LOCUS       NM_014207               3127 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens CD5 molecule (CD5), transcript variant 1, mRNA.
ACCESSION   NM_014207
VERSION     NM_014207.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3127)
  AUTHORS   Sasaki,E., Terada,H., Oishi,N., Iwakoshi,A., Masago,K.,
            Matsushita,H., Yamamoto,H., Hanai,N. and Tateyama,H.
  TITLE     Expression of CD5 in salivary gland tumors: an ancillary marker for
            carcinoma showing thymus-like differentiation (CASTLE) of the major
            salivary gland
  JOURNAL   Virchows Arch 484 (6), 945-950 (2024)
   PUBMED   37953373
  REMARK    GeneRIF: Expression of CD5 in salivary gland tumors: an ancillary
            marker for carcinoma showing thymus-like differentiation (CASTLE)
            of the major salivary gland.
REFERENCE   2  (bases 1 to 3127)
  AUTHORS   Schwarz,S. and Linnebacher,M.
  TITLE     CD5: from antiquated T cell marker to immunotherapy's new hope
  JOURNAL   Signal Transduct Target Ther 8 (1), 216 (2023)
   PUBMED   37230972
  REMARK    GeneRIF: CD5: from antiquated T cell marker to immunotherapy's new
            hope.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3127)
  AUTHORS   Casado-Llombart,S., Ajami,T., Consuegra-Fernandez,M., Carreras,E.,
            Aranda,F., Armiger,N., Alcaraz,A., Mengual,L. and Lozano,F.
  TITLE     Gene variation impact on prostate cancer progression: Lymphocyte
            modulator, activation, and cell adhesion gene variant contribution
  JOURNAL   Prostate 82 (14), 1331-1337 (2022)
   PUBMED   35767366
  REMARK    GeneRIF: Gene variation impact on prostate cancer progression:
            Lymphocyte modulator, activation, and cell adhesion gene variant
            contribution.
REFERENCE   4  (bases 1 to 3127)
  AUTHORS   Choi,Y.J., Lee,H., Kim,J.H., Kim,S.Y., Koh,J.Y., Sa,M., Park,S.H.
            and Shin,E.C.
  TITLE     CD5 Suppresses IL-15-Induced Proliferation of Human Memory CD8+ T
            Cells by Inhibiting mTOR Pathways
  JOURNAL   J Immunol 209 (6), 1108-1117 (2022)
   PUBMED   36002232
  REMARK    GeneRIF: CD5 Suppresses IL-15-Induced Proliferation of Human Memory
            CD8(+) T Cells by Inhibiting mTOR Pathways.
REFERENCE   5  (bases 1 to 3127)
  AUTHORS   Dai,Z., Mu,W., Zhao,Y., Cheng,J., Lin,H., Ouyang,K., Jia,X.,
            Liu,J., Wei,Q., Wang,M., Liu,C., Tan,T. and Zhou,J.
  TITLE     T cells expressing CD5/CD7 bispecific chimeric antigen receptors
            with fully human heavy-chain-only domains mitigate tumor antigen
            escape
  JOURNAL   Signal Transduct Target Ther 7 (1), 85 (2022)
   PUBMED   35332132
  REMARK    GeneRIF: T cells expressing CD5/CD7 bispecific chimeric antigen
            receptors with fully human heavy-chain-only domains mitigate tumor
            antigen escape.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3127)
  AUTHORS   Renaudineau,Y., Hillion,S., Saraux,A., Mageed,R.A. and Youinou,P.
  TITLE     An alternative exon 1 of the CD5 gene regulates CD5 expression in
            human B lymphocytes
  JOURNAL   Blood 106 (8), 2781-2789 (2005)
   PUBMED   15998834
  REMARK    GeneRIF: balance between the 2 alternative exons 1 might be central
            to the regulation of membrane CD5 in human B cells
REFERENCE   7  (bases 1 to 3127)
  AUTHORS   Lankester,A.C., van Schijndel,G.M., Cordell,J.L., van Noesel,C.J.
            and van Lier,R.A.
  TITLE     CD5 is associated with the human B cell antigen receptor complex
  JOURNAL   Eur J Immunol 24 (4), 812-816 (1994)
   PUBMED   7512031
REFERENCE   8  (bases 1 to 3127)
  AUTHORS   Osman,N., Ley,S.C. and Crumpton,M.J.
  TITLE     Evidence for an association between the T cell receptor/CD3 antigen
            complex and the CD5 antigen in human T lymphocytes
  JOURNAL   Eur J Immunol 22 (11), 2995-3000 (1992)
   PUBMED   1385158
REFERENCE   9  (bases 1 to 3127)
  AUTHORS   Van de Velde,H., von Hoegen,I., Luo,W., Parnes,J.R. and
            Thielemans,K.
