LOCUS       NM_000073               2690 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens CD3 gamma subunit of T-cell receptor complex (CD3G),
            mRNA.
ACCESSION   NM_000073
VERSION     NM_000073.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2690)
  AUTHORS   Li,N., Ren,P., Wang,J., Zhu,X., Qiao,X., Zeng,Z., Ye,T., Wang,S.,
            Meng,Z., Gan,H., Liu,S., Sun,Y., Zhu,X., Dou,G. and Gu,R.
  TITLE     Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers
            Associated with Sepsis
  JOURNAL   Int J Mol Sci 25 (2), 749 (2024)
   PUBMED   38255822
  REMARK    GeneRIF: Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers
            Associated with Sepsis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2690)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2690)
  AUTHORS   Dong,D., Zheng,L., Lin,J., Zhang,B., Zhu,Y., Li,N., Xie,S.,
            Wang,Y., Gao,N. and Huang,Z.
  TITLE     Structural basis of assembly of the human T cell receptor-CD3
            complex
  JOURNAL   Nature 573 (7775), 546-552 (2019)
   PUBMED   31461748
  REMARK    Erratum:[Nature. 2021 Feb;590(7846):E52. doi:
            10.1038/s41586-021-03245-4.. PMID: 33526937]
REFERENCE   4  (bases 1 to 2690)
  AUTHORS   Muro,R., Takayanagi,H. and Nitta,T.
  TITLE     T cell receptor signaling for gammadeltaT cell development
  JOURNAL   Inflamm Regen 39, 6 (2019)
   PUBMED   30976362
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2690)
  AUTHORS   Gaud,G., Lesourne,R. and Love,P.E.
  TITLE     Regulatory mechanisms in T cell receptor signalling
  JOURNAL   Nat Rev Immunol 18 (8), 485-497 (2018)
   PUBMED   29789755
  REMARK    Review article
REFERENCE   6  (bases 1 to 2690)
  AUTHORS   Lanier,L.L., Chang,C., Spits,H. and Phillips,J.H.
  TITLE     Expression of cytoplasmic CD3 epsilon proteins in activated human
            adult natural killer (NK) cells and CD3 gamma, delta, epsilon
            complexes in fetal NK cells. Implications for the relationship of
            NK and T lymphocytes
  JOURNAL   J Immunol 149 (6), 1876-1880 (1992)
   PUBMED   1387664
REFERENCE   7  (bases 1 to 2690)
  AUTHORS   Arnaiz-Villena,A., Timon,M., Corell,A., Perez-Aciego,P.,
            Martin-Villa,J.M. and Regueiro,J.R.
  TITLE     Brief report: primary immunodeficiency caused by mutations in the
            gene encoding the CD3-gamma subunit of the T-lymphocyte receptor
  JOURNAL   N Engl J Med 327 (8), 529-533 (1992)
   PUBMED   1635567
REFERENCE   8  (bases 1 to 2690)
  AUTHORS   Letourneur,F. and Klausner,R.D.
  TITLE     A novel di-leucine motif and a tyrosine-based motif independently
            mediate lysosomal targeting and endocytosis of CD3 chains
  JOURNAL   Cell 69 (7), 1143-1157 (1992)
   PUBMED   1535555
REFERENCE   9  (bases 1 to 2690)
  AUTHORS   Arnaiz-Villena,A., Perez-Aciego,P., Ballestin,C., Sotelo,T.,
            Perez-Seoane,C., Martin-Villa,J.M. and Regueiro,J.R.
  TITLE     Biochemical basis of a novel T lymphocyte receptor immunodeficiency
            by immunohistochemistry. A possible CD3 gamma abnormality
  JOURNAL   Lab Invest 64 (5), 675-681 (1991)
   PUBMED   1709425
  REMARK    GeneRIF: Protein level controlled by OTHER KINASES PROTEINS
REFERENCE   10 (bases 1 to 2690)
  AUTHORS   Alarcon,B., Ley,S.C., Sanchez-Madrid,F., Blumberg,R.S., Ju,S.T.,
            Fresno,M. and Terhorst,C.
