LOCUS       NM_012120               5412 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens CD2 associated protein (CD2AP), mRNA.
ACCESSION   NM_012120
VERSION     NM_012120.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5412)
  AUTHORS   Yu,L., Li,Y., Zhang,Y., Weng,L., Shuai,D., Zhu,J., Niu,C., Chu,M.
            and Jia,C.
  TITLE     Human cytomegalovirus pUL135 protein affects endothelial cell
            function via CD2AP in Kawasaki disease
  JOURNAL   Int J Cardiol 413, 132364 (2024)
   PUBMED   39025135
  REMARK    GeneRIF: Human cytomegalovirus pUL135 protein affects endothelial
            cell function via CD2AP in Kawasaki disease.
REFERENCE   2  (bases 1 to 5412)
  AUTHORS   Kurilla,A., Laszlo,L., Takacs,T., Tilajka,A., Lukacs,L., Novak,J.,
            Pancsa,R., Buday,L. and Vas,V.
  TITLE     Studying the Association of TKS4 and CD2AP Scaffold Proteins and
            Their Implications in the Partial Epithelial-Mesenchymal Transition
            (EMT) Process
  JOURNAL   Int J Mol Sci 24 (20), 15136 (2023)
   PUBMED   37894817
  REMARK    GeneRIF: Studying the Association of TKS4 and CD2AP Scaffold
            Proteins and Their Implications in the Partial
            Epithelial-Mesenchymal Transition (EMT) Process.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5412)
  AUTHORS   Xue,Y.Y., Chen,Y.H., Lin,R.R., Huang,H.F., Wu,Z.Y. and Tao,Q.Q.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Alzheimer's disease susceptibility locus in CD2AP is associated
            with increased cerebrospinal fluid tau levels in mild cognitive
            impairment
  JOURNAL   Neurosci Lett 771, 136419 (2022)
   PUBMED   34958910
  REMARK    GeneRIF: Alzheimer's disease susceptibility locus in CD2AP is
            associated with increased cerebrospinal fluid tau levels in mild
            cognitive impairment.
REFERENCE   4  (bases 1 to 5412)
  AUTHORS   Zhang,J., Ding,J., Yu,M., Li,F., Zhou,X. and Shuai,H.
  TITLE     Long non-coding RNA TTC28-AS1 attenuates high glucose-induced
            damage in HK-2 cells depending on the regulation of miR-320a/CD2AP
            axis
  JOURNAL   Genes Genomics 43 (12), 1471-1482 (2021)
   PUBMED   34623609
  REMARK    GeneRIF: Long non-coding RNA TTC28-AS1 attenuates high
            glucose-induced damage in HK-2 cells depending on the regulation of
            miR-320a/CD2AP axis.
REFERENCE   5  (bases 1 to 5412)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5412)
  AUTHORS   Kirsch,K.H., Georgescu,M.M., Shishido,T., Langdon,W.Y., Birge,R.B.
            and Hanafusa,H.
  TITLE     The adapter type protein CMS/CD2AP binds to the proto-oncogenic
            protein c-Cbl through a tyrosine phosphorylation-regulated Src
            homology 3 domain interaction
  JOURNAL   J Biol Chem 276 (7), 4957-4963 (2001)
   PUBMED   11067845
REFERENCE   7  (bases 1 to 5412)
  AUTHORS   Lehtonen,S., Ora,A., Olkkonen,V.M., Geng,L., Zerial,M., Somlo,S.
            and Lehtonen,E.
  TITLE     In vivo interaction of the adapter protein CD2-associated protein
            with the type 2 polycystic kidney disease protein, polycystin-2
  JOURNAL   J Biol Chem 275 (42), 32888-32893 (2000)
   PUBMED   10913159
REFERENCE   8  (bases 1 to 5412)
  AUTHORS   Li,C., Ruotsalainen,V., Tryggvason,K., Shaw,A.S. and Miner,J.H.
  TITLE     CD2AP is expressed with nephrin in developing podocytes and is
            found widely in mature kidney and elsewhere
  JOURNAL   Am J Physiol Renal Physiol 279 (4), F785-F792 (2000)
   PUBMED   10997929
REFERENCE   9  (bases 1 to 5412)
  AUTHORS   Kirsch,K.H., Georgescu,M.M., Ishimaru,S. and Hanafusa,H.
  TITLE     CMS: an adapter molecule involved in cytoskeletal rearrangements
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6211-6216 (1999)
   PUBMED   10339567
REFERENCE   10 (bases 1 to 5412)
  AUTHORS   Dustin,M.L., Olszowy,M.W., Holdorf,A.D., Li,J., Bromley,S.,
            Desai,N., Widder,P., Rosenberger,F., van der Merwe,P.A., Allen,P.M.
            and Shaw,A.S.
