LOCUS       NM_001772               1462 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens CD33 molecule (CD33), transcript variant 1, mRNA.
ACCESSION   NM_001772
VERSION     NM_001772.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Duran-Castells,C., Prats,A., Oriol-Tordera,B., Llano,A., Galvez,C.,
            Martinez-Picado,J., Ballana,E., Garcia-Vidal,E., Clotet,B.,
            Munoz-Moreno,J.A., Hanke,T., Molto,J., Mothe,B., Brander,C. and
            Ruiz-Riol,M.
  TITLE     Plasma proteomic profiling identifies CD33 as a marker of HIV
            control in natural infection and after therapeutic vaccination
  JOURNAL   EBioMedicine 95, 104732 (2023)
   PUBMED   37506557
  REMARK    GeneRIF: Plasma proteomic profiling identifies CD33 as a marker of
            HIV control in natural infection and after therapeutic vaccination.
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   Tian,Q., Sun,X., Li,C., Yang,Y., Hou,B. and Xie,A.
  TITLE     CD33 polymorphisms and Parkinson's disease Parkinson's disease in
            northern Chinese Han population: A case-control study
  JOURNAL   Neurosci Lett 812, 137400 (2023)
   PUBMED   37479176
  REMARK    GeneRIF: CD33 polymorphisms and Parkinson's disease Parkinson's
            disease in northern Chinese Han population: A case-control study.
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   Siokas,V., Liampas,I., Aloizou,A.M., Bakirtzis,C., Tsouris,Z.,
            Nousia,A., Nasios,G., Papadimitriou,D., Lavdas,E., Liakos,P.,
            Bogdanos,D.P., Hadjigeorgiou,G.M. and Dardiotis,E.
  TITLE     Lack of Association between CD33 rs3865444 and Amyotrophic Lateral
            Sclerosis: A Case-Control Study
  JOURNAL   J Integr Neurosci 22 (4), 106 (2023)
   PUBMED   37519183
  REMARK    GeneRIF: Lack of Association between CD33 rs3865444 and Amyotrophic
            Lateral Sclerosis: A Case-Control Study.
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Sereshki,N., Rafiee,M., Alipour,R., Rahimyan,K. and Wilkinson,D.
  TITLE     CD33 as a leukocyte-associated marker expressed on human
            spermatozoa
  JOURNAL   BMC Res Notes 16 (1), 57 (2023)
   PUBMED   37081561
  REMARK    GeneRIF: CD33 as a leukocyte-associated marker expressed on human
            spermatozoa.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Komuro,R., Honda,Y., Yanaizu,M., Nagahama,M. and Kino,Y.
  TITLE     Alzheimer's Disease-Associated Alternative Splicing of CD33 Is
            Regulated by the HNRNPA Family Proteins
  JOURNAL   Cells 12 (4), 602 (2023)
   PUBMED   36831269
  REMARK    GeneRIF: Alzheimer's Disease-Associated Alternative Splicing of
            CD33 Is Regulated by the HNRNPA Family Proteins.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Freeman,S.D., Kelm,S., Barber,E.K. and Crocker,P.R.
  TITLE     Characterization of CD33 as a new member of the sialoadhesin family
            of cellular interaction molecules
  JOURNAL   Blood 85 (8), 2005-2012 (1995)
   PUBMED   7718872
REFERENCE   7  (bases 1 to 1462)
  AUTHORS   Handgretinger,R., Schafer,H.J., Baur,F., Frank,D., Ottenlinger,C.,
            Buhring,H.J. and Niethammer,D.
  TITLE     Expression of an early myelopoietic antigen (CD33) on a subset of
            human umbilical cord blood-derived natural killer cells
  JOURNAL   Immunol Lett 37 (2-3), 223-228 (1993)
   PUBMED   7505004
REFERENCE   8  (bases 1 to 1462)
  AUTHORS   Egner,W., McKenzie,J.L., Smith,S.M., Beard,M.E. and Hart,D.N.
  TITLE     Identification of potent mixed leukocyte reaction-stimulatory cells
            in human bone marrow. Putative differentiation stage of human blood
            dendritic cells
  JOURNAL   J Immunol 150 (7), 3043-3053 (1993)
   PUBMED   8454872
REFERENCE   9  (bases 1 to 1462)
  AUTHORS   Adriaansen,H.J., Guerts van Kessel,A.H., Wijdenes-de Bresser,J.H.,
            van Drunen-Schoenmaker,E. and van Dongen,J.J.
  TITLE     Expression of the myeloid differentiation antigen CD33 depends on
            the presence of human chromosome 19 in human-mouse hybrids
  JOURNAL   Ann Hum Genet 54 (2), 115-119 (1990)
   PUBMED   1696442
REFERENCE   10 (bases 1 to 1462)
  AUTHORS   Simmons,D. and Seed,B.
