LOCUS       NM_001777               5292 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens CD47 molecule (CD47), transcript variant 1, mRNA.
ACCESSION   NM_001777
VERSION     NM_001777.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5292)
  AUTHORS   Dong,K., Nihal,R., Meyer,T.J., Singh,S.P., Kaur,S. and Roberts,D.D.
  TITLE     CD47 and IFT57 Are Colinear Genes That Are Highly Coexpressed in
            Most Cancers and Exhibit Parallel Cancer-Specific Correlations with
            Survival
  JOURNAL   Int J Mol Sci 25 (16), 8956 (2024)
   PUBMED   39201643
  REMARK    GeneRIF: CD47 and IFT57 Are Colinear Genes That Are Highly
            Coexpressed in Most Cancers and Exhibit Parallel Cancer-Specific
            Correlations with Survival.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5292)
  AUTHORS   Chuang,C.H., Zhen,Y.Y., Ma,J.Y., Lee,T.H., Hung,H.Y., Wu,C.C.,
            Wang,P.H., Huang,C.T., Huang,M.S., Hsiao,M., Lee,Y.R., Huang,C.F.,
            Chang,Y.C. and Yang,C.J.
  TITLE     CD47-mediated immune evasion in early-stage lung cancer progression
  JOURNAL   Biochem Biophys Res Commun 720, 150066 (2024)
   PUBMED   38749193
  REMARK    GeneRIF: CD47-mediated immune evasion in early-stage lung cancer
            progression.
REFERENCE   3  (bases 1 to 5292)
  AUTHORS   Lu,Q., Li,H., Wu,Z., Zhu,Z., Zhang,Z., Yang,D. and Tong,A.
  TITLE     BCMA/CD47-directed universal CAR-T cells exhibit excellent
            antitumor activity in multiple myeloma
  JOURNAL   J Nanobiotechnology 22 (1), 279 (2024)
   PUBMED   38783333
  REMARK    GeneRIF: BCMA/CD47-directed universal CAR-T cells exhibit excellent
            antitumor activity in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5292)
  AUTHORS   Moon,S., Han,S., Jang,I.H., Ryu,J., Rha,M.S., Cho,H.J., Yoon,S.S.,
            Nam,K.T., Kim,C.H., Park,M.S., Seong,J.K., Lee,W.J., Yoon,J.H.,
            Chung,Y.W. and Ryu,J.H.
  TITLE     Airway epithelial CD47 plays a critical role in inducing influenza
            virus-mediated bacterial super-infection
  JOURNAL   Nat Commun 15 (1), 3666 (2024)
   PUBMED   38693120
  REMARK    GeneRIF: Airway epithelial CD47 plays a critical role in inducing
            influenza virus-mediated bacterial super-infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5292)
  AUTHORS   Zhang,K., Xu,Y., Chang,X., Xu,C., Xue,W., Ding,D., Nie,M., Cai,H.,
            Xu,J., Zhan,L., Han,J., Cai,T., Ju,D., Feng,L., Zhang,X. and Yin,K.
  TITLE     Co-targeting CD47 and VEGF elicited potent anti-tumor effects in
            gastric cancer
  JOURNAL   Cancer Immunol Immunother 73 (4), 75 (2024)
   PUBMED   38532108
  REMARK    GeneRIF: Co-targeting CD47 and VEGF elicited potent anti-tumor
            effects in gastric cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5292)
  AUTHORS   Mawby,W.J., Holmes,C.H., Anstee,D.J., Spring,F.A. and Tanner,M.J.
  TITLE     Isolation and characterization of CD47 glycoprotein: a
            multispanning membrane protein which is the same as
            integrin-associated protein (IAP) and the ovarian tumour marker OA3
  JOURNAL   Biochem J 304 (Pt 2) (Pt 2), 525-530 (1994)
   PUBMED   7998989
REFERENCE   7  (bases 1 to 5292)
  AUTHORS   Lindberg,F.P., Lublin,D.M., Telen,M.J., Veile,R.A., Miller,Y.E.,
            Donis-Keller,H. and Brown,E.J.
  TITLE     Rh-related antigen CD47 is the signal-transducer
            integrin-associated protein
  JOURNAL   J Biol Chem 269 (3), 1567-1570 (1994)
   PUBMED   8294396
REFERENCE   8  (bases 1 to 5292)
  AUTHORS   Lindberg,F.P., Gresham,H.D., Schwarz,E. and Brown,E.J.
