LOCUS       NM_014880               3932 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens CD302 molecule (CD302), transcript variant 1, mRNA.
ACCESSION   NM_014880
VERSION     NM_014880.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3932)
  AUTHORS   Reinecke,B., Frericks,N., Lauber,C., Dinkelborg,K., Matthaei,A.,
            Vondran,F.W.R., Behrendt,P., Haid,S., Brown,R.J.P. and
            Pietschmann,T.
  TITLE     The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus
            Infection
  JOURNAL   J Virol 96 (7), e0199521 (2022)
   PUBMED   35297672
  REMARK    GeneRIF: The Human Liver-Expressed Lectin CD302 Restricts Hepatitis
            C Virus Infection.
REFERENCE   2  (bases 1 to 3932)
  AUTHORS   Watanabe,R., Song,C., Kayama,Y., Takemura,M. and Murata,K.
  TITLE     Particle Morphology of Medusavirus Inside and Outside the Cells
            Reveals a New Maturation Process of Giant Viruses
  JOURNAL   J Virol 96 (7), e0185321 (2022)
   PUBMED   35297671
  REMARK    GeneRIF: Particle Morphology of Medusavirus Inside and Outside the
            Cells Reveals a New Maturation Process of Giant Viruses.
REFERENCE   3  (bases 1 to 3932)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3932)
  AUTHORS   Lo,T.H., Silveira,P.A., Fromm,P.D., Verma,N.D., Vu,P.A.,
            Kupresanin,F., Adam,R., Kato,M., Cogger,V.C., Clark,G.J. and
            Hart,D.N.
  TITLE     Characterization of the Expression and Function of the C-Type
            Lectin Receptor CD302 in Mice and Humans Reveals a Role in
            Dendritic Cell Migration
  JOURNAL   J Immunol 197 (3), 885-898 (2016)
   PUBMED   27316686
  REMARK    GeneRIF: These studies confirm a functional role for CD302 in
            myeloid dendritic cells migration.
REFERENCE   5  (bases 1 to 3932)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3932)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 3932)
  AUTHORS   Yang,S., Noble,C.G. and Yang,D.
  TITLE     Characterization of DLC1-SAM equilibrium unfolding at the amino
            acid residue level
  JOURNAL   Biochemistry 48 (19), 4040-4049 (2009)
   PUBMED   19317456
  REMARK    GeneRIF: DLC1 equilibrium unfolding is characterized at the amino
            acid level.
REFERENCE   8  (bases 1 to 3932)
  AUTHORS   Kato,M., Khan,S., d'Aniello,E., McDonald,K.J. and Hart,D.N.
  TITLE     The novel endocytic and phagocytic C-Type lectin receptor
            DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting
            a role in cell adhesion and migration
  JOURNAL   J Immunol 179 (9), 6052-6063 (2007)
   PUBMED   17947679
  REMARK    GeneRIF: hDCL-1 is an unconventional lectin receptor that plays
            roles not only in endocytosis/phagocytosis but also in cell
            adhesion and migration
REFERENCE   9  (bases 1 to 3932)
  AUTHORS   Kato,M., Khan,S., Gonzalez,N., O'Neill,B.P., McDonald,K.J.,
            Cooper,B.J., Angel,N.Z. and Hart,D.N.
  TITLE     Hodgkin's lymphoma cell lines express a fusion protein encoded by
            intergenically spliced mRNA for the multilectin receptor DEC-205
            (CD205) and a novel C-type lectin receptor DCL-1
  JOURNAL   J Biol Chem 278 (36), 34035-34041 (2003)
   PUBMED   12824192
  REMARK    GeneRIF: Hodgkin's lymphoma cell lines express a fusion protein
            encoded by intergenically spliced mRNA for the multilectin receptor
            DEC-205 (CD205) and a novel C-type lectin receptor DCL-1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY314007.1, AK291279.1, AC009961.11 and CB240843.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014880.4.
