant 1, mRNA.
ACCESSION   NM_006725
VERSION     NM_006725.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Do,J.S., Arribas-Layton,D., Juan,J., Garcia,I., Saraswathy,S.,
            Qi,M., Montero,E. and Reijonen,H.
  TITLE     The CD318/CD6 axis limits type 1 diabetes islet
            autoantigen-specific human T cell activation
  JOURNAL   J Autoimmun 146, 103228 (2024)
   PUBMED   38642507
  REMARK    GeneRIF: The CD318/CD6 axis limits type 1 diabetes islet
            autoantigen-specific human T cell activation.
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Wagner,M., Sobczynski,M., Wisniewski,A., Matusiak,L.,
            Kusnierczyk,P. and Jasek,M.
  TITLE     Polymorphisms in the CD6-ALCAM axis may modulate psoriasis risk and
            outcomes
  JOURNAL   Hum Immunol 85 (3), 110797 (2024)
   PUBMED   38580538
  REMARK    GeneRIF: Polymorphisms in the CD6-ALCAM axis may modulate psoriasis
            risk and outcomes.
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Gurrea-Rubio,M., Wu,Q., Amin,M.A., Tsou,P.S., Campbell,P.L.,
            Amarista,C.I., Ikari,Y., Brodie,W.D., Mattichak,M.N., Muraoka,S.,
            Randon,P.M., Lind,M.E., Ruth,J.H., Mao-Draayer,Y., Ding,S.,
            Shen,X., Cooney,L.A., Lin,F. and Fox,D.A.
  TITLE     Activation of cytotoxic lymphocytes through CD6 enhances killing of
            cancer cells
  JOURNAL   Cancer Immunol Immunother 73 (2), 34 (2024)
   PUBMED   38280067
  REMARK    GeneRIF: Activation of cytotoxic lymphocytes through CD6 enhances
            killing of cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Aragon-Serrano,L., Carrillo-Serradell,L., Planells-Romeo,V.,
            Isamat,M., Velasco-de Andres,M. and Lozano,F.
  TITLE     CD6 and Its Interacting Partners: Newcomers to the Block of Cancer
            Immunotherapies
  JOURNAL   Int J Mol Sci 24 (24), 17510 (2023)
   PUBMED   38139340
  REMARK    GeneRIF: CD6 and Its Interacting Partners: Newcomers to the Block
            of Cancer Immunotherapies.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3252)
  AUTHORS   Casado-Llombart,S., Ajami,T., Consuegra-Fernandez,M., Carreras,E.,
            Aranda,F., Armiger,N., Alcaraz,A., Mengual,L. and Lozano,F.
  TITLE     Gene variation impact on prostate cancer progression: Lymphocyte
            modulator, activation, and cell adhesion gene variant contribution
  JOURNAL   Prostate 82 (14), 1331-1337 (2022)
   PUBMED   35767366
  REMARK    GeneRIF: Gene variation impact on prostate cancer progression:
            Lymphocyte modulator, activation, and cell adhesion gene variant
            contribution.
REFERENCE   6  (bases 1 to 3252)
  AUTHORS   Robinson,W.H., Neuman de Vegvar,H.E., Prohaska,S.S., Rhee,J.W. and
            Parnes,J.R.
  TITLE     Human CD6 possesses a large, alternatively spliced cytoplasmic
            domain
  JOURNAL   Eur J Immunol 25 (10), 2765-2769 (1995)
   PUBMED   7589069
REFERENCE   7  (bases 1 to 3252)
  AUTHORS   Whitney,G.S., Starling,G.C., Bowen,M.A., Modrell,B., Siadak,A.W.
            and Aruffo,A.
  TITLE     The membrane-proximal scavenger receptor cysteine-rich domain of
            CD6 contains the activated leukocyte cell adhesion molecule binding
            site
  JOURNAL   J Biol Chem 270 (31), 18187-18190 (1995)
   PUBMED   7543097
REFERENCE   8  (bases 1 to 3252)
  AUTHORS   Aruffo,A., Melnick,M.B., Linsley,P.S. and Seed,B.
  TITLE     The lymphocyte glycoprotein CD6 contains a repeated domain
            structure characteristic of a new family of cell surface and
            secreted proteins
  JOURNAL   J Exp Med 174 (4), 949-952 (1991)
   PUBMED   1919444
REFERENCE   9  (bases 1 to 3252)
  AUTHORS   Swack,J.A., Mier,J.W., Romain,P.L., Hull,S.R. and Rudd,C.E.
  TITLE     Biosynthesis and post-translational modification of CD6, a T cell
            signal-transducing molecule
  JOURNAL   J Biol Chem 266 (11), 7137-7143 (1991)
   PUBMED   2016320
REFERENCE   10 (bases 1 to 3252)
  AUTHORS   Tsuge,I., Utsumi,K.R., Ueda,R., Takamoto,S. and Takahashi,T.
