LOCUS       NM_000611               7563 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens CD59 molecule (CD59 blood group) (CD59), transcript
            variant 2, mRNA.
ACCESSION   NM_000611
VERSION     NM_000611.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7563)
  AUTHORS   Gebetsberger,L., Malekshahi,Z., Teutsch,A., Tajti,G., Fontaine,F.,
            Marella,N., Mueller,A., Prantl,L., Stockinger,H., Stoiber,H. and
            Ohradanova-Repic,A.
  TITLE     SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair
            antibody-dependent complement-mediated lysis
  JOURNAL   Emerg Microbes Infect 13 (1), 2417868 (2024)
   PUBMED   39435487
  REMARK    GeneRIF: SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair
            antibody-dependent complement-mediated lysis.
REFERENCE   2  (bases 1 to 7563)
  AUTHORS   Tang,J., Zhao,Z., Zhou,J., Jiao,L., Zhou,W., Ying,B. and Yang,Y.
  TITLE     Multiple CD59 Polymorphisms in Chinese Patients with Mycobacterium
            tuberculosis Infection
  JOURNAL   J Immunol Res 2023, 1216048 (2023)
   PUBMED   37050931
  REMARK    GeneRIF: Multiple CD59 Polymorphisms in Chinese Patients with
            Mycobacterium tuberculosis Infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7563)
  AUTHORS   Sun,J., Cao,H., Wen,T., Xu,Z., Zhang,X., Wang,J. and Zhu,H.
  TITLE     The bioinformatics analysis of CD59 in Helicobacter pylori infected
            gastric cancer
  JOURNAL   Cancer Biomark 38 (1), 27-35 (2023)
   PUBMED   37522198
  REMARK    GeneRIF: The bioinformatics analysis of CD59 in Helicobacter pylori
            infected gastric cancer.
REFERENCE   4  (bases 1 to 7563)
  AUTHORS   Iwasa,K., Furukawa,Y., Yoshikawa,H., Yamada,M. and Ono,K.
  TITLE     CD59 Expression in Skeletal Muscles and Its Role in Myasthenia
            Gravis
  JOURNAL   Neurol Neuroimmunol Neuroinflamm 10 (1), e200057 (2022)
   PUBMED   36396448
  REMARK    GeneRIF: CD59 Expression in Skeletal Muscles and Its Role in
            Myasthenia Gravis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7563)
  AUTHORS   Bogdanet,D., Toth Castillo,M., Doheny,H., Dervan,L., Angel
            Luque-Fernandez,M., Halperin,J., O'Shea,P.M. and Dunne,F.P.
  TITLE     The utility of first trimester plasma glycated CD59 (pGCD59) in
            predicting gestational diabetes mellitus: A prospective study of
            non-diabetic pregnant women in Ireland
  JOURNAL   Diabetes Res Clin Pract 190, 110023 (2022)
   PUBMED   35907507
  REMARK    GeneRIF: The utility of first trimester plasma glycated CD59
            (pGCD59) in predicting gestational diabetes mellitus: A prospective
            study of non-diabetic pregnant women in Ireland.
REFERENCE   6  (bases 1 to 7563)
  AUTHORS   Petranka,J.G., Fleenor,D.E., Sykes,K., Kaufman,R.E. and Rosse,W.F.
  TITLE     Structure of the CD59-encoding gene: further evidence of a
            relationship to murine lymphocyte antigen Ly-6 protein
  JOURNAL   Proc Natl Acad Sci U S A 89 (17), 7876-7879 (1992)
   PUBMED   1381503
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1993 Jun 15;90(12):5878]
REFERENCE   7  (bases 1 to 7563)
  AUTHORS   Ninomiya,H. and Sims,P.J.
