LOCUS       NM_000574               2590 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens CD55 molecule (Cromer blood group) (CD55), transcript
            variant 1, mRNA.
ACCESSION   NM_000574
VERSION     NM_000574.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2590)
  AUTHORS   Gebetsberger,L., Malekshahi,Z., Teutsch,A., Tajti,G., Fontaine,F.,
            Marella,N., Mueller,A., Prantl,L., Stockinger,H., Stoiber,H. and
            Ohradanova-Repic,A.
  TITLE     SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair
            antibody-dependent complement-mediated lysis
  JOURNAL   Emerg Microbes Infect 13 (1), 2417868 (2024)
   PUBMED   39435487
  REMARK    GeneRIF: SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair
            antibody-dependent complement-mediated lysis.
REFERENCE   2  (bases 1 to 2590)
  AUTHORS   Bharti,R., Dey,G., Khan,D., Myers,A., Huffman,O.G., Saygin,C.,
            Braley,C., Richards,E., Sangwan,N., Willard,B., Lathia,J.D.,
            Fox,P.L., Lin,F., Jha,B.K., Brown,J.M., Yu,J.S., Dwidar,M.,
            Joehlin-Price,A., Vargas,R., Michener,C.M., Longworth,M.S. and
            Reizes,O.
  TITLE     Cell surface CD55 traffics to the nucleus leading to cisplatin
            resistance and stemness by inducing PRC2 and H3K27 trimethylation
            on chromatin in ovarian cancer
  JOURNAL   Mol Cancer 23 (1), 121 (2024)
   PUBMED   38853277
  REMARK    GeneRIF: Cell surface CD55 traffics to the nucleus leading to
            cisplatin resistance and stemness by inducing PRC2 and H3K27
            trimethylation on chromatin in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2590)
  AUTHORS   Kaya,Z. and Derinoz,O.
  TITLE     Polycythemia as an Uncommon Finding in 2 Children, One With
            Systemic Capillary Leak Syndrome and the Other With Protein-losing
            Enteropathy Caused by CD55 Deficiency
  JOURNAL   J Pediatr Hematol Oncol 45 (8), e996-e1000 (2023)
   PUBMED   37565818
  REMARK    GeneRIF: Polycythemia as an Uncommon Finding in 2 Children, One
            With Systemic Capillary Leak Syndrome and the Other With
            Protein-losing Enteropathy Caused by CD55 Deficiency.
REFERENCE   4  (bases 1 to 2590)
  AUTHORS   Osuka,F., Endo,Y., Higuchi,M., Suzuki,H., Shio,Y., Fujiu,K.,
            Kanno,R., Oishi,A., Terashima,M., Fujita,T. and Gotoh,M.
  TITLE     Molecular cloning and characterization of novel splicing variants
            of human decay-accelerating factor
  JOURNAL   Genomics 88 (3), 316-322 (2006)
   PUBMED   16503113
REFERENCE   5  (bases 1 to 2590)
  AUTHORS   Shenoy-Scaria,A.M., Kwong,J., Fujita,T., Olszowy,M.W., Shaw,A.S.
            and Lublin,D.M.
  TITLE     Signal transduction through decay-accelerating factor. Interaction
            of glycosyl-phosphatidylinositol anchor and protein tyrosine
            kinases p56lck and p59fyn 1
  JOURNAL   J Immunol 149 (11), 3535-3541 (1992)
   PUBMED   1385527
REFERENCE   6  (bases 1 to 2590)
  AUTHORS   Nakano,Y., Sumida,K., Kikuta,N., Miura,N.H., Tobe,T. and Tomita,M.
  TITLE     Complete determination of disulfide bonds localized within the
            short consensus repeat units of decay accelerating factor (CD55
            antigen)
  JOURNAL   Biochim Biophys Acta 1116 (3), 235-240 (1992)
   PUBMED   1377029
REFERENCE   7  (bases 1 to 2590)
  AUTHORS   Holmes,C.H., Simpson,K.L., Okada,H., Okada,N., Wainwright,S.D.,
            Purcell,D.F. and Houlihan,J.M.
  TITLE     Complement regulatory proteins at the feto-maternal interface
            during human placental development: distribution of CD59 by
            comparison with membrane cofactor protein (CD46) and decay
            accelerating factor (CD55)
  JOURNAL   Eur J Immunol 22 (6), 1579-1585 (1992)
   PUBMED   1376264
REFERENCE   8  (bases 1 to 2590)
  AUTHORS   Ewulonu,U.K., Ravi,L. and Medof,M.E.
