LOCUS       NM_139018               1709 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens CD300 molecule like family member f (CD300LF),
            transcript variant 1, mRNA.
ACCESSION   NM_139018
VERSION     NM_139018.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1709)
  AUTHORS   Sutherland,S.I.M., Ju,X., Silveira,P.A., Kupresanin,F.,
            Horvath,L.G. and Clark,G.J.
  TITLE     CD300f signalling induces inhibitory human monocytes/macrophages
  JOURNAL   Cell Immunol 390, 104731 (2023)
   PUBMED   37302321
  REMARK    GeneRIF: CD300f signalling induces inhibitory human
            monocytes/macrophages.
REFERENCE   2  (bases 1 to 1709)
  AUTHORS   Cao,Y., Ao,T., Wang,X., Wei,W., Fan,J. and Tian,X.
  TITLE     CD300a and CD300f molecules regulate the function of leukocytes
  JOURNAL   Int Immunopharmacol 93, 107373 (2021)
   PUBMED   33548578
  REMARK    GeneRIF: CD300a and CD300f molecules regulate the function of
            leukocytes.
            Review article
REFERENCE   3  (bases 1 to 1709)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1709)
  AUTHORS   Lago,N., Kaufmann,F.N., Negro-Demontel,M.L., Ali-Ruiz,D.,
            Ghisleni,G., Rego,N., Arcas-Garcia,A., Vitureira,N., Jansen,K.,
            Souza,L.M., Silva,R.A., Lara,D.R., Pannunzio,B.,
            Abin-Carriquiry,J.A., Amo-Aparicio,J., Martin-Otal,C., Naya,H.,
            McGavern,D.B., Sayos,J., Lopez-Vales,R., Kaster,M.P. and Peluffo,H.
  TITLE     CD300f immunoreceptor is associated with major depressive disorder
            and decreased microglial metabolic fitness
  JOURNAL   Proc Natl Acad Sci U S A 117 (12), 6651-6662 (2020)
   PUBMED   32152116
  REMARK    GeneRIF: Single-nucleotide polymorphism in CD300f gene is
            associated with major depressive disorder.
REFERENCE   5  (bases 1 to 1709)
  AUTHORS   Alvarez-Errico,D., Sayos,J. and Lopez-Botet,M.
  TITLE     The IREM-1 (CD300f) inhibitory receptor associates with the
            p85alpha subunit of phosphoinositide 3-kinase
  JOURNAL   J Immunol 178 (2), 808-816 (2007)
   PUBMED   17202342
  REMARK    GeneRIF: reveal a putative functional duality of the IREM-1 myeloid
            cell receptor
REFERENCE   6  (bases 1 to 1709)
  AUTHORS   Alvarez-Errico,D., Aguilar,H., Kitzig,F., Brckalo,T., Sayos,J. and
            Lopez-Botet,M.
  TITLE     IREM-1 is a novel inhibitory receptor expressed by myeloid cells
  JOURNAL   Eur J Immunol 34 (12), 3690-3701 (2004)
   PUBMED   15549731
  REMARK    GeneRIF: a novel inhibitory receptor of the Ig superfamily in
            myeloid cells.  (IREM-1 = immune receptor expressed on myeloid
            cells-1)
REFERENCE   7  (bases 1 to 1709)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   8  (bases 1 to 1709)
  AUTHORS   Sui,L., Li,N., Liu,Q., Zhang,W., Wan,T., Wang,B., Luo,K., Sun,H.
            and Cao,X.
  TITLE     IgSF13, a novel human inhibitory receptor of the immunoglobulin
            superfamily, is preferentially expressed in dendritic cells and
            monocytes
  JOURNAL   Biochem Biophys Res Commun 319 (3), 920-928 (2004)
   PUBMED   15184070
  REMARK    GeneRIF: IgSF13 was identified from dendritic cells; preferentially
            expressed in myelo-monocytic cells, including monocytes,
            monocyte-derived DC and monocyte-related cell lines; may be
            involved in the negative regulation of specific leukocyte
            population [IgSF13]
REFERENCE   9  (bases 1 to 1709)
  AUTHORS   Chung,D.H., Humphrey,M.B., Nakamura,M.C., Ginzinger,D.G.,
            Seaman,W.E. and Daws,M.R.
