LOCUS       NM_181449               3503 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens CD300e molecule (CD300E), mRNA.
ACCESSION   NM_181449
VERSION     NM_181449.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3503)
  AUTHORS   Coletta,S., Salvi,V., Della Bella,C., Bertocco,A., Lonardi,S.,
            Trevellin,E., Fassan,M., D'Elios,M.M., Vermi,W., Vettor,R.,
            Cagnin,S., Sozzani,S., Codolo,G. and de Bernard,M.
  TITLE     The immune receptor CD300e negatively regulates T cell activation
            by impairing the STAT1-dependent antigen presentation
  JOURNAL   Sci Rep 10 (1), 16501 (2020)
   PUBMED   33020563
  REMARK    GeneRIF: The immune receptor CD300e negatively regulates T cell
            activation by impairing the STAT1-dependent antigen presentation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3503)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3503)
  AUTHORS   Martinez-Barriocanal,A., Arcas-Garcia,A., Magallon-Lorenz,M.,
            Ejarque-Ortiz,A., Negro-Demontel,M.L., Comas-Casellas,E.,
            Schwartz,S. Jr., Malhotra,S., Montalban,X., Peluffo,H., Martin,M.,
            Comabella,M. and Sayos,J.
  TITLE     Effect of Specific Mutations in Cd300 Complexes Formation;
            Potential Implication of Cd300f in Multiple Sclerosis
  JOURNAL   Sci Rep 7 (1), 13544 (2017)
   PUBMED   29051512
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3503)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: CD300E expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   5  (bases 1 to 3503)
  AUTHORS   Brckalo,T., Calzetti,F., Perez-Cabezas,B., Borras,F.E.,
            Cassatella,M.A. and Lopez-Botet,M.
  TITLE     Functional analysis of the CD300e receptor in human monocytes and
            myeloid dendritic cells
  JOURNAL   Eur J Immunol 40 (3), 722-732 (2010)
   PUBMED   20039296
REFERENCE   6  (bases 1 to 3503)
  AUTHORS   Clark,G.J., Ju,X., Tate,C. and Hart,D.N.
  TITLE     The CD300 family of molecules are evolutionarily significant
            regulators of leukocyte functions
  JOURNAL   Trends Immunol 30 (5), 209-217 (2009)
   PUBMED   19359216
  REMARK    Review article
REFERENCE   7  (bases 1 to 3503)
  AUTHORS   Clark,G.J., Ju,X., Azlan,M., Tate,C., Ding,Y. and Hart,D.N.
  TITLE     The CD300 molecules regulate monocyte and dendritic cell functions
  JOURNAL   Immunobiology 214 (9-10), 730-736 (2009)
   PUBMED   19592130
  REMARK    Review article
REFERENCE   8  (bases 1 to 3503)
  AUTHORS   Martinez-Barriocanal,A. and Sayos,J.
  TITLE     Molecular and functional characterization of CD300b, a new
            activating immunoglobulin receptor able to transduce signals
            through two different pathways
  JOURNAL   J Immunol 177 (5), 2819-2830 (2006)
   PUBMED   16920917
REFERENCE   9  (bases 1 to 3503)
  AUTHORS   Aguilar,H., Alvarez-Errico,D., Garcia-Montero,A.C., Orfao,A.,
            Sayos,J. and Lopez-Botet,M.
  TITLE     Molecular characterization of a novel immune receptor restricted to
            the monocytic lineage
  JOURNAL   J Immunol 173 (11), 6703-6711 (2004)
   PUBMED   15557162
  REMARK    GeneRIF: IREM-2 is a novel activating immunoglobulin-like receptor
            expressed on mature hemopoietic cells of the monocytic and myeloid
            dendritic cell lineages.
REFERENCE   10 (bases 1 to 3503)
  AUTHORS   Alvarez-Errico,D., Aguilar,H., Kitzig,F., Brckalo,T., Sayos,J. and
            Lopez-Botet,M.
  TITLE     IREM-1 is a novel inhibitory receptor expressed by myeloid cells
  JOURNAL   Eur J Immunol 34 (12), 3690-3701 (2004)
   PUBMED   15549731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK303545.1, BC100890.1 and AC064805.13.
            
            On Nov 23, 2018 this sequence version replaced NM_181449.2.
            
            Summary: This gene encodes a member of the CD300 glycoprotein
            family of cell surface proteins expressed on myeloid cells. The
            protein interacts with the TYRO protein tyrosine kinase-binding
            protein and is thought to act as an activating receptor. [provided
            by RefSeq, Nov 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. An in-frame
            AUG is located 41 codons upstream of the annotated translation
            start site but is not being annotated as a start site since it is
            not conserved and is in a weak Kozak sequence context.
            
            CCDS Note: This CCDS representation contains an upstream in-frame
            start codon that could result in a longer protein N-terminus.
