LOCUS       NM_000733               1361 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens CD3 epsilon subunit of T-cell receptor complex (CD3E),
            mRNA.
ACCESSION   NM_000733
VERSION     NM_000733.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1361)
  AUTHORS   Deng,S., Zhang,Y., Wang,H., Liang,W., Xie,L., Li,N., Fang,Y.,
            Wang,Y., Liu,J., Chi,H., Sun,Y., Ye,R., Shan,L., Shi,J., Shen,Z.,
            Wang,Y., Wang,S., Brosseau,J.P., Wang,F., Liu,G., Quan,Y. and Xu,J.
  TITLE     ITPRIPL1 binds CD3epsilon to impede T cell activation and enable
            tumor immune evasion
  JOURNAL   Cell 187 (9), 2305-2323 (2024)
   PUBMED   38614099
REFERENCE   2  (bases 1 to 1361)
  AUTHORS   Gebremicael,G., Gebreegziabxier,A. and Kassa,D.
  TITLE     Low transcriptomic of PTPRCv1 and CD3E is an independent predictor
            of mortality in HIV and tuberculosis co-infected patient
  JOURNAL   Sci Rep 12 (1), 10133 (2022)
   PUBMED   35710869
  REMARK    GeneRIF: Low transcriptomic of PTPRCv1 and CD3E is an independent
            predictor of mortality in HIV and tuberculosis co-infected patient.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1361)
  AUTHORS   Wu,W., Zhou,Q., Masubuchi,T., Shi,X., Li,H., Xu,X., Huang,M.,
            Meng,L., He,X., Zhu,H., Gao,S., Zhang,N., Jing,R., Sun,J., Wang,H.,
            Hui,E., Wong,C.C. and Xu,C.
  TITLE     Multiple Signaling Roles of CD3epsilon and Its Application in CAR-T
            Cell Therapy
  JOURNAL   Cell 182 (4), 855-871 (2020)
   PUBMED   32730808
  REMARK    GeneRIF: Multiple Signaling Roles of CD3epsilon and Its Application
            in CAR-T Cell Therapy.
REFERENCE   4  (bases 1 to 1361)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1361)
  AUTHORS   Erman,B., Firtina,S., Fisgin,T., Bozkurt,C. and Cipe,F.E.
  TITLE     Biallelic Form of a Known CD3E Mutation in a Patient with Severe
            Combined Immunodeficiency
  JOURNAL   J Clin Immunol 40 (3), 539-542 (2020)
   PUBMED   32016651
  REMARK    GeneRIF: Biallelic Form of a Known CD3E Mutation in a Patient with
            Severe Combined Immunodeficiency.
REFERENCE   6  (bases 1 to 1361)
  AUTHORS   Lanier,L.L., Chang,C., Spits,H. and Phillips,J.H.
  TITLE     Expression of cytoplasmic CD3 epsilon proteins in activated human
            adult natural killer (NK) cells and CD3 gamma, delta, epsilon
            complexes in fetal NK cells. Implications for the relationship of
            NK and T lymphocytes
  JOURNAL   J Immunol 149 (6), 1876-1880 (1992)
   PUBMED   1387664
REFERENCE   7  (bases 1 to 1361)
  AUTHORS   Thoenes,G., Soudais,C., le Deist,F., Griscelli,C., Fischer,A. and
            Lisowska-Grospierre,B.
  TITLE     Structural analysis of low TCR-CD3 complex expression in T cells of
            an immunodeficient patient
  JOURNAL   J Biol Chem 267 (1), 487-493 (1992)
   PUBMED   1370449
REFERENCE   8  (bases 1 to 1361)
  AUTHORS   Wong,S., Moore,S., Orisio,S., Millward,A. and Demaine,A.G.
  TITLE     Susceptibility to type I diabetes in women is associated with the
            CD3 epsilon locus on chromosome 11
  JOURNAL   Clin Exp Immunol 83 (1), 69-73 (1991)
   PUBMED   1671006
REFERENCE   9  (bases 1 to 1361)
  AUTHORS   Koning,F., Maloy,W.L. and Coligan,J.E.
  TITLE     The implications of subunit interactions for the structure of the T
            cell receptor-CD3 complex
  JOURNAL   Eur J Immunol 20 (2), 299-305 (1990)
   PUBMED   2138083
REFERENCE   10 (bases 1 to 1361)
  AUTHORS   Gold,D.P., Puck,J.M., Pettey,C.L., Cho,M., Coligan,J., Woody,J.N.
            and Terhorst,C.
  TITLE     Isolation of cDNA clones encoding the 20K non-glycosylated
            polypeptide chain of the human T-cell receptor/T3 complex
  JOURNAL   Nature 321 (6068), 431-434 (1986)
   PUBMED   3012357
  REMARK    Erratum:[Nature 1986 Dec 18-31;324(6098):702]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP366535.1, AK292612.1 and
            BC049847.1.
            
            On Aug 31, 2019 this sequence version replaced NM_000733.3.