            
            Summary: CD302 is a C-type lectin receptor involved in cell
            adhesion and migration, as well as endocytosis and phagocytosis
            (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.216017.1,
                                           SRR1660803.23779.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259053.6/ ENSP00000259053.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-743               AY314007.1         35-777
            744-1326            AK291279.1         744-1326
            1327-3928           AC009961.11        130677-133278       c
            3929-3932           CB240843.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..3932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..3932
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /note="CD302 molecule"
                     /db_xref="GeneID:9936"
                     /db_xref="HGNC:HGNC:30843"
                     /db_xref="MIM:612246"
     exon            1..77
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..709
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; C-type lectin domain family 13, member A; type
                     I transmembrane C-type lectin receptor DCL-1; CD302
                     antigen; DEC205-associated C-type lectin 1"
                     /codon_start=1
                     /product="CD302 antigen isoform 1 precursor"
                     /protein_id="NP_055695.2"
                     /db_xref="CCDS:CCDS33308.1"
                     /db_xref="GeneID:9936"
                     /db_xref="HGNC:HGNC:30843"
                     /db_xref="MIM:612246"
                     /translation="MLRAALPALLLPLLGLAAAAVADCPSSTWIQFQDSCYIFLQEAI
                     KVESIEDVRNQCTDHGADMISIHNEEENAFILDTLKKQWKGPDDILLGMFYDTDDASF
                     KWFDNSNMTFDKWTDQDDDEDLVDTCAFLHIKTGEWKKGNCEVSSVEGTLCKTAIPYK
                     RKYLSDNHILISALVIASTVILTVLGAIIWFLYKKHSDSRFTTVFSTAPQSPYNEDCV
                     LVVGEENEYPVQFD"
     exon            78..188
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..305
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..479
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..506
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..3932
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3684..3689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /note="hexamer: AATAAA"
     polyA_site      3709
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /note="major polyA site"
     regulatory      3912..3917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /note="hexamer: AATAAA"
     polyA_site      3932
                     /gene="CD302"
                     /gene_synonym="BIMLEC; CLEC13A; DCL-1; DCL1"
                     /note="major polyA site"
ORIGIN      
        1 acccgccgtc atgctccggg ccgcgctgcc cgcgctcctg ctgccgttgc tgggcctcgc
       61 cgctgctgcc gtcgcggact gtccttcatc tacttggatt cagttccaag acagttgtta
      121 catttttctc caagaagcca tcaaagtaga aagcatagag gatgtcagaa atcagtgtac
      181 tgaccatgga gcggacatga taagcataca taatgaagaa gaaaatgctt ttatactgga
      241 tactttgaaa aagcaatgga aaggcccaga tgatatccta ctaggcatgt tttatgacac
      301 agatgatgcg agtttcaagt ggtttgataa ttcaaatatg acatttgata agtggacaga
      361 ccaagatgat gatgaggatt tagttgacac ctgtgctttt ctgcacatca agacaggtga
      421 atggaaaaaa ggaaattgtg aagtttcttc tgtggaagga acactatgca aaacagctat
      481 cccatacaaa aggaaatatt tatcagataa ccacatttta atatcagcat tggtgattgc
      541 tagcacggta attttgacag ttttgggagc aatcatttgg ttcctgtaca aaaaacattc
      601 tgattctcgt ttcaccacag ttttttcaac cgcaccccaa tcaccttata atgaagactg
      661 tgttttggta gttggagaag aaaatgaata tcctgttcaa tttgactaag tttttggtaa
      721 tcttgcacta agacatcaac aaaatgccct ggcagagata acttgggaaa gattttaata
      781 taaaacttga cattggatat tagagcttta atggtattcc ttattccagt aacattttta