  TITLE     The CD3-gamma and CD3-delta subunits of the T cell antigen receptor
            can be expressed within distinct functional TCR/CD3 complexes
  JOURNAL   EMBO J 10 (4), 903-912 (1991)
   PUBMED   1826255
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC378393.1, X04145.1,
            DB116263.1, AK310622.1 and AP001582.4.
            
            On Nov 22, 2019 this sequence version replaced NM_000073.2.
            
            Summary: The protein encoded by this gene is the CD3-gamma
            polypeptide, which together with CD3-epsilon, -delta and -zeta, and
            the T-cell receptor alpha/beta and gamma/delta heterodimers, forms
            the T-cell receptor-CD3 complex. This complex plays an important
            role in coupling antigen recognition to several intracellular
            signal-transduction pathways. The genes encoding the epsilon, gamma
            and delta polypeptides are located in the same cluster on
            chromosome 11. Defects in this gene are associated with T cell
            immunodeficiency. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3282162.1,
                                           SRR14038196.1560833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000532917.3/ ENSP00000431445.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                DC378393.1         1-68
            69-865              X04145.1           26-822
            866-986             DB116263.1         433-553
            987-1311            AK310622.1         1145-1469
            1312-2690           AP001582.4         66794-68172
FEATURES             Location/Qualifiers
     source          1..2690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..2690
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /note="CD3 gamma subunit of T-cell receptor complex"
                     /db_xref="GeneID:917"
                     /db_xref="HGNC:HGNC:1675"
                     /db_xref="MIM:186740"
     exon            1..135
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..629
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /note="CD3g antigen, gamma polypeptide (TiT3 complex);
                     T-cell receptor T3 gamma chain; T-cell antigen receptor
                     complex, gamma subunit of T3; T-cell surface glycoprotein
                     CD3 gamma chain; CD3g molecule, epsilon (CD3-TCR complex);
                     CD3g molecule, gamma (CD3-TCR complex)"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD3 gamma chain
                     precursor"
                     /protein_id="NP_000064.1"
                     /db_xref="CCDS:CCDS8395.1"
                     /db_xref="GeneID:917"
                     /db_xref="HGNC:HGNC:1675"
                     /db_xref="MIM:186740"
                     /translation="MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLL
                     TCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYR
                     MCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLY
                     QPLKDREDDQYSHLQGNQLRRN"
     exon            136..159
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /inference="alignment:Splign:2.1.0"
     exon            160..387
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /inference="alignment:Splign:2.1.0"
     exon            388..519
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /inference="alignment:Splign:2.1.0"
     exon            520..563
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /inference="alignment:Splign:2.1.0"
     exon            564..647
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /inference="alignment:Splign:2.1.0"
     exon            648..2690
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2536..2541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /note="hexamer: AATAAA"
