LOCUS       NM_145273               2768 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens CD300 molecule like family member g (CD300LG),
            transcript variant 1, mRNA.
ACCESSION   NM_145273
VERSION     NM_145273.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2768)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2768)
  AUTHORS   Zhai,S., Xu,H., Jiang,X., Sun,S., Qin,L., Wei,D. and Hu,L.
  TITLE     Expression Depression of CD300LG-gamma in Human Pulmonary Carcinoma
  JOURNAL   Monoclon Antib Immunodiagn Immunother 35 (2), 94-99 (2016)
   PUBMED   26977771
  REMARK    GeneRIF: Both mRNA and protein levels of CD300LG-g in pulmonary
            carcinoma tissues were significantly lower than that in
            tumor-adjacent tissues, which might lead to inhibition of killing
            function of immunocytes, resulting in immune escape of lung cancer
            cells.
REFERENCE   3  (bases 1 to 2768)
  AUTHORS   Stoy,J., Grarup,N., Horlyck,A., Ibsen,L., Rungby,J., Poulsen,P.L.,
            Brandslund,I., Christensen,C., Hansen,T., Pedersen,O., Moller,N.
            and Kampmann,U.
  TITLE     Blood pressure levels in male carriers of Arg82Cys in CD300LG
  JOURNAL   PLoS One 9 (10), e109646 (2014)
   PUBMED   25314291
  REMARK    GeneRIF: Blood pressure, measured with a sensitive method, in a
            small sample of CD300LG rs72836561 CT-carriers was higher than in
            CC-carriers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2768)
  AUTHORS   Clark,G.J., Ju,X., Tate,C. and Hart,D.N.
  TITLE     The CD300 family of molecules are evolutionarily significant
            regulators of leukocyte functions
  JOURNAL   Trends Immunol 30 (5), 209-217 (2009)
   PUBMED   19359216
  REMARK    Review article
REFERENCE   5  (bases 1 to 2768)
  AUTHORS   Clark,G.J., Ju,X., Azlan,M., Tate,C., Ding,Y. and Hart,D.N.
  TITLE     The CD300 molecules regulate monocyte and dendritic cell functions
  JOURNAL   Immunobiology 214 (9-10), 730-736 (2009)
   PUBMED   19592130
  REMARK    Review article
REFERENCE   6  (bases 1 to 2768)
  AUTHORS   Takatsu,H., Hase,K., Ohmae,M., Ohshima,S., Hashimoto,K.,
            Taniura,N., Yamamoto,A. and Ohno,H.
  TITLE     CD300 antigen like family member G: A novel Ig receptor like
            protein exclusively expressed on capillary endothelium
  JOURNAL   Biochem Biophys Res Commun 348 (1), 183-191 (2006)
   PUBMED   16876123
REFERENCE   7  (bases 1 to 2768)
  AUTHORS   Umemoto,E., Tanaka,T., Kanda,H., Jin,S., Tohya,K., Otani,K.,
            Matsutani,T., Matsumoto,M., Ebisuno,Y., Jang,M.H., Fukuda,M.,
            Hirata,T. and Miyasaka,M.
  TITLE     Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent
            lymphocyte rolling and promotes lymphocyte adhesion under flow
  JOURNAL   J Exp Med 203 (6), 1603-1614 (2006)
   PUBMED   16754720
REFERENCE   8  (bases 1 to 2768)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (bases 1 to 2768)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK298112.1, BC025395.2, AC015937.7, AC007993.15 and AY358364.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145273.3.
