LOCUS       NM_020404               2551 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens CD248 molecule (CD248), mRNA.
ACCESSION   NM_020404
VERSION     NM_020404.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2551)
  AUTHORS   Hong,Y.K., Cheng,T.L., Hsu,C.K., Lee,F.T., Chang,B.I., Wang,K.C.,
            Chang,L.Y., Wu,H.L. and Lai,C.H.
  TITLE     Regulation of matrix reloading by tumor endothelial marker 1
            protects against abdominal aortic aneurysm
  JOURNAL   Int J Biol Sci 20 (10), 3691-3709 (2024)
   PUBMED   39113704
  REMARK    GeneRIF: Regulation of matrix reloading by tumor endothelial marker
            1 protects against abdominal aortic aneurysm.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2551)
  AUTHORS   Wu,J., Zhang,Q., Wu,J., Yang,Z., Liu,X., Lou,C., Wang,X., Peng,J.,
            Zhang,J., Shang,Z., Xiao,J., Wang,N., Zhang,R., Zhou,J., Wang,Y.,
            Hu,Z., Zhang,R., Zhang,J. and Zeng,Z.
  TITLE     IL-8 from CD248-expressing cancer-associated fibroblasts generates
            cisplatin resistance in non-small cell lung cancer
  JOURNAL   J Cell Mol Med 28 (4), e18185 (2024)
   PUBMED   38396325
  REMARK    GeneRIF: IL-8 from CD248-expressing cancer-associated fibroblasts
            generates cisplatin resistance in non-small cell lung cancer.
REFERENCE   3  (bases 1 to 2551)
  AUTHORS   Hong,Y.K., Lin,Y.C., Cheng,T.L., Lai,C.H., Chang,Y.H., Huang,Y.L.,
            Hung,C.Y., Wu,C.H., Hung,K.S., Ku,Y.C., Ho,Y.T., Tang,M.J.,
            Lin,S.W., Shi,G.Y., McGrath,J.A., Wu,H.L. and Hsu,C.K.
  TITLE     TEM1/endosialin/CD248 promotes pathologic scarring and TGF-beta
            activity through its receptor stability in dermal fibroblasts
  JOURNAL   J Biomed Sci 31 (1), 12 (2024)
   PUBMED   38254097
  REMARK    GeneRIF: TEM1/endosialin/CD248 promotes pathologic scarring and
            TGF-beta activity through its receptor stability in dermal
            fibroblasts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2551)
  AUTHORS   Zhang,Q.Y., Zhang,L.X., Han,D.H., Jiao,X.C., Zheng,Z., Guo,K. and
            Yang,Y.S.
  TITLE     [Expression of endosialin in human hypertrophic scars and its
            regulation on fibroblast phenotype]
  JOURNAL   Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi 39 (12), 1168-1174
            (2023)
   PUBMED   38129304
  REMARK    GeneRIF: [Expression of endosialin in human hypertrophic scars and
            its regulation on fibroblast phenotype].
REFERENCE   5  (bases 1 to 2551)
  AUTHORS   Payet,M., Ah-Pine,F., Guillot,X. and Gasque,P.
  TITLE     Inflammatory Mesenchymal Stem Cells Express Abundant Membrane-Bound
            and Soluble Forms of C-Type Lectin-like CD248
  JOURNAL   Int J Mol Sci 24 (11), 9546 (2023)
   PUBMED   37298499
  REMARK    GeneRIF: Inflammatory Mesenchymal Stem Cells Express Abundant
            Membrane-Bound and Soluble Forms of C-Type Lectin-like CD248.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2551)
  AUTHORS   Brady,J., Neal,J., Sadakar,N. and Gasque,P.
  TITLE     Human endosialin (tumor endothelial marker 1) is abundantly
            expressed in highly malignant and invasive brain tumors
  JOURNAL   J Neuropathol Exp Neurol 63 (12), 1274-1283 (2004)
   PUBMED   15624764
  REMARK    GeneRIF: Endosialin colocalized with thrombomodulin, suggesting the
            proteins may have complementary functions in tumor progression.
REFERENCE   7  (bases 1 to 2551)
  AUTHORS   Opavsky,R., Haviernik,P., Jurkovicova,D., Garin,M.T.,
            Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Bies,J., Garfield,S.,
            Pastorekova,S., Oue,A. and Wolff,L.
