LOCUS       NM_006678               1524 bp    mRNA    linear   PRI 27-NOV-2021
DEFINITION  Homo sapiens CD300c molecule (CD300C), mRNA.
ACCESSION   NM_006678
VERSION     NM_006678.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1524)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1524)
  AUTHORS   Zenarruzabeitia O, Vitalle J, Terren I, Orrantia A, Astigarraga I,
            Dopazo L, Gonzalez C, Santos-Diez L, Tutau C, Gamboa PM, Bilbao A
            and Borrego F.
  TITLE     CD300c costimulates IgE-mediated basophil activation, and its
            expression is increased in patients with cow's milk allergy
  JOURNAL   J Allergy Clin Immunol 143 (2), 700-711 (2019)
   PUBMED   29906528
  REMARK    GeneRIF: CD300c could be considered a biomarker and therapeutic
            target in patients with IgE-mediated allergic diseases
REFERENCE   3  (bases 1 to 1524)
  AUTHORS   Cui C, Su M, Lin Y and Lai L.
  TITLE     A CD300c-Fc Fusion Protein Inhibits T Cell Immunity
  JOURNAL   Front Immunol 9, 2657 (2018)
   PUBMED   30498497
  REMARK    GeneRIF: Administration of CD300c-Fc protein attenuates
            graft-vs.-host disease (GVHD) in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1524)
  AUTHORS   Martinez-Barriocanal A, Arcas-Garcia A, Magallon-Lorenz M,
            Ejarque-Ortiz A, Negro-Demontel ML, Comas-Casellas E, Schwartz S
            Jr, Malhotra S, Montalban X, Peluffo H, Martin M, Comabella M and
            Sayos J.
  TITLE     Effect of Specific Mutations in Cd300 Complexes Formation;
            Potential Implication of Cd300f in Multiple Sclerosis
  JOURNAL   Sci Rep 7 (1), 13544 (2017)
   PUBMED   29051512
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1524)
  AUTHORS   Dimitrova M, Zenarruzabeitia O, Borrego F and Simhadri VR.
  TITLE     CD300c is uniquely expressed on CD56 bright Natural Killer Cells
            and differs from CD300a upon ligand recognition
  JOURNAL   Sci Rep 6, 23942 (2016)
   PUBMED   27040328
  REMARK    GeneRIF: Results show that CD300c is exclusively expressed on
            CD56bright natural killer cells and differentially binds to
            phosphatidylethanolamine and phosphatidylserine. This expression is
            under the regulation of STAT5 and Il-4.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1524)
  AUTHORS   Ju X, Zenke M, Hart DN and Clark GJ.
  TITLE     CD300a/c regulate type I interferon and TNF-alpha secretion by
            human plasmacytoid dendritic cells stimulated with TLR7 and TLR9
            ligands
  JOURNAL   Blood 112 (4), 1184-1194 (2008)
   PUBMED   18535206
  REMARK    GeneRIF: CD300a and CD300c play an important role in the
            cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs;
            CD300a/c RNA and surface expression were downregulated after
            stimulation of pDCs with TLR7 and TLR9 ligands
REFERENCE   7  (bases 1 to 1524)
  AUTHORS   Clark GJ, Fitzpatrick S, Kuo B, Modra C, Jamriska L and Hart DN.
  TITLE     CMRF-35A, CMRF-35H: potential new CD
  JOURNAL   J Biol Regul Homeost Agents 16 (3), 233-235 (2002)
   PUBMED   12456026
  REMARK    GeneRIF: CMRF35A and CMRF35H have roles in immunoglobulin
            signaling; CMRF35A induces cellular activation and effector
            function [review]
            Review article
REFERENCE   8  (bases 1 to 1524)
  AUTHORS   Clark GJ, Cooper B, Fitzpatrick S, Green BJ and Hart DN.
