LOCUS       NM_001778               1097 bp    mRNA    linear   PRI 26-FEB-2024
DEFINITION  Homo sapiens CD48 molecule (CD48), transcript variant 1, mRNA.
ACCESSION   NM_001778
VERSION     NM_001778.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1097)
  AUTHORS   Ma,Y., Yang,Z., Liu,J. and Wang,D.
  TITLE     CD48 suppresses proliferation and migration as an immune-related
            prognostic signature in the cervical cancer immune microenvironment
  JOURNAL   Carcinogenesis 45 (1-2), 57-68 (2024)
   PUBMED   37279525
  REMARK    GeneRIF: CD48 suppresses proliferation and migration as an
            immune-related prognostic signature in the cervical cancer immune
            microenvironment.
REFERENCE   2  (bases 1 to 1097)
  AUTHORS   White,D., Cote-Martin,A., Bleck,M., Garaffa,N., Shaaban,A., Wu,H.,
            Liu,D., Young,D., Scheer,J., Lorenz,I.C., Nixon,A., Fine,J.S.,
            Byrne,F.R., Mbow,M.L. and Moreno-Garcia,M.E.
  TITLE     Programmed Cell Death-1 (PD-1) anchoring to the GPI-linked
            co-receptor CD48 reveals a novel mechanism to modulate
            PD-1-dependent inhibition of human T cells
  JOURNAL   Mol Immunol 156, 31-38 (2023)
   PUBMED   36889184
  REMARK    GeneRIF: Programmed Cell Death-1 (PD-1) anchoring to the GPI-linked
            co-receptor CD48 reveals a novel mechanism to modulate
            PD-1-dependent inhibition of human T cells.
REFERENCE   3  (bases 1 to 1097)
  AUTHORS   Pahima,H., Zaffran,I., Ben-Chetrit,E., Jarjoui,A., Gaur,P.,
            Manca,M.L., Reichmann,D., Orenbuch-Harroch,E., Tiligada,E.,
            Puxeddu,I., Zinner,C., Tzankov,A. and Levi-Schaffer,F.
  TITLE     Patients with coronavirus disease 2019 characterized by
            dysregulated levels of membrane and soluble cluster of
            differentiation 48
  JOURNAL   Ann Allergy Asthma Immunol 130 (2), 245-253 (2023)
   PUBMED   36280100
  REMARK    GeneRIF: Patients with coronavirus disease 2019 characterized by
            dysregulated levels of membrane and soluble cluster of
            differentiation 48.
REFERENCE   4  (bases 1 to 1097)
  AUTHORS   Kim,S.H., Lim,K.H., Yang,S. and Joo,J.Y.
  TITLE     Boosting of tau protein aggregation by CD40 and CD48 gene
            expression in Alzheimer's disease
  JOURNAL   FASEB J 37 (1), e22702 (2023)
   PUBMED   36520044
  REMARK    GeneRIF: Boosting of tau protein aggregation by CD40 and CD48 gene
            expression in Alzheimer's disease.
REFERENCE   5  (bases 1 to 1097)
  AUTHORS   Treco,E., Huan,E., Varzavand,A., Fairley,J.A. and Messingham,K.N.
  TITLE     Elevated levels of sCD48 are inversely correlated with markers of
            disease activity in bullous pemphigoid
  JOURNAL   Exp Dermatol 32 (1), 85-90 (2023)
   PUBMED   36134505
  REMARK    GeneRIF: Elevated levels of sCD48 are inversely correlated with
            markers of disease activity in bullous pemphigoid.
REFERENCE   6  (bases 1 to 1097)
  AUTHORS   Del Porto,P., Mami-Chouaib,F., Bruneau,J.M., Jitsukawa,S.,
            Dumas,J., Harnois,M. and Hercend,T.
  TITLE     TCT.1, a target molecule for gamma/delta T cells, is encoded by an
            immunoglobulin superfamily gene (Blast-1) located in the CD1 region
            of human chromosome 1
  JOURNAL   J Exp Med 173 (6), 1339-1344 (1991)
   PUBMED   1827826
REFERENCE   7  (bases 1 to 1097)
  AUTHORS   Fisher,R.C. and Thorley-Lawson,D.A.
  TITLE     Characterization of the Epstein-Barr virus-inducible gene encoding
            the human leukocyte adhesion and activation antigen BLAST-1 (CD48)
  JOURNAL   Mol Cell Biol 11 (3), 1614-1623 (1991)
   PUBMED   1847502
REFERENCE   8  (bases 1 to 1097)
  AUTHORS   Vaughan,H.A., Henning,M.M., Purcell,D.F., McKenzie,I.F. and
            Sandrin,M.S.
  TITLE     The isolation of cDNA clones for CD48
  JOURNAL   Immunogenetics 33 (2), 113-117 (1991)
   PUBMED   1999351
REFERENCE   9  (bases 1 to 1097)
  AUTHORS   Korinek,V., Stefanova,I., Angelisova,P., Hilgert,I. and Horejsi,V.
  TITLE     The human leucocyte antigen CD48 (MEM-102) is closely related to
            the activation marker Blast-1
  JOURNAL   Immunogenetics 33 (2), 108-112 (1991)
   PUBMED   1999350
REFERENCE   10 (bases 1 to 1097)
  AUTHORS   Wong,Y.W., Williams,A.F., Kingsmore,S.F. and Seldin,M.F.
  TITLE     Structure, expression, and genetic linkage of the mouse BCM1 (OX45
            or Blast-1) antigen. Evidence for genetic duplication giving rise
            to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on
            mouse chromosome 3
  JOURNAL   J Exp Med 171 (6), 2115-2130 (1990)
   PUBMED   1693656
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG505217.1, BC016182.1 and
            AL121985.13.
