LOCUS       NM_001774               1259 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens CD37 molecule (CD37), transcript variant 1, mRNA.
ACCESSION   NM_001774
VERSION     NM_001774.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1259)
  AUTHORS   Bobrowicz,M., Kusowska,A., Krawczyk,M., Zhylko,A., Forcados,C.,
            Slusarczyk,A., Barankiewicz,J., Domagala,J., Kubacz,M., Smida,M.,
            Dostalova,L., Marhelava,K., Fidyt,K., Pepek,M., Baranowska,I.,
            Szumera-Cieckiewicz,A., Inderberg,E.M., Walchli,S., Granica,M.,
            Graczyk-Jarzynka,A., Majchrzak,M., Poreba,M., Gehlert,C.L.,
            Peipp,M., Firczuk,M., Prochorec-Sobieszek,M. and Winiarska,M.
  TITLE     CD20 expression regulates CD37 levels in B-cell lymphoma -
            implications for immunotherapies
  JOURNAL   Oncoimmunology 13 (1), 2362454 (2024)
   PUBMED   38846084
  REMARK    GeneRIF: CD20 expression regulates CD37 levels in B-cell lymphoma -
            implications for immunotherapies.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1259)
  AUTHORS   Yoshimura,T., Miyoshi,H., Shimono,J., Nakashima,K., Takeuchi,M.,
            Yanagida,E., Yamada,K., Shimasaki,Y., Moritsubo,M., Furuta,T.,
            Kohno,K. and Ohshima,K.
  TITLE     CD37 expression in follicular lymphoma
  JOURNAL   Ann Hematol 101 (5), 1067-1075 (2022)
   PUBMED   35171311
  REMARK    GeneRIF: CD37 expression in follicular lymphoma.
REFERENCE   3  (bases 1 to 1259)
  AUTHORS   Zhang,Q., Han,Q., Zi,J., Song,C. and Ge,Z.
  TITLE     CD37 high expression as a potential biomarker and association with
            poor outcome in acute myeloid leukemia
  JOURNAL   Biosci Rep 40 (5) (2020)
   PUBMED   32400873
  REMARK    GeneRIF: CD37 high expression as a potential biomarker and
            association with poor outcome in acute myeloid leukemia.
REFERENCE   4  (bases 1 to 1259)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1259)
  AUTHORS   Elfrink,S., de Winde,C.M., van den Brand,M., Berendsen,M.,
            Roemer,M.G.M., Arnold,F., Janssen,L., van der Schaaf,A., Jansen,E.,
            Groenen,P.J.T.A., Eijkelenboom,A., Stevens,W., Hess,C.J., van
            Krieken,J.H., Vermaat,J.S.P., Cleven,A.H.G., de Groen,R.A.L.,
            Neviani,V., de Jong,D., van Deventer,S., Scheijen,B. and van
            Spriel,A.B.
  TITLE     High frequency of inactivating tetraspanin CD37 mutations in
            diffuse large B-cell lymphoma at immune-privileged sites
  JOURNAL   Blood 134 (12), 946-950 (2019)
   PUBMED   31366619
  REMARK    GeneRIF: From a cohort of 137 primary diffuse large B-cell lymphoma
            (DLBCL) samples. CD37 mutations were exclusively identified in
            immune-privileged site-associated DLBCL (IP-DLBCL) cases but absent
            in non-IP-DLBCL cases. Modeling and functional analysis of CD37
            missense mutations revealed loss of function by impaired CD37
            protein expression at the plasma membrane of human lymphoma B
            cells.
REFERENCE   6  (bases 1 to 1259)
  AUTHORS   Angelisova,P., Hilgert,I. and Horejsi,V.
  TITLE     Association of four antigens of the tetraspans family (CD37, CD53,
            TAPA-1, and R2/C33) with MHC class II glycoproteins
  JOURNAL   Immunogenetics 39 (4), 249-256 (1994)
   PUBMED   8119731
REFERENCE   7  (bases 1 to 1259)
  AUTHORS   Horejsi,V. and Vlcek,C.
  TITLE     Novel structurally distinct family of leucocyte surface
            glycoproteins including CD9, CD37, CD53 and CD63
  JOURNAL   FEBS Lett 288 (1-2), 1-4 (1991)
   PUBMED   1879540
  REMARK    Review article
REFERENCE   8  (bases 1 to 1259)
  AUTHORS   Classon,B.J., Williams,A.F., Willis,A.C., Seed,B. and
            Stamenkovic,I.
  TITLE     The primary structure of the human leukocyte antigen CD37, a
            species homologue of the rat MRC OX-44 antigen
  JOURNAL   J Exp Med 172 (3), 1007 (1990)
   PUBMED   2388030
  REMARK    Correction to:[J Exp Med. 1989 Apr 1;169(4):1497-502. doi:
            10.1084/jem.169.4.1497.. PMID: 2466944]
REFERENCE   9  (bases 1 to 1259)
  AUTHORS   Classon,B.J., Williams,A.F., Willis,A.C., Seed,B. and
            Stamenkovic,I.
  TITLE     The primary structure of the human leukocyte antigen CD37, a
            species homologue of the rat MRC OX-44 antigen
  JOURNAL   J Exp Med 169 (4), 1497-1502 (1989)
   PUBMED   2466944
  REMARK    Erratum:[J Exp Med. 1990 Sep 1;172(3):1007. doi:
            10.1084/jem.172.3.1007.. PMID: 2388030]
REFERENCE   10 (bases 1 to 1259)
  AUTHORS   Schwartz-Albiez,R., Dorken,B., Hofmann,W. and Moldenhauer,G.
