LOCUS       NM_000610               5431 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens CD44 molecule (IN blood group) (CD44), transcript
            variant 1, mRNA.
ACCESSION   NM_000610
VERSION     NM_000610.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5431)
  AUTHORS   Li,C., Zhang,Y., Wang,Y., Ouyang,J., Yang,Y., Zhu,Q., Lu,Y.,
            Kang,T., Li,Y., Xia,M., Chen,J., Li,Q., Zhu,C. and Ye,L.
  TITLE     RNA-binding protein LSM7 facilitates breast cancer metastasis
            through mediating alternative splicing of CD44
  JOURNAL   Life Sci 356, 123013 (2024)
   PUBMED   39182568
  REMARK    GeneRIF: RNA-binding protein LSM7 facilitates breast cancer
            metastasis through mediating alternative splicing of CD44.
REFERENCE   2  (bases 1 to 5431)
  AUTHORS   Kashif,M., Jahan,S., Minhas,S., Amar,A., Tahir,R., Nisar,H.,
            Shehzad,F., Nagi,A.H. and Afzal,N.
  TITLE     Genetic Signatures: CD44 Single-Nucleotide Polymorphisms Affect
            Cell Surface Expression and Elevate Risk in Head and Neck Squamous
            Cell Carcinoma
  JOURNAL   JCO Glob Oncol 10, e2400084 (2024)
   PUBMED   39481067
  REMARK    GeneRIF: Genetic Signatures: CD44 Single-Nucleotide Polymorphisms
            Affect Cell Surface Expression and Elevate Risk in Head and Neck
            Squamous Cell Carcinoma.
            Erratum:[JCO Glob Oncol. 2025 Jan;11:e2400651. doi:
            10.1200/GO-24-00651.. PMID: 39883899]
REFERENCE   3  (bases 1 to 5431)
  AUTHORS   Kainulainen,K., Niskanen,E.A., Kinnunen,J., Maki-Mantila,K.,
            Hartikainen,K., Paakinaho,V., Malinen,M., Ketola,K. and
            Pasonen-Seppanen,S.
  TITLE     Secreted factors from M1 macrophages drive prostate cancer stem
            cell plasticity by upregulating NANOG, SOX2, and CD44 through
            NFkappaB-signaling
  JOURNAL   Oncoimmunology 13 (1), 2393442 (2024)
   PUBMED   39175947
  REMARK    GeneRIF: Secreted factors from M1 macrophages drive prostate cancer
            stem cell plasticity by upregulating NANOG, SOX2, and CD44 through
            NFkappaB-signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5431)
  AUTHORS   Yan,H., Xing,Z., Liu,S., Gao,P., Wang,Q. and Guo,G.
  TITLE     CALCR exacerbates renal cell carcinoma progression via stabilizing
            CD44
  JOURNAL   Aging (Albany NY) 16 (13), 10765-10783 (2024)
   PUBMED   38985127
  REMARK    GeneRIF: CALCR exacerbates renal cell carcinoma progression via
            stabilizing CD44.
REFERENCE   5  (bases 1 to 5431)
  AUTHORS   Liang,S., Li,L., Guo,Z., Sun,H. and Yang,Y.
  TITLE     Co-expression of CD44v6 and MMP2 predicts lung metastasis and
            unfavorable prognosis in osteosarcoma
  JOURNAL   Future Oncol 20 (25), 1799-1806 (2024)
   PUBMED   39011948
  REMARK    GeneRIF: Co-expression of CD44v6 and MMP2 predicts lung metastasis
            and unfavorable prognosis in osteosarcoma.
REFERENCE   6  (bases 1 to 5431)
  AUTHORS   Screaton,G.R., Bell,M.V., Jackson,D.G., Cornelis,F.B., Gerth,U. and
            Bell,J.I.
  TITLE     Genomic structure of DNA encoding the lymphocyte homing receptor
            CD44 reveals at least 12 alternatively spliced exons
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 12160-12164 (1992)
   PUBMED   1465456
REFERENCE   7  (bases 1 to 5431)
  AUTHORS   Kugelman,L.C., Ganguly,S., Haggerty,J.G., Weissman,S.M. and
            Milstone,L.M.
  TITLE     The core protein of epican, a heparan sulfate proteoglycan on
            keratinocytes, is an alternative form of CD44
  JOURNAL   J Invest Dermatol 99 (6), 886-891 (1992)
   PUBMED   1281868
REFERENCE   8  (bases 1 to 5431)
  AUTHORS   Arch,R., Wirth,K., Hofmann,M., Ponta,H., Matzku,S., Herrlich,P. and
            Zoller,M.
  TITLE     Participation in normal immune responses of a metastasis-inducing
            splice variant of CD44
  JOURNAL   Science 257 (5070), 682-685 (1992)
   PUBMED   1496383
REFERENCE   9  (bases 1 to 5431)
  AUTHORS   Jackson,D.G., Buckley,J. and Bell,J.I.