  TITLE     A novel adaptor protein orchestrates receptor patterning and
            cytoskeletal polarity in T-cell contacts
  JOURNAL   Cell 94 (5), 667-677 (1998)
   PUBMED   9741631
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA040834.1, AL355353.23,
            BC069444.1, AL358178.14, AL356421.10 and BU679191.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_012120.2.
            
            Summary: This gene encodes a scaffolding molecule that regulates
            the actin cytoskeleton. The protein directly interacts with
            filamentous actin and a variety of cell membrane proteins through
            multiple actin binding sites, SH3 domains, and a proline-rich
            region containing binding sites for SH3 domains. The cytoplasmic
            protein localizes to membrane ruffles, lipid rafts, and the leading
            edges of cells. It is implicated in dynamic actin remodeling and
            membrane trafficking that occurs during receptor endocytosis and
            cytokinesis. Haploinsufficiency of this gene is implicated in
            susceptibility to glomerular disease. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.200483.1,
                                           SRR1660807.6602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359314.5/ ENSP00000352264.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               DA040834.1         1-264
            265-416             AL355353.23        72579-72730
            417-1659            BC069444.1         7-1249
            1660-1660           AL358178.14        48977-48977
            1661-2424           BC069444.1         1251-2014
            2425-2560           AL358178.14        77297-77432
            2561-4736           AL356421.10        101-2276
            4737-5412           BU679191.1         14-689              c
FEATURES             Location/Qualifiers
     source          1..5412
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..5412
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /note="CD2 associated protein"
                     /db_xref="GeneID:23607"
                     /db_xref="HGNC:HGNC:14258"
                     /db_xref="MIM:604241"
     exon            1..460
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..2376
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /note="Cas ligand with multiple Src homology 3 (SH3)
                     domains; adapter protein CMS; cas ligand with multiple SH3
                     domains; Cas ligand with multiple Src homology (SH) 3
                     domains"
                     /codon_start=1
                     /product="CD2-associated protein"
                     /protein_id="NP_036252.1"
                     /db_xref="CCDS:CCDS34472.1"
                     /db_xref="GeneID:23607"
                     /db_xref="HGNC:HGNC:14258"
                     /db_xref="MIM:604241"
                     /translation="MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG
                     RRGMFPDNFVKEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTK
                     NIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSN
                     FVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGD
                     IFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRT
                     LFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKD
                     FPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKP
                     TPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSE
                     QLPLRPKSVDFDSLTVRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGG
                     HSPTHSPEKILKLPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAFLTP
                     LEIKAKVETDDVKKNSLDELRAQIIELLCIVEALKKDHGKELEKLRKDLEEEKTMRSN
                     LEMEIEKLKKAVLSS"
     exon            461..621
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            622..775
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            776..876
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            877..997
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1185
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1264
