LOCUS       NM_001250               1682 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens CD40 molecule (CD40), transcript variant 1, mRNA.
ACCESSION   NM_001250
VERSION     NM_001250.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1682)
  AUTHORS   Ahmed,H.A., Abdelkreem,E., Hamed,E.O., Abo Elmahassen,N.M. and
            Younis,M.A.A.
  TITLE     Frequency of CD40-1C>T polymorphism (rs1883832) and association
            with response to treatment in children with primary immune
            thrombocytopenia
  JOURNAL   Pediatr Blood Cancer 71 (12), e31356 (2024)
   PUBMED   39350313
  REMARK    GeneRIF: Frequency of CD40-1C>T polymorphism (rs1883832) and
            association with response to treatment in children with primary
            immune thrombocytopenia.
REFERENCE   2  (bases 1 to 1682)
  AUTHORS   Meng,H., Li,L., Nan,M., Ding,Y., Li,Y. and Zhang,M.
  TITLE     ZG16 enhances the maturation of dendritic cells via induction of
            CD40 and contributes to the antitumor immunity in pancreatic cancer
  JOURNAL   Oncogene 43 (43), 3184-3196 (2024)
   PUBMED   39261658
  REMARK    GeneRIF: ZG16 enhances the maturation of dendritic cells via
            induction of CD40 and contributes to the antitumor immunity in
            pancreatic cancer.
REFERENCE   3  (bases 1 to 1682)
  AUTHORS   Aydin,S., Darko,K., Detchou,D. and Barrie,U.
  TITLE     A call for clinical trials in glioblastoma multiforme for
            interleukin 4, interleukin 6, interleukin 13 and CD40
  JOURNAL   Neurosurg Rev 47 (1), 571 (2024)
   PUBMED   39242402
  REMARK    GeneRIF: A call for clinical trials in glioblastoma multiforme for
            interleukin 4, interleukin 6, interleukin 13 and CD40.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1682)
  AUTHORS   Naseri,S., Cordova,M.M., Wenthe,J., Lovgren,T., Eriksson,E.,
            Loskog,A. and Ullenhag,G.J.
  TITLE     CD40 stimulation via CD40 ligand enhances adenovirus-mediated
            tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me'
            signalling
  JOURNAL   J Cell Mol Med 28 (7), e18162 (2024)
   PUBMED   38494863
REFERENCE   5  (bases 1 to 1682)
  AUTHORS   Takahashi,K., Kobayashi,M., Katsumata,H., Tokizaki,S., Anzai,T.,
            Ikeda,Y., Alcaide,D.M., Maeda,K., Ishihara,M., Tahara,K.,
            Kubota,Y., Itoh,F., Park,J., Takahashi,K., Matsunaga,Y.T.,
            Yoshimatsu,Y., Podyma-Inoue,K.A. and Watabe,T.
  TITLE     CD40 is expressed in the subsets of endothelial cells undergoing
            partial endothelial-mesenchymal transition in tumor
            microenvironment
  JOURNAL   Cancer Sci 115 (2), 490-506 (2024)
   PUBMED   38111334
  REMARK    GeneRIF: CD40 is expressed in the subsets of endothelial cells
            undergoing partial endothelial-mesenchymal transition in tumor
            microenvironment.
REFERENCE   6  (bases 1 to 1682)
  AUTHORS   Foy,T.M., Laman,J.D., Ledbetter,J.A., Aruffo,A., Claassen,E. and
            Noelle,R.J.
  TITLE     gp39-CD40 interactions are essential for germinal center formation
            and the development of B cell memory
  JOURNAL   J Exp Med 180 (1), 157-163 (1994)
   PUBMED   7516405
REFERENCE   7  (bases 1 to 1682)
  AUTHORS   Banchereau,J., Bazan,F., Blanchard,D., Briere,F., Galizzi,J.P., van
            Kooten,C., Liu,Y.J., Rousset,F. and Saeland,S.
  TITLE     The CD40 antigen and its ligand
  JOURNAL   Annu Rev Immunol 12, 881-922 (1994)
   PUBMED   7516669
  REMARK    Review article
REFERENCE   8  (bases 1 to 1682)
  AUTHORS   Stamenkovic,I., Clark,E.A. and Seed,B.
  TITLE     A B-lymphocyte activation molecule related to the nerve growth
            factor receptor and induced by cytokines in carcinomas
  JOURNAL   EMBO J 8 (5), 1403-1410 (1989)
   PUBMED   2475341
REFERENCE   9  (bases 1 to 1682)
  AUTHORS   Clark,E.A. and Ledbetter,J.A.
  TITLE     Activation of human B cells mediated through two distinct cell
            surface differentiation antigens, Bp35 and Bp50
  JOURNAL   Proc Natl Acad Sci U S A 83 (12), 4494-4498 (1986)
   PUBMED   3487090
REFERENCE   10 (bases 1 to 1682)
  AUTHORS   Paulie,S., Ehlin-Henriksson,B., Mellstedt,H., Koho,H., Ben-Aissa,H.
            and Perlmann,P.
  TITLE     A p50 surface antigen restricted to human urinary bladder
            carcinomas and B lymphocytes
  JOURNAL   Cancer Immunol Immunother 20 (1), 23-28 (1985)
   PUBMED   2998589
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM761221.1, BC012419.1,
            BC064518.1, BX364284.2 and AL035662.65.
            
            On May 17, 2019 this sequence version replaced NM_001250.5.