  TITLE     Multiple variants of the human lymphocyte homing receptor CD44
            generated by insertions at a single site in the extracellular
            domain
  JOURNAL   J Biol Chem 267 (7), 4732-4739 (1992)
   PUBMED   1537855
REFERENCE   10 (bases 1 to 5431)
  AUTHORS   Aruffo,A., Stamenkovic,I., Melnick,M., Underhill,C.B. and Seed,B.
  TITLE     CD44 is the principal cell surface receptor for hyaluronate
  JOURNAL   Cell 61 (7), 1303-1313 (1990)
   PUBMED   1694723
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL832642.2, BF872530.1,
            BC004372.1, BF828674.1, AY101192.1, CD721908.1 and AK127622.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_000610.3.
            
            Summary: The protein encoded by this gene is a cell-surface
            glycoprotein involved in cell-cell interactions, cell adhesion and
            migration. It is a receptor for hyaluronic acid (HA) and can also
            interact with other ligands, such as osteopontin, collagens, and
            matrix metalloproteinases (MMPs). This protein participates in a
            wide variety of cellular functions including lymphocyte activation,
            recirculation and homing, hematopoiesis, and tumor metastasis.
            Transcripts for this gene undergo complex alternative splicing that
            results in many functionally distinct isoforms, however, the full
            length nature of some of these variants has not been determined.
            Alternative splicing is the basis for the structural and functional
            diversity of this protein, and may be related to tumor metastasis.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. It encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record represents the CD44*001.1.1
            allele.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2726944.1, AJ251595.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428726.8/ ENSP00000398632.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-800               AL832642.2         302-1101
            801-998             BF872530.1         3-200
            999-1382            BC004372.1         868-1251
            1383-1607           BF828674.1         225-449             c
            1608-3056           AY101192.1         844-2292
            3057-3547           CD721908.1         140-630
            3548-4365           AK127622.1         527-1344
            4366-4899           AL832642.2         3525-4058
            4900-5424           AK127622.1         1879-2403
            5425-5431           AL832642.2         4584-4590
FEATURES             Location/Qualifiers
     source          1..5431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..5431
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /note="CD44 molecule (IN blood group)"
                     /db_xref="GeneID:960"
                     /db_xref="HGNC:HGNC:1681"
                     /db_xref="MIM:107269"
     exon            1..200
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2362
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; hematopoietic cell E- and L-selectin ligand;
                     chondroitin sulfate proteoglycan 8; cell surface
                     glycoprotein CD44; GP90 lymphocyte homing/adhesion
                     receptor; heparan sulfate proteoglycan; hyaluronate
                     receptor; Indian blood group antigen; Hermes antigen;
                     homing function and Indian blood group system; CD44
                     antigen; CD44 molecule (Indian blood group); phagocyte
                     glycoprotein 1; In(Lu) related-p80; homing cell adhesion
                     molecule; epican; soluble CD44; phagocytic glycoprotein 1;
                     extracellular matrix receptor III"
                     /codon_start=1
                     /product="CD44 antigen isoform 1 precursor"
                     /protein_id="NP_000601.3"
                     /db_xref="CCDS:CCDS7897.1"
                     /db_xref="GeneID:960"
                     /db_xref="HGNC:HGNC:1681"
                     /db_xref="MIM:107269"
                     /translation="MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSI
                     SRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNT
                     GVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGE
                     YRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDR
                     IPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGW
                     EPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNP
                     EVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSST
                     TEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSW
                     TDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQS
                     NSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPH
                     TKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESD
                     GHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKL
                     VINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKI
                     GV"
     exon            201..366
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..500
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..569
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..800
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..929
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1055
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1169
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1286
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1415
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1547
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1649
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1739
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1943
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2006
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2078
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2157
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..5431
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3028..3033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /note="hexamer: AATAAA"
     polyA_site      3056
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /note="major polyA site"
     regulatory      5395..5400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /note="hexamer: ATTAAA"
     regulatory      5409..5414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
                     /note="hexamer: ATTAAA"
     polyA_site      5422
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
     polyA_site      5431
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; IN; LHR; MC56; MDU2;
                     MDU3; MIC4; Pgp1"
ORIGIN      
        1 ctcattgccc agcggacccc agcctctgcc aggttcggtc cgccatcctc gtcccgtcct
       61 ccgccggccc ctgccccgcg cccagggatc ctccagctcc tttcgcccgc gccctccgtt
      121 cgctccggac accatggaca agttttggtg gcacgcagcc tggggactct gcctcgtgcc
      181 gctgagcctg gcgcagatcg atttgaatat aacctgccgc tttgcaggtg tattccacgt
      241 ggagaaaaat ggtcgctaca gcatctctcg gacggaggcc gctgacctct gcaaggcttt
      301 caatagcacc ttgcccacaa tggcccagat ggagaaagct ctgagcatcg gatttgagac
      361 ctgcaggtat gggttcatag aagggcacgt ggtgattccc cggatccacc ccaactccat
      421 ctgtgcagca aacaacacag gggtgtacat cctcacatcc aacacctccc agtatgacac
      481 atattgcttc aatgcttcag ctccacctga agaagattgt acatcagtca cagacctgcc
      541 caatgccttt gatggaccaa ttaccataac tattgttaac cgtgatggca cccgctatgt
      601 ccagaaagga gaatacagaa cgaatcctga agacatctac cccagcaacc ctactgatga
      661 tgacgtgagc agcggctcct ccagtgaaag gagcagcact tcaggaggtt acatctttta
      721 caccttttct actgtacacc ccatcccaga cgaagacagt ccctggatca ccgacagcac
      781 agacagaatc cctgctacca ctttgatgag cactagtgct acagcaactg agacagcaac
      841 caagaggcaa gaaacctggg attggttttc atggttgttt ctaccatcag agtcaaagaa
      901 tcatcttcac acaacaacac aaatggctgg tacgtcttca aataccatct cagcaggctg
      961 ggagccaaat gaagaaaatg aagatgaaag agacagacac ctcagttttt ctggatcagg
     1021 cattgatgat gatgaagatt ttatctccag caccatttca accacaccac gggcttttga
     1081 ccacacaaaa cagaaccagg actggaccca gtggaaccca agccattcaa atccggaagt
     1141 gctacttcag acaaccacaa ggatgactga tgtagacaga aatggcacca ctgcttatga
     1201 aggaaactgg aacccagaag cacaccctcc cctcattcac catgagcatc atgaggaaga
     1261 agagacccca cattctacaa gcacaatcca ggcaactcct agtagtacaa cggaagaaac
     1321 agctacccag aaggaacagt ggtttggcaa cagatggcat gagggatatc gccaaacacc
     1381 caaagaagac tcccattcga caacagggac agctgcagcc tcagctcata ccagccatcc
     1441 aatgcaagga aggacaacac caagcccaga ggacagttcc tggactgatt tcttcaaccc
     1501 aatctcacac cccatgggac gaggtcatca agcaggaaga aggatggata tggactccag
     1561 tcatagtata acgcttcagc ctactgcaaa tccaaacaca ggtttggtgg aagatttgga
     1621 caggacagga cctctttcaa tgacaacgca gcagagtaat tctcagagct tctctacatc
     1681 acatgaaggc ttggaagaag ataaagacca tccaacaact tctactctga catcaagcaa
     1741 taggaatgat gtcacaggtg gaagaagaga cccaaatcat tctgaaggct caactacttt