     polyA_site      2556
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /note="major polyA site"
     regulatory      2670..2675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
                     /note="hexamer: AATAAA"
     polyA_site      2690
                     /gene="CD3G"
                     /gene_synonym="CD3-GAMMA; CD3GAMMA; IMD17; T3G"
ORIGIN      
        1 agtctagctg ctgcacaggc tggctggctg gctggctgct aagggctgct ccacgctttt
       61 gccggaggac agagactgac atggaacagg ggaagggcct ggctgtcctc atcctggcta
      121 tcattcttct tcaaggtact ttggcccagt caatcaaagg aaaccacttg gttaaggtgt
      181 atgactatca agaagatggt tcggtacttc tgacttgtga tgcagaagcc aaaaatatca
      241 catggtttaa agatgggaag atgatcggct tcctaactga agataaaaaa aaatggaatc
      301 tgggaagtaa tgccaaggac cctcgaggga tgtatcagtg taaaggatca cagaacaagt
      361 caaaaccact ccaagtgtat tacagaatgt gtcagaactg cattgaacta aatgcagcca
      421 ccatatctgg ctttctcttt gctgaaatcg tcagcatttt cgtccttgct gttggggtct
      481 acttcattgc tggacaggat ggagttcgcc agtcgagagc ttcagacaag cagactctgt
      541 tgcccaatga ccagctctac cagcccctca aggatcgaga agatgaccag tacagccacc
      601 ttcaaggaaa ccagttgagg aggaattgaa ctcaggactc agagtagtcc aggtgttctc
      661 ctcctattca gttcccagaa tcaaagcaat gcattttgga aagctcctag cagagagact
      721 ttcagcccta aatctagact caaggttccc agagatgaca aatggagaag aaaggccatc
      781 agagcaaatt tgggggtttc tcaaataaaa taaaaataaa aacaaatact gtgtttcaga
      841 agcgccacct attggggaaa attgtaaaag aaaaatgaaa agatcaaata accccctgga
      901 tttgaatata attttttgtg ttgtaatttt tatttcgttt ttgtataggt tataattcac
      961 atggctcaaa tattcagtga aagctctccc tccaccgcca tcccctgcta cccagtgacc
     1021 ctgttgccct cttcagagac aaattagttt ctcttttttt tttttttttt tttttttttg
     1081 agacagtctg gctctgtcac ccaggctgaa atgcagtggc accatctcgg ctcactgcaa
     1141 cctctgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgggcag ctgggattac
     1201 aggcacacac taccacacct ggctaatttt tgtattttta gtagagacag ggttttgctc
     1261 tgttggccaa gctggtctcg aactcctgac ctcaagtgat ccgcccgcct cagcctccca
     1321 aagtgctggg attacaggtg tgagccacca tgcctggtct taaaaccagt ttcttatata
     1381 tctctctgga ggtattctag gcatatatga gcacattctc aagtacatat tatcctccct
     1441 tcccctatct tttagacaaa tgatatcaaa ctatacatct tgtgagatta ttgcatacca
     1501 ttatatgaag ataccattat atccttttta atgcaaccat attgtacaaa tagactatga
     1561 tttatttaac ctgttatcta tcagtggata tttaagttgg tagttggttc caatcttttg
     1621 ctcttacaac aattctgcaa tgactaacat tgtataaata tcatttttaa aaataattgc
     1681 attgaagcat aatgtacatg ccataaaatc cacccatctt aagtgatttc acctgttctc
     1741 agaaattttt agtaaattta actaattgta cagccattac cataatccag ctttaggaca
     1801 ttttcttttt tttcttttct tttctttttt ttcttttttt tttttttttg aagtggaatc
     1861 ttgctctgtg gcccaggctg gagtgcagtg gcgcgatctc agctcactgc aacctccacc
     1921 tcctgggttc aagcgattct cttgccttgg cctcccgagt agctgagact acaggcacat
     1981 gccaccacgc ccagctcatt ttttgtgtat ttagtatttg tgtatctagt atttgtgtac
     2041 ttagtagaga cagggtttca ccatgttggc caggctggtc tccaattcct gacctcaggc
     2101 gatccacccg ccttgacctc ccaaagtgct gggattacag gtgtgagcca ccgcgccagg
     2161 cccgtaactg tattttaata tagccattct atggatttaa tatggtattt tattatggcc
     2221 ttaatttgca tttccctaga tactaaccat gctgagtgtc ctgtcttgtg tttattaacc
     2281 attcatatat ttttagtgaa atgtgtatca aatcttttgc ccatttttaa gttgacttat
     2341 ttgtttgtct tcttactatt gggttgcata tgtttttgat ataagtcctt tatcagatat
     2401 atgatttgga aatattttct accaatctgt ggtttgtttt tcttaatggt gtcttttgaa
     2461 gtgcaaaagg tttgaatttt gaagtacatt ttattgattt tttcttctat atattgtgct
     2521 tttggtatca tgtctaataa atctttacca aacccacagt tacaaagatt ttctcctgtc
     2581 ttctttttat actttttaca gctttatggt tttagctcta acaataaatg tgattttgaa
     2641 catacataag actatttgta acaaacacaa ataaattgaa ttgttgggca
//