  TITLE     Isolation of a cDNA encoding CD33, a differentiation antigen of
            myeloid progenitor cells
  JOURNAL   J Immunol 141 (8), 2797-2800 (1988)
   PUBMED   3139766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP303860.1, BC028152.1 and AW007749.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001772.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1), also known as
            CD33M.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.990782.1,
                                           SRR5189658.70557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262262.5/ ENSP00000262262.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BP303860.1         2-42
            42-174              BP303860.1         44-176
            175-244             BP303860.1         178-247
            245-1459            BC028152.1         211-1425
            1460-1462           AW007749.1         4-6                 c
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1462
                     /gene="CD33"
                     /gene_synonym="CD33rSiglec; p67; SIGLEC-3; SIGLEC3"
                     /note="CD33 molecule"
                     /db_xref="GeneID:945"
                     /db_xref="HGNC:HGNC:1659"
                     /db_xref="MIM:159590"
     exon            1..76
                     /gene="CD33"
                     /gene_synonym="CD33rSiglec; p67; SIGLEC-3; SIGLEC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1134
                     /gene="CD33"
                     /gene_synonym="CD33rSiglec; p67; SIGLEC-3; SIGLEC3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD33 antigen (gp67); myeloid cell surface
                     antigen CD33; CD33 molecule transcript; sialic
                     acid-binding Ig-like lectin 3"
                     /codon_start=1
                     /product="myeloid cell surface antigen CD33 isoform 1
                     precursor"
                     /protein_id="NP_001763.3"
                     /db_xref="CCDS:CCDS33084.1"
                     /db_xref="GeneID:945"
                     /db_xref="HGNC:HGNC:1659"
                     /db_xref="MIM:159590"
                     /translation="MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFF
                     HPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCS
                     LSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKN
                     LTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAG
                     AGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGAIGGAGVTALLALCLC
                     LIFFIVKTHRRKAARTAVGRNDTHPTTGSASPKHQKKSKLHGPTETSSCSGAAPTVEM
                     DEELHYASLNFHGMNPSKDTSTEYSEVRTQ"
     exon            77..457
                     /gene="CD33"
                     /gene_synonym="CD33rSiglec; p67; SIGLEC-3; SIGLEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            458..736
                     /gene="CD33"
                     /gene_synonym="CD33rSiglec; p67; SIGLEC-3; SIGLEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            737..784
                     /gene="CD33"
                     /gene_synonym="CD33rSiglec; p67; SIGLEC-3; SIGLEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            785..881
                     /gene="CD33"
                     /gene_synonym="CD33rSiglec; p67; SIGLEC-3; SIGLEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            882..963
                     /gene="CD33"
                     /gene_synonym="CD33rSiglec; p67; SIGLEC-3; SIGLEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1462
                     /gene="CD33"
                     /gene_synonym="CD33rSiglec; p67; SIGLEC-3; SIGLEC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1437..1442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD33"
                     /gene_synonym="CD33rSiglec; p67; SIGLEC-3; SIGLEC3"
                     /note="hexamer: AATAAA"
     polyA_site      1462
                     /gene="CD33"
                     /gene_synonym="CD33rSiglec; p67; SIGLEC-3; SIGLEC3"
                     /note="major polyA site"
ORIGIN      
        1 ctgctcacac aggaagccct ggaagctgct tcctcagaca tgccgctgct gctactgctg
       61 cccctgctgt gggcaggggc cctggctatg gatccaaatt tctggctgca agtgcaggag
      121 tcagtgacgg tacaggaggg tttgtgcgtc ctcgtgccct gcactttctt ccatcccata
      181 ccctactacg acaagaactc cccagttcat ggttactggt tccgggaagg agccattata
      241 tccagggact ctccagtggc cacaaacaag ctagatcaag aagtacagga ggagactcag
      301 ggcagattcc gcctccttgg ggatcccagt aggaacaact gctccctgag catcgtagac
      361 gccaggagga gggataatgg ttcatacttc tttcggatgg agagaggaag taccaaatac
      421 agttacaaat ctccccagct ctctgtgcat gtgacagact tgacccacag gcccaaaatc
      481 ctcatccctg gcactctaga acccggccac tccaaaaacc tgacctgctc tgtgtcctgg
      541 gcctgtgagc agggaacacc cccgatcttc tcctggttgt cagctgcccc cacctccctg
      601 ggccccagga ctactcactc ctcggtgctc ataatcaccc cacggcccca ggaccacggc
      661 accaacctga cctgtcaggt gaagttcgct ggagctggtg tgactacgga gagaaccatc
      721 cagctcaacg tcacctatgt tccacagaac ccaacaactg gtatctttcc aggagatggc
      781 tcagggaaac aagagaccag agcaggagtg gttcatgggg ccattggagg agctggtgtt
      841 acagccctgc tcgctctttg tctctgcctc atcttcttca tagtgaagac ccacaggagg
      901 aaagcagcca ggacagcagt gggcaggaat gacacccacc ctaccacagg gtcagcctcc
      961 ccgaaacacc agaagaagtc caagttacat ggccccactg aaacctcaag ctgttcaggt
     1021 gccgccccta ctgtggagat ggatgaggag ctgcattatg cttccctcaa ctttcatggg
     1081 atgaatcctt ccaaggacac ctccaccgaa tactcagagg tcaggaccca gtgaggaacc
     1141 cacaagagca tcaggctcag ctagaagatc cacatcctct acaggtcggg gaccaaaggc
     1201 tgattcttgg agatttaaca ccccacaggc aatgggttta tagacattat gtgagtttcc
     1261 tgctatatta acatcatctt agactttgca agcagagagt cgtggaatca aatctgtgct
     1321 ctttcatttg ctaagtgtat gatgtcacac aagctcctta accttccatg tctccatttt
     1381 cttctctgtg aagtaggtat aagaagtcct atctcatagg gatgctgtga gcattaaata
     1441 aaggtacaca tggaaaacac ca
//