  TITLE     Molecular cloning of integrin-associated protein: an immunoglobulin
            family member with multiple membrane-spanning domains implicated in
            alpha v beta 3-dependent ligand binding
  JOURNAL   J Cell Biol 123 (2), 485-496 (1993)
   PUBMED   7691831
REFERENCE   9  (bases 1 to 5292)
  AUTHORS   Campbell,I.G., Freemont,P.S., Foulkes,W. and Trowsdale,J.
  TITLE     An ovarian tumor marker with homology to vaccinia virus contains an
            IgV-like region and multiple transmembrane domains
  JOURNAL   Cancer Res 52 (19), 5416-5420 (1992)
   PUBMED   1394148
REFERENCE   10 (bases 1 to 5292)
  AUTHORS   Brown,E., Hooper,L., Ho,T. and Gresham,H.
  TITLE     Integrin-associated protein: a 50-kD plasma membrane antigen
            physically and functionally associated with integrins
  JOURNAL   J Cell Biol 111 (6 Pt 1), 2785-2794 (1990)
   PUBMED   2277087
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB995865.1, AC012020.17 and
            X69398.1.
            
            On Apr 28, 2020 this sequence version replaced NM_001777.3.
            
            Summary: This gene encodes a membrane protein, which is involved in
            the increase in intracellular calcium concentration that occurs
            upon cell adhesion to extracellular matrix. The encoded protein is
            also a receptor for the C-terminal cell binding domain of
            thrombospondin, and it may play a role in membrane transport and
            signal transduction. This gene has broad tissue distribution, and
            is reduced in expression on Rh erythrocytes. Alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.21386.1,
                                           SRR11853560.20648.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361309.6/ ENSP00000355361.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                CB995865.1         85-164
            81-81               AC012020.17        80430-80430         c
            82-295              CB995865.1         166-379
            296-1154            X69398.1           279-1137
            1155-5292           AC012020.17        32570-36707         c
FEATURES             Location/Qualifiers
     source          1..5292
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.12"
     gene            1..5292
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /note="CD47 molecule"
                     /db_xref="GeneID:961"
                     /db_xref="HGNC:HGNC:1682"
                     /db_xref="MIM:601028"
     exon            1..169
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1095
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD47 antigen (Rh-related antigen,
                     integrin-associated signal transducer); antigen identified
                     by monoclonal antibody 1D8; antigenic surface determinant
                     protein OA3; integrin associated protein; leukocyte
                     surface antigen CD47; CD47 glycoprotein"
                     /codon_start=1
                     /product="leukocyte surface antigen CD47 isoform 1
                     precursor"
                     /protein_id="NP_001768.1"
                     /db_xref="CCDS:CCDS43126.1"
                     /db_xref="GeneID:961"
                     /db_xref="HGNC:HGNC:1682"
                     /db_xref="MIM:601028"
                     /translation="MWPLVAALLLGSACCGSAQLLFNKTKSVEFTFCNDTVVIPCFVT
                     NMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDK
                     SDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNENILIVIFPIFAILLFWGQF
                     GIKTLKYRSGGMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTG
                     ILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLLISGLS
                     ILALAQLLGLVYMKFVASNQKTIQPPRKAVEEPLNAFKESKGMMNDE"
     exon            170..523
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /inference="alignment:Splign:2.1.0"
     exon            524..613
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /inference="alignment:Splign:2.1.0"
