LOCUS       NM_001771               3274 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens CD22 molecule (CD22), transcript variant 1, mRNA.
ACCESSION   NM_001771
VERSION     NM_001771.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3274)
  AUTHORS   Okuzono,Y., Miyakawa,S., Itou,T., Sagara,M., Iwata,M.,
            Ishizuchi,K., Sekiguchi,K., Motegi,H., Oyama,M., Warude,D.,
            Kikukawa,Y. and Suzuki,S.
  TITLE     B-cell immune dysregulation with low soluble CD22 levels in
            refractory seronegative myasthenia gravis
  JOURNAL   Front Immunol 15, 1382320 (2024)
   PUBMED   38711503
  REMARK    GeneRIF: B-cell immune dysregulation with low soluble CD22 levels
            in refractory seronegative myasthenia gravis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3274)
  AUTHORS   Aminov,S., Giricz,O., Melnekoff,D.T., Sica,R.A., Polishchuk,V.,
            Papazoglu,C., Yates,B., Wang,H.W., Sahu,S., Wang,Y.,
            Gordon-Mitchell,S., Leshchenko,V.V., Schinke,C., Pradhan,K.,
            Aluri,S., Sohn,M., Barta,S.K., Agarwal,B., Goldfinger,M.,
            Mantzaris,I., Shastri,A., Matsui,W., Steidl,U., Brody,J.D.,
            Shah,N.N., Parekh,S. and Verma,A.
  TITLE     Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit
            reduced CD19 and CD22 expression and BTK pathway dependency
  JOURNAL   J Clin Invest 134 (8), e175199 (2024)
   PUBMED   38376944
  REMARK    GeneRIF: Immunotherapy-resistant acute lymphoblastic leukemia cells
            exhibit reduced CD19 and CD22 expression and BTK pathway
            dependency.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3274)
  AUTHORS   Liu,Y., Li,H., Yu,H., Wang,F., Cao,H., Jia,J. and Yan,T.
  TITLE     Deciphering prognostic value of CD22 and its contribution to
            suppression of proinflammatory cytokines production in patients
            with IgA nephropathy
  JOURNAL   Immunol Lett 255, 40-46 (2023)
   PUBMED   36848961
  REMARK    GeneRIF: Deciphering prognostic value of CD22 and its contribution
            to suppression of proinflammatory cytokines production in patients
            with IgA nephropathy.
REFERENCE   4  (bases 1 to 3274)
  AUTHORS   Bu,X.L., Sun,P.Y., Fan,D.Y., Wang,J., Sun,H.L., Cheng,Y.,
            Zeng,G.H., Chen,D.W., Li,H.Y., Yi,X., Shen,Y.Y., Miles,L.A.,
            Maruff,P., Gu,B.J., Fowler,C.J., Masters,C.L. and Wang,Y.J.
  TITLE     Associations of plasma soluble CD22 levels with brain amyloid
            burden and cognitive decline in Alzheimer's disease
  JOURNAL   Sci Adv 8 (13), eabm5667 (2022)
   PUBMED   35363517
  REMARK    GeneRIF: Associations of plasma soluble CD22 levels with brain
            amyloid burden and cognitive decline in Alzheimer's disease.
REFERENCE   5  (bases 1 to 3274)
  AUTHORS   Cordoba,S., Onuoha,S., Thomas,S., Pignataro,D.S., Hough,R.,
            Ghorashian,S., Vora,A., Bonney,D., Veys,P., Rao,K., Lucchini,G.,
            Chiesa,R., Chu,J., Clark,L., Fung,M.M., Smith,K., Peticone,C.,
            Al-Hajj,M., Baldan,V., Ferrari,M., Srivastava,S., Jha,R., Arce
            Vargas,F., Duffy,K., Day,W., Virgo,P., Wheeler,L., Hancock,J.,
            Farzaneh,F., Domning,S., Zhang,Y., Khokhar,N.Z.,
            Peddareddigari,V.G.R., Wynn,R., Pule,M. and Amrolia,P.J.
  TITLE     CAR T cells with dual targeting of CD19 and CD22 in pediatric and
            young adult patients with relapsed or refractory B cell acute
            lymphoblastic leukemia: a phase 1 trial
  JOURNAL   Nat Med 27 (10), 1797-1805 (2021)
   PUBMED   34642489
  REMARK    GeneRIF: CAR T cells with dual targeting of CD19 and CD22 in
            pediatric and young adult patients with relapsed or refractory B
            cell acute lymphoblastic leukemia: a phase 1 trial.
REFERENCE   6  (bases 1 to 3274)
  AUTHORS   Doody,G.M., Justement,L.B., Delibrias,C.C., Matthews,R.J., Lin,J.,
            Thomas,M.L. and Fearon,D.T.
