LOCUS       NM_016382               2495 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens CD244 molecule (CD244), transcript variant 1, mRNA.
ACCESSION   NM_016382
VERSION     NM_016382.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Mou,J., Xie,L., Xu,Y., Zhou,T., Liu,Y., Huang,Q., Tang,K., Tian,Z.,
            Xing,H., Qiu,S., Rao,Q., Wang,M. and Wang,J.
  TITLE     2B4 inhibits the apoptosis of natural killer cells through
            phosphorylated extracellular signal-related kinase/B-cell lymphoma
            2 signal pathway
  JOURNAL   Cytotherapy 25 (10), 1080-1090 (2023)
   PUBMED   37516949
  REMARK    GeneRIF: 2B4 inhibits the apoptosis of natural killer cells through
            phosphorylated extracellular signal-related kinase/B-cell lymphoma
            2 signal pathway.
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Mohammadi,M., Asgarian-Omran,H., Najafi,A., Valadan,R., Karami,H.,
            Naderisoraki,M., Zaboli,E., Eslami,M. and Tehrani,M.
  TITLE     Evaluation of mRNA Expression of CD244 and Its Adapter Molecules in
            CD8+ T Cells in Acute Leukemia
  JOURNAL   Iran Biomed J 27 (4), 214-218 (2023)
   PUBMED   37634081
  REMARK    GeneRIF: Evaluation of mRNA Expression of CD244 and Its Adapter
            Molecules in CD8+ T Cells in Acute Leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2495)
  AUTHORS   Guo,Y., Feng,Y., Fan,P., Yao,X., Peng,Y., Wang,R. and Kuerban,G.
  TITLE     Expression and Clinical Significance of KLRG1 and 2B4 on T Cells in
            the Peripheral Blood and Tumour of Patients with Cervical Cancer
  JOURNAL   Immunol Invest 51 (3), 670-687 (2022)
   PUBMED   33401997
  REMARK    GeneRIF: Expression and Clinical Significance of KLRG1 and 2B4 on T
            Cells in the Peripheral Blood and Tumour of Patients with Cervical
            Cancer.
REFERENCE   4  (bases 1 to 2495)
  AUTHORS   Huang,S., Liang,C., Zhao,Y., Deng,T., Tan,J., Lu,Y., Liu,S., Li,Y.
            and Chen,S.
  TITLE     Increased TOX expression concurrent with PD-1, Tim-3, and CD244 in
            T cells from patients with non-Hodgkin lymphoma
  JOURNAL   Asia Pac J Clin Oncol 18 (1), 143-149 (2022)
   PUBMED   33608984
  REMARK    GeneRIF: Increased TOX expression concurrent with PD-1, Tim-3, and
            CD244 in T cells from patients with non-Hodgkin lymphoma.
REFERENCE   5  (bases 1 to 2495)
  AUTHORS   Wu,X., Sharma,A., Oldenburg,J., Weiher,H., Essler,M., Skowasch,D.
            and Schmidt-Wolf,I.G.H.
  TITLE     NKG2D Engagement Alone Is Sufficient to Activate Cytokine-Induced
            Killer Cells While 2B4 Only Provides Limited Coactivation
  JOURNAL   Front Immunol 12, 731767 (2021)
   PUBMED   34691037
  REMARK    GeneRIF: NKG2D Engagement Alone Is Sufficient to Activate
            Cytokine-Induced Killer Cells While 2B4 Only Provides Limited
            Coactivation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2495)
  AUTHORS   Tangye,S.G., Lazetic,S., Woollatt,E., Sutherland,G.R., Lanier,L.L.
            and Phillips,J.H.
  TITLE     Cutting edge: human 2B4, an activating NK cell receptor, recruits
            the protein tyrosine phosphatase SHP-2 and the adaptor signaling
            protein SAP
  JOURNAL   J Immunol 162 (12), 6981-6985 (1999)
   PUBMED   10358138
REFERENCE   7  (bases 1 to 2495)
  AUTHORS   Brown,M.H., Boles,K., van der Merwe,P.A., Kumar,V., Mathew,P.A. and
            Barclay,A.N.