            
            Summary: This gene is a member of the TNF-receptor superfamily. The
            encoded protein is a receptor on antigen-presenting cells of the
            immune system and is essential for mediating a broad variety of
            immune and inflammatory responses including T cell-dependent
            immunoglobulin class switching, memory B cell development, and
            germinal center formation. AT-hook transcription factor AKNA is
            reported to coordinately regulate the expression of this receptor
            and its ligand, which may be important for homotypic cell
            interactions. Adaptor protein TNFR2 interacts with this receptor
            and serves as a mediator of the signal transduction. The
            interaction of this receptor and its ligand is found to be
            necessary for amyloid-beta-induced microglial activation, and thus
            is thought to be an early event in Alzheimer disease pathogenesis.
            Mutations affecting this gene are the cause of autosomal recessive
            hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively
            spliced transcript variants of this gene encoding distinct isoforms
            have been reported. [provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222896.1, SRR1660803.138274.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372285.8/ ENSP00000361359.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BM761221.1         48-76
            30-1117             BC012419.1         57-1144
            1118-1486           BC064518.1         1156-1524
            1487-1569           BX364284.2         1-83                c
            1570-1682           AL035662.65        65471-65583
FEATURES             Location/Qualifiers
     source          1..1682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1682
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /note="CD40 molecule"
                     /db_xref="GeneID:958"
                     /db_xref="HGNC:HGNC:11919"
                     /db_xref="MIM:109535"
     exon            1..81
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..864
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD40L receptor; B cell-associated molecule; B
                     cell surface antigen CD40; tumor necrosis factor receptor
                     superfamily member 5; CD40 molecule, TNF receptor
                     superfamily member 5"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 5 isoform 1 precursor"
                     /protein_id="NP_001241.1"
                     /db_xref="CCDS:CCDS13393.1"
                     /db_xref="GeneID:958"
                     /db_xref="HGNC:HGNC:11919"
                     /db_xref="MIM:109535"
                     /translation="MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPG
                     QKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTI
                     CTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEK
                     CHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKV
                     AKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQER
                     Q"
     exon            82..160
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            161..286
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            287..433
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            434..527
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            528..589
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            590..676
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            677..705
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1682
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /note="hexamer: AATAAA"
     regulatory      1326..1331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /note="hexamer: AATATA"
     polyA_site      1340
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /note="major polyA site"
     polyA_site      1345
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /note="hexamer: AATACA"
     polyA_site      1478
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
     regulatory      1488..1493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
                     /note="hexamer: AACAAG"
     polyA_site      1517
                     /gene="CD40"
                     /gene_synonym="Bp50; CDW40; p50; TNFRSF5"
ORIGIN      
        1 agtggtcctg ccgcctggtc tcacctcgct atggttcgtc tgcctctgca gtgcgtcctc
       61 tggggctgct tgctgaccgc tgtccatcca gaaccaccca ctgcatgcag agaaaaacag
      121 tacctaataa acagtcagtg ctgttctttg tgccagccag gacagaaact ggtgagtgac
      181 tgcacagagt tcactgaaac ggaatgcctt ccttgcggtg aaagcgaatt cctagacacc
      241 tggaacagag agacacactg ccaccagcac aaatactgcg accccaacct agggcttcgg
      301 gtccagcaga agggcacctc agaaacagac accatctgca cctgtgaaga aggctggcac
      361 tgtacgagtg aggcctgtga gagctgtgtc ctgcaccgct catgctcgcc cggctttggg
      421 gtcaagcaga ttgctacagg ggtttctgat accatctgcg agccctgccc agtcggcttc
      481 ttctccaatg tgtcatctgc tttcgaaaaa tgtcaccctt ggacaagctg tgagaccaaa
      541 gacctggttg tgcaacaggc aggcacaaac aagactgatg ttgtctgtgg tccccaggat
      601 cggctgagag ccctggtggt gatccccatc atcttcggga tcctgtttgc catcctcttg
      661 gtgctggtct ttatcaaaaa ggtggccaag aagccaacca ataaggcccc ccaccccaag
      721 caggaacccc aggagatcaa ttttcccgac gatcttcctg gctccaacac tgctgctcca
      781 gtgcaggaga ctttacatgg atgccaaccg gtcacccagg aggatggcaa agagagtcgc
      841 atctcagtgc aggagagaca gtgaggctgc acccacccag gagtgtggcc acgtgggcaa
      901 acaggcagtt ggccagagag cctggtgctg ctgctgctgt ggcgtgaggg tgaggggctg
      961 gcactgactg ggcatagctc cccgcttctg cctgcacccc tgcagtttga gacaggagac
     1021 ctggcactgg atgcagaaac agttcacctt gaagaacctc tcacttcacc ctggagccca
     1081 tccagtctcc caacttgtat taaagacaga ggcagaagtt tggtggtggt ggtgttgggg
     1141 tatggtttag taatatccac cagaccttcc gatccagcag tttggtgccc agagaggcat
     1201 catggtggct tccctgcgcc caggaagcca tatacacaga tgcccattgc agcattgttt
     1261 gtgatagtga acaactggaa gctgcttaac tgtccatcag caggagactg gctaaataaa
     1321 attagaatat atttatacaa cagaatctca aaaacactgt tgagtaagga aaaaaaggca
     1381 tgctgctgaa tgatgggtat ggaacttttt aaaaaagtac atgcttttat gtatgtatat
     1441 tgcctatgga tatatgtata aatacaatat gcatcatata ttgatataac aagggttctg
     1501 gaagggtaca cagaaaaccc acagctcgaa gagtggtgac gtctggggtg gggaagaagg
     1561 gtctggggga gggttggtta aagggagatt tggctttccc ataatgcttc atcatttttc
     1621 ccaaaaggag agtgaattca cataatgctt atgtaattaa aaaatcatca aacatgtaaa
     1681 aa
//
