LOCUS       NM_001359084            2156 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens CD24 molecule (CD24), transcript variant 7, mRNA.
ACCESSION   NM_001359084
VERSION     NM_001359084.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2156)
  AUTHORS   Hong,P., Xu,T., Xu,J., Chen,W., Hu,H., Chen,J., Li,L., Zheng,C.,
            Li,B., Liu,J., Dai,W., Li,E., Zhang,F. and Xu,W.
  TITLE     CD24 promotes metastasis and chemoresistance by directly targeting
            Arf6-ERK pathway in esophageal squamous cell carcinoma
  JOURNAL   Cancer Lett 594, 216994 (2024)
   PUBMED   38801885
  REMARK    GeneRIF: CD24 promotes metastasis and chemoresistance by directly
            targeting Arf6-ERK pathway in esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 2156)
  AUTHORS   Yaghjyan,L., Heng,Y.J., Baker,G.M., Murthy,D., Mahoney,M.B.,
            Rosner,B. and Tamimi,R.M.
  TITLE     Associations of stem cell markers CD44, CD24 and ALDH1A1 with
            mammographic breast density in women with benign breast biopsies
  JOURNAL   Br J Cancer 131 (2), 325-333 (2024)
   PUBMED   38849477
  REMARK    GeneRIF: Associations of stem cell markers CD44, CD24 and ALDH1A1
            with mammographic breast density in women with benign breast
            biopsies.
REFERENCE   3  (bases 1 to 2156)
  AUTHORS   Grigoropoulos,I., Tsioulos,G., Kastrissianakis,A., Shapira,S.,
            Green,O., Rapti,V., Tsakona,M., Konstantinos,T., Savva,A.,
            Kavatha,D., Boumpas,D., Syrigos,K., Xynogalas,I., Leontis,K.,
            Ntousopoulos,V., Sakka,V., Sardelis,Z., Fotiadis,A., Vlassi,L.,
            Kontogianni,C., Levounets,A., Poulakou,G., Gaga,M., MacLoughlin,R.,
            Stebbing,J., Arber,N., Antoniadou,A. and Tsiodras,S.
  TITLE     The safety and potential efficacy of exosomes overexpressing CD24
            (EXO-CD24) in mild-moderate COVID-19 related ARDS
  JOURNAL   Respir Res 25 (1), 151 (2024)
   PUBMED   38561798
  REMARK    GeneRIF: The safety and potential efficacy of exosomes
            overexpressing CD24 (EXO-CD24) in mild-moderate COVID-19 related
            ARDS.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2156)
  AUTHORS   Thomas,S., Harding,M.A., Smith,S.C., Overdevest,J.B., Nitz,M.D.,
            Frierson,H.F., Tomlins,S.A., Kristiansen,G. and Theodorescu,D.
  TITLE     CD24 is an effector of HIF-1-driven primary tumor growth and
            metastasis
  JOURNAL   Cancer Res 72 (21), 5600-5612 (2012)
   PUBMED   22926560
  REMARK    GeneRIF: Our results establish a mechanistic linkage between 2
            critically important molecules in cancer, identifying CD24 as a
            critical HIF-1alpha transcriptional target and biologic effector
REFERENCE   5  (bases 1 to 2156)
  AUTHORS   Huang,L.R. and Hsu,H.C.
  TITLE     Cloning and expression of CD24 gene in human hepatocellular
            carcinoma: a potential early tumor marker gene correlates with p53
            mutation and tumor differentiation
  JOURNAL   Cancer Res 55 (20), 4717-4721 (1995)
   PUBMED   7553654
REFERENCE   6  (bases 1 to 2156)
  AUTHORS   Zarn,J.A., Jackson,D.G., Bell,M.V., Jones,T., Weber,E., Sheer,D.,
            Waibel,R. and Stahel,R.A.
  TITLE     The small cell lung cancer antigen cluster-4 and the leukocyte
            antigen CD24 are allelic isoforms of the same gene (CD24) on
            chromosome band 6q21
  JOURNAL   Cytogenet Cell Genet 70 (1-2), 119-125 (1995)
   PUBMED   7736776
REFERENCE   7  (bases 1 to 2156)
  AUTHORS   Hough,M.R., Rosten,P.M., Sexton,T.L., Kay,R. and Humphries,R.K.