  TITLE     The human complement regulatory protein CD59 binds to the
            alpha-chain of C8 and to the 'b'domain of C9
  JOURNAL   J Biol Chem 267 (19), 13675-13680 (1992)
   PUBMED   1377690
REFERENCE   8  (bases 1 to 7563)
  AUTHORS   Hahn,W.C., Menu,E., Bothwell,A.L., Sims,P.J. and Bierer,B.E.
  TITLE     Overlapping but nonidentical binding sites on CD2 for CD58 and a
            second ligand CD59
  JOURNAL   Science 256 (5065), 1805-1807 (1992)
   PUBMED   1377404
REFERENCE   9  (bases 1 to 7563)
  AUTHORS   Holmes,C.H., Simpson,K.L., Okada,H., Okada,N., Wainwright,S.D.,
            Purcell,D.F. and Houlihan,J.M.
  TITLE     Complement regulatory proteins at the feto-maternal interface
            during human placental development: distribution of CD59 by
            comparison with membrane cofactor protein (CD46) and decay
            accelerating factor (CD55)
  JOURNAL   Eur J Immunol 22 (6), 1579-1585 (1992)
   PUBMED   1376264
REFERENCE   10 (bases 1 to 7563)
  AUTHORS   Tandon,N., Morgan,B.P. and Weetman,A.P.
  TITLE     Expression and function of membrane attack complex inhibitory
            proteins on thyroid follicular cells
  JOURNAL   Immunology 75 (2), 372-377 (1992)
   PUBMED   1372592
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU136899.1, BC001506.2,
            AL049629.28 and BM680161.1.
            
            On Sep 30, 2019 this sequence version replaced NM_000611.5.
            
            Summary: This gene encodes a cell surface glycoprotein that
            regulates complement-mediated cell lysis, and it is involved in
            lymphocyte signal transduction. This protein is a potent inhibitor
            of the complement membrane attack complex, whereby it binds
            complement C8 and/or C9 during the assembly of this complex,
            thereby inhibiting the incorporation of multiple copies of C9 into
            the complex, which is necessary for osmolytic pore formation. This
            protein also plays a role in signal transduction pathways in the
            activation of T cells. Mutations in this gene cause CD59
            deficiency, a disease resulting in hemolytic anemia and thrombosis,
            and which causes cerebral infarction. Multiple alternatively
            spliced transcript variants, which encode the same protein, have
            been identified for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All variants (1-8) encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.350787.1,
                                           SRR11853563.5106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000642928.2/ ENSP00000494884.1
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AU136899.1         57-85
            30-1896             BC001506.2         10-1876
            1897-6877           AL049629.28        38029-43009
            6878-7563           BM680161.1         17-702              c
FEATURES             Location/Qualifiers
     source          1..7563
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..7563
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /note="CD59 molecule (CD59 blood group)"
                     /db_xref="GeneID:966"
