LOCUS       NM_001775               5620 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens CD38 molecule (CD38), transcript variant 1, mRNA.
ACCESSION   NM_001775
VERSION     NM_001775.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5620)
  AUTHORS   Katsuyama,E., Humbel,M., Suarez-Fueyo,A., Satyam,A., Yoshida,N.,
            Kyttaris,V.C., Tsokos,M.G. and Tsokos,G.C.
  TITLE     CD38 in SLE CD4 T cells promotes Ca2+ flux and suppresses
            interleukin-2 production by enhancing the expression of GM2 on the
            surface membrane
  JOURNAL   Nat Commun 15 (1), 8304 (2024)
   PUBMED   39333474
  REMARK    GeneRIF: CD38 in SLE CD4 T cells promotes Ca[2+] flux and
            suppresses interleukin-2 production by enhancing the expression of
            GM2 on the surface membrane.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5620)
  AUTHORS   Nguyen,C.T., Nakayama,M., Ishigaki,H., Kitagawa,Y., Kakino,A.,
            Ohno,M., Shingai,M., Suzuki,Y., Sawamura,T., Kida,H. and Itoh,Y.
  TITLE     Increased expression of CD38 on endothelial cells in SARS-CoV-2
            infection in cynomolgus macaques
  JOURNAL   Virology 594, 110052 (2024)
   PUBMED   38507920
  REMARK    GeneRIF: Increased expression of CD38 on endothelial cells in
            SARS-CoV-2 infection in cynomolgus macaques.
REFERENCE   3  (bases 1 to 5620)
  AUTHORS   Zhao,Y.J., Lam,C.M. and Lee,H.C.
  TITLE     The membrane-bound enzyme CD38 exists in two opposing orientations
  JOURNAL   Sci Signal 5 (241), ra67 (2012)
   PUBMED   22969159
  REMARK    GeneRIF: The identification of these two forms of CD38 suggests
            that flipping the catalytic domain from the outside to the inside
            of the cell may be a mechanism regulating its signaling activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5620)
  AUTHORS   Liu,Q., Kriksunov,I.A., Graeff,R., Munshi,C., Lee,H.C. and Hao,Q.
  TITLE     Crystal structure of human CD38 extracellular domain
  JOURNAL   Structure 13 (9), 1331-1339 (2005)
   PUBMED   16154090
  REMARK    GeneRIF: The crystal structure of the soluble extracellular domain
            of human CD38 to 1.9 A resolution was determined.
REFERENCE   5  (bases 1 to 5620)
  AUTHORS   Nata,K., Takamura,T., Karasawa,T., Kumagai,T., Hashioka,W.,
            Tohgo,A., Yonekura,H., Takasawa,S., Nakamura,S. and Okamoto,H.
  TITLE     Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose
            hydrolase): organization, nucleotide sequence and alternative
            splicing
  JOURNAL   Gene 186 (2), 285-292 (1997)
   PUBMED   9074508
REFERENCE   6  (bases 1 to 5620)
  AUTHORS   Dianzani,U., Bragardo,M., Buonfiglio,D., Redoglia,V., Funaro,A.,
            Portoles,P., Rojo,J., Malavasi,F. and Pileri,A.
  TITLE     Modulation of CD4 lateral interaction with lymphocyte surface
            molecules induced by HIV-1 gp120
  JOURNAL   Eur J Immunol 25 (5), 1306-1311 (1995)
   PUBMED   7539755
REFERENCE   7  (bases 1 to 5620)
  AUTHORS   Takasawa,S., Tohgo,A., Noguchi,N., Koguma,T., Nata,K., Sugimoto,T.,
            Yonekura,H. and Okamoto,H.
  TITLE     Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte
            antigen CD38 and inhibition of the hydrolysis by ATP
  JOURNAL   J Biol Chem 268 (35), 26052-26054 (1993)
   PUBMED   8253715
REFERENCE   8  (bases 1 to 5620)
  AUTHORS   Takasawa,S., Nata,K., Yonekura,H. and Okamoto,H.
  TITLE     Cyclic ADP-ribose in insulin secretion from pancreatic beta cells
  JOURNAL   Science 259 (5093), 370-373 (1993)
   PUBMED   8420005
REFERENCE   9  (bases 1 to 5620)
  AUTHORS   States,D.J., Walseth,T.F. and Lee,H.C.
