LOCUS       NM_001024736            3295 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens CD276 molecule (CD276), transcript variant 1, mRNA.
ACCESSION   NM_001024736 XM_942275 XM_945865 XM_945867 XM_945869 XM_945870
            XM_945872 XM_945874
VERSION     NM_001024736.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3295)
  AUTHORS   Lynch,M.M., Al-Marayaty,R., Obeidin,F., Alexiev,B.A., Chen,E.Y.,
            Viveiros,P., Schroeder,B.A., Hudkins,K., Fan,T.M., Redman,M.W.,
            Baker,K.K., Jour,G., Cranmer,L.D. and Pollack,S.M.
  TITLE     B7-H3 is widely expressed in soft tissue sarcomas
  JOURNAL   BMC Cancer 24 (1), 1336 (2024)
   PUBMED   39478506
  REMARK    GeneRIF: B7-H3 is widely expressed in soft tissue sarcomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3295)
  AUTHORS   Zhao,A., Zhu,X., Wu,H., Wang,J., Zhang,M., Xiang,J., Xia,S., Shi,T.
            and Xi,Q.
  TITLE     B7-H3 promotes the migration and invasion of colorectal cancer
            cells via regulating the actin cytoskeleton and RhoA/ROCK1/LIMK1
            signaling pathway
  JOURNAL   Tissue Cell 90, 102518 (2024)
   PUBMED   39173456
  REMARK    GeneRIF: B7-H3 promotes the migration and invasion of colorectal
            cancer cells via regulating the actin cytoskeleton and
            RhoA/ROCK1/LIMK1 signaling pathway.
REFERENCE   3  (bases 1 to 3295)
  AUTHORS   Song,P., Xu,Y. and Ye,G.
  TITLE     B7-H3 and ICAM-1 are potentially therapeutic targets for thyroid
            carcinoma
  JOURNAL   Diagn Pathol 19 (1), 77 (2024)
   PUBMED   38858715
  REMARK    GeneRIF: B7-H3 and ICAM-1 are potentially therapeutic targets for
            thyroid carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3295)
  AUTHORS   Zhang,Z.Y., Xu,J.H., Zhang,J.L., Lin,Y.X. and Ou-Yang,J.
  TITLE     CD276 enhances sunitinib resistance in clear cell renal cell
            carcinoma by promoting DNA damage repair and activation of FAK-MAPK
            signaling pathway
  JOURNAL   BMC Cancer 24 (1), 650 (2024)
   PUBMED   38802739
  REMARK    GeneRIF: CD276 enhances sunitinib resistance in clear cell renal
            cell carcinoma by promoting DNA damage repair and activation of
            FAK-MAPK signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3295)
  AUTHORS   Xiong,G., Chen,Z., Liu,Q., Peng,F., Zhang,C., Cheng,M., Ling,R.,
            Chen,S., Liang,Y., Chen,D. and Zhou,Q.
  TITLE     CD276 regulates the immune escape of esophageal squamous cell
            carcinoma through CXCL1-CXCR2 induced NETs
  JOURNAL   J Immunother Cancer 12 (5), e008662 (2024)
   PUBMED   38724465
  REMARK    GeneRIF: CD276 regulates the immune escape of esophageal squamous
            cell carcinoma through CXCL1-CXCR2 induced NETs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3295)
  AUTHORS   Steinberger,P., Majdic,O., Derdak,S.V., Pfistershammer,K.,
            Kirchberger,S., Klauser,C., Zlabinger,G., Pickl,W.F., Stockl,J. and
            Knapp,W.
  TITLE     Molecular characterization of human 4Ig-B7-H3, a member of the B7
            family with four Ig-like domains
  JOURNAL   J Immunol 172 (4), 2352-2359 (2004)
   PUBMED   14764704
REFERENCE   7  (bases 1 to 3295)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 3295)
  AUTHORS   Ling,V., Wu,P.W., Spaulding,V., Kieleczawa,J., Luxenberg,D.,
            Carreno,B.M. and Collins,M.
  TITLE     Duplication of primate and rodent B7-H3 immunoglobulin V- and
            C-like domains: divergent history of functional redundancy and exon
            loss
  JOURNAL   Genomics 82 (3), 365-377 (2003)
   PUBMED   12906861
REFERENCE   9  (bases 1 to 3295)
  AUTHORS   Sun,M., Richards,S., Prasad,D.V., Mai,X.M., Rudensky,A. and Dong,C.
