LOCUS       NM_198053               1600 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens CD247 molecule (CD247), transcript variant 1, mRNA.
ACCESSION   NM_198053
VERSION     NM_198053.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1600)
  AUTHORS   Zhang,Z., Zhang,D., Wang,F., Liu,J., Jiang,X., Anuchapreeda,S.,
            Tima,S., Xiao,Z. and Duangmano,S.
  TITLE     CD3zeta as a novel predictive biomarker of PD-1 inhibitor
            resistance in melanoma
  JOURNAL   Mol Cell Probes 72, 101925 (2023)
   PUBMED   37567322
  REMARK    GeneRIF: CD3zeta as a novel predictive biomarker of PD-1 inhibitor
            resistance in melanoma.
REFERENCE   2  (bases 1 to 1600)
  AUTHORS   Dexiu,C., Xianying,L., Yingchun,H. and Jiafu,L.
  TITLE     Advances in CD247
  JOURNAL   Scand J Immunol 96 (1), e13170 (2022)
   PUBMED   35388926
  REMARK    Review article
REFERENCE   3  (bases 1 to 1600)
  AUTHORS   Higashi,M., Momose,S., Takayanagi,N., Tanaka,Y., Anan,T.,
            Yamashita,T., Kikuchi,J., Tokuhira,M., Kizaki,M. and Tamaru,J.I.
  TITLE     CD24 is a surrogate for 'immune-cold' phenotype in aggressive large
            B-cell lymphoma
  JOURNAL   J Pathol Clin Res 8 (4), 340-354 (2022)
   PUBMED   35289116
  REMARK    GeneRIF: CD24 is a surrogate for 'immune-cold' phenotype in
            aggressive large B-cell lymphoma.
REFERENCE   4  (bases 1 to 1600)
  AUTHORS   Haddock,S., Alban,T.J., Turcan,S., Husic,H., Rosiek,E., Ma,X.,
            Wang,Y., Bale,T., Desrichard,A., Makarov,V., Monette,S., Wu,W.,
            Gardner,R., Manova,K., Boire,A. and Chan,T.A.
  TITLE     Phenotypic and molecular states of IDH1 mutation-induced
            CD24-positive glioma stem-like cells
  JOURNAL   Neoplasia 28, 100790 (2022)
   PUBMED   35398668
  REMARK    GeneRIF: Phenotypic and molecular states of IDH1 mutation-induced
            CD24-positive glioma stem-like cells.
REFERENCE   5  (bases 1 to 1600)
  AUTHORS   Aguilar,O.A., Fong,L.K., Ishiyama,K., DeGrado,W.F. and Lanier,L.L.
  TITLE     The CD3zeta adaptor structure determines functional differences
            between human and mouse CD16 Fc receptor signaling
  JOURNAL   J Exp Med 219 (5) (2022)
   PUBMED   35320345
  REMARK    GeneRIF: The CD3zeta adaptor structure determines functional
            differences between human and mouse CD16 Fc receptor signaling.
REFERENCE   6  (bases 1 to 1600)
  AUTHORS   da Silva,A.J., Yamamoto,M., Zalvan,C.H. and Rudd,C.E.
  TITLE     Engagement of the TcR/CD3 complex stimulates p59fyn(T) activity:
            detection of associated proteins at 72 and 120-130 kD
  JOURNAL   Mol Immunol 29 (12), 1417-1425 (1992)
   PUBMED   1454062
REFERENCE   7  (bases 1 to 1600)
  AUTHORS   Osman,N., Ley,S.C. and Crumpton,M.J.
  TITLE     Evidence for an association between the T cell receptor/CD3 antigen
            complex and the CD5 antigen in human T lymphocytes
  JOURNAL   Eur J Immunol 22 (11), 2995-3000 (1992)
   PUBMED   1385158
REFERENCE   8  (bases 1 to 1600)
  AUTHORS   Jensen,J.P., Hou,D., Ramsburg,M., Taylor,A., Dean,M. and
            Weissman,A.M.
  TITLE     Organization of the human T cell receptor zeta/eta gene and its
            genetic linkage to the Fc gamma RII-Fc gamma RIII gene cluster
  JOURNAL   J Immunol 148 (8), 2563-2571 (1992)
   PUBMED   1532817
REFERENCE   9  (bases 1 to 1600)
  AUTHORS   Gassmann,M., Guttinger,M., Amrein,K.E. and Burn,P.
  TITLE     Protein tyrosine kinase p59fyn is associated with the T cell
            receptor-CD3 complex in functional human lymphocytes
  JOURNAL   Eur J Immunol 22 (1), 283-286 (1992)
   PUBMED   1530920
REFERENCE   10 (bases 1 to 1600)
  AUTHORS   Dang,N.H., Torimoto,Y., Shimamura,K., Tanaka,T., Daley,J.F.,
            Schlossman,S.F. and Morimoto,C.
  TITLE     1F7 (CD26): a marker of thymic maturation involved in the
            differential regulation of the CD3 and CD2 pathways of human
            thymocyte activation
  JOURNAL   J Immunol 147 (9), 2825-2832 (1991)
   PUBMED   1717577
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031733.3 and AL359962.15.