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1359
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1464
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1501
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1564
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1730
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1873
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1986
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2088
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2270
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2334
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..5412
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5052..5057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /note="hexamer: AATAAA"
     polyA_site      5074
                     /gene="CD2AP"
                     /gene_synonym="CMS"
     regulatory      5267..5272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /note="hexamer: ATTAAA"
     polyA_site      5286
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /note="major polyA site"
     regulatory      5384..5389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /note="hexamer: AATAAA"
     regulatory      5391..5396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD2AP"
                     /gene_synonym="CMS"
                     /note="hexamer: AGTAAA"
     polyA_site      5403
                     /gene="CD2AP"
                     /gene_synonym="CMS"
     polyA_site      5412
                     /gene="CD2AP"
                     /gene_synonym="CMS"
ORIGIN      
        1 ctctgtctgg gtccccacct tagtctacgg tgtcgccttt tctaactgcg agtgctaagg
       61 aagaggcgag gggcgggctc cgaggctagg cgggcgctcg gggttggagc cgagggtctg
      121 ggcaaaccgg tgggtccctc cccactgcgg gagcggccag ggtgggaaaa ccgcggtcgg
      181 gcgggcgggg tagggccctc ccgccgccgt ggctcctggg gaggccaggg gtgaggagct
      241 gtcgccgcct ttgcctctgc ctcgagggcc gcgctgaaga gactggtagg agagcgccgc
      301 gggcggatgg aggcgactct tcgccccgcc tgagctcagg aggggctagc gcggagcgcg
      361 ggtcccgcct ccagccgcgg gagcggccgc gcgagccacc actggaggag gaggaggagg
      421 agcggacgtc ggcttctccc cgcgggagcc cccagcatgg ttgactatat tgtggagtat
      481 gactatgatg ctgtacatga tgatgaatta actattcgag ttggagaaat catcaggaat
      541 gtgaaaaagc tacaggagga agggtggctg gaaggagaac taaatgggag aagaggaatg
      601 ttccctgaca atttcgttaa ggaaattaaa agagagacgg aattcaagga tgacagtttg
      661 cccatcaaac gggaaaggca tgggaatgta gcaagtcttg tacaacgaat aagcacctat
      721 ggacttccag ctggaggaat tcagccacat ccacaaacca aaaacattaa gaagaagacc
      781 aagaagcgtc agtgtaaagt tctttttgag tacattccac aaaatgagga tgaactggag
      841 ctgaaagtgg gagatattat tgatattaat gaagaggtag aagaaggctg gtggagtgga
      901 accctgaata acaagttggg actgtttccc tcaaattttg tgaaagaatt agaggtaaca
      961 gatgatggtg aaactcatga agcccaggac gattcagaaa ctgttttggc tgggcctact
     1021 tcacctatac cttctctggg aaatgtgagt gaaactgcat ctggatcagt tacacagcca
     1081 aagaaaattc gaggaattgg atttggagac atttttaaag aaggctctgt gaaacttcgg
     1141 acaagaacat ccagtagtga aacagaagag aaaaaaccag aaaagccctt aatcctacag
     1201 tcactgggac ccaaaactca gagtgtggag ataacaaaaa cagataccga aggtaaaatt
     1261 aaagctaaag aatattgtag aacattattt gcctatgaag gtactaatga agatgaactt
     1321 acttttaaag agggggagat aatccatttg ataagtaagg agactggaga agctggctgg
     1381 tggaggggcg aacttaatgg taaagaagga gtatttccag acaattttgc tgtccagata
     1441 aatgaacttg ataaagactt tccaaaacca aagaaaccac cacctcctgc taaggctcca
     1501 gctccaaagc ctgaactgat agctgcagag aagaaatatt tttctttaaa gcctgaagaa
     1561 aaggatgaaa aatcaacact ggaacagaaa ccttctaaac cagcagctcc acaagtccca
     1621 cccaagaaac ctactccacc taccaaagcc agtaatttac tgagatcttc tggaacagtg
     1681 tacccaaagc gacctgaaaa accagttcct ccaccacctc ctatagccaa gattaatggg
     1741 gaagtttcta gcatttcatc aaaatttgaa actgagccag tatcaaaact aaagctagat
     1801 tctgaacagc tgccccttag accaaaatca gtagactttg attcacttac agtaaggacc
     1861 tccaaagaaa cagatgttgt aaattttgat gacatagctt cctcagaaaa cttgcttcat
     1921 ctcactgcaa atagaccaaa gatgcctgga agaaggttgc cgggccgttt caatggtgga
     1981 cattctccaa ctcacagccc cgaaaaaatc ttgaagttac caaaagaaga agacagtgcc
     2041 aacctgaagc catctgaatt aaaaaaagat acatgctact ctccaaagcc atctgtgtac