  TITLE     A role in B cell activation for CD22 and the protein tyrosine
            phosphatase SHP
  JOURNAL   Science 269 (5221), 242-244 (1995)
   PUBMED   7618087
REFERENCE   7  (bases 1 to 3274)
  AUTHORS   Sgroi,D., Koretzky,G.A. and Stamenkovic,I.
  TITLE     Regulation of CD45 engagement by the B-cell receptor CD22
  JOURNAL   Proc Natl Acad Sci U S A 92 (9), 4026-4030 (1995)
   PUBMED   7537381
REFERENCE   8  (bases 1 to 3274)
  AUTHORS   Torres,R.M., Law,C.L., Santos-Argumedo,L., Kirkham,P.A.,
            Grabstein,K., Parkhouse,R.M. and Clark,E.A.
  TITLE     Identification and characterization of the murine homologue of
            CD22, a B lymphocyte-restricted adhesion molecule
  JOURNAL   J Immunol 149 (8), 2641-2649 (1992)
   PUBMED   1401903
REFERENCE   9  (bases 1 to 3274)
  AUTHORS   Wilson,G.L., Fox,C.H., Fauci,A.S. and Kehrl,J.H.
  TITLE     cDNA cloning of the B cell membrane protein CD22: a mediator of B-B
            cell interactions
  JOURNAL   J Exp Med 173 (1), 137-146 (1991)
   PUBMED   1985119
REFERENCE   10 (bases 1 to 3274)
  AUTHORS   Stamenkovic,I. and Seed,B.
  TITLE     The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion
  JOURNAL   Nature 345 (6270), 74-77 (1990)
   PUBMED   1691828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK225625.1, AK225694.1, BC109306.1, DB333800.1 and X59350.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001771.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225694.1, X59350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000085219.10/ ENSP00000085219.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1051              AK225625.1         1-1051
            1052-2299           AK225694.1         1052-2299
            2300-2842           BC109306.1         2100-2642
            2843-3253           DB333800.1         20-430              c
            3254-3274           X59350.1           3232-3252
FEATURES             Location/Qualifiers
     source          1..3274
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..3274
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /note="CD22 molecule"
                     /db_xref="GeneID:933"
                     /db_xref="HGNC:HGNC:1643"
                     /db_xref="MIM:107266"
     exon            1..44
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            45..100
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2610
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD22 antigen; B-cell receptor CD22; BL-CAM;
                     T-cell surface antigen Leu-14; B-lymphocyte cell adhesion
                     molecule; sialic acid-binding Ig-like lectin 2"
                     /codon_start=1
                     /product="B-cell receptor CD22 isoform 1 precursor"
                     /protein_id="NP_001762.2"
                     /db_xref="CCDS:CCDS12457.1"
                     /db_xref="GeneID:933"
                     /db_xref="HGNC:HGNC:1643"
                     /db_xref="MIM:107266"
                     /translation="MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPC
                     TYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNC
                     TLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLT
                     CLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVT
                     CQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTT
                     VSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPS
                     TVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAG
                     TYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPS
                     VTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDV
                     RVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDA
                     GSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPV
                     SHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPE
                     TIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRA
                     PLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSA
                     LHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH"
     exon            101..478
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..784
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1051
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1315
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1573
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1837
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2101
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2198
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2274