  TITLE     Mapping of CD24 and homologous sequences to multiple chromosomal
            loci
  JOURNAL   Genomics 22 (1), 154-161 (1994)
   PUBMED   7959762
REFERENCE   8  (bases 1 to 2156)
  AUTHORS   Jackson,D., Waibel,R., Weber,E., Bell,J. and Stahel,R.A.
  TITLE     CD24, a signal-transducing molecule expressed on human B cells, is
            a major surface antigen on small cell lung carcinomas
  JOURNAL   Cancer Res 52 (19), 5264-5270 (1992)
   PUBMED   1327504
REFERENCE   9  (bases 1 to 2156)
  AUTHORS   Kay,R., Rosten,P.M. and Humphries,R.K.
  TITLE     CD24, a signal transducer modulating B cell activation responses,
            is a very short peptide with a glycosyl phosphatidylinositol
            membrane anchor
  JOURNAL   J Immunol 147 (4), 1412-1416 (1991)
   PUBMED   1831224
REFERENCE   10 (bases 1 to 2156)
  AUTHORS   Fischer,G.F., Majdic,O., Gadd,S. and Knapp,W.
  TITLE     Signal transduction in lymphocytic and myeloid cells via CD24, a
            new member of phosphoinositol-anchored membrane molecules
  JOURNAL   J Immunol 144 (2), 638-641 (1990)
   PUBMED   2153173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA521039.1, AK026603.1 and
            FP885534.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a sialoglycoprotein that is expressed on
            mature granulocytes and B cells and modulates growth and
            differentiation signals to these cells. The precursor protein is
            cleaved to a short 32 amino acid mature peptide which is anchored
            via a glycosyl phosphatidylinositol (GPI) link to the cell surface.
            This gene was missing from previous genome assemblies, but is
            properly located on chromosome 6. Non-transcribed pseudogenes have
            been designated on chromosomes 1, 15, 20, and Y. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Apr 2014].
            
            Transcript Variant: This variant (7) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, 3 and 7 encode isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026603.1, SRR1803616.67025.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000606017.2/ ENSP00000475625.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               DA521039.1         50-567
            519-1265            AK026603.1         525-1271
            1266-1624           FP885534.9         28100-28458         c
            1625-2156           AK026603.1         1631-2162
FEATURES             Location/Qualifiers
     source          1..2156
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..2156
                     /gene="CD24"
                     /gene_synonym="CD24A"
                     /note="CD24 molecule"
                     /db_xref="GeneID:100133941"
                     /db_xref="HGNC:HGNC:1645"
                     /db_xref="MIM:600074"
     exon            1..152
                     /gene="CD24"
                     /gene_synonym="CD24A"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..326
                     /gene="CD24"
                     /gene_synonym="CD24A"
                     /note="isoform a preproprotein is encoded by transcript
                     variant 7; CD24 antigen (small cell lung carcinoma cluster
                     4 antigen); signal transducer CD24"
                     /codon_start=1
                     /product="signal transducer CD24 isoform a preproprotein"
                     /protein_id="NP_001346013.1"
                     /db_xref="CCDS:CCDS75499.1"
                     /db_xref="GeneID:100133941"
                     /db_xref="HGNC:HGNC:1645"
                     /db_xref="MIM:600074"