     exon            614..721
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /inference="alignment:Splign:2.1.0"
     exon            722..814
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /inference="alignment:Splign:2.1.0"
     exon            815..907
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1000
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1032
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1057
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1090
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..5292
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /note="hexamer: AATAAA"
     regulatory      1290..1295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /note="hexamer: AATAAT"
     polyA_site      1304
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /note="major polyA site"
     polyA_site      1318
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /note="major polyA site"
     regulatory      5066..5071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /note="hexamer: AATAAA"
     polyA_site      5084
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
     regulatory      5269..5274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
                     /note="hexamer: ATTAAA"
     polyA_site      5292
                     /gene="CD47"
                     /gene_synonym="IAP; MER6; OA3"
ORIGIN      
        1 gcagcctggg cagtgggtcc tgcctgtgac gcgcggcggc ggtcggtcct gcctgtaacg
       61 gcggcggcgg ctgctgctcc ggacacctgc ggcggcggcg gcgaccccgc ggcgggcgcg
      121 gagatgtggc ccctggtagc ggcgctgttg ctgggctcgg cgtgctgcgg atcagctcag
      181 ctactattta ataaaacaaa atctgtagaa ttcacgtttt gtaatgacac tgtcgtcatt
      241 ccatgctttg ttactaatat ggaggcacaa aacactactg aagtatacgt aaagtggaaa
      301 tttaaaggaa gagatattta cacctttgat ggagctctaa acaagtccac tgtccccact
      361 gactttagta gtgcaaaaat tgaagtctca caattactaa aaggagatgc ctctttgaag
      421 atggataaga gtgatgctgt ctcacacaca ggaaactaca cttgtgaagt aacagaatta
      481 accagagaag gtgaaacgat catcgagcta aaatatcgtg ttgtttcatg gttttctcca
      541 aatgaaaata ttcttattgt tattttccca atttttgcta tactcctgtt ctggggacag
      601 tttggtatta aaacacttaa atatagatcc ggtggtatgg atgagaaaac aattgcttta
      661 cttgttgctg gactagtgat cactgtcatt gtcattgttg gagccattct tttcgtccca
      721 ggtgaatatt cattaaagaa tgctactggc cttggtttaa ttgtgacttc tacagggata
      781 ttaatattac ttcactacta tgtgtttagt acagcgattg gattaacctc cttcgtcatt
      841 gccatattgg ttattcaggt gatagcctat atcctcgctg tggttggact gagtctctgt
      901 attgcggcgt gtataccaat gcatggccct cttctgattt caggtttgag tatcttagct
      961 ctagcacaat tacttggact agtttatatg aaatttgtgg cttccaatca gaagactata
     1021 caacctccta ggaaagctgt agaggaaccc cttaatgcat tcaaagaatc aaaaggaatg
     1081 atgaatgatg aataactgaa gtgaagtgat ggactccgat ttggagagta gtaagacgtg
     1141 aaaggaatac acttgtgttt aagcaccatg gccttgatga ttcactgttg gggagaagaa
     1201 acaagaaaag taactggttg tcacctatga gacccttacg tgattgttag ttaagttttt
     1261 attcaaagca gctgtaattt agttaataaa ataattatga tctatgttgt ttgcccaatt
     1321 gagatccagt tttttgttgt tatttttaat caattagggg caatagtaga atggacaatt
     1381 tccaagaatg atgcctttca ggtcctaggg cctctggcct ctaggtaacc agtttaaatt
     1441 ggttcagggt gataactact tagcactgcc ctggtgatta cccagagata tctatgaaaa
     1501 ccagtggctt ccatcaaacc tttgccaact caggttcaca gcagctttgg gcagttatgg
     1561 cagtatggca ttagctgaga ggtgtctgcc acttctgggt caatggaata ataaattaag
     1621 tacaggcagg aatttggttg ggagcatctt gtatgatctc cgtatgatgt gatattgatg
     1681 gagatagtgg tcctcattct tgggggttgc cattcccaca ttcccccttc aacaaacagt
     1741 gtaacaggtc cttcccagat ttagggtact tttattgatg gatatgtttt ccttttattc
     1801 acataacccc ttgaaaccct gtcttgtcct cctgttactt gcttctgctg tacaagatgt
     1861 agcacctttt ctcctctttg aacatggtct agtgacacgg tagcaccagt tgcaggaagg
     1921 agccagactt gttctcagag cactgtgttc acacttttca gcaaaaatag ctatggttgt
     1981 aacatatgta ttcccttcct ctgatttgaa ggcaaaaatc tacagtgttt cttcacttct
     2041 tttctgatct ggggcatgaa aaaagcaaga ttgaaatttg aactatgagt ctcctgcatg
