LOCUS       NM_001242               1245 bp    mRNA    linear   PRI 12-JUN-2025
DEFINITION  Homo sapiens CD27 molecule (CD27), transcript variant 2, mRNA.
ACCESSION   NM_001242
VERSION     NM_001242.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1245)
  AUTHORS   Xiao,F.K. and Wang,L.
  TITLE     Comprehensive Analysis of Expression and Pathway for CD27 in
            Esophageal Cancer
  JOURNAL   Mol Biotechnol 66 (8), 2087-2094 (2024)
   PUBMED   37584826
  REMARK    GeneRIF: Comprehensive Analysis of Expression and Pathway for CD27
            in Esophageal Cancer.
REFERENCE   2  (bases 1 to 1245)
  AUTHORS   Nagato,T., Komatsuda,H., Hayashi,R., Takahara,M., Ujiie,N.,
            Kosaka,A., Ohkuri,T., Oikawa,K., Sato,R., Wakisaka,R., Kono,M.,
            Yamaki,H., Ohara,K., Kumai,T., Kishibe,K., Katada,A., Hayashi,T.
            and Kobayashi,H.
  TITLE     Soluble CD27 as a predictive biomarker for intra-tumoral CD70/CD27
            interaction in nasopharyngeal carcinoma
  JOURNAL   Cancer Sci 115 (4), 1073-1084 (2024)
   PUBMED   38279834
  REMARK    GeneRIF: Soluble CD27 as a predictive biomarker for intra-tumoral
            CD70/CD27 interaction in nasopharyngeal carcinoma.
REFERENCE   3  (bases 1 to 1245)
  AUTHORS   Jaeger-Ruckstuhl,C.A., Lo,Y., Fulton,E., Waltner,O.G.,
            Shabaneh,T.B., Simon,S., Muthuraman,P.V., Correnti,C.E.,
            Newsom,O.J., Engstrom,I.A., Kanaan,S.B., Bhise,S.S.,
            Peralta,J.M.C., Ruff,R., Price,J.P., Stull,S.M., Stevens,A.R.,
            Bugos,G., Kluesner,M.G., Voillet,V., Muhunthan,V., Morrish,F.,
            Olson,J.M., Gottardo,R., Sarthy,J.F., Henikoff,S., Sullivan,L.B.,
            Furlan,S.N. and Riddell,S.R.
  TITLE     Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell
            activation promotes memory-associated gene regulatory networks
  JOURNAL   Immunity 57 (2), 287-302 (2024)
   PUBMED   38354704
REFERENCE   4  (bases 1 to 1245)
  AUTHORS   El Mahdaoui,S., Husted,S.R., Hansen,M.B., Cobanovic,S.,
            Mahler,M.R., Buhelt,S., von Essen,M.R., Sellebjerg,F. and Romme
            Christensen,J.
  TITLE     Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B
            cells and biomarkers of B cell activity in relapsing-remitting
            multiple sclerosis
  JOURNAL   J Neuroimmunol 381, 578128 (2023)
   PUBMED   37321014
  REMARK    GeneRIF: Cerebrospinal fluid soluble CD27 is associated with CD8[+]
            T cells, B cells and biomarkers of B cell activity in
            relapsing-remitting multiple sclerosis.
            Erratum:[J Neuroimmunol. 2025 Jun 15;403:578607. doi:
            10.1016/j.jneuroim.2025.578607. PMID: 40215560]
REFERENCE   5  (bases 1 to 1245)
  AUTHORS   Bowakim-Anta,N., Acolty,V., Azouz,A., Yagita,H., Leo,O.,
            Goriely,S., Oldenhove,G. and Moser,M.
  TITLE     Chronic CD27-CD70 costimulation promotes type 1-specific
            polarization of effector Tregs
  JOURNAL   Front Immunol 14, 1023064 (2023)
   PUBMED   36993956
  REMARK    GeneRIF: Chronic CD27-CD70 costimulation promotes type 1-specific
            polarization of effector Tregs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1245)
  AUTHORS   Kobata,T., Jacquot,S., Kozlowski,S., Agematsu,K., Schlossman,S.F.
            and Morimoto,C.