  TITLE     Assignment of gene coding human T-cell differentiation antigen,
            Tp120, to chromosome 11
  JOURNAL   Somat Cell Mol Genet 11 (3), 217-222 (1985)
   PUBMED   3923629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB155411.1, BC078669.1 and BC033755.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006725.4.
            
            Summary: This gene encodes a protein found on the outer membrane of
            T-lymphocytes as well as some other immune cells. The encoded
            protein contains three scavenger receptor cysteine-rich (SRCR)
            domains and a binding site for an activated leukocyte cell adhesion
            molecule. The gene product is important for continuation of T cell
            activation. This gene may be associated with susceptibility to
            multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078669.1, AK292704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313421.11/ ENSP00000323280.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DB155411.1         40-61
            23-835              BC078669.1         1-813
            836-2023            BC033755.1         791-1978
            2024-3252           BC078669.1         2002-3230
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..3252
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /note="CD6 molecule"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
     exon            1..235
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..2193
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD6 antigen; T-cell differentiation antigen
                     CD6; T12"
                     /codon_start=1
                     /product="T-cell differentiation antigen CD6 isoform 1
                     precursor"
                     /protein_id="NP_006716.3"
                     /db_xref="CCDS:CCDS7999.1"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
                     /translation="MWLFFGITGLLTAALSGHPSPAPPDQLNTSSAESELWEPGERLP
                     VRLTNGSSSCSGTVEVRLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTP
                     ELPPPPAAGNTSVAANATLAGAPALLCSGAEWRLCEVVEHACRSDGRRARVTCAENRA
                     LRLVDGGGACAGRVEMLEHGEWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTP
                     GRGPIHRDQVNCSGAEAYLWDCPGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADRCEG
                     QVEVHFRGVWNTVCDSEWYPSEAKVLCQSLGCGTAVERPKGLPHSLSGRMYYSCNGEE
                     LTLSNCSWRFNNSNLCSQSLAARVLCSASRSLHNLSTPEVPASVQTVTIESSVTVKIE
                     NKESRELMLLIPSIVLGILLLGSLIFIAFILLRIKGKYALPVMVNHQHLPTTIPAGSN
                     SYQPVPITIPKEVFMLPIQVQAPPPEDSDSGSDSDYEHYDFSAQPPVALTTFYNSQRH
                     RVTDEEVQQSRFQMPPLEEGLEELHASHIPTANPGHCITDPPSLGPQYHPRSNSESST
                     SSGEDYCNSPKSKLPPWNPQVFSSERSSFLEQPPNLELAGTQPAFSAGPPADDSSSTS
                     SGEWYQNFQPPPQPPSEEQFGCPGSPSPQPDSTDNDDYDDISAA"
     exon            236..304
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     exon            305..655
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     exon            656..967
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1270
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1336
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1477
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1573
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1696
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1768
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..2023
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2128
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..3252
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3229..3234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /note="hexamer: ATTAAA"
     polyA_site      3252
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /note="major polyA site"
ORIGIN      
        1 actcacaggt tgggtttgat cgcatgcgtg tcggagagga gagagcagag agagacacag