     2101 gcaacaaaat gtgtgtcacc atcaggccaa caggccagcc cttgaatggg gatttattac
     2161 tgttgtatct atgttgcatg ataaacattc atcaccttcc tcctgtagtc ctgcctcgta
     2221 ctccccttcc cctatgattg aaaagtaaac aaaacccaca tttcctatcc tggttagaag
     2281 aaaattaatg ttctgacagt tgtgatcgcc tggagtactt ttagactttt agcattcgtt
     2341 ttttacctgt ttgtggatgt gtgtttgtat gtgcatacgt atgagatagg cacatgcatc
     2401 ttctgtatgg acaaaggtgg ggtacctaca ggagagcaaa ggttaatttt gtgcttttag
     2461 taaaaacatt taaatacaaa gttctttatt gggtggaatt atatttgatg caaatatttg
     2521 atcacttaaa acttttaaaa cttctaggta atttgccacg ctttttgact gctcaccaat
     2581 accctgtaaa aatacgtaat tcttcctgtt tgtgtaataa gatattcata tttgtagttg
     2641 cattaataat agttatttct tagtccatca gatgttcccg tgtgcctctt ttatgccaaa
     2701 ttgattgtca tatttcatgt tgggaccaag tagtttgccc atggcaaacc taaatttatg
     2761 acctgctgag gcctctcaga aaactgagca tactagcaag acagctcttc ttgaaaaaaa
     2821 aaatatgtat acacaaatat atacgtatat ctatatatac gtatgtatat acacacatgt
     2881 atattcttcc ttgattgtgt agctgtccaa aataataaca tatatagagg gagctgtatt
     2941 cctttataca aatctgatgg ctcctgcagc actttttcct tctgaaaata tttacatttt
     3001 gctaacctag tttgttactt taaaaatcag ttttgatgaa aggagggaaa agcagatgga
     3061 cttgaaaaag atccaagctc ctattagaaa aggtatgaaa atctttatag taaaattttt
     3121 tataaactaa agttgtacct tttaatatgt agtaaactct catttatttg gggttcgctc
     3181 ttggatctca tccatccatt gtgttctctt taatgctgcc tgccttttga ggcattcact
     3241 gccctagaca atgccaccag agatagtggg ggaaatgcca gatgaaacca actcttgctc
     3301 tcactagttg tcagcttctc tggataagtg accacagaag caggagtcct cctgcttggg
     3361 catcattggg ccagttcctt ctctttaaat cagatttgta atggctccca aattccatca
     3421 catcacattt aaattgcaga cagtgttttg cacatcatgt atctgttttg tcccataata
     3481 tgctttttac tccctgatcc cagtttctgc tgttgactct tccattcagt tttatttatt
     3541 gtgtgttctc acagtgacac catttgtcct tttctgcaac aacctttcca gctacttttg
     3601 ccaaattcta tttgtcttct ccttcaaaac attctccttt gcagttcctc ttcatctgtg
     3661 tagctgctct tttgtctctt aacttaccat tcctatagta ctttatgcat ctctgcttag
     3721 ttctattagt tttttggcct tgctcttctc cttgatttta aaattccttc tatagctaga
     3781 gcttttcttt ctttcattct ctcttcctgc agtgttttgc atacatcaga agctaggtac
     3841 ataagttaaa tgattgagag ttggctgtat ttagatttat cactttttaa tagggtgagc
     3901 ttgagagttt tctttctttc tgtttttttt ttttgttttt tttttttttt tttttttttt
     3961 tttttttgac taatttcaca tgctctaaaa accttcaaag gtgattattt ttctcctgga
     4021 aactccaggt ccattctgtt taaatcccta agaatgtcag aattaaaata acagggctat
     4081 cccgtaattg gaaatatttc ttttttcagg atgctatagt caatttagta agtgaccacc
     4141 aaattgttat ttgcactaac aaagctcaaa acacgataag tttactcctc catctcagta
     4201 ataaaaatta agctgtaatc aaccttctag gtttctcttg tcttaaaatg ggtattcaaa
     4261 aatggggatc tgtggtgtat gtatggaaac acatactcct taatttacct gttgttggaa
     4321 actggagaaa tgattgtcgg gcaaccgttt attttttatt gtattttatt tggttgaggg
     4381 atttttttat aaacagtttt acttgtgtca tattttaaaa ttactaactg ccatcacctg
     4441 ctggggtcct ttgttaggtc attttcagtg actaataggg ataatccagg taactttgaa
     4501 gagatgagca gtgagtgacc aggcagtttt tctgccttta gctttgacag ttcttaatta
     4561 agatcattga agaccagctt tctcataaat ttctcttttt gaaaaaaaga aagcatttgt
     4621 actaagctcc tctgtaagac aacatcttaa atcttaaaag tgttgttatc atgactggtg
     4681 agagaagaaa acattttgtt tttattaaat ggagcattat ttacaaaaag ccattgttga
     4741 gaattagatc ccacatcgta taaatatcta ttaaccattc taaataaaga gaactccagt
     4801 gttgctatgt gcaagatcct ctcttggagc ttttttgcat agcaattaaa ggtgtgctat
     4861 ttgtcagtag ccattttttt gcagtgattt gaagaccaaa gttgttttac agctgtgtta
     4921 ccgttaaagg tttttttttt tatatgtatt aaatcaattt atcactgttt aaagctttga
     4981 atatctgcaa tctttgccaa ggtacttttt tatttaaaaa aaaacataac tttgtaaata
     5041 ttaccctgta atattatata tacttaataa aacattttaa gctattttgt tgggctattt
     5101 ctattgctgc tacagcagac cacaagcaca tttctgaaaa atttaattta ttaatgtatt
     5161 tttaagttgc ttatattcta ggtaacaatg taaagaatga tttaaaatat taattatgaa
     5221 ttttttgagt ataataccca ataagctttt aattagagca gagttttaat taaaagtttt
     5281 aaatcagtcc aa
//