  TITLE     Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase
            and human lymphocyte antigen CD38
  JOURNAL   Trends Biochem Sci 17 (12), 495 (1992)
   PUBMED   1471258
  REMARK    Review article
REFERENCE   10 (bases 1 to 5620)
  AUTHORS   Jackson,D.G. and Bell,J.I.
  TITLE     Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell
            surface glycoprotein with an unusual discontinuous pattern of
            expression during lymphocyte differentiation
  JOURNAL   J Immunol 144 (7), 2811-2815 (1990)
   PUBMED   2319135
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK303169.1, BC007964.2 and
            AC005798.10.
            
            On Nov 22, 2018 this sequence version replaced NM_001775.3.
            
            Summary: The protein encoded by this gene is a
            non-lineage-restricted, type II transmembrane glycoprotein that
            synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose,
            an intracellular calcium ion mobilizing messenger. The release of
            soluble protein and the ability of membrane-bound protein to become
            internalized indicate both extracellular and intracellular
            functions for the protein. This protein has an N-terminal
            cytoplasmic tail, a single membrane-spanning domain, and a
            C-terminal extracellular region with four N-glycosylation sites.
            Crystal structure analysis demonstrates that the functional
            molecule is a dimer, with the central portion containing the
            catalytic site. It is used as a prognostic marker for patients with
            chronic lymphocytic leukemia. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.271551.1,
                                           SRR1660805.73007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226279.8/ ENSP00000226279.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AK303169.1         54-201
            149-990             BC007964.2         110-951
            991-5620            AC005798.10        88128-92757         c
FEATURES             Location/Qualifiers
     source          1..5620
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.32"
     gene            1..5620
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /note="CD38 molecule"
                     /db_xref="GeneID:952"
                     /db_xref="HGNC:HGNC:1667"
                     /db_xref="MIM:107270"
     exon            1..320
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..990
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /EC_number="3.2.2.6"
                     /EC_number="2.4.99.20"
                     /note="CD38 antigen (p45); NAD(+) nucleosidase;
                     ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase 1;
                     2'-phospho-ADP-ribosyl cyclase;
                     2'-phospho-cyclic-ADP-ribose transferase; cluster of
                     differentiation 38; ecto-nicotinamide adenine dinucleotide
                     glycohydrolase"
                     /codon_start=1
                     /product="ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
                     1"
                     /protein_id="NP_001766.2"
                     /db_xref="CCDS:CCDS3417.1"
                     /db_xref="GeneID:952"
                     /db_xref="HGNC:HGNC:1667"
                     /db_xref="MIM:107270"
                     /translation="MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVP
                     RWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNIT
                     EEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWC
                     GEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDK
                     NSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCK
                     NIYRPDKFLQCVKNPEDSSCTSEI"