  TITLE     The gene encoding the immunoregulatory signaling molecule CMRF-35A
            localized to human chromosome 17 in close proximity to other
            members of the CMRF-35 family
  JOURNAL   Tissue Antigens 57 (5), 415-423 (2001)
   PUBMED   11556966
REFERENCE   9  (bases 1 to 1524)
  AUTHORS   Clark GJ, Green BJ and Hart DN.
  TITLE     The CMRF-35H gene structure predicts for an independently expressed
            member of an ITIM/ITAM pair of molecules localized to human
            chromosome 17
  JOURNAL   Tissue Antigens 55 (2), 101-109 (2000)
   PUBMED   10746781
REFERENCE   10 (bases 1 to 1524)
  AUTHORS   Jackson DG, Hart DN, Starling G and Bell JI.
  TITLE     Molecular cloning of a novel member of the immunoglobulin gene
            superfamily homologous to the polymeric immunoglobulin receptor
  JOURNAL   Eur J Immunol 22 (5), 1157-1163 (1992)
   PUBMED   1349532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC022279.1, AC079325.10 and BF508242.1.
            
            On May 17, 2019 this sequence version replaced NM_006678.4.
            
            Summary: The CMRF35 antigen, which was identified by reactivity
            with a monoclonal antibody, is present on monocytes, neutrophils,
            and some T and B lymphocytes (Jackson et al., 1992 [PubMed
            1349532]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022279.1, SRR3476690.251893.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2158569
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330793.2/ ENSP00000329507.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               BC022279.1         29-302
            275-275             AC079325.10        50321-50321
            276-1489            BC022279.1         304-1517
            1490-1491           AC079325.10        55055-55056
            1492-1524           BF508242.1         23-55               c
FEATURES             Location/Qualifiers
     source          1..1524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1524
                     /gene="CD300C"
                     /gene_synonym="CLM-6; CMRF-35; CMRF-35A; CMRF35;
                     CMRF35-A1; CMRF35A; CMRF35A1; IGSF16; LIR"
                     /note="CD300c molecule"
                     /db_xref="GeneID:10871"
                     /db_xref="HGNC:HGNC:19320"
                     /db_xref="MIM:606786"
     exon            1..394
                     /gene="CD300C"
                     /gene_synonym="CLM-6; CMRF-35; CMRF-35A; CMRF35;
                     CMRF35-A1; CMRF35A; CMRF35A1; IGSF16; LIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1008
                     /gene="CD300C"
                     /gene_synonym="CLM-6; CMRF-35; CMRF-35A; CMRF35;
                     CMRF35-A1; CMRF35A; CMRF35A1; IGSF16; LIR"
                     /note="CMRF35 antigen; CMRF35A leukocyte
                     immunoglobulin-like receptor; CMRF35 leukocyte
                     immunoglobulin-like receptor; CD300c antigen; CMRF35-like
                     molecule 6; CD300 antigen-like family member C;
                     immunoglobulin superfamily member 16"
                     /codon_start=1
                     /product="CMRF35-like molecule 6 precursor"
                     /protein_id="NP_006669.1"
                     /db_xref="CCDS:CCDS11701.1"
                     /db_xref="GeneID:10871"
                     /db_xref="HGNC:HGNC:19320"
                     /db_xref="MIM:606786"