                     /db_xref="HGNC:HGNC:1689"
                     /db_xref="MIM:107271"
     exon            1..42
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /inference="alignment:Splign:2.1.0"
     exon            43..127
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..447
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /note="CD59 antigen p18-20 (antigen identified by
                     monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344);
                     protectin; human leukocyte antigen MIC11; CD59 molecule,
                     complement regulatory protein; surface anitgen recognized
                     by monoclonal antibody 16.3A5; lymphocytic antigen
                     CD59/MEM43; T cell-activating protein; Ly-6-like protein;
                     CD59 glycoprotein; membrane inhibitor of reactive lysis;
                     20 kDa homologous restriction factor; membrane attack
                     complex (MAC) inhibition factor; CD59 blood group antigen;
                     1F5 antigen; MEM43 antigen; membrane attack complex
                     inhibition factor"
                     /codon_start=1
                     /product="CD59 glycoprotein preproprotein"
                     /protein_id="NP_000602.1"
                     /db_xref="CCDS:CCDS7886.1"
                     /db_xref="GeneID:966"
                     /db_xref="HGNC:HGNC:1689"
                     /db_xref="MIM:107271"
                     /translation="MGIQGGSVLFGLLLVLAVFCHSGHSLQCYNCPNPTADCKTAVNC
                     SSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCNFNEQLEN
                     GGTSLSEKTVLLLVTPFLAAAWSLHP"
     exon            128..229
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /inference="alignment:Splign:2.1.0"
     exon            230..7563
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      558..563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /note="hexamer: AATAAA"
     polyA_site      577
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /note="major polyA site"
     polyA_site      1138
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /note="major polyA site"
     regulatory      1687..1692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /note="hexamer: ATTATA"
     polyA_site      1710
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /note="major polyA site"
     regulatory      1871..1876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /note="hexamer: AATAGA"
     polyA_site      1896
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
     regulatory      5268..5273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /note="hexamer: AATAAA"
     polyA_site      5290
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /note="major polyA site"
     regulatory      7534..7539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
                     /note="hexamer: AATATA"
     polyA_site      7563
                     /gene="CD59"
                     /gene_synonym="16.3A5; 1F5; EJ16; EJ30; EL32; G344;
                     HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
                     MIN3; MIRL; MSK21; p18-20"
ORIGIN      