  TITLE     The B cell-associated CD37 antigen (gp40-52). Structure and
            subcellular expression of an extensively glycosylated glycoprotein
  JOURNAL   J Immunol 140 (3), 905-914 (1988)
   PUBMED   3257508
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011450.4, BP309557.1,
            AC010524.6 and AA767248.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001774.2.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            This encoded protein is a cell surface glycoprotein that is known
            to complex with integrins and other transmembrane 4 superfamily
            proteins. It may play a role in T-cell-B-cell interactions.
            Alternate splicing results in multiple transcript variants encoding
            different isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.274576.1,
                                           SRR1163657.303000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323906.9/ ENSP00000325708.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC011450.4         14296-14309         c
            15-26               BP309557.1         21-32
            27-204              AC011450.4         14106-14283         c
            205-277             AC011450.4         13929-14001         c
            278-402             AC011450.4         12682-12806         c
            403-477             AC011450.4         12494-12568         c
            478-582             AC011450.4         11686-11790         c
            583-819             AC011450.4         10779-11015         c
            820-903             AC011450.4         10302-10385         c
            904-1218            AC010524.6         1412-1726
            1219-1259           AA767248.1         19-59               c
FEATURES             Location/Qualifiers
     source          1..1259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1259
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /note="CD37 molecule"
                     /db_xref="GeneID:951"
                     /db_xref="HGNC:HGNC:1666"
                     /db_xref="MIM:151523"
     exon            1..204
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..981
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /note="isoform A is encoded by transcript variant 1; cell
                     differentiation antigen 37; leukocyte surface antigen
                     CD37; tetraspanin-26; tspan-26"
                     /codon_start=1
                     /product="leukocyte antigen CD37 isoform A"
                     /protein_id="NP_001765.1"
                     /db_xref="CCDS:CCDS12760.1"
                     /db_xref="GeneID:951"
                     /db_xref="HGNC:HGNC:1666"
                     /db_xref="MIM:151523"
                     /translation="MSAQESCLSLIKYFLFVFNLFFFVLGSLIFCFGIWILIDKTSFV
                     SFVGLAFVPLQIWSKVLAISGIFTMGIALLGCVGALKELRCLLGLYFGMLLLLFATQI
                     TLGILISTQRAQLERSLRDVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQD
                     WFQVLILRGNGSEAHRVPCSCYNLSATNDSTILDKVILPQLSRLGHLARSRHSADICA
                     VPAESHIYREGCAQGLQKWLHNNLISIVGICLGVGLLELGFMTLSIFLCRNLDHVYNR
                     LARYR"
     exon            205..277
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /inference="alignment:Splign:2.1.0"
     exon            278..402
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /inference="alignment:Splign:2.1.0"
     exon            403..477
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /inference="alignment:Splign:2.1.0"
     exon            478..582
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /inference="alignment:Splign:2.1.0"
     exon            583..819
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /inference="alignment:Splign:2.1.0"
     exon            820..903
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1259
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1233..1238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /note="hexamer: AATAAA"
     polyA_site      1259
                     /gene="CD37"
                     /gene_synonym="GP52-40; TSPAN26"
                     /note="major polyA site"
ORIGIN      
        1 ctcttttggg gttcttcctt tctctctcag ctctccgtct ctctttctct ctcagcctct
       61 ttctttctcc ctgtctcccc cactgtcagc acctcttctg tgtggtgagt ggaccgctta
      121 ccccactagg tgaagatgtc agcccaggag agctgcctca gcctcatcaa gtacttcctc
      181 ttcgttttca acctcttctt cttcgtcctc ggcagcctga tcttctgctt cggcatctgg
      241 atcctcattg acaagaccag cttcgtgtcc tttgtgggct tggccttcgt gcctctgcag
      301 atctggtcca aagtcctggc catctcagga atcttcacca tgggcatcgc cctcctgggt
      361 tgtgtggggg ccctcaagga gctccgctgc ctcctgggcc tgtattttgg gatgctgctg
      421 ctcctgtttg ccacacagat caccctggga atcctcatct ccactcagcg ggcccagctg
      481 gagcgaagct tgcgggacgt cgtagagaaa accatccaaa agtacggcac caaccccgag
      541 gagaccgcgg ccgaggagag ctgggactat gtgcagttcc agctgcgctg ctgcggctgg
      601 cactacccgc aggactggtt ccaagtcctc atcctgagag gtaacgggtc ggaggcgcac
      661 cgcgtgccct gctcctgcta caacttgtcg gcgaccaacg actccacaat cctagataag
      721 gtgatcttgc cccagctcag caggcttgga cacctggcgc ggtccagaca cagtgcagac
      781 atctgcgctg tccctgcaga gagccacatc taccgcgagg gctgcgcgca gggcctccag
      841 aagtggctgc acaacaacct tatttccata gtgggcattt gcctgggcgt cggcctactc
      901 gagctcgggt tcatgacgct ctcgatattc ctgtgcagaa acctggacca cgtctacaac
      961 cggctcgctc gataccgtta ggccccgccc tccccaaagt cccgccccgc ccccgtcacg
     1021 tgcgctgggc acttccctgc tgcctgtaaa tatttgttta atccccagtt cgcctggagc
     1081 cctccgcctt cacattcccc tggggaccca cgtggctgcg tgcccctgct gctgtcacct
     1141 ctcccacggg acctggggct ttcgtccaca gcttcctgtc cccatctgtc ggcctaccac
     1201 cacccacaag attatttttc acccaaacct caaataaatc ccctgcgttt ttggtaaaa
//