                     /translation="MTARAWASWRSSALLLLLVPGYFPLSHPMTVAGPVGGSLSVQCR
                     YEKEHRTLNKFWCRPPQILRCDKIVETKGSAGKRNGRVSIRDSPANLSFTVTLENLTE
                     EDAGTYWCGVDTPWLRDFHDPIVEVEVSVFPAGTTTASSPQSSMGTSGPPTKLPVHTW
                     PSVTRKDSPEPSPHPGSLFSNVRFLLLVLLELPLLLSMLGAVLWVNRPQRSSRSRQNW
                     PKGENQ"
     exon            395..733
                     /gene="CD300C"
                     /gene_synonym="CLM-6; CMRF-35; CMRF-35A; CMRF35;
                     CMRF35-A1; CMRF35A; CMRF35A1; IGSF16; LIR"
                     /inference="alignment:Splign:2.1.0"
     exon            734..860
                     /gene="CD300C"
                     /gene_synonym="CLM-6; CMRF-35; CMRF-35A; CMRF35;
                     CMRF35-A1; CMRF35A; CMRF35A1; IGSF16; LIR"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1524
                     /gene="CD300C"
                     /gene_synonym="CLM-6; CMRF-35; CMRF-35A; CMRF35;
                     CMRF35-A1; CMRF35A; CMRF35A1; IGSF16; LIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1470..1475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD300C"
                     /gene_synonym="CLM-6; CMRF-35; CMRF-35A; CMRF35;
                     CMRF35-A1; CMRF35A; CMRF35A1; IGSF16; LIR"
                     /note="hexamer: AATAAA"
     polyA_site      1491
                     /gene="CD300C"
                     /gene_synonym="CLM-6; CMRF-35; CMRF-35A; CMRF35;
                     CMRF35-A1; CMRF35A; CMRF35A1; IGSF16; LIR"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgtgag taacacactg aagccagaag ctgtgggctg tggggaagtg gctgcatcgc
       61 cacccaaggg accctggact ttgccagacg tcagggttga gaggagccac tagcaccatc
      121 ccagagctgt cagcaccggc ctcagcccag gcggctctct ccctgagctt cctgtaccct
      181 gaccctctcc agcctcagac ctgagacagg gctggacaag gaagcagaga gcagaagaaa
      241 agcagaagcg aagctcagat ctgctgggag gagattacat tttgtcccct cctggggtct
      301 tgcacagtgg caggtgacat tcgtgttaca ggaatgactg ccagggcctg ggcctcgtgg
      361 cggtcttcag ctctgctcct cctgcttgtc ccaggctatt ttcctctgag ccaccccatg
      421 accgtggcgg gccccgtggg gggatccctg agtgtgcagt gtcgctatga gaaggaacac
      481 aggaccctca acaaattctg gtgcagacca ccacagattc tccgatgtga caagattgtg
      541 gagaccaaag ggtcagcagg gaaaaggaat ggccgagtgt ccatcaggga cagtcctgca
      601 aacctcagct tcacagtgac cctggagaat ctcacagagg aggacgcagg cacctactgg
      661 tgtggggtgg atacaccgtg gctccgagac tttcatgatc ccattgtcga ggttgaggtg
      721 tccgtgttcc cggccgggac gaccacagcc tccagccccc agagctccat gggcacctca
      781 ggtcctccca cgaagctgcc cgtgcacacc tggcccagcg tgaccagaaa ggacagcccc
      841 gaacccagcc cacaccctgg ctccctgttc agcaatgtcc gcttcctgct cctggtcctc
      901 ttggagctgc ccctgctcct gagcatgctg ggtgccgtcc tctgggtgaa cagacctcag
      961 agaagctcta gaagcaggca gaattggccc aagggtgaga accagtagca tctgctgtcc
     1021 atcaaggccc tgtgctgcaa cagagcccct ctgggggact ggaatgacct cctgaccact
     1081 ccctcccggg ctgctctctc cacatctcct ggaatccttt gtgagcctcc ttcagccttt
     1141 tccctgtgcc cgatcctcat gtgtcacatg tgaacctgac ggacatggac gccctgagct
     1201 gtgagtccac gtctcatgtg cacgccccgg ccagctaagc ctcgggccgt cagcaatacc
     1261 tctgagtgcc cggatgccct ccctgcaccc ttccatttct ccaggagcct ggcactgctt
     1321 cctccaccgt tttcacaggg agaagcaggt ctaggactcc cctgcacctt tgccaccata
     1381 atggcccaca ctccctgggt ccaggagtgt agaatatgcg gctgcttcca tttgctgagt
     1441 gtgtcgattc aatgatgctt tcaaacttta ataaatgaca atgtgtaggt ttgggatgta
     1501 tcaggcccac tcagtcagac ctga
//
