LOCUS       NM_174892               2295 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens CD300 molecule like family member b (CD300LB), mRNA.
ACCESSION   NM_174892
VERSION     NM_174892.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2295)
  AUTHORS   Martinez-Barriocanal,A., Arcas-Garcia,A., Magallon-Lorenz,M.,
            Ejarque-Ortiz,A., Negro-Demontel,M.L., Comas-Casellas,E.,
            Schwartz,S. Jr., Malhotra,S., Montalban,X., Peluffo,H., Martin,M.,
            Comabella,M. and Sayos,J.
  TITLE     Effect of Specific Mutations in Cd300 Complexes Formation;
            Potential Implication of Cd300f in Multiple Sclerosis
  JOURNAL   Sci Rep 7 (1), 13544 (2017)
   PUBMED   29051512
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2295)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: CD300LB expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   3  (bases 1 to 2295)
  AUTHORS   Voss,O.H., Murakami,Y., Pena,M.Y., Lee,H.N., Tian,L.,
            Margulies,D.H., Street,J.M., Yuen,P.S., Qi,C.F., Krzewski,K. and
            Coligan,J.E.
  TITLE     Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like
            Receptor 4 Alters Signaling to Drive Cytokine Responses that
            Enhance Septic Shock
  JOURNAL   Immunity 44 (6), 1365-1378 (2016)
   PUBMED   27261276
  REMARK    GeneRIF: this paper identified CD300b as an
            lipopolysaccharide-recognizing receptor that regulated TLR4
            signaling
REFERENCE   4  (bases 1 to 2295)
  AUTHORS   Gasiorowski,R.E., Ju,X., Hart,D.N. and Clark,G.J.
  TITLE     CD300 molecule regulation of human dendritic cell functions
  JOURNAL   Immunol Lett 149 (1-2), 93-100 (2013)
   PUBMED   23072861
  REMARK    GeneRIF: CD300 molecules are all expressed by DC; CD300b, d, e and
            f are restricted to different subpopulations of the myeloid DC
            lineage. They have been shown to regulate DC function both in vitro
            and in vivo.
            Review article
REFERENCE   5  (bases 1 to 2295)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2295)
  AUTHORS   Clark,G.J., Ju,X., Tate,C. and Hart,D.N.
  TITLE     The CD300 family of molecules are evolutionarily significant
            regulators of leukocyte functions
  JOURNAL   Trends Immunol 30 (5), 209-217 (2009)
   PUBMED   19359216
  REMARK    Review article
REFERENCE   7  (bases 1 to 2295)
  AUTHORS   Clark,G.J., Ju,X., Azlan,M., Tate,C., Ding,Y. and Hart,D.N.
  TITLE     The CD300 molecules regulate monocyte and dendritic cell functions
  JOURNAL   Immunobiology 214 (9-10), 730-736 (2009)
   PUBMED   19592130
  REMARK    Review article
REFERENCE   8  (bases 1 to 2295)
  AUTHORS   Yamanishi,Y., Kitaura,J., Izawa,K., Matsuoka,T., Oki,T., Lu,Y.,
            Shibata,F., Yamazaki,S., Kumagai,H., Nakajima,H.,
            Maeda-Yamamoto,M., Tybulewicz,V.L., Takai,T. and Kitamura,T.
  TITLE     Analysis of mouse LMIR5/CLM-7 as an activating receptor:
            differential regulation of LMIR5/CLM-7 in mouse versus human cells
  JOURNAL   Blood 111 (2), 688-698 (2008)
   PUBMED   17928527
  REMARK    GeneRIF: although both mouse and human LMIR5 play activatory roles
            in innate immunity cells, the functions of LMIR5 were
            differentially regulated in mouse versus human cells.
REFERENCE   9  (bases 1 to 2295)
  AUTHORS   Martinez-Barriocanal,A. and Sayos,J.
