LOCUS       NM_001803                467 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens CD52 molecule (CD52), mRNA.
ACCESSION   NM_001803
VERSION     NM_001803.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   de Vos-Hillebrand,L., Fietz,S., Hillebrand,P., Kulcsar,Z.,
            Diop,M.Y., Hollick,S., Maas,A.P., Strieth,S., Landsberg,J. and
            Dietrich,D.
  TITLE     CD52 mRNA expression predicts prognosis and response to immune
            checkpoint blockade in melanoma
  JOURNAL   Pigment Cell Melanoma Res 37 (2), 309-315 (2024)
   PUBMED   37975535
  REMARK    GeneRIF: CD52 mRNA expression predicts prognosis and response to
            immune checkpoint blockade in melanoma.
            Review article
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Chiesa,R., Georgiadis,C., Syed,F., Zhan,H., Etuk,A., Gkazi,S.A.,
            Preece,R., Ottaviano,G., Braybrook,T., Chu,J., Kubat,A., Adams,S.,
            Thomas,R., Gilmour,K., O'Connor,D., Vora,A. and Qasim,W.
  CONSRTM   Base-Edited CAR T Group
  TITLE     Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic
            Leukemia
  JOURNAL   N Engl J Med 389 (10), 899-910 (2023)
   PUBMED   37314354
  REMARK    GeneRIF: Base-Edited CAR7 T Cells for Relapsed T-Cell Acute
            Lymphoblastic Leukemia.
REFERENCE   3  (bases 1 to 467)
  AUTHORS   Mao,R., Yang,F., Zhang,Y., Liu,H., Guo,P., Liu,Y. and Zhang,T.
  TITLE     High expression of CD52 in adipocytes: a potential therapeutic
            target for obesity with type 2 diabetes
  JOURNAL   Aging (Albany NY) 13 (8), 11043-11060 (2021)
   PUBMED   33705353
  REMARK    GeneRIF: High expression of CD52 in adipocytes: a potential
            therapeutic target for obesity with type 2 diabetes.
REFERENCE   4  (bases 1 to 467)
  AUTHORS   Bhamidipati,K., Silberstein,J.L., Chaichian,Y., Baker,M.C.,
            Lanz,T.V., Zia,A., Rasheed,Y.S., Cochran,J.R. and Robinson,W.H.
  TITLE     CD52 Is Elevated on B cells of SLE Patients and Regulates B Cell
            Function
  JOURNAL   Front Immunol 11, 626820 (2021)
   PUBMED   33658999
  REMARK    GeneRIF: CD52 Is Elevated on B cells of SLE Patients and Regulates
            B Cell Function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 467)
  AUTHORS   Johansson,P., Klein-Hitpass,L., Roth,A., Mollmann,M.,
            Reinhardt,H.C., Duhrsen,U. and Durig,J.
  TITLE     Mutations in PIGA cause a CD52-/GPI-anchor-deficient phenotype
            complicating alemtuzumab treatment in T-cell prolymphocytic
            leukemia
  JOURNAL   Eur J Haematol 105 (6), 786-796 (2020)
   PUBMED   32875608
  REMARK    GeneRIF: Mutations in PIGA cause a CD52-/GPI-anchor-deficient
            phenotype complicating alemtuzumab treatment in T-cell
            prolymphocytic leukemia.
REFERENCE   6  (bases 1 to 467)
  AUTHORS   Rowan,W.C., Hale,G., Tite,J.P. and Brett,S.J.
  TITLE     Cross-linking of the CAMPATH-1 antigen (CD52) triggers activation
            of normal human T lymphocytes
  JOURNAL   Int Immunol 7 (1), 69-77 (1995)
   PUBMED   7718516
REFERENCE   7  (bases 1 to 467)
  AUTHORS   Xia,M.Q., Hale,G., Lifely,M.R., Ferguson,M.A., Campbell,D.,
            Packman,L. and Waldmann,H.
  TITLE     Structure of the CAMPATH-1 antigen, a
            glycosylphosphatidylinositol-anchored glycoprotein which is an
            exceptionally good target for complement lysis
  JOURNAL   Biochem J 293 (Pt 3) (Pt 3), 633-640 (1993)
   PUBMED   7688956
REFERENCE   8  (bases 1 to 467)
  AUTHORS   Hale,G., Rye,P.D., Warford,A., Lauder,I. and Brito-Babapulle,A.
