LOCUS       NM_001779               1086 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens CD58 molecule (CD58), transcript variant 1, mRNA.
ACCESSION   NM_001779
VERSION     NM_001779.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1086)
  AUTHORS   Xu,X., Zhang,Y., Lu,Y., Zhang,X., Zhao,C., Wang,J., Guan,Q.,
            Feng,Y., Gao,M., Yu,J., Song,Z., Liu,X., Golchehre,Z., Li,L.,
            Ren,W., Pan-Hammarstrom,Q., Zhang,H. and Wang,X.
  TITLE     CD58 Alterations Govern Antitumor Immune Responses by Inducing PDL1
            and IDO in Diffuse Large B-Cell Lymphoma
  JOURNAL   Cancer Res 84 (13), 2123-2140 (2024)
   PUBMED   38635903
  REMARK    GeneRIF: CD58 Alterations Govern Antitumor Immune Responses by
            Inducing PDL1 and IDO in Diffuse Large B-Cell Lymphoma.
REFERENCE   2  (bases 1 to 1086)
  AUTHORS   Ahmed,A., Rawshan,A.E.M., Tishe,Z.H., Shawkat,S., Popy,M.N.,
            Shohag,M.H., Hossain,M. and Mostaid,M.S.
  TITLE     Association of CD58 rs12044852 and rs2300747 polymorphisms with the
            risk of multiple sclerosis: A systematic review and meta-analysis
  JOURNAL   Mult Scler Relat Disord 82, 105411 (2024)
   PUBMED   38176285
  REMARK    GeneRIF: Association of CD58 rs12044852 and rs2300747 polymorphisms
            with the risk of multiple sclerosis: A systematic review and
            meta-analysis.
REFERENCE   3  (bases 1 to 1086)
  AUTHORS   Ariel,O., Kukulansky,T., Raz,N. and Hollander,N.
  TITLE     Distinct membrane localization and kinase association of the two
            isoforms of CD58
  JOURNAL   Cell Signal 16 (6), 667-673 (2004)
   PUBMED   15093607
  REMARK    GeneRIF: Transmembrane CD58 may trigger signaling independently of
            the GPI-linked isoform.
REFERENCE   4  (bases 1 to 1086)
  AUTHORS   Kirby,A.C., Cahen,P., Porter,S.R. and Olsen,I.
  TITLE     Soluble and cell-associated forms of the adhesion molecule LFA-3
            (CD58) are differentially regulated by inflammatory cytokines
  JOURNAL   Cell Adhes Commun 7 (6), 453-464 (2000)
   PUBMED   11051456
REFERENCE   5  (bases 1 to 1086)
  AUTHORS   Itzhaky,D., Raz,N. and Hollander,N.
  TITLE     The glycosylphosphatidylinositol-anchored form and the
            transmembrane form of CD58 associate with protein kinases
  JOURNAL   J Immunol 160 (9), 4361-4366 (1998)
   PUBMED   9574540
REFERENCE   6  (bases 1 to 1086)
  AUTHORS   Wallich,R., Brenner,C., Brand,Y., Roux,M., Reister,M. and Meuer,S.
  TITLE     Gene structure, promoter characterization, and basis for
            alternative mRNA splicing of the human CD58 gene
  JOURNAL   J Immunol 160 (6), 2862-2871 (1998)
   PUBMED   9510189
REFERENCE   7  (bases 1 to 1086)
  AUTHORS   Kirby,A.C., Hill,V., Olsen,I. and Porter,S.R.
  TITLE     LFA-3 delta D2: a novel in vivo isoform of lymphocyte
            function-associated antigen 3
  JOURNAL   Biochem Biophys Res Commun 214 (1), 200-205 (1995)
   PUBMED   7545392
REFERENCE   8  (bases 1 to 1086)
  AUTHORS   Hahn,W.C., Menu,E., Bothwell,A.L., Sims,P.J. and Bierer,B.E.
  TITLE     Overlapping but nonidentical binding sites on CD2 for CD58 and a
            second ligand CD59
  JOURNAL   Science 256 (5065), 1805-1807 (1992)
   PUBMED   1377404
REFERENCE   9  (bases 1 to 1086)
  AUTHORS   Seed,B.
  TITLE     An LFA-3 cDNA encodes a phospholipid-linked membrane protein
            homologous to its receptor CD2
  JOURNAL   Nature 329 (6142), 840-842 (1987)
   PUBMED   3313052
REFERENCE   10 (bases 1 to 1086)
  AUTHORS   Wallner,B.P., Frey,A.Z., Tizard,R., Mattaliano,R.J., Hession,C.,
            Sanders,M.E., Dustin,M.L. and Springer,T.A.
  TITLE     Primary structure of lymphocyte function-associated antigen 3
            (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein
  JOURNAL   J Exp Med 166 (4), 923-932 (1987)
   PUBMED   3309127
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355794.5, Y00636.1 and
            CA312671.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001779.2.
