LOCUS       NM_001115152            1303 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens CD300 molecule like family member d (CD300LD), mRNA.
ACCESSION   NM_001115152 XM_001719176 XM_001725656 XM_001726565
VERSION     NM_001115152.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1303)
  AUTHORS   Wang,C., Zheng,X., Zhang,J., Jiang,X., Wang,J., Li,Y., Li,X.,
            Shen,G., Peng,J., Zheng,P., Gu,Y., Chen,J., Lin,M., Deng,C.,
            Gao,H., Lu,Z., Zhao,Y. and Luo,M.
  TITLE     CD300ld on neutrophils is required for tumour-driven immune
            suppression
  JOURNAL   Nature 621 (7980), 830-839 (2023)
   PUBMED   37674079
  REMARK    GeneRIF: CD300ld on neutrophils is required for tumour-driven
            immune suppression.
REFERENCE   2  (bases 1 to 1303)
  AUTHORS   Martinez-Barriocanal,A., Arcas-Garcia,A., Magallon-Lorenz,M.,
            Ejarque-Ortiz,A., Negro-Demontel,M.L., Comas-Casellas,E.,
            Schwartz,S. Jr., Malhotra,S., Montalban,X., Peluffo,H., Martin,M.,
            Comabella,M. and Sayos,J.
  TITLE     Effect of Specific Mutations in Cd300 Complexes Formation;
            Potential Implication of Cd300f in Multiple Sclerosis
  JOURNAL   Sci Rep 7 (1), 13544 (2017)
   PUBMED   29051512
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1303)
  AUTHORS   Gasiorowski,R.E., Ju,X., Hart,D.N. and Clark,G.J.
  TITLE     CD300 molecule regulation of human dendritic cell functions
  JOURNAL   Immunol Lett 149 (1-2), 93-100 (2013)
   PUBMED   23072861
  REMARK    GeneRIF: CD300 molecules are all expressed by DC; CD300b, d, e and
            f are restricted to different subpopulations of the myeloid DC
            lineage. They have been shown to regulate DC function both in vitro
            and in vivo.
            Review article
REFERENCE   4  (bases 1 to 1303)
  AUTHORS   Comas-Casellas,E., Martinez-Barriocanal,A., Miro,F.,
            Ejarque-Ortiz,A., Schwartz,S. Jr., Martin,M. and Sayos,J.
  TITLE     Cloning and characterization of CD300d, a novel member of the human
            CD300 family of immune receptors
  JOURNAL   J Biol Chem 287 (13), 9682-9693 (2012)
   PUBMED   22291008
  REMARK    GeneRIF: the function of CD300d would be related to the regulation
            of the expression of other CD300 molecules and the composition of
            CD300 complexes on the cell surface.
REFERENCE   5  (bases 1 to 1303)
  AUTHORS   Clark,G.J., Ju,X., Tate,C. and Hart,D.N.
  TITLE     The CD300 family of molecules are evolutionarily significant
            regulators of leukocyte functions
  JOURNAL   Trends Immunol 30 (5), 209-217 (2009)
   PUBMED   19359216
  REMARK    Review article
REFERENCE   6  (bases 1 to 1303)
  AUTHORS   Clark,G.J., Ju,X., Azlan,M., Tate,C., Ding,Y. and Hart,D.N.
  TITLE     The CD300 molecules regulate monocyte and dendritic cell functions
  JOURNAL   Immunobiology 214 (9-10), 730-736 (2009)
   PUBMED   19592130
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358148.1 and AC079325.10.