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2393
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2478
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..3274
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3243..3248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /note="hexamer: AATAAA"
     polyA_site      3274
                     /gene="CD22"
                     /gene_synonym="SIGLEC-2; SIGLEC2"
                     /note="major polyA site"
ORIGIN      
        1 agatgctgcc agggtccctg aagagggaag acacgcggaa acaggcttgc acccagacac
       61 gacaccatgc atctcctcgg cccctggctc ctgctcctgg ttctagaata cttggctttc
      121 tctgactcaa gtaaatgggt ttttgagcac cctgaaaccc tctacgcctg ggagggggcc
      181 tgcgtctgga tcccctgcac ctacagagcc ctagatggtg acctggaaag cttcatcctg
      241 ttccacaatc ctgagtataa caagaacacc tcgaagtttg atgggacaag actctatgaa
      301 agcacaaagg atgggaaggt tccttctgag cagaaaaggg tgcaattcct gggagacaag
      361 aataagaact gcacactgag tatccacccg gtgcacctca atgacagtgg tcagctgggg
      421 ctgaggatgg agtccaagac tgagaaatgg atggaacgaa tacacctcaa tgtctctgaa
      481 aggccttttc cacctcatat ccagctccct ccagaaattc aagagtccca ggaagtcact
      541 ctgacctgct tgctgaattt ctcctgctat gggtatccga tccaattgca gtggctccta
      601 gagggggttc caatgaggca ggctgctgtc acctcgacct ccttgaccat caagtctgtc
      661 ttcacccgga gcgagctcaa gttctcccca cagtggagtc accatgggaa gattgtgacc
      721 tgccagcttc aggatgcaga tgggaagttc ctctccaatg acacggtgca gctgaacgtg
      781 aagcacaccc cgaagttgga gatcaaggtc actcccagtg atgccatagt gagggagggg
      841 gactctgtga ccatgacctg cgaggtcagc agcagcaacc cggagtacac gacggtatcc
      901 tggctcaagg atgggacctc gctgaagaag cagaatacat tcacgctaaa cctgcgcgaa
      961 gtgaccaagg accagagtgg gaagtactgc tgtcaggtct ccaatgacgt gggcccggga
     1021 aggtcggaag aagtgttcct gcaagtgcag tatgccccgg aaccttccac ggttcagatc
     1081 ctccactcac cggctgtgga gggaagtcaa gtcgagtttc tttgcatgtc actggccaat
     1141 cctcttccaa caaattacac gtggtaccac aatgggaaag aaatgcaggg aaggacagag
     1201 gagaaagtcc acatcccaaa gatcctcccc tggcacgctg ggacttattc ctgtgtggca
     1261 gaaaacattc ttggtactgg acagaggggc ccgggagctg agctggatgt ccagtatcct
     1321 cccaagaagg tgaccacagt gattcaaaac cccatgccga ttcgagaagg agacacagtg
     1381 accctttcct gtaactacaa ttccagtaac cccagtgtta cccggtatga atggaaaccc
     1441 catggcgcct gggaggagcc atcgcttggg gtgctgaaga tccaaaacgt tggctgggac
     1501 aacacaacca tcgcctgcgc agcttgtaat agttggtgct cgtgggcctc ccctgtcgcc
     1561 ctgaatgtcc agtatgcccc ccgagacgtg agggtccgga aaatcaagcc cctttccgag
     1621 attcactctg gaaactcggt cagcctccaa tgtgacttct caagcagcca ccccaaagaa
     1681 gtccagttct tctgggagaa aaatggcagg cttctgggga aagaaagcca gctgaatttt
     1741 gactccatct ccccagaaga tgctgggagt tacagctgct gggtgaacaa ctccatagga
     1801 cagacagcgt ccaaggcctg gacacttgaa gtgctgtatg cacccaggag gctgcgtgtg
     1861 tccatgagcc cgggggacca agtgatggag gggaagagtg caaccctgac ctgtgagagc
     1921 gacgccaacc ctcccgtctc ccactacacc tggtttgact ggaataacca aagcctcccc
     1981 taccacagcc agaagctgag attggagccg gtgaaggtcc agcactcggg tgcctactgg
     2041 tgccagggga ccaacagtgt gggcaagggc cgttcgcctc tcagcaccct caccgtctac
     2101 tatagcccgg agaccatcgg caggcgagtg gctgtgggac tcgggtcctg cctcgccatc
     2161 ctcatcctgg caatctgtgg gctcaagctc cagcgacgtt ggaagaggac acagagccag
     2221 caggggcttc aggagaattc cagcggccag agcttctttg tgaggaataa aaaggttaga
     2281 agggcccccc tctctgaagg cccccactcc ctgggatgct acaatccaat gatggaagat
     2341 ggcattagct acaccaccct gcgctttccc gagatgaaca taccacgaac tggagatgca
     2401 gagtcctcag agatgcagag acctcccccg gactgcgatg acacggtcac ttattcagca
     2461 ttgcacaagc gccaagtggg cgactatgag aacgtcattc cagattttcc agaagatgag
     2521 gggattcatt actcagagct gatccagttt ggggtcgggg agcggcctca ggcacaagaa
     2581 aatgtggact atgtgatcct caaacattga cactggatgg gctgcagcag aggcactggg
     2641 ggcagcgggg gccagggaag tccccgagtt tccccagaca ccgccacatg gcttcctcct
     2701 gcgcgcatgt gcgcacacac acacacacac gcacacacac acacacacac tcactgcgga
     2761 gaaccttgtg cctggctcag agccagtctt tttggtgagg gtaaccccaa acctccaaaa
     2821 ctcctgcccc tgttctcttc cactctcctt gctacccaga aatccatcta aatacctgcc
     2881 ctgacatgca cacctccccc tgcccccacc acggccactg gccatctcca cccccagctg
     2941 cttgtgtccc tcctgggatc tgctcgtcat catttttcct tcccttctcc atctctctgg
     3001 ccctctaccc ctgatctgac atccccactc acgaatatta tgcccagttt ctgcctctga
     3061 gggaaagccc agaaaaggac agaaacgaag tagaaagggg cccagtcctg gcctggcttc
     3121 tcctttggaa gtgaggcatt gcacggggag acgtacgtat cagcggcccc ttgactctgg
     3181 ggactccggg tttgagatgg acacactggt gtggattaac ctgccaggga gacagagctc
     3241 acaataaaaa tggctcagat gccacttcaa agaa
//