     exon            321..450
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..586
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..672
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..746
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..839
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..926
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..5620
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5601..5606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /note="hexamer: AATAAA"
     polyA_site      5620
                     /gene="CD38"
                     /gene_synonym="ADPRC 1; ADPRC1; cADPR1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtttcag aacccagcca gcctctctct tgctgcctag cctcctgccg gcctcatctt
       61 cgcccagcca accccgcctg gagccctatg gccaactgcg agttcagccc ggtgtccggg
      121 gacaaaccct gctgccggct ctctaggaga gcccaactct gtcttggcgt cagtatcctg
      181 gtcctgatcc tcgtcgtggt gctcgcggtg gtcgtcccga ggtggcgcca gcagtggagc
      241 ggtccgggca ccaccaagcg ctttcccgag accgtcctgg cgcgatgcgt caagtacact
      301 gaaattcatc ctgagatgag acatgtagac tgccaaagtg tatgggatgc tttcaagggt
      361 gcatttattt caaaacatcc ttgcaacatt actgaagaag actatcagcc actaatgaag
      421 ttgggaactc agaccgtacc ttgcaacaag attcttcttt ggagcagaat aaaagatctg
      481 gcccatcagt tcacacaggt ccagcgggac atgttcaccc tggaggacac gctgctaggc
      541 taccttgctg atgacctcac atggtgtggt gaattcaaca cttccaaaat aaactatcaa
      601 tcttgcccag actggagaaa ggactgcagc aacaaccctg tttcagtatt ctggaaaacg
      661 gtttcccgca ggtttgcaga agctgcctgt gatgtggtcc atgtgatgct caatggatcc
      721 cgcagtaaaa tctttgacaa aaacagcact tttgggagtg tggaagtcca taatttgcaa
      781 ccagagaagg ttcagacact agaggcctgg gtgatacatg gtggaagaga agattccaga
      841 gacttatgcc aggatcccac cataaaagag ctggaatcga ttataagcaa aaggaatatt
      901 caattttcct gcaagaatat ctacagacct gacaagtttc ttcagtgtgt gaaaaatcct
      961 gaggattcat cttgcacatc tgagatctga gccagtcgct gtggttgttt tagctccttg
     1021 actccttgtg gtttatgtca tcatacatga ctcagcatac ctgctggtgc agagctgaag
     1081 attttggagg gtcctccaca ataaggtcaa tgccagagac ggaagccttt ttccccaaag
     1141 tcttaaaata acttatatca tcagcatacc tttattgtga tctatcaata gtcaagaaaa
     1201 attattgtat aagattagaa tgaaaattgt atgttaagtt acttcacttt aattctcatg
     1261 tgatcctttt atgttattta tatattggta acatcctttc tattgaaaaa tcaccacacc
     1321 aaacctctct tattagaaca ggcaagtgaa gaaaagtgaa tgctcaagtt tttcagaaag
     1381 cattacattt ccaaatgaat gaccttgttg catgatgtat ttttgtaccc ttcctacaga
     1441 tagtcaaacc ataaacttca tggtcatggg tcatgttggt gaaaattatt ctgtaggata
     1501 taagctaccc acgtacttgg tgctttaccc caacccttcc aacagtgctg tgaggttggt
     1561 attatttcat tttttagatg agaaaatggg agctcagaga ggttatatat ttaagttggt
     1621 gcaaaagtaa ttgcaagttt tgccaccgaa aggaatggca aaaccacaat tatttttgaa
     1681 ccaacctaat aatttaccgt aagtcctaca tttagtatca agctagagac tgaatttgaa
     1741 ctcaactctg tccaactcca aaattcatgt gctttttcct tctaggcctt tcataccaaa
     1801 ctaatagtag tttatattct cttccaacaa atgcatattg gattaaattg actagaatgg
     1861 aatctggaat atagttcttc tggatggctc caaaacacat gtttttcttc ccccgtcttc
     1921 ctcctcctct tcatgctcag tgttttatat atgtagtata cagttaaaat atacttgttg
     1981 ctggtactgg cagcttatat tttctctctt ttttcatgga ttaaccttgc ttgagggctt
     2041 taacaattgt attacttttt caaagaacta agctttagct tcattgattt ttttctattt
     2101 aattgggttt tgctcttctc tttagcattg gaaacataga aatgctttct gatttctttg
     2161 ggtagattta cgtattcagc ttcttgagat ggaagtttag atcactgatc cttcagcttg
     2221 ttttcttttt tgtatacata gattttagga cgatatattt tcccttgagt tctgctttag
     2281 ctgcagctct tatgttttga tatgcctctc tttattatcc ttcagttaaa aatatctttc
     2341 aattcattgt tatataaaaa tatgtgccta gtttttaaca tctggagatt ttctagtttt
     2401 gaaaaaaaca taagccaggc atggtggctc acacctgtat ccccagcact ttgggaggcc
     2461 gagacgggag gatcgcctga gctcaggagt ttttacacca gcctgggaat aacagtgaga