  TITLE     Characterization of mouse and human B7-H3 genes
  JOURNAL   J Immunol 168 (12), 6294-6297 (2002)
   PUBMED   12055244
  REMARK    GeneRIF: A novel structural variant of B7-H3 (named B7-H3b) with
            four Ig-like domains, is the major isoform expressed in several
            tissues and results from gene duplication and differential
            splicing.
REFERENCE   10 (bases 1 to 3295)
  AUTHORS   Chapoval,A.I., Ni,J., Lau,J.S., Wilcox,R.A., Flies,D.B., Liu,D.,
            Dong,H., Sica,G.L., Zhu,G., Tamada,K. and Chen,L.
  TITLE     B7-H3: a costimulatory molecule for T cell activation and IFN-gamma
            production
  JOURNAL   Nat Immunol 2 (3), 269-274 (2001)
   PUBMED   11224528
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC062581.1, AK075549.1 and
            CA420873.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001024736.1.
            
            Summary: The protein encoded by this gene belongs to the
            immunoglobulin superfamily, and thought to participate in the
            regulation of T-cell-mediated immune response. Studies show that
            while the transcript of this gene is ubiquitously expressed in
            normal tissues and solid tumors, the protein is preferentially
            expressed only in tumor tissues. Additionally, it was observed that
            the 3' UTR of this transcript contains a target site for miR29
            microRNA, and there is an inverse correlation between the
            expression of this protein and miR29 levels, suggesting regulation
            of expression of this gene product by miR29. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075549.1, SRR3476690.986521.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318443.10/ ENSP00000320084.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1515              BC062581.1         103-1617
            1516-3290           AK075549.1         1546-3320
            3291-3295           CA420873.1         23-27               c
FEATURES             Location/Qualifiers
     source          1..3295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..3295
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /note="CD276 molecule"
                     /db_xref="GeneID:80381"
                     /db_xref="HGNC:HGNC:19137"
                     /db_xref="MIM:605715"
     exon            1..78
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            79..211
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1737
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; CD276 antigen; B7 homolog 3; costimulatory
                     molecule"
                     /codon_start=1
                     /product="CD276 antigen isoform a precursor"
                     /protein_id="NP_001019907.1"
                     /db_xref="CCDS:CCDS32288.1"
                     /db_xref="GeneID:80381"
                     /db_xref="HGNC:HGNC:19137"
                     /db_xref="MIM:605715"
                     /translation="MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGT
                     DATLCCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQ
                     GNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDT
                     VTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTY
                     SCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGF
                     SLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVAD
                     EGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEA
                     EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAH
                     GSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDG
                     EGEGSKTALQPLKHSDSKEDDGQEIA"
     exon            212..550
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..865
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1204
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1501
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1636
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1678
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1714
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..3295
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3276..3281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /note="hexamer: AATAAA"