  TITLE     The glycosylphosphatidylinositol-anchored lymphocyte antigen CDw52
            is associated with the epididymal maturation of human spermatozoa
  JOURNAL   J Reprod Immunol 23 (2), 189-205 (1993)
   PUBMED   7685389
REFERENCE   9  (bases 1 to 467)
  AUTHORS   Valentin,H., Gelin,C., Coulombel,L., Zoccola,D., Morizet,J. and
            Bernard,A.
  TITLE     The distribution of the CDW52 molecule on blood cells and
            characterization of its involvement in T cell activation
  JOURNAL   Transplantation 54 (1), 97-104 (1992)
   PUBMED   1352921
REFERENCE   10 (bases 1 to 467)
  AUTHORS   Xia,M.Q., Tone,M., Packman,L., Hale,G. and Waldmann,H.
  TITLE     Characterization of the CAMPATH-1 (CDw52) antigen: biochemical
            analysis and cDNA cloning reveal an unusually small peptide
            backbone
  JOURNAL   Eur J Immunol 21 (7), 1677-1684 (1991)
   PUBMED   1711975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI835519.1, BC000644.2 and X62466.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001803.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.327494.1, BG535652.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374213.3/ ENSP00000363330.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BI835519.1         41-58
            19-178              BC000644.2         1-160
            179-460             X62466.1           152-433
            461-467             BC000644.2         443-449
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..467
                     /gene="CD52"
                     /gene_synonym="CDW52; EDDM5; HE5"
                     /note="CD52 molecule"
                     /db_xref="GeneID:1043"
                     /db_xref="HGNC:HGNC:1804"
                     /db_xref="MIM:114280"
     exon            1..114
                     /gene="CD52"
                     /gene_synonym="CDW52; EDDM5; HE5"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..246
                     /gene="CD52"
                     /gene_synonym="CDW52; EDDM5; HE5"
                     /note="CDW52 antigen (CAMPATH-1 antigen); CD52 antigen
                     (CAMPATH-1 antigen); cambridge pathology 1 antigen;
                     epididymal secretory protein E5; human epididymis-specific
                     protein 5; HEL-S-171mP; epididymis secretory sperm binding
                     protein Li 171mP"
                     /codon_start=1
                     /product="CAMPATH-1 antigen precursor"
                     /protein_id="NP_001794.2"
                     /db_xref="CCDS:CCDS30647.1"
                     /db_xref="GeneID:1043"
                     /db_xref="HGNC:HGNC:1804"
                     /db_xref="MIM:114280"
                     /translation="MKRFLFLLLTISLLVMVQIQTGLSGQNDTSQTSSPSASSNISGG
                     IFLFFVANAIIHLFCFS"
     exon            115..467
                     /gene="CD52"
                     /gene_synonym="CDW52; EDDM5; HE5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      444..449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD52"
                     /gene_synonym="CDW52; EDDM5; HE5"
                     /note="hexamer: AATAAA"
     polyA_site      467
                     /gene="CD52"
                     /gene_synonym="CDW52; EDDM5; HE5"
                     /note="major polyA site"
ORIGIN      
        1 agacagccct gagatcacct aaaaagctgc taccaagaca gccacgaaga tcctaccaaa
       61 atgaagcgct tcctcttcct cctactcacc atcagcctcc tggttatggt acagatacaa
      121 actggactct caggacaaaa cgacaccagc caaaccagca gcccctcagc atccagcaac
      181 ataagcggag gcattttcct tttcttcgtg gccaatgcca taatccacct cttctgcttc
      241 agttgaggtg acacgtctca gccttagccc tgtgccccct gaaacagctg ccaccatcac
      301 tcgcaagaga atcccctcca tctttgggag gggttgatgc cagacatcac caggttgtag
      361 aagttgacag gcagtgccat gggggcaaca gccaaaatag gggggtaatg atgtaggggc
      421 caagcagtgc ccagctgggg gtcaataaag ttacccttgt acttgca
//