                     /translation="MGRAMVARLGLGLLLLALLLPTQIYSSETTTGTSSNSSQSTSNS
                     GLAPNPTNATTKAAGGALQSTASLFVVSLSLLHLYS"
     exon            153..2156
                     /gene="CD24"
                     /gene_synonym="CD24A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      664..669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD24"
                     /gene_synonym="CD24A"
                     /note="hexamer: AATAAA"
     polyA_site      689
                     /gene="CD24"
                     /gene_synonym="CD24A"
                     /note="major polyA site"
     regulatory      2136..2141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD24"
                     /gene_synonym="CD24A"
                     /note="hexamer: AAGAAA"
     polyA_site      2156
                     /gene="CD24"
                     /gene_synonym="CD24A"
                     /note="major polyA site"
ORIGIN      
        1 accttgcctg cgcccgcccg gagccagcgg ttctccaagc acccagcatc ctgctagacg
       61 cgccgcgcac cgacggaggg gacatgggca gagcaatggt ggccaggctc gggctggggc
      121 tgctgctgct ggcactgctc ctacccacgc agatttattc cagtgaaaca acaactggaa
      181 cttcaagtaa ctcctcccag agtacttcca actctgggtt ggccccaaat ccaactaatg
      241 ccaccaccaa ggcggctggt ggtgccctgc agtcaacagc cagtctcttc gtggtctcac
      301 tctctcttct gcatctctac tcttaagaga ctcaggccaa gaaacgtctt ctaaatttcc
      361 ccatcttcta aacccaatcc aaatggcgtc tggaagtcca atgtggcaag gaaaaacagg
      421 tcttcatcga atctactaat tccacacctt ttattgacac agaaaatgtt gagaatccca
      481 aatttgattg atttgaagaa catgtgagag gtttgactag atgatggatg ccaatattaa
      541 atctgctgga gtttcatgta caagatgaag gagaggcaac atccaaaata gttaagacat
      601 gatttccttg aatgtggctt gagaaatatg gacacttaat actaccttga aaataagaat
      661 agaaataaag gatgggattg tggaatggag attcagtttt catttggttc attaattcta
      721 taaggccata aaacaggtaa tataaaaagc ttccatgatt ctatttatat gtacatgaga
      781 aggaacttcc aggtgttact gtaattcctc aacgtattgt ttcgacagca ctaatttaat
      841 gccgatatac tctagatgaa gttttacatt gttgagctat tgctgttctc ttgggaactg
      901 aactcacttt cctcctgagg ctttggattt gacattgcat ttgacctttt atgtagtaat
      961 tgacatgtgc cagggcaatg atgaatgaga atctaccccc agatccaagc atcctgagca
     1021 actcttgatt atccatattg agtcaaatgg taggcatttc ctatcacctg tttccattca
     1081 acaagagcac tacattcatt tagctaaacg gattccaaag agtagaattg cattgaccac
     1141 gactaatttc aaaatgcttt ttattattat tattttttag acagtctcac tttgtcgccc
     1201 aggccggagt gcagtggtgc gatctcagat cagtgtacca tttgcctccc gggctcaagc
     1261 gattctcctg cctcagcctc ccaagtagct gggattacag gcacctgcca ccatgcccgg
     1321 ctaatttttg taattttagt agagacaggg tttcaccatg ttgcccaggc tggtttcgaa
     1381 ctcctgacct caggtgatcc acccgcctcg gcctcccaaa gtgctgggat tacaggcttg
     1441 agcccccgcg cccagccatc aaaatgcttt ttatttctgc atatgttgaa tactttttac
     1501 aatttaaaaa aatgatctgt tttgaaggca aaattgcaaa tcttgaaatt aagaaggcaa
     1561 aaatgtaaag gagtcaaaac tataaatcaa gtatttggga agtgaagact ggaagctaat
     1621 ttgcattaaa ttcacaaact tttatactct ttctgtatat acattttttt tctttaaaaa
     1681 acaactatgg atcagaatag ccacatttag aacacttttt gttatcagtc aatattttta
     1741 gatagttaga acctggtcct aagcctaaaa gtgggcttga ttctgcagta aatcttttac
     1801 aactgcctcg acacacataa acctttttaa aaatagacac tccccgaagt cttttgttcg
     1861 catggtcaca cactgatgct tagatgttcc agtaatctaa tatggccaca gtagtcttga
     1921 tgaccaaagt cctttttttc catctttaga aaactacatg ggaacaaaca gatcgaacag
     1981 ttttgaagct actgtgtgtg tgaatgaaca ctcttgcttt attccagaat gctgtacatc
     2041 tattttggat tgtatattgt gtttgtgtat ttacgctttg attcatagta acttcttatg
     2101 gaattgattt gcattgaaca caaactgtaa ataaaaagaa atggctgaaa gagcaa
//