  TITLE     Characterization of the decay-accelerating factor gene promoter
            region
  JOURNAL   Proc Natl Acad Sci U S A 88 (11), 4675-4679 (1991)
   PUBMED   1711208
REFERENCE   9  (bases 1 to 2590)
  AUTHORS   Medof,M.E., Lublin,D.M., Holers,V.M., Ayers,D.J., Getty,R.R.,
            Leykam,J.F., Atkinson,J.P. and Tykocinski,M.L.
  TITLE     Cloning and characterization of cDNAs encoding the complete
            sequence of decay-accelerating factor of human complement
  JOURNAL   Proc Natl Acad Sci U S A 84 (7), 2007-2011 (1987)
   PUBMED   2436222
REFERENCE   10 (bases 1 to 2590)
  AUTHORS   Caras,I.W., Davitz,M.A., Rhee,L., Weddell,G., Martin,D.W. Jr. and
            Nussenzweig,V.
  TITLE     Cloning of decay-accelerating factor suggests novel use of splicing
            to generate two proteins
  JOURNAL   Nature 325 (6104), 545-549 (1987)
   PUBMED   2433596
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC386415.1, BC001288.1,
            M31516.1 and AW316643.1.
            
            On Jun 2, 2019 this sequence version replaced NM_000574.4.
            
            Summary: This gene encodes a glycoprotein involved in the
            regulation of the complement cascade. Binding of the encoded
            protein to complement proteins accelerates their decay, thereby
            disrupting the cascade and preventing damage to host cells.
            Antigens present on this protein constitute the Cromer blood group
            system (CROM). Alternative splicing results in multiple transcript
            variants. The predominant transcript variant encodes a
            membrane-bound protein, but alternatively spliced transcripts may
            produce soluble proteins. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) encodes isoform 1 (also known
            as gDAF), which is membrane-associated.
            
            Sequence Note: This RefSeq record represents the CD55*001.1.1
            allele.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.29214.1,
                                           SRR5189658.132959.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367064.9/ ENSP00000356031.4
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DC386415.1         207-215
            10-1337             BC001288.1         1-1328
            1338-2125           M31516.1           1315-2102
            2126-2590           AW316643.1         2-466               c
FEATURES             Location/Qualifiers
     source          1..2590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..2590
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /note="CD55 molecule (Cromer blood group)"
                     /db_xref="GeneID:1604"
                     /db_xref="HGNC:HGNC:2665"
                     /db_xref="MIM:125240"
     exon            1..188
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1234
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; CD55 antigen; complement decay-accelerating
                     factor; Cromer blood group antigen; Rh blood group D
                     antigen; CD55 molecule, decay accelerating factor for
                     complement (Cromer blood group)"
                     /codon_start=1
                     /product="complement decay-accelerating factor isoform 1
                     preproprotein"
                     /protein_id="NP_000565.1"
                     /db_xref="CCDS:CCDS31006.1"
                     /db_xref="GeneID:1604"
                     /db_xref="HGNC:HGNC:2665"
                     /db_xref="MIM:125240"
                     /translation="MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPN
                     AQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPT
                     RLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKK
                     KSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLP
                     ECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEW
                     SGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVS
                     RTTKHFHETTPNKGSGTTSGTTRLLSGHTCFTLTGLLGTLVTMGLLT"
     exon            189..374
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /inference="alignment:Splign:2.1.0"
     exon            375..566
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /inference="alignment:Splign:2.1.0"
     exon            567..666