            
            On Aug 16, 2017 this sequence version replaced NM_001115152.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358148.1, EF137868.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA2142670 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375352.1/ ENSP00000364501.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1026              AY358148.1         5-1030
            1027-1027           AC079325.10        16521-16521
            1028-1303           AY358148.1         1032-1307
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1303
                     /gene="CD300LD"
                     /gene_synonym="CD300D; CLM-4; CLM-5; CMRF35-A4; CMRF35A4"
                     /note="CD300 molecule like family member d"
                     /db_xref="GeneID:100131439"
                     /db_xref="HGNC:HGNC:16848"
                     /db_xref="MIM:616301"
     exon            1..121
                     /gene="CD300LD"
                     /gene_synonym="CD300D; CLM-4; CLM-5; CMRF35-A4; CMRF35A4"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..666
                     /gene="CD300LD"
                     /gene_synonym="CD300D; CLM-4; CLM-5; CMRF35-A4; CMRF35A4"
                     /note="CMRF35-like molecule 4; immune receptor CD300d;
                     CD300 antigen-like family member D; CMRF35-like molecule
                     5"
                     /codon_start=1
                     /product="CMRF35-like molecule 5 precursor"
                     /protein_id="NP_001108624.1"
                     /db_xref="CCDS:CCDS42379.1"
                     /db_xref="GeneID:100131439"
                     /db_xref="HGNC:HGNC:16848"
                     /db_xref="MIM:616301"
                     /translation="MWLSPSLLLLILPGYSIAAKITGPTTVNGSEQGSLTVQCAYGSG
                     WETYLKWRCQGADWNYCNILVKTNGSEQEVKKNRVSIRDNQKNHVFTVTMENLKRDDA
                     DSYWCGTERPGIDLGVKVQVTINPGTQTAVSEWTTTTASLAFTAAATQKTSSPLTRSP
                     LKSTHFLFLFLLELPLLLSMLGTVLWVNRPQRRS"
     exon            122..460
                     /gene="CD300LD"
                     /gene_synonym="CD300D; CLM-4; CLM-5; CMRF35-A4; CMRF35A4"
                     /inference="alignment:Splign:2.1.0"
     exon            461..554
                     /gene="CD300LD"
                     /gene_synonym="CD300D; CLM-4; CLM-5; CMRF35-A4; CMRF35A4"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1303
                     /gene="CD300LD"
                     /gene_synonym="CD300D; CLM-4; CLM-5; CMRF35-A4; CMRF35A4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgacttcc gagcttggat tcaagtccct gaagggcacc agacacctgt gatcaccaag
       61 gagaggagag gagacaggac catgtggctg tccccatctc tgctgcttct catcctccca
      121 ggttactcca ttgccgctaa aatcactggt ccaacaacag tgaatggctc ggagcagggc
      181 tcattgactg tgcagtgtgc ttatggctca ggctgggaga cctacttgaa gtggcggtgt
      241 caaggagctg attggaatta ctgtaacatc cttgttaaaa caaatggatc agagcaggag
      301 gtaaagaaga atcgagtttc catcagggac aatcagaaaa accacgtgtt caccgtgacc
      361 atggagaatc tcaaaagaga tgatgctgac agttattggt gtgggactga gagacctgga
      421 attgatcttg gggtcaaagt tcaagtgacc attaacccag gcacacaaac tgcagtctca
      481 gaatggacaa ccacaacagc aagcctggct ttcacagctg cagccaccca gaagaccagc
      541 agccccctca ccaggtcccc gctcaagagc acccacttcc tgttcctgtt cctcctggag
      601 ctgcctctgc tcctgagcat gctggggacc gtcctctggg taaacagacc acaaagaagg
      661 tcttgaagga ggaggagtca gcccgatgat gagagtccca atgcccattg acgtcctgtc
      721 cagggcgaaa ggccctccca cagaagaaaa aacattttct tttctcttct ttttttcttt
      781 ctagagatag agtcttgctc tgtcacccag gctggaatgc aatggtgtaa tctctgctca
      841 ctgcaacttt cccctcccag gctcaagcga tcctcctgcc tcaacctcca gagtagctgg
      901 ggctacaggc acatgccacc acccccagct aatttttaaa tttttttgta gagatgggct
      961 tccaccacgt tgcccaggct ggtctcgaac tcttgacctc aagagatcct cccgcttcgc
     1021 ctcccaaagt ggtgggatta caggtgtgag ccaccgcacc tggcagaaaa acaacatttc
     1081 tatggggaat tgactgtggt tctagaggca gtgctggccc cagcttcagg gaacagcctc
     1141 ctagtcccct atctcctgca gccgtgccac ctggggctat tcccttctct gcacagtccc
     1201 tggggcctga cagagccctt cttccttctg aggtctccaa tgcagtagaa aacatgagaa
     1261 gaatgtgttt cccccgagag gcacctatgc cgtagtggac att
//