            
            Summary: Members of the CD300 (see MIM 606786)-like (CD300L)
            family, such as CD300LG, are widely expressed on hematopoietic
            cells. All CD300L proteins are type I cell surface glycoproteins
            that contain a single immunoglobulin (Ig) V-like domain (Takatsu et
            al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025395.2, AY358364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317310.5/ ENSP00000321005.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK298112.1         31-33
            4-701               BC025395.2         4-701
            702-702             AC015937.7         7832-7832           c
            703-1175            BC025395.2         703-1175
            1176-2121           AC007993.15        138528-139473       c
            2122-2756           BC025395.2         2122-2756
            2757-2758           AY358364.1         2735-2736
            2759-2768           AC007993.15        137881-137890       c
FEATURES             Location/Qualifiers
     source          1..2768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2768
                     /gene="CD300LG"
                     /gene_synonym="CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4"
                     /note="CD300 molecule like family member g"
                     /db_xref="GeneID:146894"
                     /db_xref="HGNC:HGNC:30455"
                     /db_xref="MIM:610520"
     exon            1..84
                     /gene="CD300LG"
                     /gene_synonym="CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1040
                     /gene="CD300LG"
                     /gene_synonym="CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CMRF35-like molecule 9; triggering receptor
                     expressed on myeloid cells 4; CD300 antigen-like family
                     member G"
                     /codon_start=1
                     /product="CMRF35-like molecule 9 isoform 1 precursor"
                     /protein_id="NP_660316.2"
                     /db_xref="CCDS:CCDS11470.1"
                     /db_xref="GeneID:146894"
                     /db_xref="HGNC:HGNC:30455"
                     /db_xref="MIM:610520"
                     /translation="MRLLVLLWGCLLLPGYEALEGPEEISGFEGDTVSLQCTYREELR
                     DHRKYWCRKGGILFSRCSGTIYAEEEGQETMKGRVSIRDSRQELSLIVTLWNLTLQDA
                     GEYWCGVEKRGPDESLLISLFVFPGPCCPPSPSPTFQPLATTRLQPKAKAQQTQPPGL
                     TSPGLYPAATTAKQGKTGAEAPPLPGTSQYGHERTSQYTGTSPHPATSPPAGSSRPPM
                     QLDSTSAEDTSPALSSGSSKPRVSIPMVRILAPVLVLLSLLSAAGLIAFCSHLLLWRK
                     EAQQATETQRNEKFCLSRLTAEEKEAPSQAPEGDVISMPPLHTSEEELGFSKFVSA"
     exon            85..420
                     /gene="CD300LG"
                     /gene_synonym="CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4"
                     /inference="alignment:Splign:2.1.0"
     exon            421..522
                     /gene="CD300LG"
                     /gene_synonym="CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4"
                     /inference="alignment:Splign:2.1.0"
     exon            523..760
                     /gene="CD300LG"
                     /gene_synonym="CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4"
                     /inference="alignment:Splign:2.1.0"
     exon            761..873
                     /gene="CD300LG"
                     /gene_synonym="CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4"
                     /inference="alignment:Splign:2.1.0"
     exon            874..926
                     /gene="CD300LG"
                     /gene_synonym="CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4"
                     /inference="alignment:Splign:2.1.0"
     exon            927..2768
                     /gene="CD300LG"