      841 tgtactcatc tgctgtgaaa agtctttagg ttcattaaaa aaacaggttt tagaaatgat
      901 cttagatcta atatagtgat tttaagcatc ccgtcaaagg cagaatctgt cacttgaatg
      961 aaggaaagct taaagcccaa gcagataaaa ataaaagccc agcctatttg tcttgcctgc
     1021 tgtatcttcc ctatttagtt gacccacttt agtttatatg tttattagta aacatgaaat
     1081 ggggaataag tgattttaag tacatcccat acatttaaat atctttgata attgttattt
     1141 ttttggcaga taattcctct agaatgtgta tctttttatg atttagatga agaaaatttt
     1201 acaactttta acaccccaca ccaattttag tttcattact tttacacaca ccattttatc
     1261 acaaatgact caagttttaa tgaatgttta taaattattt gaaacaaaat atgatcgctg
     1321 tgtccaggat ggcatagaga aagctggcaa ttaggttaac acttacatat tatagtgccc
     1381 ctttaaggat ttctctcttg ccaccatacc ttttgtactt tcccctatac aagatgtatc
     1441 tcattctcct caagcattta taaatttttc cttcaatgac atgaaaactg tgcaagcaaa
     1501 aaccgaagaa aaacacttaa gtacaactgt agtgacagtg atcaaagttt tcagtgcatt
     1561 tattgtacat tttaagaaaa aggtgaaaat catttgggga gtaaaaaaat gaaaaagctg
     1621 aaacgagtaa ttttcctcac catcaataaa ccaaaaacag gaaagataaa gaatgtataa
     1681 atttcacgta aattagtcac gtatcactta tcaatgggga tacgttctaa gaaatgcata
     1741 gttagggaat cttgtgtgaa aatcagcttg tatttacaca aacccagatg gtagagccta
     1801 ttttgtccca aacctacaca gcatgttact gtgctgaata ctgcagacaa ttgtaacaca
     1861 atatttgtgt atctaaatat agaaaaggta cagtaaaaat atggtctact aaggaaacac
     1921 tgttctatat gtggtccatt actgactgaa gtatactgtc tagaagtctg aggctcaaag
     1981 aaaagtaatc cctcttctga atccacaccc catcaattat cttactttct tctggggaga
     2041 tagatagata tactatctca ctagcttgac taatggcaac aaagttccag cttgtgtagt
     2101 ctctttttat tgaccacatg aatcgaaaac actcatcaca attaatggca ctatcattaa
     2161 tgagacatga gtaactaaaa agtgatagaa aactattaac agtgcggcta catggtactg
     2221 aaaatgcagg cattacacca gctgttacac aagcacaagc atgctctgta agagctttac
     2281 atttctgaga ttttgtatag tgattgagat gtctatttta ttattgatag actattacta
     2341 atgtcaatat tgaacactac cctggaattc ctgcctggtt ttcctaccca aattgtacca
     2401 ctccttgaag aactacaggc acagtaaaaa aaatatggcg tattatgtga actaaaagag
     2461 ttctaaagga gttcttaaag gagtggtaga atttgggtag gaaagtgatt aagtccaact
     2521 taaaaccaac agtctcaaac gtctacaact acaatgtcca atgagccact agccacatga
     2581 ggctatttaa gtaaatttag tttaaaatcc agttttcgaa ttacattagc cacattgtca
     2641 agtgttcaaa tcacaggtgg ttagtggcta ctgtactggg caacatacat tatagaacat
     2701 tttcattata ggaagtttta ttgggcagtg ctgctcttaa atcctacctt ccactcaact
     2761 cccatacaac tttcttttgt acattttgat actttctacc taatggcagc tcttccaaaa
     2821 tagctgcttt aaactctgat ttaattttca atatttggtt tcatttttca acaggccaag
     2881 aggcctctgg taatgaagtg ctatatatat atatatgatg gagtctcact gtgctgccca
     2941 ggctacagtg cagtggctcg atcttggctc tctccaatct ccgccttgca ggttttcaag
     3001 caattctcct gcctcagcct ccttagtagc tgggaccaca gacatctgtc accacaccca
     3061 gctaactttt tgtatttttg gtagagacgg ggtttcgcca tattgactgg gctggtctca
     3121 aactcctgac ctcaagtgat ccacccacct tggtctccca aagtgctggg attacatgcg
     3181 tgagccacca cacttggcct acattttttc tttatatacc agaacatcta taacaggcac
     3241 cttatctact cattagtgaa gagataattg gattacacag gcaggcttgt ttactacatc
     3301 cagaatgtag aaactgcttt cttcaacatc ttggttctag ctagtaataa caatataatt
     3361 ctttggcaga tattcagaat aacattttaa actacatttt cttagaaaat tgcattcttg
     3421 tagtgagcag tgtatggtct cttttgttca gaatttaaaa ctgataacca atgaaagcct
     3481 tttctcttat tcctctaccg tcatttacat gataatctga agctaatatg acaatattta
     3541 aatactaagt ggtactaggg aactacaaga atactgtaaa gcttaagcca ttgttatcac
     3601 tgtcatttag catttaataa caaaactata cagaattatg tgcataccaa tgaatgtttt
     3661 gtaccatcta gttaaatttt ttaaataaag ttttatgggt taagcagaag acaactgtca
     3721 tactgaattt tattaaaagt atatatactt caaattcaaa gcatccctta ggacccacag
     3781 aatatattaa aactaccacc cttaaatttt atatttttgc tttaagacag acaatgcaaa
     3841 ggtaactggc aagaggtgag caaatgtttt agaacattta tattattgct taaaatgaga
     3901 tttgaaattg taataaaatt cttggttatg aa
//