        1 agaagcggct cgaggctgga agaggatctt gggcgccgcc aggttctgtg gacaatcaca
       61 atgggaatcc aaggagggtc tgtcctgttc gggctgctgc tcgtcctggc tgtcttctgc
      121 cattcaggtc atagcctgca gtgctacaac tgtcctaacc caactgctga ctgcaaaaca
      181 gccgtcaatt gttcatctga ttttgatgcg tgtctcatta ccaaagctgg gttacaagtg
      241 tataacaagt gttggaagtt tgagcattgc aatttcaacg acgtcacaac ccgcttgagg
      301 gaaaatgagc taacgtacta ctgctgcaag aaggacctgt gtaactttaa cgaacagctt
      361 gaaaatggtg ggacatcctt atcagagaaa acagttcttc tgctggtgac tccatttctg
      421 gcagcagcct ggagccttca tccctaagtc aacaccagga gagcttctcc caaactcccc
      481 gttcctgcgt agtccgcttt ctcttgctgc cacattctaa aggcttgata ttttccaaat
      541 ggatcctgtt gggaaagaat aaaattagct tgagcaacct ggctaagata gaggggctct
      601 gggagacttt gaagaccagt cctgtttgca gggaagcccc acttgaagga agaagtctaa
      661 gagtgaagta ggtgtgactt gaactagatt gcatgcttcc tcctttgctc ttgggaagac
      721 cagctttgca gtgacagctt gagtgggttc tctgcagccc tcagattatt tttcctctgg
      781 ctccttggat gtagtcagtt agcatcatta gtacatcttt ggagggtggg gcaggagtat
      841 atgagcatcc tctctcacat ggaacgcttt cataaacttc agggatcccg tgttgccatg
      901 gaggcatgcc aaatgttcca tatgtgggtg tcagtcaggg acaacaagat ccttaatgca
      961 gagctagagg acttctggca gggaagtggg gaagtgttcc agatagcagg gcatgaaaac
     1021 ttagagaggt acaagtggct gaaaatcgag tttttcctct gtctttaaat tttatatggg
     1081 ctttgttatc ttccactgga aaagtgtaat agcatacatc aatggtgtgt taaagctatt
     1141 tccttgcctt ttttttattg gaatggtagg atatcttggc tttgccacac acagttacag
     1201 agtgaacact ctactacatg tgactggcag tattaagtgt gcttatttta aatgttactg
     1261 gtagaaaggc agttcaggta tgtgtgtata tagtatgaat gcagtgggga caccctttgt
     1321 ggttacagtt tgagacttcc aaaggtcatc cttaataaca acagatctgc aggggtatgt
     1381 tttaccatct gcatccagcc tcctgctaac tcctagctga ctcagcatag attgtataaa
     1441 atacctttgt aacggctctt agcacactca cagatgtttg aggctttcag aagctcttct
     1501 aaaaaatgat acacaccttt cacaagggca aactttttcc ttttccctgt gtattctagt
     1561 gaatgaatct caagattcag tagacctaat gacatttgta ttttatgatc ttggctgtat
     1621 ttaatggcat aggctgactt ttgcagatgg aggaatttct tgattaatgt tgaaaaaaaa
     1681 cccttgatta tactctgttg gacaaaccga gtgcaatgaa tgatgctttt ctgaaaatga
     1741 aatataacaa gtgggtgaat gtggttatgg ccgaaaagga tatgcagtat gcttaatggt
     1801 agcaactgaa agaagacatc ctgagcagtg ccagctttct tctgttgatg ccgttccctg
     1861 aacataggaa aatagaaact tgcttatcaa aacttagcat taccttggtg ctctgtgttc
     1921 tctgttagct cagtgtcttt ccttacatca ataggttttt tttttttttt ttggcctgag
     1981 gaagtactga ccatgcccac agccaccggc tgagcaaaga agctcatttc atgtgagttc
     2041 taaggaatga gaaacaattt tgatgaattt aagcagaaaa tgaatttctg ggaacttttt
     2101 tgggggcggg ggggtgggga attcagccac actccagaaa gccaggagtc gacagttttg
     2161 gaagcctctc tcaggattga gattctagga tgagattggc ttactgctat cttgtgtcat
     2221 gtacccactt tttggccaga ctacactggg aagaaggtag tcctctaaag caaaatctga
     2281 gtgccactaa atggggagat ggggctgtta agctgtccaa atcaacaagg gtcatataaa
     2341 tggccttaaa ctttggggtt gctttctgca aaaagttgct gtgactcatg ccatagacaa
     2401 ggttgagtgc ctggacccaa aggcaatact gtaatgtaaa gacatttata gtactaggca
     2461 aacagcaccc caggtactcc aggccctcct ggctggagag ggctgtggca atagaaaatt