     2101 ctttcaacac cttccagtgc ttctaaagca aatacaactg ctttcctgac tccattagaa
     2161 atcaaagcta aagtggaaac agatgatgtg aaaaaaaatt ccctggatga acttagagcc
     2221 cagattattg aattgttgtg cattgtagaa gcactgaaaa aggatcacgg gaaagaactg
     2281 gaaaaactgc gaaaagattt ggaagaagag aagacaatga gaagtaatct agagatggaa
     2341 atagagaagc tgaaaaaagc tgtcctgtct tcttgagtgg tgtggacctg gtgttcataa
     2401 tgttccaggg attcagaagc aacgctatga acttcagctg acttgttact taaaaattgt
     2461 gaattctgtt gttgtgataa atatgagcaa atgaagtgta atatctatag aaaagtagag
     2521 tgagggtgaa tttatatata tattttgttt tgccaatatg aagaaaaaga ggccttattt
     2581 cttaactgtg ctgggattgc aaacactttt taaaaaattg tttgcttgaa aatactactg
     2641 aatataaata agaatgtgca cagtagtttt tttattgaaa cttgtattat ttttaaagag
     2701 atctatacta taaatatggt gatatattta caagtaatct gttaagatat actatttgag
     2761 agggacagat tagcctttta gtaactatag tcactacttt ttccataatg cataagggat
     2821 ataaactctg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tatatatata
     2881 tatatatttt tacttttatc ctcttaccga aggttacact gttgtgcctg tttgtctgca
     2941 atgctgttta tattttgggt gatgaaatag gagtttccta gctatataaa ccagattact
     3001 cacccatgca tatagtaaga actaatgaat aatcaaaata atttcatcaa cttttagaat
     3061 attttatgtt gcttgcacta taggagtcat aaaaggaact tagttaaaat atgttggatt
     3121 gttaaacatt tggggaaata tgaactgtat tttaaatttg ttaggtctga agaatctaaa
     3181 actgttaatt taacccttaa cttgtgccta gaaactacag cacatataaa atatgtaaac
     3241 accagcctgt tgctgtactt ttctgcttat tttacagcct caaatatttc tcattatctt
     3301 gtcacttagt tcttcatgtt tctccttctg acttttaata atggtaatag gaaaacaaaa
     3361 cccaaagctt ttcagaactt cagtgtgagg tttcctattt tgacaagtta acttgtaaat
     3421 actcaggttt tacgatgtat aatttaccta atagaccaaa ctaactcatg gagatatttt
     3481 gaactattat ttaggtacaa actttataaa gaatgttagt atgtcataaa atataacatt
     3541 acagcttatt taaaaccaaa tatagttgaa catatttaaa atacattttc acagaatgga
     3601 tgaattagtt gtttcttcag agttacttat gaacagttga atgctttaaa atgttctgtc
     3661 tgtaggtaac atctaaaaca caagtgggtt tatttaaatt tttaaaattt gaaatttttt
     3721 atttgcaaaa aattgtttta tgctttatta tatcgcaaat gagtgtcaga tttttgagta
     3781 ccaatgatca tgcttccatt ttttttagtt ttaaaccacc aaaccaatat ttttccttta
     3841 aattttaatc ttataatata gaaatcttat gtaaatgaaa ttttgtcatg tttcaaataa
     3901 agagaactga agtagaaaat agaaatgcca gtaaacaaca taatgtttaa tttacaactt
     3961 acattagggg tttgggggaa tgctaattat atattgagaa tatacattag aactcttcaa
     4021 aatgggctct tctaatgagg tcactactga acaaaattgt tccctcttct gttaaataga
     4081 ataggtttaa atgactagtc aaatgaatta ttttcttctt gttaaataaa ttaaatctta
     4141 ctttctttta atgaccaacc ttaggtaaaa caaaaatatt gtaatcctag aaattatcct
     4201 ccagctttct cacctgaaaa tctattgaag tgatccctgg tcatcctaat aatgggatga
     4261 gggaagtttc cagcagattt caggctgttc ttaaagtttt tgttggtcat tttctcaata
     4321 gtacatgaaa tcaagatgct tatgagcatg gaaatgtatt taaagttttt gcttgtgtcc
     4381 tcctcagtca gaatagaaaa gtaactgaaa tacttttacc tttctgtcct tgataaaata
     4441 gtaaagaaaa ccaaacaaac ccaggcctga tgggaaaaat gattccttta ttctagcaac
     4501 ttactttctg ttggtatggg aaatgttatt aatttctatt actaaagttc atatcacaaa
     4561 atgatattta ataataacct tggggtaaat catgaatttt ttttctacgt gtgagtataa
     4621 aagacaaaag ttgaacagca tggaatctca ttgccaaatt attagtgaat gtatagttca
     4681 ggtattcttt gagacacaca gtatcattaa tttctgaatt gtatttcagt gttatttttt
     4741 gtttgtgacc actaagcttc tgtcttaata caaagctgtt accttctaca gaatttaagt
     4801 ctgaagatgt aaagagagaa caggccttgt gtaacagaag atactctttt ttatgctcct
     4861 tactgtgatc acagaaaaat taaaaatcca agtgctctct agatttgttg ataaacattt
     4921 tatgcttgca tttaaacttg aaatgtatga gcagaatgag acaatcagtt aaatcagaaa
     4981 tgagaagtat tataatgtaa aggccttgtt ttgctgtagc aataaaatga ccaagtgcaa
     5041 tgacttgatt taataaaatc atattttaaa agttgctgct atgaatattt ttggctataa
     5101 aattttaccc tgacttgctt tcaataactg ttacgtaatg cagttgatgt tgtaacctaa
     5161 cattccaaaa aaaaaattga gagggggaat ctcaaaatag tatatacttc actaacttgt
     5221 ttacaggtgc tgtatttaaa agcatgcttc tctctcaaaa agaaaaatta aaggatttta
     5281 ttgccagtcg tgtcagtctt tattggttat tttttgttaa ctttagcatt tgtgtatttc
     5341 agagtatgat gaaaattata ttacttcaat ttccaaatac aagaataaat agtaaaccaa
     5401 aaacattaaa aa
//