  TITLE     CMRF-35-like molecule-1, a novel mouse myeloid receptor, can
            inhibit osteoclast formation
  JOURNAL   J Immunol 171 (12), 6541-6548 (2003)
   PUBMED   14662855
REFERENCE   10 (bases 1 to 1709)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358545.1, DA673169.1,
            BM923728.1 and BM680508.1.
            
            On Nov 22, 2018 this sequence version replaced NM_139018.4.
            
            Summary: This gene encodes a member of the CD300 protein family.
            Members of this family are cell surface glycoproteins with a single
            IgV-like extracellular domain, and are involved in the regulation
            of immune response. The encoded protein is an inhibitory receptor.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358545.1, AF251706.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326165.11/ ENSP00000327075.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AY358545.1         25-136
            113-113             DA673169.1         191-191
            114-709             AY358545.1         138-733
            710-1374            BM923728.1         125-789
            1375-1709           BM680508.1         25-359              c
FEATURES             Location/Qualifiers
     source          1..1709
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1709
                     /gene="CD300LF"
                     /gene_synonym="CD300f; CLM-1; CLM1; IgSF13; IREM-1; IREM1;
                     LMIR3; NKIR"
                     /note="CD300 molecule like family member f"
                     /db_xref="GeneID:146722"
                     /db_xref="HGNC:HGNC:29883"
                     /db_xref="MIM:609807"
     exon            1..100
                     /gene="CD300LF"
                     /gene_synonym="CD300f; CLM-1; CLM1; IgSF13; IREM-1; IREM1;
                     LMIR3; NKIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..930
                     /gene="CD300LF"
                     /gene_synonym="CD300f; CLM-1; CLM1; IgSF13; IREM-1; IREM1;
                     LMIR3; NKIR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; immunoglobin superfamily member 13; CMRF35-like
                     molecule 1; NK inhibitory receptor; inhibitory receptor
                     IREM1; CD300 antigen-like family member F; immunoglobulin
                     superfamily member 13; immune receptor expressed on
                     myeloid cells 1"
                     /codon_start=1
                     /product="CMRF35-like molecule 1 isoform 1 precursor"
                     /protein_id="NP_620587.2"
                     /db_xref="CCDS:CCDS11704.1"
                     /db_xref="GeneID:146722"
                     /db_xref="HGNC:HGNC:29883"
                     /db_xref="MIM:609807"
                     /translation="MPLLTLYLLLFWLSGYSIVTQITGPTTVNGLERGSLTVQCVYRS
                     GWETYLKWWCRGAIWRDCKILVKTSGSEQEVKRDRVSIKDNQKNRTFTVTMEDLMKTD
                     ADTYWCGIEKTGNDLGVTVQVTIDPAPVTQEETSSSPTLTGHHLDNRHKLLKLSVLLP
                     LIFTILLLLLVAASLLAWRMMKYQQKAAGMSPEQVLQPLEGDLCYADLTLQLAGTSPQ
                     KATTKLSSAQVDQVEVEYVTMASLPKEDISYASLTLGAEDQEPTYCNMGHLSSHLPGR
                     GPEEPTEYSTISRP"
     exon            101..439
                     /gene="CD300LF"
                     /gene_synonym="CD300f; CLM-1; CLM1; IgSF13; IREM-1; IREM1;
                     LMIR3; NKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            440..503
                     /gene="CD300LF"
                     /gene_synonym="CD300f; CLM-1; CLM1; IgSF13; IREM-1; IREM1;