            
            On Nov 22, 2018 this sequence version replaced NM_001778.3.
            
            Summary: This gene encodes a member of the CD2 subfamily of
            immunoglobulin-like receptors which includes SLAM (signaling
            lymphocyte activation molecules) proteins. The encoded protein is
            found on the surface of lymphocytes and other immune cells,
            dendritic cells and endothelial cells, and participates in
            activation and differentiation pathways in these cells. The encoded
            protein does not have a transmembrane domain, however, but is held
            at the cell surface by a GPI anchor via a C-terminal domain which
            maybe cleaved to yield a soluble form of the receptor. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.91496.1,
                                           SRR1163655.239671.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368046.8/ ENSP00000357025.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BG505217.1         30-56
            28-506              BC016182.1         1-479
            507-507             AL121985.13        68680-68680         c
            508-1083            BC016182.1         481-1056
            1084-1084           AL121985.13        66033-66033         c
            1085-1097           BC016182.1         1058-1070
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1097
                     /gene="CD48"
                     /gene_synonym="BCM1; BLAST; BLAST1; hCD48; mCD48; MEM-102;
                     SLAMF2"
                     /note="CD48 molecule"
                     /db_xref="GeneID:962"
                     /db_xref="HGNC:HGNC:1683"
                     /db_xref="MIM:109530"
     exon            1..141
                     /gene="CD48"
                     /gene_synonym="BCM1; BLAST; BLAST1; hCD48; mCD48; MEM-102;
                     SLAMF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..791
                     /gene="CD48"
                     /gene_synonym="BCM1; BLAST; BLAST1; hCD48; mCD48; MEM-102;
                     SLAMF2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD48 antigen (B-cell membrane protein); TCT.1;
                     BCM1 surface antigen; leukocyte antigen MEM-102;
                     B-lymphocyte activation marker BLAST-1; SLAM family member
                     2; signaling lymphocytic activation molecule 2"
                     /codon_start=1
                     /product="CD48 antigen isoform 1 precursor"
                     /protein_id="NP_001769.2"
                     /db_xref="CCDS:CCDS1208.1"
                     /db_xref="GeneID:962"
                     /db_xref="HGNC:HGNC:1683"
                     /db_xref="MIM:109530"
                     /translation="MCSRGWDSCLALELLLLPLSLLVTSIQGHLVHMTVVSGSNVTLN
                     ISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQKE
                     DNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGES
                     VNYTWYGDKRPFPKELQNSVLETTLMPHNYSRCYTCQVSNSVSSKNGTVCLSPPCTLA
                     RSFGVEWIASWLVVTVPTILGLLLT"
     exon            142..444
                     /gene="CD48"
                     /gene_synonym="BCM1; BLAST; BLAST1; hCD48; mCD48; MEM-102;
                     SLAMF2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..711
                     /gene="CD48"
                     /gene_synonym="BCM1; BLAST; BLAST1; hCD48; mCD48; MEM-102;
                     SLAMF2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..1097
                     /gene="CD48"
                     /gene_synonym="BCM1; BLAST; BLAST1; hCD48; mCD48; MEM-102;
                     SLAMF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1064..1069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD48"
                     /gene_synonym="BCM1; BLAST; BLAST1; hCD48; mCD48; MEM-102;
                     SLAMF2"
                     /note="hexamer: AATAAA"
     polyA_site      1097
                     /gene="CD48"
                     /gene_synonym="BCM1; BLAST; BLAST1; hCD48; mCD48; MEM-102;
                     SLAMF2"
                     /note="major polyA site"
ORIGIN      
        1 ctttttctag ccaggctctc aactgtctcc tgcgttgctg ggaagttctg gaaggaagca
       61 tgtgctccag aggttgggat tcgtgtctgg ctctggaatt gctactgctg cctctgtcac
      121 tcctggtgac cagcattcaa ggtcacttgg tacatatgac cgtggtctcc ggcagcaacg
      181 tgactctgaa catctctgag agcctgcctg agaactacaa acaactaacc tggttttata
      241 ctttcgacca gaagattgta gaatgggatt ccagaaaatc taagtacttt gaatccaaat
      301 ttaaaggcag ggtcagactt gatcctcaga gtggcgcact gtacatctct aaggtccaga
      361 aagaggacaa cagcacctac atcatgaggg tgttgaaaaa gactgggaat gagcaagaat
      421 ggaagatcaa gctgcaagtg cttgaccctg tacccaagcc tgtcatcaaa attgagaaga
      481 tagaagacat ggatgacaac tgttatctga aactgtcatg tgtgatacct ggcgagtctg
      541 taaactacac ctggtatggg gacaaaaggc ccttcccaaa ggagctccag aacagtgtgc
      601 ttgaaaccac ccttatgcca cataattact ccaggtgtta tacttgccaa gtcagcaatt
      661 ctgtgagcag caagaatggc acggtctgcc tcagtccacc ctgtaccctg gcccggtcct
      721 ttggagtaga atggattgca agttggctag tggtcacggt gcccaccatt cttggcctgt
      781 tacttacctg agatgagctc ttttaactca agcgaaactt caaggccaga agatcttgcc
      841 tgttggtgat catgctcctc accaggacag agactgtata ggctgaccag aagcatgctg
      901 ctgaattatc aacgaggatt ttcaagttaa cttttaaata ctggttatta tttaatttta
      961 tatccctttg ttgttttcta gtacacagag atatagagat acacatgctt ttttcccacc
     1021 caaaattgtg acaacattat gtgaatgttt tattattttt taaaataaac atttgatata
     1081 attgtcaatt aactgaa
//