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /inference="alignment:Splign:2.1.0"
     exon            667..752
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /inference="alignment:Splign:2.1.0"
     exon            753..941
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1067
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1148
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1169
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..2590
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /note="hexamer: AATAAA"
     polyA_site      1337
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /note="major polyA site"
     regulatory      2103..2108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /note="hexamer: AATAAA"
     polyA_site      2126
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /note="major polyA site"
     regulatory      2567..2572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
                     /note="hexamer: AATAAA"
     polyA_site      2590
                     /gene="CD55"
                     /gene_synonym="CHAPLE; CR; CROM; DAF; TC"
ORIGIN      
        1 ctgcttactg caactcgctc cggccgctgg gcgtagctgc gactcggcgg agtcccggcg
       61 gcgcgtcctt gttctaaccc ggcgcgccat gaccgtcgcg cggccgagcg tgcccgcggc
      121 gctgcccctc ctcggggagc tgccccggct gctgctgctg gtgctgttgt gcctgccggc
      181 cgtgtggggt gactgtggcc ttcccccaga tgtacctaat gcccagccag ctttggaagg
      241 ccgtacaagt tttcccgagg atactgtaat aacgtacaaa tgtgaagaaa gctttgtgaa
      301 aattcctggc gagaaggact cagtgatctg ccttaagggc agtcaatggt cagatattga
      361 agagttctgc aatcgtagct gcgaggtgcc aacaaggcta aattctgcat ccctcaaaca
      421 gccttatatc actcagaatt attttccagt cggtactgtt gtggaatatg agtgccgtcc
      481 aggttacaga agagaacctt ctctatcacc aaaactaact tgccttcaga atttaaaatg
      541 gtccacagca gtcgaatttt gtaaaaagaa atcatgccct aatccgggag aaatacgaaa
      601 tggtcagatt gatgtaccag gtggcatatt atttggtgca accatctcct tctcatgtaa
      661 cacagggtac aaattatttg gctcgacttc tagtttttgt cttatttcag gcagctctgt
      721 ccagtggagt gacccgttgc cagagtgcag agaaatttat tgtccagcac caccacaaat
      781 tgacaatgga ataattcaag gggaacgtga ccattatgga tatagacagt ctgtaacgta
      841 tgcatgtaat aaaggattca ccatgattgg agagcactct atttattgta ctgtgaataa
      901 tgatgaagga gagtggagtg gcccaccacc tgaatgcaga ggaaaatctc taacttccaa
      961 ggtcccacca acagttcaga aacctaccac agtaaatgtt ccaactacag aagtctcacc
     1021 aacttctcag aaaaccacca caaaaaccac cacaccaaat gctcaagcaa cacggagtac
     1081 acctgtttcc aggacaacca agcattttca tgaaacaacc ccaaataaag gaagtggaac
     1141 cacttcaggt actacccgtc ttctatctgg gcacacgtgt ttcacgttga caggtttgct
     1201 tgggacgcta gtaaccatgg gcttgctgac ttagccaaag aagagttaag aagaaaatac
     1261 acacaagtat acagactgtt cctagtttct tagacttatc tgcatattgg ataaaataaa
     1321 tgcaattgtg ctcttcattt aggatgcttt cattgtcttt aagatgtgtt aggaatgtca
     1381 acagagcaag gagaaaaaag gcagtcctgg aatcacattc ttagcacacc tacacctctt
     1441 gaaaatagaa caacttgcag aattgagagt gattcctttc ctaaaagtgt aagaaagcat
     1501 agagatttgt tcgtatttag aatgggatca cgaggaaaag agaaggaaag tgattttttt
     1561 ccacaagatc tgtaatgtta tttccactta taaaggaaat aaaaaatgaa aaacattatt
     1621 tggatatcaa aagcaaataa aaacccaatt cagtctcttc taagcaaaat tgctaaagag
     1681 agatgaacca cattataaag taatctttgg ctgtaaggca ttttcatctt tccttcgggt
     1741 tggcaaaata ttttaaaggt aaaacatgct ggtgaaccag gggtgttgat ggtgataagg
     1801 gaggaatata gaatgaaaga ctgaatcttc ctttgttgca caaatagagt ttggaaaaag
     1861 cctgtgaaag gtgtcttctt tgacttaatg tctttaaaag tatccagaga tactacaata
     1921 ttaacataag aaaagattat atattatttc tgaatcgaga tgtccatagt caaatttgta
     1981 aatcttattc ttttgtaata tttatttata tttatttatg acagtgaaca ttctgatttt
     2041 acatgtaaaa caagaaaagt tgaagaagat atgtgaagaa aaatgtattt ttcctaaata
     2101 gaaataaatg atcccatttt ttggtatcat gtagtatgtg aaatttattc ttaaacgtga
     2161 ctactttatt tctaaataag aaattcccta cctgcttcct acaagcagtt cagaatgcca
     2221 tgccttggtt gtcctagtgt gaataatttt cagctacttt aaaattatat tgtactttct
     2281 caagcatgtc atatcctttc ctattagagt atctatatta cttgttactg atttacctga
     2341 aggcaatctg attaatttct aggtttttac catattcttg tcatcttgcc aattacattt
     2401 taagtgttag actagactaa gatgtactag ttgtatagaa tataactaga tttattatgg
     2461 caatgtttat tttgtcattt tgcttcatct gttttgttgt tgaagtactt taaatttcat
     2521 acgttcatgg catttcactg taaagacttt aatgtgtatt tcttaaaata aaactttttt
     2581 tcctccttaa
//