  TITLE     CD27-CD70 interactions regulate B-cell activation by T cells
  JOURNAL   Proc Natl Acad Sci U S A 92 (24), 11249-11253 (1995)
   PUBMED   7479974
REFERENCE   7  (bases 1 to 1245)
  AUTHORS   Loenen,W.A., Gravestein,L.A., Beumer,S., Melief,C.J., Hagemeijer,A.
            and Borst,J.
  TITLE     Genomic organization and chromosomal localization of the human CD27
            gene
  JOURNAL   J Immunol 149 (12), 3937-3943 (1992)
   PUBMED   1334106
REFERENCE   8  (bases 1 to 1245)
  AUTHORS   Camerini,D., Walz,G., Loenen,W.A., Borst,J. and Seed,B.
  TITLE     The T cell activation antigen CD27 is a member of the nerve growth
            factor/tumor necrosis factor receptor gene family
  JOURNAL   J Immunol 147 (9), 3165-3169 (1991)
   PUBMED   1655907
REFERENCE   9  (bases 1 to 1245)
  AUTHORS   Bigler,R.D., Bushkin,Y. and Chiorazzi,N.
  TITLE     S152 (CD27). A modulating disulfide-linked T cell activation
            antigen
  JOURNAL   J Immunol 141 (1), 21-28 (1988)
   PUBMED   2837508
REFERENCE   10 (bases 1 to 1245)
  AUTHORS   van Lier,R.A., Borst,J., Vroom,T.M., Klein,H., Van Mourik,P.,
            Zeijlemaker,W.P. and Melief,C.J.
  TITLE     Tissue distribution and biochemical and functional properties of
            Tp55 (CD27), a novel T cell differentiation antigen
  JOURNAL   J Immunol 139 (5), 1589-1596 (1987)
   PUBMED   2442250
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005840.2.
            
            On Mar 28, 2020 this sequence version replaced NM_001242.4.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor is required for generation
            and long-term maintenance of T cell immunity. It binds to ligand
            CD70, and plays a key role in regulating B-cell activation and
            immunoglobulin synthesis. This receptor transduces signals that
            lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins
            TRAF2 and TRAF5 have been shown to mediate the signaling process of
            this receptor. CD27-binding protein (SIVA), a proapoptotic protein,
            can bind to this receptor and is thought to play an important role
            in the apoptosis induced by this receptor. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M63928.1, BC012160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266557.4/ ENSP00000266557.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AC005840.2         39513-39789         c
            278-409             AC005840.2         39189-39320         c
            410-589             AC005840.2         34392-34571         c
            590-679             AC005840.2         34114-34203         c
            680-799             AC005840.2         33730-33849         c
            800-1245            AC005840.2         33031-33476         c
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1245
                     /gene="CD27"
                     /gene_synonym="S152; S152. LPFS2; T14; TNFRSF7; Tp55"
                     /note="CD27 molecule"
                     /db_xref="GeneID:939"
                     /db_xref="HGNC:HGNC:11922"
                     /db_xref="MIM:186711"
     exon            1..277
                     /gene="CD27"
                     /gene_synonym="S152; S152. LPFS2; T14; TNFRSF7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..924
                     /gene="CD27"
                     /gene_synonym="S152; S152. LPFS2; T14; TNFRSF7; Tp55"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; tumor necrosis factor receptor superfamily,
                     member 7; CD27L receptor; T cell activation antigen S152;