     polyA_site      3295
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /note="major polyA site"
ORIGIN      
        1 attcgggccg ggcctcgctg cggcggcgac tgagccaggc tgggccgcgt ccctgagtcc
       61 cagagtcggc gcggcgcggc aggggcagcc ttccaccacg gggagcccag ctgtcagccg
      121 cctcacagga agatgctgcg tcggcggggc agccctggca tgggtgtgca tgtgggtgca
      181 gccctgggag cactgtggtt ctgcctcaca ggagccctgg aggtccaggt ccctgaagac
      241 ccagtggtgg cactggtggg caccgatgcc accctgtgct gctccttctc ccctgagcct
      301 ggcttcagcc tggcacagct caacctcatc tggcagctga cagataccaa acagctggtg
      361 cacagctttg ctgagggcca ggaccagggc agcgcctatg ccaaccgcac ggccctcttc
      421 ccggacctgc tggcacaggg caacgcatcc ctgaggctgc agcgcgtgcg tgtggcggac
      481 gagggcagct tcacctgctt cgtgagcatc cgggatttcg gcagcgctgc cgtcagcctg
      541 caggtggccg ctccctactc gaagcccagc atgaccctgg agcccaacaa ggacctgcgg
      601 ccaggggaca cggtgaccat cacgtgctcc agctaccagg gctaccctga ggctgaggtg
      661 ttctggcagg atgggcaggg tgtgcccctg actggcaacg tgaccacgtc gcagatggcc
      721 aacgagcagg gcttgtttga tgtgcacagc atcctgcggg tggtgctggg tgcaaatggc
      781 acctacagct gcctggtgcg caaccccgtg ctgcagcagg atgcgcacag ctctgtcacc
      841 atcacacccc agagaagccc cacaggagcc gtggaggtcc aggtccctga ggacccggtg
      901 gtggccctag tgggcaccga tgccaccctg cgctgctcct tctcccccga gcctggcttc
      961 agcctggcac agctcaacct catctggcag ctgacagaca ccaaacagct ggtgcacagt
     1021 ttcaccgaag gccgggacca gggcagcgcc tatgccaacc gcacggccct cttcccggac
     1081 ctgctggcac aaggcaatgc atccctgagg ctgcagcgcg tgcgtgtggc ggacgagggc
     1141 agcttcacct gcttcgtgag catccgggat ttcggcagcg ctgccgtcag cctgcaggtg
     1201 gccgctccct actcgaagcc cagcatgacc ctggagccca acaaggacct gcggccaggg
     1261 gacacggtga ccatcacgtg ctccagctac cggggctacc ctgaggctga ggtgttctgg
     1321 caggatgggc agggtgtgcc cctgactggc aacgtgacca cgtcgcagat ggccaacgag
     1381 cagggcttgt ttgatgtgca cagcgtcctg cgggtggtgc tgggtgcgaa tggcacctac
     1441 agctgcctgg tgcgcaaccc cgtgctgcag caggatgcgc acggctctgt caccatcaca
     1501 gggcagccta tgacattccc cccagaggcc ctgtgggtga ccgtggggct gtctgtctgt
     1561 ctcattgcac tgctggtggc cctggctttc gtgtgctgga gaaagatcaa acagagctgt
     1621 gaggaggaga atgcaggagc tgaggaccag gatggggagg gagaaggctc caagacagcc
     1681 ctgcagcctc tgaaacactc tgacagcaaa gaagatgatg gacaagaaat agcctgacca
     1741 tgaggaccag ggagctgcta cccctcccta cagctcctac cctctggctg caatggggct
     1801 gcactgtgag ccctgccccc aacagatgca tcctgctctg acaggtgggc tccttctcca
     1861 aaggatgcga tacacagacc actgtgcagc cttatttctc caatggacat gattcccaag
     1921 tcatcctgct gccttttttc ttatagacac aatgaacaga ccacccacaa ccttagttct
     1981 ctaagtcatc ctgcctgctg ccttatttca cagtacatac atttcttagg gacacagtac
     2041 actgaccaca tcaccaccct cttcttccag tgctgcgtgg accatctggc tgcctttttt
     2101 ctccaaaaga tgcaatattc agactgactg accccctgcc ttatttcacc aaagacacga
     2161 tgcatagtca ccccggcctt gtttctccaa tggccgtgat acactagtga tcatgttcag
     2221 ccctgcttcc acctgcatag aatcttttct tctcagacag ggacagtgcg gcctcaacat
     2281 ctcctggagt ctagaagctg tttcctttcc cctccttcct cctcttgctc tagccttaat
     2341 actggccttt tccctccctg ccccaagtga agacagggca ctctgcgccc accacatgca
     2401 cagctgtgca tggagacctg caggtgcacg tgctggaaca cgtgtggttc ccccctggcc
     2461 cagcctcctc tgcagtgccc ctctcccctg cccatcctcc ccacggaagc atgtgctggt
     2521 cacactggtt ctccaggggt ctgtgatggg gcccctgggg gtcagcttct gtccctctgc
     2581 cttctcacct ctttgttcct ttcttttcat gtatccattc agttgatgtt tattgagcaa
     2641 ctacagatgt cagcactgtg ttaggtgctg ggggccctgc gtgggaagat aaagttcctc
     2701 cctcaaggac tccccatcca gctgggagac agacaactaa ctacactgca ccctgcggtt
     2761 tgcagggggc tcctgcctgg ctccctgctc cacacctcct ctgtggctca aggcttcctg
     2821 gatacctcac ccccatccca cccataattc ttacccagag catggggttg gggcggaaac
     2881 ctggagagag ggacatagcc cctcgccacg gctagagaat ctggtggtgt ccaaaatgtc
     2941 tgtccaggtg tgggcaggtg ggcaggcacc aaggccctct ggacctttca tagcagcaga
     3001 aaaggcagag cctggggcag ggcagggcca ggaatgcttt ggggacaccg aggggactgc
     3061 cccccacccc caccatggtg ctattctggg gctggggcag tcttttcctg gcttgcctct
     3121 ggccagctcc tggcctctgg tagagtgaga cttcagacgt tctgatgcct tccggatgtc
     3181 atctctccct gccccaggaa tggaagatgt gaggacttct aatttaaatg tgggactcgg
     3241 agggattttg taaactgggg gtatattttg gggaaaataa atgtctttgt aaaaa
//
