LOCUS       NM_001040651             690 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens CD3 delta subunit of T-cell receptor complex (CD3D),
            transcript variant 2, mRNA.
ACCESSION   NM_001040651
VERSION     NM_001040651.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 690)
  AUTHORS   Zhang,C. and Wu,S.
  TITLE     Hypomethylation of CD3D promoter induces immune cell infiltration
            and supports malignant phenotypes in uveal melanoma
  JOURNAL   FASEB J 37 (10), e23128 (2023)
   PUBMED   37651092
  REMARK    GeneRIF: Hypomethylation of CD3D promoter induces immune cell
            infiltration and supports malignant phenotypes in uveal melanoma.
REFERENCE   2  (bases 1 to 690)
  AUTHORS   Zhu,Z., Ye,W., Wu,X., Lin,S., Xu,J., Li,L., Li,J., Wang,H. and
            Huang,Z.
  TITLE     Comprehensive analysis reveals a prognostic and therapeutic
            biomarker CD3D in the breast carcinoma microenvironment
  JOURNAL   Biosci Rep 41 (1) (2021)
   PUBMED   33350431
  REMARK    GeneRIF: Comprehensive analysis reveals a prognostic and
            therapeutic biomarker CD3D in the breast carcinoma
            microenvironment.
REFERENCE   3  (bases 1 to 690)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 690)
  AUTHORS   Dong,D., Zheng,L., Lin,J., Zhang,B., Zhu,Y., Li,N., Xie,S.,
            Wang,Y., Gao,N. and Huang,Z.
  TITLE     Structural basis of assembly of the human T cell receptor-CD3
            complex
  JOURNAL   Nature 573 (7775), 546-552 (2019)
   PUBMED   31461748
  REMARK    Erratum:[Nature. 2021 Feb;590(7846):E52. doi:
            10.1038/s41586-021-03245-4.. PMID: 33526937]
REFERENCE   5  (bases 1 to 690)
  AUTHORS   Gaud,G., Lesourne,R. and Love,P.E.
  TITLE     Regulatory mechanisms in T cell receptor signalling
  JOURNAL   Nat Rev Immunol 18 (8), 485-497 (2018)
   PUBMED   29789755
  REMARK    Review article
REFERENCE   6  (bases 1 to 690)
  AUTHORS   Luzzati,A.L., Giacomini,E., Giordani,L., Pugliese,O., Viora,M. and
            Chersi,A.
  TITLE     The antigen-specific induction of normal human lymphocytes in vitro
            is down-regulated by a conserved HIV p24 epitope
  JOURNAL   Immunol Lett 33 (3), 307-314 (1992)
   PUBMED   1385321
  REMARK    Erratum:[Immunol Lett 1993 Jan;35(1):82]
REFERENCE   7  (bases 1 to 690)
  AUTHORS   Phillips,J.H., Hori,T., Nagler,A., Bhat,N., Spits,H. and
            Lanier,L.L.
  TITLE     Ontogeny of human natural killer (NK) cells: fetal NK cells mediate
            cytolytic function and express cytoplasmic CD3 epsilon,delta
            proteins
  JOURNAL   J Exp Med 175 (4), 1055-1066 (1992)
   PUBMED   1372642
REFERENCE   8  (bases 1 to 690)
  AUTHORS   Ko,L.J., Yamamoto,M., Leonard,M.W., George,K.M., Ting,P. and
            Engel,J.D.
  TITLE     Murine and human T-lymphocyte GATA-3 factors mediate transcription
            through a cis-regulatory element within the human T-cell receptor
            delta gene enhancer
  JOURNAL   Mol Cell Biol 11 (5), 2778-2784 (1991)
   PUBMED   2017177
REFERENCE   9  (bases 1 to 690)
  AUTHORS   Hori,T., de Waal Malefyt,R., Duncan,B.W., Harrison,M.R.,
            Roncarolo,M.G. and Spits,H.
  TITLE     Cloning of a novel cell type from human fetal liver expressing
            cytoplasmic CD3 delta and epsilon but not membrane CD3
  JOURNAL   Int Immunol 3 (4), 353-357 (1991)
   PUBMED   1831653
REFERENCE   10 (bases 1 to 690)
  AUTHORS   Alarcon,B., Ley,S.C., Sanchez-Madrid,F., Blumberg,R.S., Ju,S.T.,
            Fresno,M. and Terhorst,C.
  TITLE     The CD3-gamma and CD3-delta subunits of the T cell antigen receptor
            can be expressed within distinct functional TCR/CD3 complexes
  JOURNAL   EMBO J 10 (4), 903-912 (1991)
   PUBMED   1826255
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC070321.1, CD014058.1 and
            AP001582.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001040651.1.