  TITLE     Molecular characterization of the mouse Tem1/endosialin gene
            regulated by cell density in vitro and expressed in normal tissues
            in vivo
  JOURNAL   J Biol Chem 276 (42), 38795-38807 (2001)
   PUBMED   11489895
REFERENCE   8  (bases 1 to 2551)
  AUTHORS   Christian,S., Ahorn,H., Koehler,A., Eisenhaber,F., Rodi,H.P.,
            Garin-Chesa,P., Park,J.E., Rettig,W.J. and Lenter,M.C.
  TITLE     Molecular cloning and characterization of endosialin, a C-type
            lectin-like cell surface receptor of tumor endothelium
  JOURNAL   J Biol Chem 276 (10), 7408-7414 (2001)
   PUBMED   11084048
REFERENCE   9  (bases 1 to 2551)
  AUTHORS   St Croix,B., Rago,C., Velculescu,V., Traverso,G., Romans,K.E.,
            Montgomery,E., Lal,A., Riggins,G.J., Lengauer,C., Vogelstein,B. and
            Kinzler,K.W.
  TITLE     Genes expressed in human tumor endothelium
  JOURNAL   Science 289 (5482), 1197-1202 (2000)
   PUBMED   10947988
REFERENCE   10 (bases 1 to 2551)
  AUTHORS   Rettig,W.J., Garin-Chesa,P., Healey,J.H., Su,S.L., Jaffe,E.A. and
            Old,L.J.
  TITLE     Identification of endosialin, a cell surface glycoprotein of
            vascular endothelial cells in human cancer
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10832-10836 (1992)
   PUBMED   1438285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ295846.1 and BC051340.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020404.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ295846.1, BC051340.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311330.4/ ENSP00000308117.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-733               AJ295846.1         1-733
            734-2551            BC051340.1         721-2538
FEATURES             Location/Qualifiers
     source          1..2551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..2551
                     /gene="CD248"
                     /gene_synonym="CD164L1; TEM1"
                     /note="CD248 molecule"
                     /db_xref="GeneID:57124"
                     /db_xref="HGNC:HGNC:18219"
                     /db_xref="MIM:606064"
     exon            1..2551
                     /gene="CD248"
                     /gene_synonym="CD164L1; TEM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..2291
                     /gene="CD248"
                     /gene_synonym="CD164L1; TEM1"
                     /note="CD164 sialomucin-like 1; 2610111G01Rik; CD248
                     antigen, endosialin; tumor endothelial marker 1; CD248
                     molecule, endosialin"
                     /codon_start=1
                     /product="endosialin precursor"
                     /protein_id="NP_065137.1"
                     /db_xref="CCDS:CCDS8134.1"
                     /db_xref="GeneID:57124"
                     /db_xref="HGNC:HGNC:18219"
                     /db_xref="MIM:606064"
                     /translation="MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTF
                     LEAWRACRELGGDLATPRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRG
                     FTWTTGDQDTAFTNWAQPASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGF
                     EGACPALQDEAGQAGPAVYTTPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPE
                     GGVGWSRAGPLCLGTGCSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCA
                     QAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFE
                     CYCSEGHELEADGISCSPAGAMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEM
                     PGILWMEPTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRP
                     VVVSATHPTLPSAHQPPVIPATHPALSRDHQIPVIAANYPDLPSAYQPGILSVSHSAQ
                     PPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLP
                     PQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPVSPAHQISVPAATQPAALPTLLPSQ
                     SPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQR
                     DDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNKRITDCYRWVIHAGSKSPTEP
                     MPPRGSLTGVQTCRTSV"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD248"
                     /gene_synonym="CD164L1; TEM1"
                     /note="hexamer: AATAAA"
     polyA_site      2551
                     /gene="CD248"
                     /gene_synonym="CD164L1; TEM1"
                     /note="major polyA site"
ORIGIN      
        1 agtccggggg catcgcgatg ctgctgcgcc tgttgctggc ctgggcggcc gcagggccca
       61 cactgggcca ggacccctgg gctgctgagc cccgtgccgc ctgcggcccc agcagctgct
      121 acgctctctt cccacggcgc cgcaccttcc tggaggcctg gcgggcctgc cgcgagctgg
      181 ggggcgacct ggccactcct cggacccccg aggaggccca gcgtgtggac agcctggtgg
      241 gtgcgggccc agccagccgg ctgctgtgga tcgggctgca gcggcaggcc cggcaatgcc
      301 agctgcagcg cccactgcgc ggcttcacgt ggaccacagg ggaccaggac acggctttca
      361 ccaactgggc ccagccagcc tctggaggcc cctgcccggc ccagcgctgt gtggccctgg
      421 aggcaagtgg cgagcaccgc tggctggagg gctcgtgcac gctggctgtc gacggctacc
      481 tgtgccagtt tggcttcgag ggcgcctgcc cggcgctgca agatgaggcg ggccaggccg
      541 gcccagccgt gtataccacg cccttccacc tggtctccac agagtttgag tggctgccct
      601 tcggctctgt ggccgctgtg cagtgccagg ctggcagggg agcctctctg ctctgcgtga
      661 agcagcctga gggaggtgtg ggctggtcac gggctgggcc cctgtgcctg gggactggct
      721 gcagccctga caacgggggc tgcgaacacg aatgtgtgga ggaggtggat ggtcacgtgt
      781 cctgccgctg cactgagggc ttccggctgg cagcagacgg gcgcagttgc gaggacccct
      841 gtgcccaggc tccgtgcgag cagcagtgtg agcccggtgg gccacaaggc tacagctgcc
      901 actgtcgcct gggtttccgg ccagcggagg atgatccgca ccgctgtgtg gacacagatg
      961 agtgccagat tgccggtgtg tgccagcaga tgtgtgtcaa ctacgttggt ggcttcgagt
     1021 gttattgtag cgagggacat gagctggagg ctgatggcat cagctgcagc cctgcagggg
     1081 ccatgggtgc ccaggcttcc caggacctcg gagatgagtt gctggatgac ggggaggatg
     1141 aggaagatga agacgaggcc tggaaggcct tcaacggtgg ctggacggag atgcctggga
     1201 tcctgtggat ggagcctacg cagccgcctg actttgccct ggcctataga ccgagcttcc
     1261 cagaggacag agagccacag ataccctacc cggagcccac ctggccaccc ccgctcagtg
     1321 cccccagggt cccctaccac tcctcagtgc tctccgtcac ccggcctgtg gtggtctctg
     1381 ccacgcatcc cacactgcct tctgcccacc agcctcctgt gatccctgcc acacacccag
     1441 ctttgtcccg tgaccaccag atccccgtga tcgcagccaa ctatccagat ctgccttctg
     1501 cctaccaacc cggtattctc tctgtctctc attcagcaca gcctcctgcc caccagcccc
     1561 ctatgatctc aaccaaatat ccggagctct tccctgccca ccagtccccc atgtttccag
     1621 acacccgggt cgctggcacc cagaccacca ctcatttgcc tggaatccca cctaaccatg
     1681 cccctctggt caccaccctc ggtgcccagc taccccctca agccccagat gcccttgtcc
     1741 tcagaaccca ggccacccag cttcccatta tcccaactgc ccagccctct ctgaccacca
     1801 cctccaggtc ccctgtgtct cctgcccatc aaatctctgt gcctgctgcc acccagcccg
     1861 cagccctccc caccctcctg ccctctcaga gccccactaa ccagacctca cccatcagcc
     1921 ctacacatcc ccattccaaa gccccccaaa tcccaaggga agatggcccc agtcccaagt
     1981 tggccctgtg gctgccctca ccagctccca cagcagcccc aacagccctg ggggaggctg
     2041 gtcttgccga gcacagccag agggatgacc ggtggctgct ggtggcactc ctggtgccaa
     2101 cgtgtgtctt tttggtggtc ctgcttgcac tgggcatcgt gtactgcacc cgctgtggcc
     2161 cccatgcacc caacaagcgc atcactgact gctatcgctg ggtcatccat gctgggagca
     2221 agagcccaac agaacccatg ccccccaggg gcagcctcac aggggtgcag acctgcagaa
     2281 ccagcgtgtg atggggtgca gacccccctc atggagtatg gggcgctgga cacatggccg
     2341 gggctgcacc agggacccat gggggctgcc cagctggaca gatggcttcc tgctccccag
     2401 gcccagccag ggtcctctct caaccactag acttggctct caggaactct gcttcctggc
     2461 ccagcgctcg tgaccaagga tacaccaaag cccttaagac ctcagggggc gggtgctggg
     2521 gtcttctcca ataaatgggg tgtcaacctt a
//