                     /gene_synonym="CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2735..2740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD300LG"
                     /gene_synonym="CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4"
                     /note="hexamer: AATAAA"
     polyA_site      2768
                     /gene="CD300LG"
                     /gene_synonym="CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4"
                     /note="major polyA site"
ORIGIN      
        1 acagttccca gcgtctgctc ccacggtgtc cagcgcccag aatgcggctt ctggtcctgc
       61 tatggggttg cctgctgctc ccaggttatg aagccctgga gggcccagag gaaatcagcg
      121 ggttcgaagg ggacactgtg tccctgcagt gcacctacag ggaagagctg agggaccacc
      181 ggaagtactg gtgcaggaag ggtgggatcc tcttctctcg ctgctctggc accatctatg
      241 cagaagaaga aggccaggag acaatgaagg gcagggtgtc catccgtgac agccgccagg
      301 agctctcgct cattgtgacc ctgtggaacc tcaccctgca agacgctggg gagtactggt
      361 gtggggtcga aaaacggggc cccgatgagt ctttactgat ctctctgttc gtctttccag
      421 gaccctgctg tcctccctcc ccttctccca ccttccagcc tctggctaca acacgcctgc
      481 agcccaaggc aaaagctcag caaacccagc ccccaggatt gacttctcct gggctctacc
      541 cggcagccac cacagccaag caggggaaga caggggctga ggcccctcca ttgccaggga
      601 cttcccagta cgggcacgaa aggacttctc agtacacagg aacctctcct cacccagcga
      661 cctctcctcc tgcagggagc tcccgccccc ccatgcagct ggactccacc tcagcagagg
      721 acaccagtcc agctctcagc agtggcagct ctaagcccag ggtgtccatc ccgatggtcc
      781 gcatactggc cccagtcctg gtgctgctga gccttctgtc agccgcaggc ctgatcgcct
      841 tctgcagcca cctgctcctg tggagaaagg aagctcaaca ggccacggag acacagagga
      901 acgagaagtt ctgcctctca cgcttgactg cggaggaaaa ggaagcccct tcccaggccc
      961 ctgaggggga cgtgatctcg atgcctcccc tccacacatc tgaggaggag ctgggcttct
     1021 cgaagtttgt ctcagcgtag ggcaggaggc cctcctggcc aggccagcag tgaagcagta
     1081 tggctggctg gatcagcacc gattcccgaa agctttccac ctcagcctca gagtccagct
     1141 gcccggactc cagggctctc cccaccctcc ccaggctctc ctcttgcatg ttccagcctg
     1201 acctagaagc gtttgtcagc cctggagccc agagcggtgg ccttgctctt ccggctggag
     1261 actgggacat ccctgatagg ttcacatccc tgggcagagt accaggctgc tgaccctcag
     1321 cagggccaga caaggctcag tggatctggt ctgagtttca atctgccagg aactcctggg
     1381 cctcatgccc agtgtcggac cctgccttcc tcccactcca gaccccacct tgtcttccct
     1441 ccctggcgtc ctcagactta gtcccacggt ctcctgcatc agctggtgat gaagaggagc
     1501 atgctggggt gagactggga ttctggcttc tctttgaacc acctgcatcc cagcccttca
     1561 ggaagcctgt gaaaaacgtg attcctgggc cccaccaaga cccaccaaaa ccatctctgg
     1621 ggcttggtgc aggactctga atttctaaca atgcccagtg actgtcgcac ttgagtttga
     1681 gggccagtgg gcctgatgaa cgctcagacc cctccagctt agagtctgca tttgggctgt
     1741 gacgtctccc acctgcccca ataagatctg ctctgtctgc gacaccaaga tccagctggg
     1801 gactcccctg aggcctgcct aagtccaggc cttggtcagg tcaggtgcac attgcaggga
     1861 taagcccagg accggcagag agtggttgcc tttccatttg ccctccctgg ccatgccttc
     1921 ttgcctttgg aaaaatgatg aagaaaacct tggctccttc cttgtctgga aagggttact
     1981 tgcctatggg ttctggtggc tagagagaaa agtagaaaac cagagtgcac gtaggtgtct
     2041 aacacagagg agagtaggaa cagggcggat acctgaaggt gactccgagt ccagccccct
     2101 ggagaagggg tcgggggtgg gggtaaagta gcacaactac tatttttttt ctttttccat
     2161 tattattgtt ttttaagaca gaatctcgtg ctgctgccca ggctggagtg cagtggcacg
     2221 atctgcaaac tccgcctcct gggttcaagt gattcttctg cctcagcctc ccgagtagct
     2281 gggattacag gcacgcacca ccacacctgg ctaatttttg tacttttagt agagatgggg
     2341 tttcaccatg ttggccaggc tggtcttgaa ctcctgacct caaatgagcc tcctgcttca
     2401 gtctcccaaa ttgccgggat tacaggcatg agccactgtg tctggcccta tttcctttaa
     2461 aaagtgaaat taagagttgt tcagtatgca aaacttggaa agatggagga gaaaaagaaa
     2521 aggaagaaaa aaatgtcacc catagtctca ccagagacta tcattatttc gttttgttgt
     2581 acttccttcc actcttttct tcttcacata atttgccggt gttcttttta cagagcaatt
     2641 atcttgtata tacaactttg tatcctgcct tttccacctt atcgttccat cactttattc
     2701 cagcacttct ctgtgtttta cagacctttt tataaataaa atgttcatca gctgcatatt
     2761 ccatccta
//