                     T-cell activation antigen CD27"
                     /codon_start=1
                     /product="CD27 antigen isoform b precursor"
                     /protein_id="NP_001233.2"
                     /db_xref="CCDS:CCDS8545.1"
                     /db_xref="GeneID:939"
                     /db_xref="HGNC:HGNC:11922"
                     /db_xref="MIM:186711"
                     /translation="MARPHPWWLCVLGTLVGLSATPAPKSCPERHYWAQGKLCCQMCE
                     PGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANA
                     ECACRNGWQCRDKECTECDPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHM
                     QTLADFRQLPARTLSTHWPPQRSLCSSDFIRILVIFSGMFLVFTLAGALFLHQRRKYR
                     SNKGESPVEPAEPCHYSCPREEEGSTIPIQEDYRKPEPACSP"
     exon            278..409
                     /gene="CD27"
                     /gene_synonym="S152; S152. LPFS2; T14; TNFRSF7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     exon            410..589
                     /gene="CD27"
                     /gene_synonym="S152; S152. LPFS2; T14; TNFRSF7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     exon            590..679
                     /gene="CD27"
                     /gene_synonym="S152; S152. LPFS2; T14; TNFRSF7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     exon            680..799
                     /gene="CD27"
                     /gene_synonym="S152; S152. LPFS2; T14; TNFRSF7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1245
                     /gene="CD27"
                     /gene_synonym="S152; S152. LPFS2; T14; TNFRSF7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1224..1229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD27"
                     /gene_synonym="S152; S152. LPFS2; T14; TNFRSF7; Tp55"
                     /note="hexamer: AATAAA"
     polyA_site      1245
                     /gene="CD27"
                     /gene_synonym="S152; S152. LPFS2; T14; TNFRSF7; Tp55"
                     /note="major polyA site"
ORIGIN      
        1 cttcaaaggt tggcttgcca cctgaagcag ccactgccca gggggtgcaa agaagagaca
       61 gcagcgccca gcttggaggt gctaactcca gaggccagca tcagcaactg ggcacagaaa
      121 ggagccgcct gggcagggac catggcacgg ccacatccct ggtggctgtg cgttctgggg
      181 accctggtgg ggctctcagc tactccagcc cccaagagct gcccagagag gcactactgg
      241 gctcagggaa agctgtgctg ccagatgtgt gagccaggaa cattcctcgt gaaggactgt
      301 gaccagcata gaaaggctgc tcagtgtgat ccttgcatac cgggggtctc cttctctcct
      361 gaccaccaca cccggcccca ctgtgagagc tgtcggcact gtaactctgg tcttctcgtt
      421 cgcaactgca ccatcactgc caatgctgag tgtgcctgtc gcaatggctg gcagtgcagg
      481 gacaaggagt gcaccgagtg tgatcctctt ccaaaccctt cgctgaccgc tcggtcgtct
      541 caggccctga gcccacaccc tcagcccacc cacttacctt atgtcagtga gatgctggag
      601 gccaggacag ctgggcacat gcagactctg gctgacttca ggcagctgcc tgcccggact
      661 ctctctaccc actggccacc ccaaagatcc ctgtgcagct ccgattttat tcgcatcctt
      721 gtgatcttct ctggaatgtt ccttgttttc accctggccg gggccctgtt cctccatcaa
      781 cgaaggaaat atagatcaaa caaaggagaa agtcctgtgg agcctgcaga gccttgtcat
      841 tacagctgcc ccagggagga ggagggcagc accatcccca tccaggagga ttaccgaaaa
      901 ccggagcctg cctgctcccc ctgagccagc acctgcggga gctgcactac agccctggcc
      961 tccaccccca ccccgccgac catccaaggg agagtgagac ctggcagcca caactgcagt
     1021 cccatcctct tgtcagggcc ctttcctgtg tacacgtgac agagtgcctt ttcgagactg
     1081 gcagggacga ggacaaatat ggatgaggtg gagagtggga agcaggagcc cagccagctg
     1141 cgcctgcgct gcaggagggc gggggctctg gttgtaaaac acacttcctg ctgcgaaaga
     1201 cccacatgct acaagacggg caaaataaag tgacagatga ccacc
//