     2521 agtgccaact gcagtgagtc agcctaggtt aaatagagag tgtaagagtg ctggacagga
     2581 acctccaccc tcatgtcaca tttcttcaat gtgacccttc tggcccctct cctcctgaca
     2641 gcggaacaat gactgccccg ataggtgagg ctggaggaag aatcagtcct gtccttggca
     2701 agctcttcac tatgacagta aaggctctct gcctgctgcc aaggcctgtg actttctaac
     2761 ctggcctcac gctgggtaag cttaaggtag aggtgcagga ttagcaagcc cacctggcta
     2821 ccaggccgac agctacatcc tccaactgac cctgatcaac gaagagggat tcatgtgtct
     2881 gtctcagttg gttccaaatg aaaccaggga gcaggggagt taggaatcga acaccagtca
     2941 tgcctactgg ctctctgctc gagagccaat accctgtgcc ctccactcat ctggatttac
     3001 aggaactgtc atagtgttca gtattgggtg gtgataagcc cattggattg tccccttggg
     3061 gggatgagct aggggtgcaa ggaacacctg atgagtagat aagtggagct catggtattt
     3121 cctgaaagat gctaatctat ttgccaaact tggtcttgaa tgtactgggg gcttcaaggt
     3181 atgggtatat ttttcttgtg tccttgcagt tagcccccat gtcttatgtg tgtcctgaaa
     3241 aaataagagc ctgcccaaga ctttgggcct cttgacagaa ttaaccactt ttatacatct
     3301 gagttctctt ggtaagttct ttagcagtgt tcaaagtcta ctagctcgca ttagtttctg
     3361 ttgctgccaa cagatctgaa ctaatgctaa cagatccccc tgagggattc ttgatgggct
     3421 gagcagctgg ctggagctag tactgactga cattcattgt gatgagggca gctttctggt
     3481 acaggattct aagctctatg ttttatatac attttcatct gtacttgcac ctcactttac
     3541 acaagaggaa actatgcaaa gttagctgga tcgctcaagg tcacttaggt aagttggcaa
     3601 gtccatgctt cccactcagc tcctcaggtc agcaagtcta cttctctgcc tattttgtat
     3661 actctcttta atatgtgcct agctttggaa agtctagaat gggtccctgg tgccttttta
     3721 ctttgaagaa atcagtttct gcctcttttt ggaaaagaaa acaaagtgca attgtttttt
     3781 actggaaagt tacccaatag catgaggtga acaggacgta gttaggcctt cctgtaaaca
     3841 gaaaatcata tcaaaacact atcttcccat ctgtttctca atgcctgcta cttcttgtag
     3901 atatttcatt tcaggagagc agcagttaaa cccgtggatt ttgtagttag gaacctgggt
     3961 tcaaaccctc ttccactaat tggctatgtc tctggacaag tttttttttt tttttttttt
     4021 taaacccttt ctgaactttc actttctatg tctacctcaa agaattgttg tgaggcttga
     4081 gataatgcat ttgtaaaggg tctgccagat aggaagatgc tagttatgga tttacaaggt
     4141 tgttaaggct gtaagagtct aaaacctaca gtgaatcaca atgcatttac ccccactgac
     4201 ttggacataa gtgaaaacta gccagaagtc tctttttcaa attacttaca ggttattcaa
     4261 tataaaattt ttgtaatgga taatcttatt tatctaaact aaagcttcct gtttatacac
     4321 actcctgtta ttctgggata agataaatga ccacagtacc ttaatttcta ggtgggtgcc
     4381 tgtgatggtt cattgtaggt aaggacattt tctctttttc agcagctgtg taggtccaga
     4441 gcctctggga gaggaggggg gtagcatgca cccagcaggg gactgaactg ggaaactcaa
     4501 ggttcttttt actgtggggt agtgagctgc ctttctgtga tcggtttccc tagggatgtt
     4561 gctgttcccc tccttgctat tcgcagctac atacaacgtg gccaacccca gtaggctgat
     4621 cctatatatg atcagtgctg gtgctgactc tcaatagccc cacccaagct ggctataggt
     4681 ttacagatac attaattagg caacctaaaa tattgatgct ggtgttggtg tgacataatg
     4741 ctatggccag aactgaaact tagagttata attcatgtat tagggttctc cagagggaca
     4801 gaattagtag gatatatgta tatatgaaag ggaggttatt agggagaact ggctcccaca
     4861 gttagaaggc gaagtcgcac aataggccgt ctgcaagctg ggttagagag aagccagtag
     4921 tggctcagcc tgagttcaaa aacctcaaaa ctggggaagc tgacagtgca gccagccttc
     4981 agtctgtggc caaaggccca agagcccctg gcaaccaacc cactggtgca agtcctagat