  TITLE     2B4, the natural killer and T cell immunoglobulin superfamily
            surface protein, is a ligand for CD48
  JOURNAL   J Exp Med 188 (11), 2083-2090 (1998)
   PUBMED   9841922
REFERENCE   8  (bases 1 to 2495)
  AUTHORS   Latchman,Y., McKay,P.F. and Reiser,H.
  TITLE     Identification of the 2B4 molecule as a counter-receptor for CD48
  JOURNAL   J Immunol 161 (11), 5809-5812 (1998)
   PUBMED   9834056
REFERENCE   9  (bases 1 to 2495)
  AUTHORS   Valiante,N.M. and Trinchieri,G.
  TITLE     Identification of a novel signal transduction surface molecule on
            human cytotoxic lymphocytes
  JOURNAL   J Exp Med 178 (4), 1397-1406 (1993)
   PUBMED   8376943
REFERENCE   10 (bases 1 to 2495)
  AUTHORS   Siu,G., Strauss,E.C., Lai,E. and Hood,L.E.
  TITLE     Analysis of a human V beta gene subfamily
  JOURNAL   J Exp Med 164 (5), 1600-1614 (1986)
   PUBMED   3772297
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC028073.1 and BC041607.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016382.3.
            
            Summary: This gene encodes a cell surface receptor expressed on
            natural killer (NK) cells (and some T cells) that mediate non-major
            histocompatibility complex (MHC) restricted killing. The
            interaction between NK-cell and target cells via this receptor is
            thought to modulate NK-cell cytolytic activity. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene.[provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041607.1, BC028073.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368034.9/ ENSP00000357013.4
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2447              BC028073.1         16-2462
            2448-2495           BC041607.1         2265-2312
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2495
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /note="CD244 molecule"
                     /db_xref="GeneID:51744"
                     /db_xref="HGNC:HGNC:18171"
                     /db_xref="MIM:605554"
     exon            1..271
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1308
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; NK cell activation inducing ligand NAIL; h2B4;
                     NK cell activation-inducing ligand; NK cell type I
                     receptor protein 2B4; SLAM family member 4; signaling
                     lymphocytic activation molecule 4; CD244 molecule, natural
                     killer cell receptor 2B4"
                     /codon_start=1
                     /product="natural killer cell receptor 2B4 isoform 1
                     precursor"
                     /protein_id="NP_057466.1"
                     /db_xref="CCDS:CCDS1210.1"
                     /db_xref="GeneID:51744"
                     /db_xref="HGNC:HGNC:18171"
                     /db_xref="MIM:605554"
                     /translation="MLGQVVTLILLLLLKVYQGKGCQGSADHVVSISGVPLQLQPNSI
                     QTKVDSIAWKKLLPSQNGFHHILKWENGSLPSNTSNDRFSFIVKNLSLLIKAAQQQDS
                     GLYCLEVTSISGKVQTATFQVFVFDKVEKPRLQGQGKILDRGRCQVALSCLVSRDGNV
                     SYAWYRGSKLIQTAGNLTYLDEEVDINGTHTYTCNVSNPVSWESHTLNLTQDCQNAHQ
                     EFRFWPFLVIIVILSALFLGTLACFCVWRRKRKEKQSETSPKEFLTIYEDVKDLKTRR
                     NHEQEQTFPGGGSTIYSMIQSQSSAPTSQEPAYTLYSLIQPSRKSGSRKRNHSPSFNS
                     TIYEVIGKSQPKAQNPARLSRKELENFDVYS"
     exon            272..589
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            590..865
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            866..976
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1044
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1104