  TITLE     Molecular and functional characterization of CD300b, a new
            activating immunoglobulin receptor able to transduce signals
            through two different pathways
  JOURNAL   J Immunol 177 (5), 2819-2830 (2006)
   PUBMED   16920917
  REMARK    GeneRIF: CD300b defines a nonclassical Ig receptor able to trigger
            signals by coupling distinct mediators and thus initiating
            different signaling pathways
REFERENCE   10 (bases 1 to 2295)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079325.10, AK290925.1 and BC028091.1.
            
            On Nov 22, 2018 this sequence version replaced NM_174892.3.
            
            Summary: CD300LB is a nonclassical activating receptor of the
            immunoglobulin (Ig) superfamily expressed on myeloid cells
            (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied
            by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028091.1, AY359025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000392621.6/
                                                ENSP00000376397.2
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC079325.10        64687-64687
            2-42                AK290925.1         1-41
            43-2295             BC028091.1         34-2286
FEATURES             Location/Qualifiers
     source          1..2295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..2295
                     /gene="CD300LB"
                     /gene_synonym="CD300b; CLM-7; CLM7; CMRF35-A2; IREM-3;
                     IREM3; TREM-5; TREM5"
                     /note="CD300 molecule like family member b"
                     /db_xref="GeneID:124599"
                     /db_xref="HGNC:HGNC:30811"
                     /db_xref="MIM:610705"
     exon            1..165
                     /gene="CD300LB"
                     /gene_synonym="CD300b; CLM-7; CLM7; CMRF35-A2; IREM-3;
                     IREM3; TREM-5; TREM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..731
                     /gene="CD300LB"
                     /gene_synonym="CD300b; CLM-7; CLM7; CMRF35-A2; IREM-3;
                     IREM3; TREM-5; TREM5"
                     /note="CD300 antigen like family member B; triggering
                     receptor expressed on myeloid cells 5; CMRF35-like
                     molecule 7; leukocyte mono-Ig-like receptor 5; immune
                     receptor expressed on myeloid cells 3"
                     /codon_start=1
                     /product="CMRF35-like molecule 7 precursor"
                     /protein_id="NP_777552.3"
                     /db_xref="CCDS:CCDS11700.2"
                     /db_xref="GeneID:124599"
                     /db_xref="HGNC:HGNC:30811"
                     /db_xref="MIM:610705"
                     /translation="MWLPPALLLLSLSGCFSIQGPESVRAPEQGSLTVQCHYKQGWET
                     YIKWWCRGVRWDTCKILIETRGSEQGEKSDRVSIKDNQKDRTFTVTMEGLRRDDADVY
                     WCGIERRGPDLGTQVKVIVDPEGAASTTASSPTNSNMAVFIGSHKRNHYMLLVFVKVP
                     ILLILVTAILWLKGSQRVPEEPGEQPIYMNFSEPLTKDMAT"
     exon            166..495
                     /gene="CD300LB"
                     /gene_synonym="CD300b; CLM-7; CLM7; CMRF35-A2; IREM-3;
                     IREM3; TREM-5; TREM5"
                     /inference="alignment:Splign:2.1.0"
     exon            496..568
                     /gene="CD300LB"
                     /gene_synonym="CD300b; CLM-7; CLM7; CMRF35-A2; IREM-3;
                     IREM3; TREM-5; TREM5"
                     /inference="alignment:Splign:2.1.0"
     exon            569..2295
