LOCUS       NM_007261               1638 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens CD300a molecule (CD300A), transcript variant 1, mRNA.
ACCESSION   NM_007261 XM_046925
VERSION     NM_007261.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1638)
  AUTHORS   Cao,Y., Ao,T., Wang,X., Wei,W., Fan,J. and Tian,X.
  TITLE     CD300a and CD300f molecules regulate the function of leukocytes
  JOURNAL   Int Immunopharmacol 93, 107373 (2021)
   PUBMED   33548578
  REMARK    GeneRIF: CD300a and CD300f molecules regulate the function of
            leukocytes.
            Review article
REFERENCE   2  (bases 1 to 1638)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   3  (bases 1 to 1638)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1638)
  AUTHORS   Vitalle,J., Terren,I., Orrantia,A., Zenarruzabeitia,O. and
            Borrego,F.
  TITLE     CD300 receptor family in viral infections
  JOURNAL   Eur J Immunol 49 (3), 364-374 (2019)
   PUBMED   30485414
  REMARK    GeneRIF: CD300 molecules participate in the mechanisms that viruses
            employ to develop immune evasion strategies and to infect host
            cells [Review].
            Review article
REFERENCE   5  (bases 1 to 1638)
  AUTHORS   Martinez-Barriocanal,A., Arcas-Garcia,A., Magallon-Lorenz,M.,
            Ejarque-Ortiz,A., Negro-Demontel,M.L., Comas-Casellas,E.,
            Schwartz,S. Jr., Malhotra,S., Montalban,X., Peluffo,H., Martin,M.,
            Comabella,M. and Sayos,J.
  TITLE     Effect of Specific Mutations in Cd300 Complexes Formation;
            Potential Implication of Cd300f in Multiple Sclerosis
  JOURNAL   Sci Rep 7 (1), 13544 (2017)
   PUBMED   29051512
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1638)
  AUTHORS   Clark,G.J., Fitzpatrick,S., Kuo,B., Modra,C., Jamriska,L. and
            Hart,D.N.
  TITLE     CMRF-35A, CMRF-35H: potential new CD
  JOURNAL   J Biol Regul Homeost Agents 16 (3), 233-235 (2002)
   PUBMED   12456026
  REMARK    GeneRIF: CMRF35A and CMRF35H have roles in immunoglobulin
            signaling; CMRF35H is an inhibitory molecule [review]
            Review article
REFERENCE   7  (bases 1 to 1638)
  AUTHORS   Clark,G.J., Green,B.J. and Hart,D.N.
  TITLE     The CMRF-35H gene structure predicts for an independently expressed
            member of an ITIM/ITAM pair of molecules localized to human
            chromosome 17
  JOURNAL   Tissue Antigens 55 (2), 101-109 (2000)
   PUBMED   10746781
REFERENCE   8  (bases 1 to 1638)
  AUTHORS   Cantoni,C., Bottino,C., Augugliaro,R., Morelli,L., Marcenaro,E.,
            Castriconi,R., Vitale,M., Pende,D., Sivori,S., Millo,R.,
            Biassoni,R., Moretta,L. and Moretta,A.
  TITLE     Molecular and functional characterization of IRp60, a member of the
            immunoglobulin superfamily that functions as an inhibitory receptor
            in human NK cells
  JOURNAL   Eur J Immunol 29 (10), 3148-3159 (1999)
   PUBMED   10540326
REFERENCE   9  (bases 1 to 1638)
  AUTHORS   Green,B.J., Clark,G.J. and Hart,D.N.
  TITLE     The CMRF-35 mAb recognizes a second leukocyte membrane molecule
            with a domain similar to the poly Ig receptor
  JOURNAL   Int Immunol 10 (7), 891-899 (1998)
   PUBMED   9701027
REFERENCE   10 (bases 1 to 1638)
  AUTHORS   Jackson,D.G., Hart,D.N., Starling,G. and Bell,J.I.
  TITLE     Molecular cloning of a novel member of the immunoglobulin gene
            superfamily homologous to the polymeric immunoglobulin receptor
  JOURNAL   Eur J Immunol 22 (5), 1157-1163 (1992)
   PUBMED   1349532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC032352.1.
            
            On May 17, 2019 this sequence version replaced NM_007261.3.