            However, a downstream start codon is annotated because use of the
            upstream start codon would eliminate an N-terminal signal peptide,
            whose presence is consistent with functional support for CD300
            family members (e.g., PMIDs 16920917, 19359216).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648376.1, AK298031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000392619.2/
                                                ENSP00000376395.2
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AK303545.1         21-102
            83-588              BC100890.1         1-506
            589-589             AC064805.13        23370-23370         c
            590-807             BC100890.1         508-725
            808-3503            AC064805.13        19305-22000         c
FEATURES             Location/Qualifiers
     source          1..3503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..3503
                     /gene="CD300E"
                     /gene_synonym="CD300LE; CLM-2; CLM2; CMRF35-A5; IREM-2;
                     IREM2; PIgR-2; PIgR2"
                     /note="CD300e molecule"
                     /db_xref="GeneID:342510"
                     /db_xref="HGNC:HGNC:28874"
                     /db_xref="MIM:609801"
     exon            1..157
                     /gene="CD300E"
                     /gene_synonym="CD300LE; CLM-2; CLM2; CMRF35-A5; IREM-2;
                     IREM2; PIgR-2; PIgR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..735
                     /gene="CD300E"
                     /gene_synonym="CD300LE; CLM-2; CLM2; CMRF35-A5; IREM-2;
                     IREM2; PIgR-2; PIgR2"
                     /note="CD300e antigen; CMRF35-like molecule 2; immune
                     receptor expressed on myeloid cells 2; poly-Ig receptor 2;
                     CD300 antigen-like family member E; polymeric
                     immunoglobulin receptor 2"
                     /codon_start=1
                     /product="CMRF35-like molecule 2 precursor"
                     /protein_id="NP_852114.2"
                     /db_xref="CCDS:CCDS11702.1"
                     /db_xref="GeneID:342510"
                     /db_xref="HGNC:HGNC:28874"
                     /db_xref="MIM:609801"
                     /translation="MWLLPALLLLCLSGCLSLKGPGSVTGTAGDSLTVWCQYESMYKG
                     YNKYWCRGQYDTSCESIVETKGEEKVERNGRVSIRDHPEALAFTVTMQNLNEDDAGSY
                     WCKIQTVWVLDSWSRDPSDLVRVYVSPAITTPRRTTHPATPPIFLVVNPGRNLSTGEV
                     LTQNSGFRLSSPHFLLVVLLKLPLLLSMLGAVFWVNRPQWAPPGR"
     exon            158..505
                     /gene="CD300E"
                     /gene_synonym="CD300LE; CLM-2; CLM2; CMRF35-A5; IREM-2;
                     IREM2; PIgR-2; PIgR2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..614
                     /gene="CD300E"
                     /gene_synonym="CD300LE; CLM-2; CLM2; CMRF35-A5; IREM-2;
                     IREM2; PIgR-2; PIgR2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..3503
                     /gene="CD300E"
                     /gene_synonym="CD300LE; CLM-2; CLM2; CMRF35-A5; IREM-2;
                     IREM2; PIgR-2; PIgR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3483..3488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD300E"
                     /gene_synonym="CD300LE; CLM-2; CLM2; CMRF35-A5; IREM-2;
                     IREM2; PIgR-2; PIgR2"
                     /note="hexamer: AATAAA"
     polyA_site      3503
                     /gene="CD300E"
                     /gene_synonym="CD300LE; CLM-2; CLM2; CMRF35-A5; IREM-2;
                     IREM2; PIgR-2; PIgR2"
                     /note="major polyA site"
ORIGIN      
        1 gagaacacaa aggaaacttg gacaagtaga aagtggatga cccaggctcc gttacatata
       61 cttggattcc agctgggacc tagatttgct gaggacggaa gccaaggaga caggaacatg
      121 tggctgctcc cagctctact ccttctctgc ctctcaggct gtttgtctct gaagggcccc
      181 ggctctgtga ctggcactgc gggggactct ctgacagtgt ggtgtcagta tgagagcatg
      241 tacaagggat ataacaagta ctggtgccga ggacagtacg acacgtcatg tgagagcatt