                     /gene="CD300LB"
                     /gene_synonym="CD300b; CLM-7; CLM7; CMRF35-A2; IREM-3;
                     IREM3; TREM-5; TREM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2272..2277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD300LB"
                     /gene_synonym="CD300b; CLM-7; CLM7; CMRF35-A2; IREM-3;
                     IREM3; TREM-5; TREM5"
                     /note="hexamer: AATGAA"
     polyA_site      2295
                     /gene="CD300LB"
                     /gene_synonym="CD300b; CLM-7; CLM7; CMRF35-A2; IREM-3;
                     IREM3; TREM-5; TREM5"
                     /note="major polyA site"
ORIGIN      
        1 caaaggcggt ctagatgtgc agaaggtgca agccagagct caggcagaac ttccagagtg
       61 catctgggat ctgcatttgc cactggttgc agatcaggcg gacgaggagc cgggaaggca
      121 gagccatgtg gctgccccct gctctgctcc ttctcagcct ctcaggctgt ttctccatcc
      181 aaggcccaga gtctgtgaga gccccagagc aggggtccct gacggttcaa tgccactata
      241 agcaaggatg ggagacctac attaagtggt ggtgccgagg ggtgcgctgg gatacatgca
      301 agatcctcat tgaaaccaga gggtcggagc aaggagagaa gagtgaccgt gtgtccatca
      361 aggacaatca gaaagaccgc acgttcactg tgaccatgga ggggctcagg cgagatgacg
      421 cagatgttta ctggtgtggg attgaaagaa gaggacctga ccttgggact caagtgaaag
      481 tgatcgttga cccagaggga gcggcttcca caacagcaag ctcacctacc aacagcaata
      541 tggcagtgtt catcggctcc cacaagagga accactacat gctcctggta tttgtgaagg
      601 tgcccatctt gctcatcttg gtcactgcca tcctctggtt gaaggggtct cagagggtcc
      661 ctgaggagcc aggggaacag cctatctaca tgaacttctc cgaacctctg actaaagaca
      721 tggccactta gagagatgga tctgcagagc cttcctgccc tggccacgtt tccagaagag
      781 actcgggctg tggaaggaac atctacgagt cctcgggatg cagtgactga gataggggcc
      841 ctgggcctcc gccctggcct tggagctggt gggcacctcc ctgttctgca cagctcaggg
      901 acttagccag gtcctctcct gagccaccat cacctcctgg ggtgccagca cctgttctct
      961 tggtcaggag ctgtagagat ggagctcaag cactggacga ctctgtcccc actgctggaa
     1021 taactcgggc acagagcatg ggaccaaagt acagaaagag gttgggggag acccccccag
     1081 ccctagactt ccatcattcc ggagaccaac tcaacaccgt ctttgcctga gaacctgata
     1141 tatccgtgtt tttaaatttt tttttttcta gcaaagttgg gttttaatga cttatgttca
     1201 taggaaacct ctctgatccc acacacaagg agggtgattc tgggatgagt tcctggttct
     1261 agggcatgag gggctggatg gaccctgtcc ccagggagga catggctctg agtccacagg
     1321 gctgaggagg caatgggaac ctccctggcc cggcccggtg cttgtcctcc ccctcccacc
     1381 tcttcctcct cctagctccc caagctccct gcctattccc ccacctccga ggggctgcag
     1441 cttgggagcc tcctcagcat gacagcttgg gtctcctccc caaaagagcc tgtcaggcct
     1501 caagaaccac ctccaggtgg ggagggcagt aacgaaaacc atcgcaggaa atggcaccct
     1561 cccttttcgg tgatgttgaa atcatgttac taatgaaaac tgtcctaggg aagtggttct
     1621 gtctcctcac aggcttcacc cacggcgatg aggcccttga atgtggtcac tttgtgctgt
     1681 atggttgagg gaccctcaca ccaaagggac cttcccatgt gagatgtgct cccgccccca
     1741 cctgcccaca agcaaacaca ccacacatgt tcggcatgtt gccctttgaa cacccatgag
     1801 gacgcctcca acctgctctt ggttctaata gggagtactg actgtcagca gtggataaag
     1861 gagaggggac cctctggtcc ctagcatggc acccagagcc tcccctcttc ttgtccttca
     1921 gccaaagaga aactttctct gactttgaac tgaatttagg tctctggcca atgatgggcc
     1981 tgaaaattcc ataatggcca gagaggagag ttcgagcccg gctaagatcc cctgagtcat
     2041 tctgtgaggg accaagaccc acagtccacc agccccaggg ccctacctcc tggaatgctt
     2101 tcctggatcc agcttcccga agatccgacc agacccaggg aggacggcac cgctccgcgg
     2161 gagggaaagc caaagcatgg tgcttcacca gctggactca ggggcgaggg gacatgggcg
     2221 cttgtcaacg tgatgtcatt cttttcccac cgtttcttcc tgttgatatt caatgaatcc
     2281 gtcaatctct ctgga
//