            
            Summary: This gene encodes a member of the immunoglobulin
            superfamily. The encoded protein is a ligand of the T lymphocyte
            CD2 protein, and functions in adhesion and activation of T
            lymphocytes. The protein is localized to the plasma membrane.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00636.1, SRR14038196.2421896.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369489.10/ ENSP00000358501.5
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL355794.5         37074-37118         c
            46-1085             Y00636.1           1-1040
            1086-1086           CA312671.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.1"
     gene            1..1086
                     /gene="CD58"
                     /gene_synonym="ag3; LFA-3; LFA3"
                     /note="CD58 molecule"
                     /db_xref="GeneID:965"
                     /db_xref="HGNC:HGNC:1688"
                     /db_xref="MIM:153420"
     exon            1..124
                     /gene="CD58"
                     /gene_synonym="ag3; LFA-3; LFA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..807
                     /gene="CD58"
                     /gene_synonym="ag3; LFA-3; LFA3"
                     /note="isoform 1 is encoded by transcript variant 1; CD58
                     antigen, (lymphocyte function-associated antigen 3);
                     surface glycoprotein LFA-3"
                     /codon_start=1
                     /product="lymphocyte function-associated antigen 3 isoform
                     1"
                     /protein_id="NP_001770.1"
                     /db_xref="CCDS:CCDS888.1"
                     /db_xref="GeneID:965"
                     /db_xref="HGNC:HGNC:1688"
                     /db_xref="MIM:153420"
                     /translation="MVAGSDAGRALGVLSVVCLLHCFGFISCFSQQIYGVVYGNVTFH
                     VPSNVPLKEVLWKKQKDKVAELENSEFRAFSSFKNRVYLDTVSGSLTIYNLTSSDEDE
                     YEMESPNITDTMKFFLYVLESLPSPTLTCALTNGSIEVQCMIPEHYNSHRGLIMYSWD
                     CPMEQCKRNSTSIYFKMENDLPQKIQCTLSNPLFNTTSSIILTTCIPSSGHSRHRYAL
                     IPIPLAVITTCIVLYMNGILKCDRKPDRTNSN"
     exon            125..418
                     /gene="CD58"
                     /gene_synonym="ag3; LFA-3; LFA3"
                     /inference="alignment:Splign:2.1.0"
     exon            419..682
                     /gene="CD58"
                     /gene_synonym="ag3; LFA-3; LFA3"
                     /inference="alignment:Splign:2.1.0"
     exon            683..760
                     /gene="CD58"
                     /gene_synonym="ag3; LFA-3; LFA3"
                     /inference="alignment:Splign:2.1.0"
     exon            761..797
                     /gene="CD58"
                     /gene_synonym="ag3; LFA-3; LFA3"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1086
                     /gene="CD58"
                     /gene_synonym="ag3; LFA-3; LFA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1060..1065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD58"
                     /gene_synonym="ag3; LFA-3; LFA3"
                     /note="hexamer: AATAAA"
     polyA_site      1086
                     /gene="CD58"
                     /gene_synonym="ag3; LFA-3; LFA3"
                     /note="major polyA site"
ORIGIN      
        1 gaacttaggg ctgcttgtgg ctgggcactc gcgcagaggc cggcccgacg agccatggtt
       61 gctgggagcg acgcggggcg ggccctgggg gtcctcagcg tggtctgcct gctgcactgc
      121 tttggtttca tcagctgttt ttcccaacaa atatatggtg ttgtgtatgg gaatgtaact
      181 ttccatgtac caagcaatgt gcctttaaaa gaggtcctat ggaaaaaaca aaaggataaa
      241 gttgcagaac tggaaaattc tgaattcaga gctttctcat cttttaaaaa tagggtttat
      301 ttagacactg tgtcaggtag cctcactatc tacaacttaa catcatcaga tgaagatgag
      361 tatgaaatgg aatcgccaaa tattactgat accatgaagt tctttcttta tgtgcttgag
      421 tctcttccat ctcccacact aacttgtgca ttgactaatg gaagcattga agtccaatgc
      481 atgataccag agcattacaa cagccatcga ggacttataa tgtactcatg ggattgtcct
      541 atggagcaat gtaaacgtaa ctcaaccagt atatatttta agatggaaaa tgatcttcca
      601 caaaaaatac agtgtactct tagcaatcca ttatttaata caacatcatc aatcattttg
      661 acaacctgta tcccaagcag cggtcattca agacacagat atgcacttat acccatacca
      721 ttagcagtaa ttacaacatg tattgtgctg tatatgaatg gtattctgaa atgtgacaga
      781 aaaccagaca gaaccaactc caattgattg gtaacagaag atgaagacaa cagcataact
      841 aaattatttt aaaaactaaa aagccatctg atttctcatt tgagtattac aatttttgaa
      901 caactgttgg aaatgtaact tgaagcagct gctttaagaa gaaataccca ctaacaaaga
      961 acaagcatta gttttggctg tcatcaactt attatatgac taggtgcttg ctttttttgt
     1021 cagtaaattg tttttactga tgatgtagat acttttgtaa ataaatgtaa atatgtacac
     1081 aagtga
//