     2521 cattatctcc aaaaaaatta cctgggtatg gtgttgtgca cctgtagtcc cagctactct
     2581 ggagactgag gtgggaggat tgtttgagct tgggaggttg aggctgcagg gagctgtgat
     2641 cacaccactg cactctggcc tgagtgacag attgagaccc tgtctcaata aaagcaaaaa
     2701 taaagaaaat aaaccatatg tgttgaacaa aggattaata aattaatttg agactccttc
     2761 agggaatgac cacaatttat tgaaaatagc ctaaatgttg gagtcaggca tttctggatt
     2821 catattttga catcatgctg tcatcttgaa caaaatgcct aacctttctg aacttcaact
     2881 tccttgccac tcaaataagg attacaaaac ttaaaatgtg gtaagtacta aagacgacag
     2941 caaaaattga gtccagcaca gagcttccta aataagcaag cactcaacag agttggttcc
     3001 tttcttcctc ccctgcttga caatccagtt tcccacagga gcctttgtag ctgtagccac
     3061 catggtcagt ccagggattc ttcactagcc ccttctcccc tggcagacat ccttgtggga
     3121 gtttagtctt ggctcgacat gaggatgggg gtttgggacc agttctgagt gagaatcaga
     3181 cttgccccaa gttgccatta gctccccctg cagaatgtct tcagaatcgg ggcccggtca
     3241 gtctcctggg tgacctgctg ttttcctctt aagatccttt ccactttggt tgctgctttc
     3301 gggactcatc gagtccttgc tcaacaggat accccttgaa gtggctgcct gggccacatc
     3361 cccttccaaa caagaaatca aaatattaga aatcaatttt tgaaatttcc cctaggaaga
     3421 ctcatttgag tgttcaagtt cagagccagt ggagacctta ggggagggtg gtcacaagga
     3481 ttttgcacag tgctttagag ggtcccaggg agccacagag gtggtgaggg gctgggtgct
     3541 cttttctccg tgcatgacct tgtgtgtcta tcttcattac cacaatgcct catctctacc
     3601 tcctttcccc ctgtagttcc aacgtgggta tctttgccat ctctggcccg aaggactttc
     3661 tgacctacat gtataaatac cccctcacaa tatatattac ttttcctata agtgacttct
     3721 ctactggatt actggttgct catacacctc atattttact cgtaaatcta ctactccctg
     3781 tctgcctact ccattctcat ttgctgtaga aaattctctt accatcccaa ctttcaccca
     3841 ccatcatgct tacccaaagg ctgtgggaat gacctgggcc ctaatgcccc ttttctaaat
     3901 tcctaaggct caccattttc ctattgtaat ggttcttgac cttataatgt ttgaggcacc
     3961 ttttcaaata tagtcctttg atttcagact gaatacttga aaggacacac acacacatac
     4021 gtaagtgcat atgactgcat acacccacac acacacacgt gcctgtatac agtcatatga
     4081 tacatacaca aacacacgca cacaagcctg catacatcat atgccaacag tggggatatg
     4141 ttctgagaaa tgcatcatta gatgattttg tcattgtgtg aacatcatag agtgtactta
     4201 cactaaccta gatggtctaa cctactacac acccaggcta catggtatca cctattcctc
     4261 ctaggctaca agcctgtaca gcgtgtgtct gtactaaatg ctgtgggcaa ttttaacctg
     4321 atggtaaatg tttgtgtatc taaacatatc taaacataga aaaggtacag taaacatgca
     4381 gtattataat cttatgagac cgtcatcata tatgtggtcc actgtttggg ccatcattgg
     4441 ctgaaaagtg gttatgcgac acatgactgt atatatactt tcctgttaca acaacagtgt
     4501 ctctcaatcc acagtaattg cagcatccag taggtcttac tttagccctg agtcaccatt
     4561 tgtgtcaacg tgtttagtgc catgtccacg tctctcatgt aactggcaga gctatcaaat
     4621 attttggcaa aacacattgt ttctttggct ttgccttggt aactttctgt gccttttgta
     4681 gctcttgttt ggaagaagct caacccatgt ctgcacactg tgatacaagg gggacagcat
     4741 cgacatcgac ttacttcttg gtgccttatt cctccttaga acaattccta aatctgtaac
     4801 ttaagtttct caggaagatt ccatactgca cagaaaactg cttttgtggg tttttaaaag
     4861 gcaagttgtt atatgtgctg gatagttttt aagtatgaca taaaaattgt ataaagtaaa
     4921 atattaaaat acacctagaa tactgtataa ctttaagtca ttttatcaac acattgctaa
     4981 tccagatatt ttcccgcagt ttttctttga ataacagagc aattaattta cttttactat
     5041 gaagagtcat cattttagta tgtattttaa gcaatccacc aagaactcag taggcagctg
     5101 agaggtgctg cccagagaag tggtgattag cttggcctta gctcacccac acaaagcaca
     5161 acaggctttg aactattccc taacggggca tttattcttt tttttttttt tttttgggag
     5221 acggagtctc gctgtcgccc aggctagagt gcagtggcgc gatctcggct cactgcaggc
     5281 tccaccccct ggggttcacg ccattctcct gcctcagcct cccaagtagc tgggactgca
     5341 ggcgcccgcc atctcgcccg gctaattttt tgtattttta gtagagacgg ggtttcaccg
     5401 tgttagccag gatagggcat ttattcttga acttgattca gagaggcaca cattaccatt
     5461 ctctaatcag aatgcaagta gcgcaaggcg gtggaaacta tggaattcgg aggcaggtga
     5521 tgcattgggc gagtttatta acatctgtga ctctctagtt tgaaatttat ttgtaacaga
     5581 caaaaatgaa ttaaacaaac aataaaagta taataaagaa
//