     5041 tccaaaggct gaagaacctg gagtctgatg tccaagagca ggaagagtgg aagaaagcca
     5101 gaagactcag caaacaaggt agacagtgtc taccaccata gtggccatac caaagaggct
     5161 accgattcct tcctgctacc tggatccctg aagttgccct ggtctctgca ccttctaaac
     5221 ctagttctta agagctttcc attacatgag ctgtctcaaa gccctccaat aaattctcag
     5281 tgtaagcttc tgttgcttgt ggacagaaaa ttctgacaga cctaccctat aagtgttact
     5341 gtcaggataa catgagaacg cacaacagta agtggtcact aagtgttagc tacggttatt
     5401 ttgcccaagg tagcatggct agttgatgcc ggttgatggg gcttaaaccc agctccctca
     5461 tcttccaggc ctctgtactc cctattccac taaactacct ctcaggttta tttttttaaa
     5521 ttcttactct gcaagtacat aggaccacat ttacctggga aaacaagaat aaaggctgct
     5581 ctgcattttt tagaaacttt tttgaaaggg agatgggaat gcctgcaccc ccaagtccag
     5641 accaacacaa tggttaattg agatgaataa taaaggaaag actgttctgg gcttcccaga
     5701 atagcttggt ccttaaattg tggcacaaac aacctcctgt cagagccagc ctcctgccag
     5761 gaagaggggt aggagactag aggccgtgtg tgcagccttg ccctgaaggc tagggtgaca
     5821 atttggaggc tgtccaaaca ccctggcctc tagagctggc ctgtctattt gaaatgccgg
     5881 ctctgatgct aatcggcgac cctcaggcaa gttacttaac cttacatgcc tcagttttct
     5941 catctggaaa atgagaaccc taggtttagg gttgttagaa aagttaaatg agttaagaca
     6001 agtgcctggg acacagtagc ctcttgtgtg tgtttatcat tatgtcctca gcaggtcgta
     6061 gaagcagctt ctcaggtgtg aggctggcgc gattatctgg agtgggttgg gttttctagg
     6121 atggaccccc tgctgcattt tcctcattca tccaccaggg cttaatgggg aatcaaggaa
     6181 tccatgtgta actgtataat aactgtagcc acactccaat gaccacctac tagttgtccc
     6241 tggcactgct tatacatatg tccatcaaat caatcctatg aagtagatac tgtcttcatt
     6301 ttatagatca gagacaattg gggttcagag agctgatgtg attttcccag ggtcacagag
     6361 agtcccagat tcaggcacaa ctcttgtatt ccaagacaca accactacat gtccaaaggc
     6421 tgcccagagc caccgggcac ggcaaattgt gacatatccc taaagaggct gagcacctgg
     6481 tcaggatctg atggctgaca gtgtgtccag atgcagagct ggagtggggg aggggaaggg
     6541 gggctccttg ggacagagaa ggctttctgt gctttctctg aagggagcag tctgaggacc
     6601 aagggaaccc ggcaaacagc acctcaggta ctccaggccc tcctggctgg agagggctgt
     6661 ggcaatggaa aattagtgcc aactgcaatg agtcagcctc ggttaaatag agagtgaaga
     6721 atgctggaca ggaacctcca ccctcatgtc acatttcttc agtgtgaccc ttctggcccc
     6781 tctcctcctg acagcggaac aatgactgcc ccgataggtg aggctggagg aagaatcagt
     6841 cctgtccttg gcaagctctt cactatgaca gtaaaggctc tctgcctgct gccaaggcct
     6901 gtgactttct aacctggcct cacgctgggt aagcttaagg tagaggtgca ggattagcaa
     6961 gcccacctgg ctaccaggcc gacagctaca tctttcaact gaccctgatc aacgaagagg
     7021 gacttgtgtc tctcagttgg ttccaaatga aaccagggag caggggcgtt aggaagctcc
     7081 aacaggatgg tacttaatgg ggcatttgag tggagaggta ggtgacatag tgctttggag
     7141 cccagggagg gaaaggttct gctgaagttg aattcaagac tgttctttca tcacaaactt
     7201 gagtttcctg gacatttgtt tgcagaaaca accgtagggt tttgccttaa cctcgtgggt
     7261 ttattattac ctcataggga ctttgcctcc tgacagcagt ttatgggtgt tcattgtggc
     7321 acttgagttt tcttgcatac ttgttagaga aaccaagttt gtcatcaact tcttatttaa
     7381 ccccctggct ataacttcat ggattatgtt ataattaagc catccagagt aaaatctgtt
     7441 tagattatct tggagtaagg gggaaaaaat ctgtaatttt ttctcctcaa ctagatatat
     7501 acataaaaaa tgattgtatt gcttcattta aaaaatataa cgcaaaatct cttttccttc
     7561 taa
//