  TITLE     The B-cell surface protein CD72/Lyb-2 is the ligand for CD5
  JOURNAL   Nature 351 (6328), 662-665 (1991)
   PUBMED   1711157
REFERENCE   10 (bases 1 to 3127)
  AUTHORS   Jones,N.H., Clabby,M.L., Dialynas,D.P., Huang,H.J., Herzenberg,L.A.
            and Strominger,J.L.
  TITLE     Isolation of complementary DNA clones encoding the human lymphocyte
            glycoprotein T1/Leu-1
  JOURNAL   Nature 323 (6086), 346-349 (1986)
   PUBMED   3093892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB143341.1, X04391.1,
            AP000437.5, AK292698.1 and BC027901.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014207.3.
            
            Summary: This gene encodes a member of the scavenger receptor
            cysteine-rich (SRCR) superfamily. Members of this family are
            secreted or membrane-anchored proteins mainly found in cells
            associated with the immune system. This protein is a type-I
            transmembrane glycoprotein found on the surface of thymocytes, T
            lymphocytes and a subset of B lymphocytes. The encoded protein
            contains three SRCR domains and may act as a receptor to regulate
            T-cell proliferation. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). The protein encoded represents an isoform found on the surface
            of T lymphocytes, B lymphocytes and thymocytes.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027901.1, GQ901015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347785.8/ ENSP00000342681.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               DB143341.1         32-536
            506-1453            X04391.1           506-1453
            1454-1471           AP000437.5         48187-48204
            1472-1893           AK292698.1         1472-1893
            1894-2653           AP000437.5         49672-50431
            2654-3127           BC027901.1         2656-3129
FEATURES             Location/Qualifiers
     source          1..3127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..3127
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /note="CD5 molecule"
                     /db_xref="GeneID:921"
                     /db_xref="HGNC:HGNC:1685"
                     /db_xref="MIM:153340"
     exon            1..127
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1560
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD5 antigen (p56-62); T-cell surface
                     glycoprotein CD5; lymphocyte antigen T1/Leu-1; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD5 isoform 1
                     precursor"
                     /protein_id="NP_055022.2"
                     /db_xref="CCDS:CCDS8000.1"
                     /db_xref="GeneID:921"
                     /db_xref="HGNC:HGNC:1685"
                     /db_xref="MIM:153340"
                     /translation="MPMGSLQPLATLYLLGMLVASCLGRLSWYDPDFQARLTRSNSKC
                     QGQLEVYLKDGWHMVCSQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQ
                     SSIICYGQLGSFSNCSHSRNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQ
                     LVAQSGGQHCAGVVEFYSGSLGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEA
                     GRAQDPGEPREHQPLPIQWKIQNSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQS
                     RLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGD
                     PTSRGLFCPHQKLSQCHELWERNSYCKKVFVTCQDPNPAGLAAGTVASIILALVLLVV
                     LLVVCGPLAYKKLVKKFRQKKQRQWIGPTGMNQNMSFHRNHTATVRSHAENPTASHVD
                     NEYSQPPRNSHLSAYPALEGALHRSSMQPDNSSDSDYDLHGAQRL"
     exon            128..166
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..472
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..535
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..877
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1171
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1297
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1351
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1471
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1562
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..3127