            
            Summary: The protein encoded by this gene is part of the T-cell
            receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell
            development and signal transduction. The encoded membrane protein
            represents the delta subunit of the CD3 complex, and along with
            four other CD3 subunits, binds either TCR alpha/beta or TCR
            gamma/delta to form the TCR/CD3 complex on the surface of T-cells.
            Defects in this gene are a cause of severe combined
            immunodeficiency autosomal recessive
            T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two
            transcript variants encoding different isoforms have been found for
            this gene. Other variants may also exist, but the full-length
            natures of their transcripts has yet to be defined. [provided by
            RefSeq, Feb 2009].
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region, compared to variant 1. The encoded protein (B) is shorter
            and lacks the transmembrane domain, compared to isoform A.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD014058.1, AI219691.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2146236,
                                           SAMEA2150385 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BC070321.1         40-113
            75-550              CD014058.1         1-476
            551-570             BC070321.1         722-741
            571-690             AP001582.4         51965-52084         c
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..690
                     /gene="CD3D"
                     /gene_synonym="CD3-DELTA; CD3DELTA; IMD19; T3D"
                     /note="CD3 delta subunit of T-cell receptor complex"
                     /db_xref="GeneID:915"
                     /db_xref="HGNC:HGNC:1673"
                     /db_xref="MIM:186790"
     exon            1..153
                     /gene="CD3D"
                     /gene_synonym="CD3-DELTA; CD3DELTA; IMD19; T3D"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..482
                     /gene="CD3D"
                     /gene_synonym="CD3-DELTA; CD3DELTA; IMD19; T3D"
                     /note="isoform B precursor is encoded by transcript
                     variant 2; CD3d antigen, delta polypeptide (TiT3 complex);
                     OKT3, delta chain; CD3 antigen, delta subunit; T-cell
                     receptor T3 delta chain; CD3 delta; CD3d molecule, delta
                     (CD3-TCR complex)"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD3 delta chain
                     isoform B precursor"
                     /protein_id="NP_001035741.1"
                     /db_xref="CCDS:CCDS41724.1"
                     /db_xref="GeneID:915"
                     /db_xref="HGNC:HGNC:1673"
                     /db_xref="MIM:186790"
                     /translation="MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWV
                     EGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRTADTQALLRND
                     QVYQPLRDRDDAQYSHLGGNWARNK"
     exon            154..372
                     /gene="CD3D"
                     /gene_synonym="CD3-DELTA; CD3DELTA; IMD19; T3D"
                     /inference="alignment:Splign:2.1.0"
     exon            373..416
                     /gene="CD3D"
                     /gene_synonym="CD3-DELTA; CD3DELTA; IMD19; T3D"
                     /inference="alignment:Splign:2.1.0"
     exon            417..690
                     /gene="CD3D"
                     /gene_synonym="CD3-DELTA; CD3DELTA; IMD19; T3D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      546..551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD3D"
                     /gene_synonym="CD3-DELTA; CD3DELTA; IMD19; T3D"
                     /note="hexamer: AATAAA"
     polyA_site      569
                     /gene="CD3D"
                     /gene_synonym="CD3-DELTA; CD3DELTA; IMD19; T3D"
                     /note="major polyA site"
ORIGIN      
        1 ctttccggta cctgtgagtc agctagggga gggcagctct cacccaggct gatagttcgg
       61 tgacctggct ttatctactg gatgagttcc gctgggagat ggaacatagc acgtttctct
      121 ctggcctggt actggctacc cttctctcgc aagtgagccc cttcaagata cctatagagg
      181 aacttgagga cagagtgttt gtgaattgca ataccagcat cacatgggta gagggaacgg
      241 tgggaacact gctctcagac attacaagac tggacctggg aaaacgcatc ctggacccac
      301 gaggaatata taggtgtaat gggacagata tatacaagga caaagaatct accgtgcaag
      361 ttcattatcg aactgccgac acacaagctc tgttgaggaa tgaccaggtc tatcagcccc
      421 tccgagatcg agatgatgct cagtacagcc accttggagg aaactgggct cggaacaagt
      481 gaacctgaga ctggtggctt ctagaagcag ccattaccaa ctgtaccttc ccttcttgct
      541 cagccaataa atatatcctc tttcactcag caggtgcctg ggcttcttaa ggctcctggg
      601 caaggcgtgg gagttgtcct gacttgcttg ggatctcgcc ctcctaccta cctgtttctt
      661 ccttcatctc cttccttcct ctgcctcaca
//