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1170
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1227
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..2495
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2473..2478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /note="hexamer: ATTAAA"
     polyA_site      2495
                     /gene="CD244"
                     /gene_synonym="2B4; NAIL; NKR2B4; Nmrk; SLAMF4"
                     /note="major polyA site"
ORIGIN      
        1 agaccagctc caggcgctgg ggctttctca gtggccttgt cagctcacag caggcgttaa
       61 cagcctctaa ttgaggaaac tgtggctgga caggttgcaa ggcagttctg ctccccatcg
      121 tcctcttgct gactggggac tgctgagccc gtgcacggca gagagtctgg tggggtggag
      181 gggctggcct ggcccctctg tcctgtggaa atgctggggc aagtggtcac cctcatactc
      241 ctcctgctcc tcaaggtgta tcagggcaaa ggatgccagg gatcagctga ccatgtggtt
      301 agcatctcgg gagtgcctct tcagttacaa ccaaacagca tacagacgaa ggttgacagc
      361 attgcatgga agaagttgct gccctcacaa aatggatttc atcacatatt gaagtgggag
      421 aatggctctt tgccttccaa tacttccaat gatagattca gttttatagt caagaacttg
      481 agtcttctca tcaaggcagc tcagcagcag gacagtggcc tctactgcct ggaggtcacc
      541 agtatatctg gaaaagttca gacagccacg ttccaggttt ttgtatttga taaagttgag
      601 aaaccccgcc tacaggggca ggggaagatc ctggacagag ggagatgcca agtggctctg
      661 tcttgcttgg tctccaggga tggcaatgtg tcctatgctt ggtacagagg gagcaagctg
      721 atccagacag cagggaacct cacctacctg gacgaggagg ttgacattaa tggcactcac
      781 acatatacct gcaatgtcag caatcctgtt agctgggaaa gccacaccct gaatctcact
      841 caggactgtc agaatgccca tcaggaattc agattttggc cgtttttggt gatcatcgtg
      901 attctaagcg cactgttcct tggcaccctt gcctgcttct gtgtgtggag gagaaagagg
      961 aaggagaagc agtcagagac cagtcccaag gaatttttga caatttacga agatgtcaag
     1021 gatctgaaaa ccaggagaaa tcacgagcag gagcagactt ttcctggagg ggggagcacc
     1081 atctactcta tgatccagtc ccagtcttct gctcccacgt cacaagaacc tgcatataca
     1141 ttatattcat taattcagcc ttccaggaag tctggatcca ggaagaggaa ccacagccct
     1201 tccttcaata gcactatcta tgaagtgatt ggaaagagtc aacctaaagc ccagaaccct
     1261 gctcgattga gccgcaaaga gctggagaac tttgatgttt attcctagtt gctgcagcaa
     1321 ttctcacctt tcttgcacat cagcatctgc tttgggaatt ggcacagtgg atgacggcac
     1381 aggagtctct atagaacagt tcctagtctg gagaggatat ggaaatttgt tcttgttcta
     1441 tattttgttt tgaaaatgat gtctaacaac catgataaga gcaaggctgt taaataatat
     1501 cttccaattt acagatcaga catgaatggg tggaggggtt aggttgttca caaaaggcca
     1561 cattccaagt atttgtaatc tagaaagtgt tatgtaagtg atgttattag catcgagatt
     1621 ccctccacct gattttcaag ctgtcacttg tttccttttc tcccctctct gggttgactg
     1681 catttctaga ctctcgccgg cccaggccca tcttccaaag caagaggaag gaatgataat
     1741 ggtgactcag gggaagaaga aacagccctc ctctgaaagc ctggactgtc cggctgtgaa
     1801 ctggctggca ggttctgcac gtgggtgggg gccagggcct gggctttact caattgcaga
     1861 gaaaaaactt tctccctgca tctcatacct ttacctctgg ccagttggcc accaggggga
     1921 gtgggctgaa gggagagtag atggtgcaaa gcaagcccat ctctaagtag aaaaatcacc
     1981 cagagcacat gctgacctga taactggggt gttgagacca gctttgtcca tggtatgatg
     2041 tttgatttat gaagacgcat tgttagaaat ccatttggct tcttcataga agtggcttcc
     2101 cagaggaaga ggcctctcag aaaccatgtt ctatttaagt tctgagtcct gatgagtgtt
     2161 ccccaggatg cacattgaag ggagggctca ggcagctgag ggctgagaat gaggcagttg
     2221 gaatctagac actatgctgg gttccctgag tcgtcaggcc agacatttca acaaggctgt
     2281 ggggagcagg gctgtgactc tggctgagcc caggaaagcg acaagggtga actgggagag
     2341 gacttactca gagaccccaa caggtgatac tgcacaaagc ctggttcttc aattttccta
     2401 ccctgtatct aacataggag tttcatataa aacggtgata tcatgcagat gcagtctgaa
     2461 ttccttgcct gaattaaatt tatgtatcct ctcca
//