                     LMIR3; NKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            504..616
                     /gene="CD300LF"
                     /gene_synonym="CD300f; CLM-1; CLM1; IgSF13; IREM-1; IREM1;
                     LMIR3; NKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            617..639
                     /gene="CD300LF"
                     /gene_synonym="CD300f; CLM-1; CLM1; IgSF13; IREM-1; IREM1;
                     LMIR3; NKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            640..774
                     /gene="CD300LF"
                     /gene_synonym="CD300f; CLM-1; CLM1; IgSF13; IREM-1; IREM1;
                     LMIR3; NKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            775..1709
                     /gene="CD300LF"
                     /gene_synonym="CD300f; CLM-1; CLM1; IgSF13; IREM-1; IREM1;
                     LMIR3; NKIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1685..1690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD300LF"
                     /gene_synonym="CD300f; CLM-1; CLM1; IgSF13; IREM-1; IREM1;
                     LMIR3; NKIR"
                     /note="hexamer: AATAAA"
     polyA_site      1709
                     /gene="CD300LF"
                     /gene_synonym="CD300f; CLM-1; CLM1; IgSF13; IREM-1; IREM1;
                     LMIR3; NKIR"
                     /note="major polyA site"
ORIGIN      
        1 agtttgttcc tgctgccagg ctccactgag gggaacgggg acctgtctga agagaagatg
       61 cccctgctga cactctacct gctcctcttc tggctctcag gctactccat tgtcactcaa
      121 atcaccggtc caacaacagt gaatggcttg gagcggggct ccttgaccgt gcagtgtgtt
      181 tacagatcag gctgggagac ctacttgaag tggtggtgtc gaggagctat ttggcgtgac
      241 tgcaagatcc ttgttaaaac cagtgggtca gagcaggagg tgaagaggga ccgggtgtcc
      301 atcaaggaca atcagaaaaa ccgcacgttc actgtgacca tggaggatct catgaaaact
      361 gatgctgaca cttactggtg tggaattgag aaaactggaa atgaccttgg ggtcacagtt
      421 caagtgacca ttgacccagc accagtcacc caagaagaaa ctagcagctc cccaactctg
      481 accggccacc acttggacaa caggcacaag ctcctgaagc tcagtgtcct cctgcccctc
      541 atcttcacca tattgctgct gcttttggtg gccgcctcac tcttggcttg gaggatgatg
      601 aagtaccagc agaaagcagc cgggatgtcc ccagagcagg tactgcagcc cctggagggc
      661 gacctctgct atgcagacct gaccctgcag ctggccggaa cctccccgca aaaggctacc
      721 acgaagcttt cctctgccca ggttgaccag gtggaagtgg aatatgtcac catggcttcc
      781 ttgccgaagg aggacatttc ctatgcatct ctgaccttgg gtgctgagga tcaggaaccg
      841 acctactgca acatgggcca cctcagtagc cacctccccg gcaggggccc tgaggagccc
      901 acggaataca gcaccatcag caggccttag cctgcactcc aggctccttc ttggacccca
      961 ggctgtgagc acactcctgc ctcatcgacc gtctgccccc tgctcccctc atcaggacca
     1021 acccggggac tggtgcctct gcctgatcag ccagcattgc ccctagctct gggttgggct
     1081 tggggccaag tctcaggggg cttctaggag ttggggtttt ctaaacgtcc cctcctctcc
     1141 tacatagttg aggagggggc tagggatatg ctctggggct ttcatgggaa tgatgaagat
     1201 gataatgaga aaaatgttat cattattatc atgaagtacc attatcgtaa tacaatgaac
     1261 ctttatttat tgcctaccac atgttatggg ctgaataatg gcccccaaag atatctgtgt
     1321 cctaatcctc agaacctgtg actgttacct tctgtggcag aaagggacag tgcagatgta
     1381 tgtaagttaa ggactttgag atagagaggt tattcttgct gattcaggtg ggcccaaaat
     1441 atcaccacaa gggtcctcat aagaaagagg ccagaaggtc aaagaggtag agacaaagtg
     1501 atgatggaag tggacgtggg tgtgacgtga gcaggggcca tgaatgccgc agccttcaga
     1561 tgccagaaag ggaaaggaat ggattcccct gcctggagcc tccaaaagaa accagccctg
     1621 cccacgcctt gacttgagcc cattgaaact gatcttgagc tcctggcctc cagaattgca
     1681 ggagaataaa tttgtgttgt ttttaatga
//