     1801 actggaaggt tatacctctc attacccaca cacgaaggaa agcaggacct tcatcccagt
     1861 gacctcagct aagactgggt cctttggagt tactgcagtt actgttggag attccaactc
     1921 taatgtcaat cgttccttat caggagacca agacacattc caccccagtg gggggtccca
     1981 taccactcat ggatctgaat cagatggaca ctcacatggg agtcaagaag gtggagcaaa
     2041 cacaacctct ggtcctataa ggacacccca aattccagaa tggctgatca tcttggcatc
     2101 cctcttggcc ttggctttga ttcttgcagt ttgcattgca gtcaacagtc gaagaaggtg
     2161 tgggcagaag aaaaagctag tgatcaacag tggcaatgga gctgtggagg acagaaagcc
     2221 aagtggactc aacggagagg ccagcaagtc tcaggaaatg gtgcatttgg tgaacaagga
     2281 gtcgtcagaa actccagacc agtttatgac agctgatgag acaaggaacc tgcagaatgt
     2341 ggacatgaag attggggtgt aacacctaca ccattatctt ggaaagaaac aaccgttgga
     2401 aacataacca ttacagggag ctgggacact taacagatgc aatgtgctac tgattgtttc
     2461 attgcgaatc ttttttagca taaaattttc tactcttttt gttttttgtg ttttgttctt
     2521 taaagtcagg tccaatttgt aaaaacagca ttgctttctg aaattagggc ccaattaata
     2581 atcagcaaga atttgatcgt tccagttccc acttggaggc ctttcatccc tcgggtgtgc
     2641 tatggatggc ttctaacaaa aactacacat atgtattcct gatcgccaac ctttccccca
     2701 ccagctaagg acatttccca gggttaatag ggcctggtcc ctgggaggaa atttgaatgg
     2761 gtccattttg cccttccata gcctaatccc tgggcattgc tttccactga ggttgggggt
     2821 tggggtgtac tagttacaca tcttcaacag accccctcta gaaatttttc agatgcttct
     2881 gggagacacc caaagggtga agctatttat ctgtagtaaa ctatttatct gtgtttttga
     2941 aatattaaac cctggatcag tcctttgatc agtataattt tttaaagtta ctttgtcaga
     3001 ggcacaaaag ggtttaaact gattcataat aaatatctgt acttcttcga tcttcacctt
     3061 ttgtgctgtg attcttcagt ttctaaacca gcactgtctg ggtccctaca atgtatcagg
     3121 aagagctgag aatggtaagg agactcttct aagtcttcat ctcagagacc ctgagttccc
     3181 actcagaccc actcagccaa atctcatgga agaccaagga gggcagcact gtttttgttt
     3241 tttgtttttt gttttttttt tttgacactg tccaaaggtt ttccatcctg tcctggaatc
     3301 agagttggaa gctgaggagc ttcagcctct tttatggttt aatggccacc tgttctctcc
     3361 tgtgaaaggc tttgcaaagt cacattaagt ttgcatgacc tgttatccct ggggccctat
     3421 ttcatagagg ctggccctat tagtgatttc caaaaacaat atggaagtgc cttttgatgt
     3481 cttacaataa gagaagaagc caatggaaat gaaagagatt ggcaaagggg aaggatgatg
     3541 ccatgtagat cctgtttgac atttttatgg ctgtatttgt aaacttaaac acaccagtgt
     3601 ctgttcttga tgcagttgct atttaggatg agttaagtgc ctggggagtc cctcaaaagg
     3661 ttaaagggat tcccatcatt ggaatcttat caccagatag gcaagtttat gaccaaacaa
     3721 gagagtactg gctttatcct ctaacctcat attttctccc acttggcaag tcctttgtgg
     3781 catttattca tcagtcaggg tgtccgattg gtcctagaac ttccaaaggc tgcttgtcat
     3841 agaagccatt gcatctataa agcaacggct cctgttaaat ggtatctcct ttctgaggct
     3901 cctactaaaa gtcatttgtt acctaaactt atgtgcttaa caggcaatgc ttctcagacc
     3961 acaaagcaga aagaagaaga aaagctcctg actaaatcag ggctgggctt agacagagtt
     4021 gatctgtaga atatctttaa aggagagatg tcaactttct gcactattcc cagcctctgc
     4081 tcctccctgt ctaccctctc ccctccctct ctccctccac ttcaccccac aatcttgaaa
     4141 aacttccttt ctcttctgtg aacatcattg gccagatcca ttttcagtgg tctggatttc
     4201 tttttatttt cttttcaact tgaaagaaac tggacattag gccactatgt gttgttactg
     4261 ccactagtgt tcaagtgcct cttgttttcc cagagatttc ctgggtctgc cagaggccca
     4321 gacaggctca ctcaagctct ttaactgaaa agcaacaagc cactccagga caaggttcaa
     4381 aatggttaca acagcctcta cctgtcgccc cagggagaaa ggggtagtga tacaagtctc
     4441 atagccagag atggttttcc actccttcta gatattccca aaaagaggct gagacaggag
     4501 gttattttca attttatttt ggaattaaat acttttttcc ctttattact gttgtagtcc
     4561 ctcacttgga tatacctctg ttttcacgat agaaataagg gaggtctaga gcttctattc
     4621 cttggccatt gtcaacggag agctggccaa gtcttcacaa acccttgcaa cattgcctga
     4681 agtttatgga ataagatgta ttctcactcc cttgatctca agggcgtaac tctggaagca
     4741 cagcttgact acacgtcatt tttaccaatg attttcaggt gacctgggct aagtcattta
     4801 aactgggtct ttataaaagt aaaaggccaa catttaatta ttttgcaaag caacctaaga
     4861 gctaaagatg taatttttct tgcaattgta aatcttttgt gtctcctgaa gacttccctt
     4921 aaaattagct ctgagtgaaa aatcaaaaga gacaaaagac atcttcgaat ccatatttca
     4981 agcctggtag aattggcttt tctagcagaa cctttccaaa agttttatat tgagattcat
     5041 aacaacacca agaattgatt ttgtagccaa cattcattca atactgttat atcagaggag
     5101 taggagagag gaaacatttg acttatctgg aaaagcaaaa tgtacttaag aataagaata
     5161 acatggtcca ttcaccttta tgttatagat atgtctttgt gtaaatcatt tgttttgagt
     5221 tttcaaagaa tagcccattg ttcattcttg tgctgtacaa tgaccactgt tattgttact
     5281 ttgacttttc agagcacacc cttcctctgg tttttgtata tttattgatg gatcaataat
     5341 aatgaggaaa gcatgatatg tatattgctg agttgaaagc acttattgga aaatattaaa
     5401 aggctaacat taaaagacta aaggaaacag a
//