            
            Summary: The protein encoded by this gene is the CD3-epsilon
            polypeptide, which together with CD3-gamma, -delta and -zeta, and
            the T-cell receptor alpha/beta and gamma/delta heterodimers, forms
            the T-cell receptor-CD3 complex. This complex plays an important
            role in coupling antigen recognition to several intracellular
            signal-transduction pathways. The genes encoding the epsilon, gamma
            and delta polypeptides are located in the same cluster on
            chromosome 11. The epsilon polypeptide plays an essential role in
            T-cell development. Defects in this gene cause immunodeficiency.
            This gene has also been linked to a susceptibility to type I
            diabetes in women. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292612.1, BC049847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361763.9/ ENSP00000354566.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BP366535.1         168-168
            2-730               AK292612.1         1-729
            731-1361            BC049847.1         693-1323
FEATURES             Location/Qualifiers
     source          1..1361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..1361
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /note="CD3 epsilon subunit of T-cell receptor complex"
                     /db_xref="GeneID:916"
                     /db_xref="HGNC:HGNC:1674"
                     /db_xref="MIM:186830"
     exon            1..47
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /inference="alignment:Splign:2.1.0"
     exon            48..155
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..730
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /note="CD3e antigen, epsilon polypeptide (TiT3 complex);
                     CD3-epsilon; T-cell antigen receptor complex, epsilon
                     subunit of T3; T-cell surface antigen T3/Leu-4 epsilon
                     chain; T-cell surface glycoprotein CD3 epsilon chain; CD3e
                     molecule, epsilon (CD3-TCR complex)"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD3 epsilon chain
                     precursor"
                     /protein_id="NP_000724.1"
                     /db_xref="CCDS:CCDS31685.1"
                     /db_xref="GeneID:916"
                     /db_xref="HGNC:HGNC:1674"
                     /db_xref="MIM:186830"
                     /translation="MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTT
                     VILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRG
                     SKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAK
                     PVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI"
     exon            156..176
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /inference="alignment:Splign:2.1.0"
     exon            177..191
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /inference="alignment:Splign:2.1.0"
     exon            192..209
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /inference="alignment:Splign:2.1.0"
     exon            210..458
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /inference="alignment:Splign:2.1.0"
     exon            459..626
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /inference="alignment:Splign:2.1.0"
     exon            627..673
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /inference="alignment:Splign:2.1.0"
     exon            674..1361
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1340..1345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /note="hexamer: AATAAA"
     polyA_site      1361
                     /gene="CD3E"
                     /gene_synonym="CD3epsilon; IMD18; T3E; TCRE"
                     /note="major polyA site"
ORIGIN      
        1 agaaaccctc ctcccctccc agcctcaggt gcctgcttca gaaaatgaag tagtaagtct
       61 gctggcctcc gccatcttag taaagtaaca gtcccatgaa acaaagatgc agtcgggcac
      121 tcactggaga gttctgggcc tctgcctctt atcagttggc gtttgggggc aagatggtaa
      181 tgaagaaatg ggtggtatta cacagacacc atataaagtc tccatctctg gaaccacagt
      241 aatattgaca tgccctcagt atcctggatc tgaaatacta tggcaacaca atgataaaaa
      301 cataggcggt gatgaggatg ataaaaacat aggcagtgat gaggatcacc tgtcactgaa
      361 ggaattttca gaattggagc aaagtggtta ttatgtctgc taccccagag gaagcaaacc
      421 agaagatgcg aacttttatc tctacctgag ggcaagagtg tgtgagaact gcatggagat
      481 ggatgtgatg tcggtggcca caattgtcat agtggacatc tgcatcactg ggggcttgct
      541 gctgctggtt tactactgga gcaagaatag aaaggccaag gccaagcctg tgacacgagg
      601 agcgggtgct ggcggcaggc aaaggggaca aaacaaggag aggccaccac ctgttcccaa
      661 cccagactat gagcccatcc ggaaaggcca gcgggacctg tattctggcc tgaatcagag
      721 acgcatctga ccctctggag aacactgcct cccgctggcc caggtctcct ctccagtccc
      781 cctgcgactc cctgtttcct gggctagtct tggaccccac gagagagaat cgttcctcag
      841 cctcatggtg aactcgcgcc ctccagcctg atcccccgct ccctcctccc tgccttctct
      901 gctggtaccc agtcctaaaa tattgctgct tcctcttcct ttgaagcatc atcagtagtc
      961 acaccctcac agctggcctg ccctcttgcc aggatattta tttgtgctat tcactccctt
     1021 ccctttggat gtaacttctc cgttcagttc cctccttttc ttgcatgtaa gttgtccccc
     1081 atcccaaagt attccatcta cttttctatc gccgtcccct tttgcagccc tctctgggga
     1141 tggactgggt aaatgttgac agaggccctg ccccgttcac agatcctggc cctgagccag
     1201 ccctgtgctc ctccctcccc caacactccc taccaacccc ctaatcccct actccctcca
     1261 ccccccctcc actgtaggcc actggatggt catttgcatc tccgtaaatg tgctctgctc
     1321 ctcagctgag agagaaaaaa ataaactgta tttggctgca a
//