      301 gtggagacca agggagaaga gaaggtggag aggaatggcc gcgtgtccat cagagaccac
      361 ccggaggctc tcgccttcac tgtgaccatg cagaacctca atgaagatga tgctggatct
      421 tactggtgca aaattcagac agtgtgggtc ctggattcat ggtcacgcga tccctcggac
      481 ctggttaggg tgtatgtttc cccagcaatt acaaccccaa ggaggaccac acatccagcc
      541 acacctccca tcttcctggt ggtgaaccct gggcgaaacc tcagcaccgg ggaggtgttg
      601 acccaaaatt cagggttccg gctcagcagc cctcacttcc tgctcgtggt ccttctgaag
      661 ctgcccctgc tcctgagcat gctgggtgct gtcttctggg tgaacaggcc tcagtgggct
      721 cctcctggaa gatagagcca ggctgacccg aagccctgca gagccccatc cccaggagtg
      781 ccccgtgcag ggagtcaacc tttcagactg gatgcgagag acctgtggac tctggaggga
      841 tttattgttc ctgtgcctca aaggagggtc ctggctctta gaggacactc ctctggagtc
      901 ctcaatgtgc agcttggggg tcctcctttc tcctccccag tcccctgcct ccctgccctc
      961 atgcccactt cccaagggca agaattccct ggaagttggc cgggcaccat agcgagtgcc
     1021 tataatccca gctcaggagg ctgaggcagg aggatcggct gaacgtaaga gttccaggcc
     1081 agcctgggca acatagagag ccctgtctca gagagagaga gagagagaga gagagagaga
     1141 cagagagaga gagagagaga gagcgagaga gagagagaga gagagaaaag gacggaggaa
     1201 gggagggaaa aaattttctg gaggagcctg gcccttcatt cttcttggca caaatgcttc
     1261 tcaggccagt ttcccccagg gcaataacta cctccttcct gcagacagga gtctccctga
     1321 ggacacaccc ctcacagccc cagcctttag gctcacagag ctccatctct tctctgggac
     1381 aaccccaagg gagcttggtc ccggcagagc ttgctcatgc agttgcccag tgtcccacat
     1441 gctcagggct cctctcgtct tctgacgccc cttgggtctc cctggcttta aggccccttc
     1501 tctccctgta accaggcagt gtgtggctgg gctcagaaca tctctgcctg ggtgggccgt
     1561 ggatgagctg ctccaggtta aagttctggg gcgagttgaa acagtaaagg gagaaggagc
     1621 tggtgggtgc ccctgatatc actcctggaa ttcccccacc tggaggtgtc caatgcacaa
     1681 ggtcaacaga gtcagttctg tccactttag aagtctggct gagaccacct gttagcaatt
     1741 aaccttttcc acaggcagag cagatatcgt ttttcaaaga caggatggag ggcacagagg
     1801 tgaaggatac ttgtccacac ttgaagtgca cagtgctatc accactactg gtgacccctg
     1861 gctcgggaat gagctcagtt ggttttctga atgtttgtca attactctgt ttccctaaag
     1921 tttgtgggga ggactcccac agtctgccac aagcaagcat caccatctcc acttgctacc
     1981 tacatctgga ccagtgctcc ccctctgccc ccaggcctga gctcatcctg agctagtgat
     2041 gccagtgtcc agagcacatg gagtgaccct ctgagtgccg agtgcttagg cagagctgcc
     2101 gtgctctgaa cttgagctct ggtggggctc ccagctccat catgcatggt gactagggga
     2161 aagatggggc tggcccagga ctcatgctga aagagaaatt caatctaaca aggcccatat
     2221 taattatatt aacccgggaa atatgatgat gagcaagaaa ggagcttatg attcatttta
     2281 tgagaaggat aagctcccaa gtcattacag cataggaaga actctagagc cacaagagat
     2341 gcttcctgat gtcagggggt tggtgaggag aatatcatgc caagctggcc aggtcaggga
     2401 aagaaggtga cattcatgtt gatgttgaag gaggtatagg atttcagcgg agcagggatg
     2461 gagcaacagg gagagagaga ggacagagaa acagcataag tgaaagcaga gaggcgggaa
     2521 ataatcttca taacaatagt cacttataga agacctatca gcaaatggac tgtactgttc
     2581 acatacagat gctcatggta ggatgtgtct aagattccaa tggagtgaaa ttttcctgtg
     2641 gcaggccaga tggaactaat ctagaagaac tcaggtggtg gcaggttcag gaggcttagg
     2701 actcaactct tacttaaact ttgattagct atggtgggat ggatttgagc agaacaagat
     2761 gggattgcag atgtgcttta ggaggacttg cctagcagat gtagcaaagt ctgaaaggaa
     2821 gaatctggga gtccggagtc ttaagcctgg aaaaccagag gaatcgggca tcattgacag
     2881 aagtaggaaa gtcaagagca ggcttggatg atgcagagct tagttttctg tgtgtttgga
     2941 atcatcaggc agagaggtct agcagatagc tagagatgtg ggttagcaga gtgttgaggg
     3001 ctggagagga atgtgtgtag agagattaac tggaacccag caagaagtga aaacatggag
     3061 ggaagagttc agaaccaagg acagagccct cggggcacct gcatttaaag acaaagggta
     3121 ggaggaagac attgatcaag gtgctggagc agaatcaaac aggtggaaga tgagaagtca
     3181 agagccatga atgtttcaag gaggagagca gagctagaga ggtggaggag gaccgggatt
     3241 gagaggaggc tattgaactt atcattcaca aggtcactaa tgaagttcag aagagcagat
     3301 caacagagca atgacagcag aagccagaag agaagagtta agaaagagta gacagatggc
     3361 agacagcagg tgcaggagaa acaaacagtg gcttctccat gctttgaatt ttcccttctc
     3421 ccttactccc tttttttccc ctattcttcc tttctttttt ccctttattt actcattcat
     3481 tcaataaact tttattgtgt gtc
//