       61 gaacaagaac agcaaagggt agagcagacc tgcgccaggg gcgcacaacg gccgtgtcca
      121 cctcccggcc ccaagatggt gcttcccaca ggcagccacg cgtagcagcc agagacagct
      181 ccagacatgt ggctcttctt cgggatcact ggattgctga cggcagccct ctcaggtcat
      241 ccatctccag ccccacctga ccagctcaac accagcagtg cagagagtga gctctgggag
      301 ccaggggagc ggcttccggt ccgtctgaca aacgggagca gcagctgcag cgggacggtg
      361 gaggtgcggc tcgaggcgtc ctgggagccc gcgtgcgggg cgctctggga cagccgcgcc
      421 gccgaggccg tgtgccgagc actgggctgc ggcggggcgg aggccgcctc tcagctcgcc
      481 ccgccgaccc ctgagctgcc gcccccgcct gcagccggga acaccagcgt agcagctaat
      541 gccactctgg ccggggcgcc cgccctcctg tgcagcggcg ccgagtggcg gctctgcgag
      601 gtggtggagc acgcgtgccg cagcgacggg aggcgggccc gtgtcacctg tgcagagaac
      661 cgcgcgctgc gcctggtgga cggtggcggc gcctgcgccg gccgcgtgga gatgctggag
      721 catggcgagt ggggatcagt gtgcgatgac acttgggacc tggaggacgc ccacgtggtg
      781 tgcaggcaac tgggctgcgg ctgggcagtc caggccctgc ccggcttgca cttcacgccc
      841 ggccgcgggc ctatccaccg ggaccaggtg aactgctcgg gggccgaagc ttacctgtgg
      901 gactgcccgg ggctgccagg acagcactac tgcggccaca aagaggacgc gggcgcggtg
      961 tgctcagagc accagtcctg gcgcctgaca gggggcgctg accgctgcga ggggcaggtg
     1021 gaggtacact tccgaggggt ctggaacaca gtgtgtgaca gtgagtggta cccatcggag
     1081 gccaaggtgc tctgccagtc cttgggctgt ggaactgcgg ttgagaggcc caaggggctg
     1141 ccccactcct tgtccggcag gatgtactac tcatgcaatg gggaggagct caccctctcc
     1201 aactgctcct ggcggttcaa caactccaac ctctgcagcc agtcgctggc agccagggtc
     1261 ctctgctcag cttcccggag tttgcacaat ctgtccactc ccgaagtccc tgcaagtgtt
     1321 cagacagtca ctatagaatc ttctgtgaca gtgaaaatag agaacaagga atctcgggag
     1381 ctaatgctcc tcatcccctc catcgttctg ggaattctcc tccttggctc cctcatcttc
     1441 atagccttca tcctcttgag aattaaagga aaatatgccc tccccgtaat ggtgaaccac
     1501 cagcacctac ccaccaccat cccggcaggg agcaatagct atcaaccggt ccccatcacc
     1561 atccccaaag aagttttcat gctgcccatc caggtccagg ccccgccccc tgaggactca
     1621 gactctggct cggactcaga ctatgagcac tatgacttca gcgcccagcc tcctgtggcc
     1681 ctgaccacct tctacaattc ccagcggcat cgggtcacag atgaggaggt ccagcaaagc
     1741 aggttccaga tgccaccctt ggaggaagga cttgaagagt tgcatgcctc ccacatccca
     1801 actgccaacc ctggacactg cattacagac ccgccatccc tgggccctca gtatcacccg
     1861 aggagcaaca gtgagtcgag cacctcttca ggggaggatt actgcaatag tcccaaaagc
     1921 aagctgcctc catggaaccc ccaggtgttt tcttcagaga ggagttcctt cctggagcag
     1981 cccccaaact tggagctggc cggcacccag ccagcctttt cagcagggcc cccggctgat
     2041 gacagctcca gcacctcatc cggggagtgg taccagaact tccagccacc accccagccc
     2101 ccttcggagg agcagtttgg ctgtccaggg tcccccagcc ctcagcctga ctccaccgac
     2161 aacgatgact acgatgacat cagcgcagcc taggccgggg ccagccgagg ctcctggggt
     2221 ggctctgacc ctctggcctc ctgctctacc tactcccttt cccctttccc accctcccag
     2281 ctcacctccc catggagctg agaggcctcc cttggagaga tggaaggaaa cgttatacct
     2341 tgtacccctc ggtctccatc catcaagcca aacctgctgc cacagccctc ccccggcccc
     2401 agatagcagc cccagggagg atgctgcctc caagaggtgt gagccctctg tctcggggat
     2461 gaacaagcag agtctgggct acctcttgac agctggtgga ggggagttgg ggagctggac
     2521 tggatgactc tggaggcccc ttccaaacct caagtgtccg gcgctttgat tgcctgagtt
     2581 tctgacactt cagggcccag aggtcctgcg aggggcagaa ctggaccccc atgccagtgc
     2641 tgctgcagga gggcccatat actagggtct gctgagctgt tgtcactgat cggtgggcgc
     2701 tgggggggta gggtagcaca ccagctgtcc caggctttgc tccgggcggt aactgcactt
     2761 gggcagggaa tatagccttc ctgggcacaa ctagctgaca atgacaggtt gactgtgtac
     2821 ccccaaccaa ggagctgggg cccaaggcca gtcctgcccc agagacactc caagtccgcc
     2881 aggggcacag accagttctg cagtgactgt ccctggacaa tgggtcttta ttctgagttt
     2941 cctatggttt acaaagaggg ccccagccca gccccaccac agatcccaga gataggggcc
     3001 cagtctccat gggggcaagg agcatagaga tgttttccag gaaggggctc agaagctgca
     3061 ctaggccccg agtccccatg tgtctccttg aattgatgag gatgctcctg ggagggatgc
     3121 gtgactatgt ggtgttgcac ccggggctgc aaacgtctcc gtgcagcccc cagagagagg
     3181 cccatgggct cagaccaggc tttgttgtcc tgctctgagt atcctgagat taaactgaat
     3241 tgctgaatga aa
//