            
            Summary: This gene encodes a member of the CD300 glycoprotein
            family of cell surface proteins found on leukocytes involved in
            immune response signaling pathways. This gene is located on
            chromosome 17 in a cluster with all but one of the other family
            members. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1), also
            referred to as IRC1a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032352.1, SRR5189664.55736.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360141.8/ ENSP00000353259.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1638              BC032352.1         217-1854
FEATURES             Location/Qualifiers
     source          1..1638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1638
                     /gene="CD300A"
                     /gene_synonym="CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H;
                     CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2;
                     IRC2; IRp60"
                     /note="CD300a molecule"
                     /db_xref="GeneID:11314"
                     /db_xref="HGNC:HGNC:19319"
                     /db_xref="MIM:606790"
     exon            1..110
                     /gene="CD300A"
                     /gene_synonym="CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H;
                     CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2;
                     IRC2; IRp60"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..970
                     /gene="CD300A"
                     /gene_synonym="CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H;
                     CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2;
                     IRC2; IRp60"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CMRF35H leukocyte immunoglobulin-like receptor;
                     leukocyte membrane antigen; CD300a antigen; CMRF35-like
                     molecule 8; NK inhibitory receptor; inhibitory receptor
                     protein 60; CD300 antigen-like family member A;
                     immunoglobulin superfamily member 12"
                     /codon_start=1
                     /product="CMRF35-like molecule 8 isoform 1 precursor"
                     /protein_id="NP_009192.2"
                     /db_xref="CCDS:CCDS32720.1"
                     /db_xref="GeneID:11314"
                     /db_xref="HGNC:HGNC:19319"
                     /db_xref="MIM:606790"
                     /translation="MWLPWALLLLWVPGCFALSKCRTVAGPVGGSLSVQCPYEKEHRT
                     LNKYWCRPPQIFLCDKIVETKGSAGKRNGRVSIRDSPANLSFTVTLENLTEEDAGTYW
                     CGVDTPWLRDFHDPVVEVEVSVFPASTSMTPASITAAKTSTITTAFPPVSSTTLFAVG
                     ATHSASIQEETEEVVNSQLPLLLSLLALLLLLLVGASLLAWRMFQKWIKAGDHSELSQ
                     NPKQAATQSELHYANLELLMWPLQEKPAPPREVEVEYSTVASPREELHYASVVFDSNT
                     NRIAAQRPREEEPDSDYSVIRKT"
     exon            111..449
                     /gene="CD300A"
                     /gene_synonym="CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H;
                     CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2;
                     IRC2; IRp60"
                     /inference="alignment:Splign:2.1.0"
     exon            450..603
                     /gene="CD300A"
                     /gene_synonym="CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H;
                     CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2;
                     IRC2; IRp60"
                     /inference="alignment:Splign:2.1.0"
     exon            604..698
                     /gene="CD300A"
                     /gene_synonym="CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H;
                     CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2;
                     IRC2; IRp60"
                     /inference="alignment:Splign:2.1.0"
     exon            699..736
                     /gene="CD300A"
                     /gene_synonym="CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H;
                     CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2;
                     IRC2; IRp60"
                     /inference="alignment:Splign:2.1.0"
     exon            737..844
                     /gene="CD300A"
                     /gene_synonym="CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H;
                     CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2;
                     IRC2; IRp60"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1638
                     /gene="CD300A"
                     /gene_synonym="CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H;
                     CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2;
                     IRC2; IRp60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1618..1623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD300A"
                     /gene_synonym="CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H;
                     CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2;
                     IRC2; IRp60"
                     /note="hexamer: AGTAAA"
     polyA_site      1638
                     /gene="CD300A"
                     /gene_synonym="CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H;
                     CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2;
                     IRC2; IRp60"
                     /note="major polyA site"
ORIGIN      
        1 gtgactttcc cctcgggtcc aggtagggcc tggagctgct gcaagtgccg cctgtgctgg
       61 ggaagggacc atgtggctgc cttgggctct gttgcttctc tgggtcccag gatgttttgc
      121 tctgagcaaa tgcaggaccg tggcgggccc cgtgggggga tccctgagtg tgcagtgtcc
      181 ctatgagaag gaacacagga ccctcaacaa atactggtgc agaccaccac agattttcct
      241 atgtgacaag attgtggaga ccaaagggtc agcaggaaaa aggaacggcc gagtgtccat
      301 cagggacagt cctgcaaacc tcagcttcac agtgaccctg gagaatctca cagaggagga
      361 tgcaggcacc tactggtgtg gggtggatac accatggctc cgagactttc atgatcccgt
      421 tgtcgaggtt gaggtgtccg tgttcccggc atcaacgtca atgacacctg caagtatcac
      481 tgcggccaag acctcaacaa tcacaactgc atttccacct gtatcatcca ctaccctgtt
      541 tgcagtgggt gccacccaca gtgccagcat ccaggaggaa actgaggagg tggtgaactc
      601 acagctcccg ctgctcctct ccctgctggc attgttgctg cttctgttgg tgggggcctc
      661 cctgctagcc tggaggatgt ttcagaaatg gatcaaagct ggtgaccatt cagagctgtc
      721 ccagaacccc aagcaggctg ccacgcagag tgagctgcac tacgcaaatc tggagctgct
      781 gatgtggcct ctgcaggaaa agccagcacc accaagggag gtggaggtgg aatacagcac
      841 tgtggcctcc cccagggaag aacttcacta tgcctcggtg gtgtttgatt ctaacaccaa
      901 caggatagct gctcagaggc ctcgggagga ggaaccagat tcagattaca gtgtgataag
      961 gaagacatag gcttttgtcc tgcctcgcca tcggagctct catgggcccc aggaagtcca
     1021 gggacagctc ccttatacct ggcccacgtc cttctcagcc tgccctcgac aacagtgacc
     1081 aacagacagg cagctgggtt tcccaggcca tccctctgtt gccatcagct tgattggctt
     1141 ccccgagggc cagcagggct gggggctccg gagagcagca ggaagcactc ccagccacca
     1201 gtgcctgtca cctctttccc ctttgcccct gcttcatccc agctctgtgt gtggaggaca
     1261 aagcttcttc ctgcgtggct ccaggaaaag atgtggctca cgtaggtggc acctgccaat
     1321 agctttgtca atcacagccc cataggaacg tctggaattg cttgggagtt ggggagaact
     1381 gtcaagaaga gtgaagagag tgccaaagcg gagatctgtt cacctggggg ccatggaggg
     1441 gggacccact aaagatcaag atcaaagatt ctccccatct cacagacaag gaaactgagg
     1501 ccagagggag gagagaattg ctcatggctc cagaactggt ggcaagtttc tctggactct
     1561 taggtttatt tttaatatga aatataaaaa cagtttcaaa tatcttattg agggagaagt
     1621 aaaaacttat ttaaacaa
//