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3103..3108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /note="hexamer: AATAAA"
     polyA_site      3127
                     /gene="CD5"
                     /gene_synonym="LEU1; T1"
                     /note="major polyA site"
ORIGIN      
        1 gagatacccg gccagacacc ctcacctgcg gtgcccagct gcccaggctg aggcaagaga
       61 aggccagaaa ccatgcccat ggggtctctg caaccgctgg ccaccttgta cctgctgggg
      121 atgctggtcg cttcctgcct cggacggctc agctggtatg acccagattt ccaggcaagg
      181 ctcacccgtt ccaactcgaa gtgccagggc cagctggagg tctacctcaa ggacggatgg
      241 cacatggttt gcagccagag ctggggccgg agctccaagc agtgggagga ccccagtcaa
      301 gcgtcaaaag tctgccagcg gctgaactgt ggggtgccct taagccttgg ccccttcctt
      361 gtcacctaca cacctcagag ctcaatcatc tgctacggac aactgggctc cttctccaac
      421 tgcagccaca gcagaaatga catgtgtcac tctctgggcc tgacctgctt agaaccccag
      481 aagacaacac ctccaacgac aaggcccccg cccaccacaa ctccagagcc cacagctcct
      541 cccaggctgc agctggtggc acagtctggc ggccagcact gtgccggcgt ggtggagttc
      601 tacagcggca gcctgggggg taccatcagc tatgaggccc aggacaagac ccaggacctg
      661 gagaacttcc tctgcaacaa cctccagtgt ggctccttct tgaagcatct gccagagact
      721 gaggcaggca gagcccaaga cccaggggag ccacgggaac accagccctt gccaatccaa
      781 tggaagatcc agaactcaag ctgtacctcc ctggagcatt gcttcaggaa aatcaagccc
      841 cagaaaagtg gccgagttct tgccctcctt tgctcaggtt tccagcccaa ggtgcagagc
      901 cgtctggtgg ggggcagcag catctgtgaa ggcaccgtgg aggtgcgcca gggggctcag
      961 tgggcagccc tgtgtgacag ctcttcagcc aggagctcgc tgcggtggga ggaggtgtgc
     1021 cgggagcagc agtgtggcag cgtcaactcc tatcgagtgc tggacgctgg tgacccaaca
     1081 tcccgggggc tcttctgtcc ccatcagaag ctgtcccagt gccacgaact ttgggagaga
     1141 aattcctact gcaagaaggt gtttgtcaca tgccaggatc caaaccccgc aggcctggcc
     1201 gcaggcacgg tggcaagcat catcctggcc ctggtgctcc tggtggtgct gctggtcgtg
     1261 tgcggccccc ttgcctacaa gaagctagtg aagaaattcc gccagaagaa gcagcgccag
     1321 tggattggcc caacgggaat gaaccaaaac atgtctttcc atcgcaacca cacggcaacc
     1381 gtccgatccc atgctgagaa ccccacagcc tcccacgtgg ataacgaata cagccaacct
     1441 cccaggaact cccacctgtc agcttatcca gctctggaag gggctctgca tcgctcctcc
     1501 atgcagcctg acaactcctc cgacagtgac tatgatctgc atggggctca gaggctgtaa
     1561 agaactggga tccatgagca aaaagccgag agccagacct gtttgtcctg agaaaactgt
     1621 ccgctcttca cttgaaatca tgtccctatt tctaccccgg ccagaacatg gacagaggcc
     1681 agaagccttc cggacaggcg ctgctgcccc gagtggcagg ccagctcaca ctctgctgca
     1741 caacagctcg gccgcccctc cacttgtgga agctgtggtg ggcagagccc caaaacaagc
     1801 agccttccaa ctagagactc gggggtgtct gaagggggcc ccctttccct gcccgctggg
     1861 gagcggcgtc tcagtgaaat cggctttctc ctcagactct gtccctggta aggagtgaca
     1921 aggaagctca cagctgggcg agtgcatttt gaatagtttt ttgtaagtag tgcttttcct
     1981 ccttcctgac aaatcgagcg ctttggcctc ttctgtgcag catccacccc tgcggatccc
     2041 tctggggagg acaggaaggg gactcccgga gacctctgca gccgtggtgg tcagaggctg
     2101 ctcacctgag cacaaagaca gctctgcaca ttcaccgcag ctgccagcca ggggtctggg
     2161 tgggcaccac cctgacccac agcgtcaccc cactccctct gtcttatgac tcccctcccc
     2221 aaccccctca tctaaagaca ccttcctttc cactggctgt caagcccaca gggcaccagt
     2281 gccacccagg gcccggcaca aaggggcgcc tagtaaacct taaccaactt ggttttttgc
     2341 ttcacccagc aattaaaagt cccaagctga ggtagtttca gtccatcaca gttcatcttc
     2401 taacccaaga gtcagagatg gggctggtca tgttcctttg gtttgaataa ctcccttgac
     2461 gaaaacagac tcctctagta cttggagatc ttggacgtac acctaatccc atggggcctc
     2521 ggcttcctta actgcaagtg agaagaggag gtctacccag gagcctcggg tctgatcaag
     2581 ggagaggcca ggcgcagctc actgcggcgg ctccctaaga aggtgaagca acatgggaac
     2641 acatcctaag acaggtcctt tctccacgcc atttgatgct gtatctcctg ggagcacagg
     2701 catcaatggt ccaagccgca taataagtct ggaagagcaa aagggagtta ctaggatatg
     2761 gggtgggctg ctcccagaat ctgctcagct ttctgccccc accaacaccc tccaaccagg
     2821 ccttgccttc tgagagcccc cgtggccaag cccaggtcac agatcttccc ccgaccatgc
     2881 tgggaatcca gaaacaggga ccccatttgt cttcccatat ctggtggagg tgagggggct
     2941 cctcaaaagg gaactgagag gctgctctta gggagggcaa aggttcgggg gcagccagtg
     3001 tctcccatca gtgccttttt taataaaagc tctttcatct atagtttggc caccatacag
     3061 tggcctcaaa gcaaccatgg cctacttaaa aaccaaacca aaaataaaga gtttagttga
     3121 ggagaaa
//