            
            On Feb 20, 2020 this sequence version replaced NM_198053.2.
            
            Summary: The protein encoded by this gene is T-cell receptor zeta,
            which together with T-cell receptor alpha/beta and gamma/delta
            heterodimers, and with CD3-gamma, -delta and -epsilon, forms the
            T-cell receptor-CD3 complex. The zeta chain plays an important role
            in coupling antigen recognition to several intracellular
            signal-transduction pathways. Low expression of the antigen results
            in impaired immune response. Two alternatively spliced transcript
            variants encoding distinct isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025703.1, BP367042.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362089.10/ ENSP00000354782.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AL031733.3         180669-180790
            123-226             AL359962.15        22501-22604         c
            227-283             AL359962.15        21181-21237         c
            284-364             AL359962.15        20407-20487         c
            365-400             AL359962.15        17236-17271         c
            401-457             AL359962.15        15857-15913         c
            458-493             AL359962.15        14861-14896         c
            494-1600            AL359962.15        12477-13583         c
FEATURES             Location/Qualifiers
     source          1..1600
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..1600
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /note="CD247 molecule"
                     /db_xref="GeneID:919"
                     /db_xref="HGNC:HGNC:1677"
                     /db_xref="MIM:186780"
     exon            1..122
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..559
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD3Z antigen, zeta polypeptide (TiT3 complex);
                     T-cell surface glycoprotein CD3 zeta chain; T-cell antigen
                     receptor complex, zeta subunit of CD3; T-cell receptor T3
                     zeta chain; CD247 antigen, zeta subunit; TCR zeta chain;
                     CD3zeta chain; tissue factor-targeting CAR1 monomer;
                     tissue factor-targeting CAR1 dimer"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD3 zeta chain
                     isoform 1 precursor"
                     /protein_id="NP_932170.1"
                     /db_xref="CCDS:CCDS1261.1"
                     /db_xref="GeneID:919"
                     /db_xref="HGNC:HGNC:1677"
                     /db_xref="MIM:186780"
                     /translation="MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGV
                     ILTALFLRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQR
                     RKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQA
                     LPPR"
     exon            123..226
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            227..283
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            284..364
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            365..400
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            401..457
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            458..493
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            494..1600
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1577..1582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /note="hexamer: AATAAA"
     polyA_site      1600
                     /gene="CD247"
                     /gene_synonym="CD3-ZETA; CD3H; CD3Q; CD3Z; CD3ZETA; IMD25;
                     T3Z; TCRZ"
                     /note="major polyA site"
ORIGIN      
        1 aaccgtcccg gccaccgctg cctcagcctc tgcctcccag cctctttctg agggaaagga
       61 caagatgaag tggaaggcgc ttttcaccgc ggccatcctg caggcacagt tgccgattac
      121 agaggcacag agctttggcc tgctggatcc caaactctgc tacctgctgg atggaatcct
      181 cttcatctat ggtgtcattc tcactgcctt gttcctgaga gtgaagttca gcaggagcgc
      241 agacgccccc gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg
      301 aagagaggag tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa
      361 gccgcagaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat
      421 ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga
      481 tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca
      541 ggccctgccc cctcgctaac agccagggga tttcaccact caaaggccag acctgcagac
      601 gcccagatta tgagacacag gatgaagcat ttacaacccg gttcactctt ctcagccact
      661 gaagtattcc cctttatgta caggatgctt tggttatatt tagctccaaa ccttcacaca
      721 cagactgttg tccctgcact ctttaaggga gtgtactccc agggcttacg gccctggcct
      781 tgggccctct ggtttgccgg tggtgcaggt agacctgtct cctggcggtt cctcgttctc
      841 cctgggaggc gggcgcactg cctctcacag ctgagttgtt gagtctgttt tgtaaagtcc
      901 ccagagaaag cgcagatgct agcacatgcc ctaatgtctg tatcactctg tgtctgagtg
      961 gcttcactcc tgctgtaaat ttggcttctg ttgtcacctt cacctccttt caaggtaact
     1021 gtactgggcc atgttgtgcc tccctggtga gagggccggg cagaggggca gatggaaagg
     1081 agcctaggcc aggtgcaacc agggagctgc aggggcatgg gaaggtgggc gggcagggga
     1141 gggtcagcca gggcctgcga gggcagcggg agcctccctg cctcaggcct ctgtgccgca
     1201 ccattgaact gtaccatgtg ctacaggggc cagaagatga acagactgac cttgatgagc
     1261 tgtgcacaaa gtggcataaa aaacatgtgg ttacacagtg tgaataaagt gctgcggagc
     1321 aagaggaggc cgttgattca cttcacgctt tcagcgaatg acaaaatcat ctttgtgaag
     1381 gcctcgcagg aagacccaac acatgggacc tataactgcc cagcggacag tggcaggaca
     1441 ggaaaaaccc gtcaatgtac taggatactg ctgcgtcatt acagggcaca ggccatggat
     1501 ggaaaacgct ctctactctg ctttttttct actgttttaa tttatactgg catgctaaag
     1561 ccttcctatt ttgcataata aatgcttcag tgaaaatgca
//
